Search Results - "SHARMINI RAJANAYAGAM, M. A"

A role for cyclooxygenase in aging-related changes of beta-adrenoceptor-mediated relaxation in rat aortas by Kang, Khong Bee, Rajanayagam, M A Sharmini, van der Zypp, Andrea, Majewski, Henryk

“…beta-Adrenoceptor-mediated vasorelaxation decreases with age in various vascular beds. The present study investigated the roles of cyclooxygenase (COX) on…”
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Effects of chronic systemic administration of basic fibroblast growth factor on collateral development in the canine heart by LAZAROUS, D. F, SCHEINOWITZ, M, UNGER, E. F, SHOU, M, HODGE, E, SHARMINI RAJANAYAGAM, M. A, HUNGSBERGER, S, ROBISON, W. G, STIBER, J. A, CORREA, R, EPSTEIN, S. E

“…Recently we reported that intracoronary administration of basic fibroblast growth factor (bFGF), a potent angiogenic peptide, increases collateral blood flow…”
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Intracoronary basic fibroblast growth factor enhances myocardial collateral perfusion in dogs by Rajanayagam, M.A.Sharmini, Shou, Matie, Thirumurti, Venugopal, Lazarous, Daisy F, Quyyumi, Arshed A, Goncalves, Lino, Stiber, Jonathan, Epstein, Stephen E, Unger, Ellis F

“…OBJECTIVES In preparation for clinical trials of basic fibroblast growth factor (bFGF) to treat ischemic heart disease, we sought to identify a clinically…”
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Inhibition of vascular smooth muscle cell proliferation and neointimal accumulation by adenovirus-mediated gene transfer of cytosine deaminase by HARRELL, R. L, SHARMINI RAJANAYAGAM, M. A, MASHARN DOANES, A, GUZMAN, R. J, HIRSCHOWITZ, E. A, CRYSTAL, R. G, EPSTEIN, S. E, FINKEL, T

“…Restenosis remains a significant problem after balloon angioplasty. Previous studies have demonstrated that recombinant adenoviruses are efficient vectors for…”
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Myogenic reactivity of rat epineurial arterioles: potential role in local vasoregulatory events by Wang, H X, Davis, M J, Rajanayagam, M A, Potocnik, S J, Hill, M A

“…Local control of neural blood flow is considered to reside in innervation of epineurial and endoneurial arterioles rather than in intrinsic autoregulatory…”
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Approaches for introducing peptides into intact and functional arteriolar smooth muscle: manipulation of protein kinase-based signalling by Davis, Michael J, Potocnik, Simon J, Murphy, Timothy V, Bishara, Nour B, Rajanayagam, MA Sharmini, Darby, Ian A, Hill, Michael A

“…Summary 1. An exact understanding of signal transduction pathways within intact and functional arteriolar smooth muscle is made difficult by limited access to…”
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Greater activation of smooth muscle alpha-2 adrenoceptors by epinephrine in distal than in proximal segments of rat tail artery by Rajanayagam, M A, Medgett, I C

“…The effects of selective blockade of alpha-1 and alpha-2 adrenoceptors on the vasoconstrictor responses to epinephrine (EPI) and norepinephrine (NOR) were…”
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Matrix protein glycation impairs agonist-induced intracellular Ca2+ signaling in endothelial cells by Bishara, Nour B., Dunlop, Marjorie E., Murphy, Timothy V., Darby, Ian. A., Sharmini Rajanayagam, M.A., Hill, Michael A.

“…Studies have shown diabetes to be associated with alterations in composition of extracellular matrix and that such proteins modulate signal transduction. The…”
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Effect of basic fibroblast growth factor on myocardial angiogenesis in dogs with mature collateral vessels. Commentary by SHOU, M, THIRUMURTI, V, HIRSCH, D. D, PANTELY, G. A, SHARMINI RAJANAYAGAM, M. A, LAZAROUS, D. F, HODGE, E, STIBER, J. A, PETTIFORD, M, ELLIOTT, E, SHAH, S. M, UNGER, E. F

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Effects of reduced calcium ion concentration and of diltiazem on vasoconstrictor responses to noradrenaline and sympathetic nerve stimulation in rat isolated tail artery by Medgett, Iain C., Rajanayagam, M. A. Sharmini

“…1 In isolated, perfused proximal segments of Sprague‐Dawley rat tail artery, idazoxan (100 nmoll1) displaced the concentration‐response curve to noradrenaline…”
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