Search Results - "SHARMA, Ricky A"

DNA repair pathways as targets for cancer therapy by Helleday, Thomas, Petermann, Eva, Lundin, Cecilia, Hodgson, Ben, Sharma, Ricky A

“…Key Points Several cancer chemotherapy drugs work by producing excessive DNA damage that causes cell death directly or following DNA replication. Survival is…”
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Curcumin: preventive and therapeutic properties in laboratory studies and clinical trials by Strimpakos, Alexios S, Sharma, Ricky A

“…Curcumin is a natural polyphenol used in ancient Asian medicine. Since the first article referring to the use of curcumin to treat human disease was published…”
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Recommendations for Radioembolization of Hepatic Malignancies Using Yttrium-90 Microsphere Brachytherapy: A Consensus Panel Report from the Radioembolization Brachytherapy Oncology Consortium by Kennedy, Andrew, M.D., F.A.C.R.O, Nag, Subir, M.D., F.A.C.R., F.A.C.R.O, Salem, Riad, M.D., M.B.A., F.S.I.R, Murthy, Ravi, M.D., F.A.C.P, McEwan, Alexander J., M.D, Nutting, Charles, D.O, Benson, Al, M.D., F.A.C.P, Espat, Joseph, M.D., M.S., F.A.C.S, Bilbao, Jose Ignacio, M.D, Sharma, Ricky A., M.D., Ph.D, Thomas, James P., M.D., Ph.D, Coldwell, Douglas, M.D., Ph.D

“…Purpose To standardize the indications, techniques, multimodality treatment approaches, and dosimetry to be used for yttrium-90 (Y90) microsphere hepatic…”
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Poly(ADP-Ribose) Polymerase Is Hyperactivated in Homologous Recombination―Defective Cells by GOTTIPATI, Ponnari, VISCHIONI, Barbara, SCHULTZ, Niklas, SOLOMONS, Joyce, BRYANT, Helen E, DJUREINOVIC, Tatjana, ISSAEVA, Natalia, SLEETH, Kate, SHARMA, Ricky A, HELLEDAY, Thomas

“…Poly(ADP-ribose) (PAR) polymerase 1 (PARP1) is activated by DNA single-strand breaks (SSB) or at stalled replication forks to facilitate DNA repair. Inhibitors…”
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Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy by Findlay, John M., Castro-Giner, Francesc, Makino, Seiko, Rayner, Emily, Kartsonaki, Christiana, Cross, William, Kovac, Michal, Ulahannan, Danny, Palles, Claire, Gillies, Richard S., MacGregor, Thomas P., Church, David, Maynard, Nicholas D., Buffa, Francesca, Cazier, Jean-Baptiste, Graham, Trevor A., Wang, Lai-Mun, Sharma, Ricky A., Middleton, Mark, Tomlinson, Ian

“…How chemotherapy affects carcinoma genomes is largely unknown. Here we report whole-exome and deep sequencing of 30 paired oesophageal adenocarcinomas sampled…”
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Imaging oligometastatic cancer before local treatment by Franklin, James M, Dr, Sharma, Ricky A, Prof, Harris, Adrian L, Prof, Gleeson, Fergus V, Prof

“…Summary With the advent of novel treatment strategies to help widen the therapeutic window for patients with oligometastatic cancer, improved biomarkers are…”
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Radioembolization of Liver Metastases From Colorectal Cancer Using Yttrium-90 Microspheres With Concomitant Systemic Oxaliplatin, Fluorouracil, and Leucovorin Chemotherapy by SHARMA, Ricky A, VAN HAZEL, Guy A, MORGAN, Bruno, BERRY, David P, BLANSHARD, Keith, PRICE, David, BOWER, Geoffrey, SHANNON, Jennifer A, GIBBS, Peter, STEWARD, William P

“…Liver metastases represent the principal cause of death in patients with advanced colorectal cancer (CRC). Injection of resin microspheres (SIR…”
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Combination of ablation and embolization for intermediate-sized liver metastases from colorectal cancer: what can we learn from treating primary liver cancer? by Seager, Matthew J, Jakobs, Tobias F, Sharma, Ricky A, Bandula, Steve

“…Colorectal cancer liver metastases (CRLMs) are common. Treating CRLMs with thermal ablation can prolong survival, but compared to lesions smaller than 3 cm,…”
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Consumption of the Putative Chemopreventive Agent Curcumin by Cancer Patients: Assessment of Curcumin Levels in the Colorectum and their Pharmacodynamic Consequences by GARCEA, Giuseppe, BERRY, David P, JONES, Donald J. L, SINGH, Raj, DENNISON, Ashley R, FARMER, Peter B, SHARMA, Ricky A, STEWARD, William P, GESCHER, Andreas J

“…Curcumin, a constituent of the spice turmeric, has been shown to reduce the adenoma burden in rodent models of colorectal cancer accompanied by a reduction of…”
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Lung Organotypic Slices Enable Rapid Quantification of Acute Radiotherapy Induced Toxicity by Dubail, Maxime, Heinrich, Sophie, Portier, Lucie, Bastian, Jessica, Giuliano, Lucia, Aggar, Lilia, Berthault, Nathalie, Londoño-Vallejo, José-Arturo, Vilalta, Marta, Boivin, Gael, Sharma, Ricky A., Dutreix, Marie, Fouillade, Charles

“…To rapidly assess healthy tissue toxicities induced by new anti-cancer therapies (i.e., radiation alone or in combination with drugs), there is a critical need…”
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Pharmacodynamic and Pharmacokinetic Study of Oral Curcuma Extract in Patients with Colorectal Cancer by SHARMA, Ricky A, MCLELLAND, Heather R, HILL, Kirsti A, IRESON, Christopher R, EUDEN, Stephanie A, MANSON, Margaret M, PIRMOHAMED, Munir, MARNETT, Lawrence J, GESCHER, Andreas J, STEWARD, William P

“…Curcuma spp. extracts, particularly the dietary polyphenol curcumin, prevent colon cancer in rodents. In view of the sparse information on the pharmacodynamics…”
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Identification of anticancer drugs to radiosensitise BRAF -wild-type and mutant colorectal cancer by Carter, Rebecca, Cheraghchi-Bashi, Azadeh, Westhorpe, Adam, Yu, Sheng, Shanneik, Yasmin, Seraia, Elena, Ouaret, Djamila, Inoue, Yasuhiro, Koch, Catherine, Wilding, Jenny, Ebner, Daniel, Ryan, Anderson J, Buffa, Francesca M, Sharma, Ricky A

“…Patients with -mutant colorectal cancer (CRC) have a poor prognosis. Molecular status is not currently used to select which drug to use in combination with…”
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Challenges and Opportunities With the Use of Hypofractionated Radiation Therapy in Cancer Care: Regional Perspectives From South Korea, Japan, Singapore, and Australia by Akimoto, Tetsuo, Aoyama, Hidefumi, Chua, Melvin L.K., Jayamanne, Dasantha, Mizowaki, Takashi, Morris, Lucinda, Onishi, Hiroshi, Song, Si Yeol, Zeidan, Youssef H., Sharma, Ricky A.

“…Hypofractionated radiotherapy schedules provide higher per-fraction radiation doses delivered in fewer fractions than conventional schedules. This novel…”
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Oxaliplatin as a radiosensitiser for upper and lower gastrointestinal tract malignancies: What have we learned from a decade of translational research? by Hill, Esme J, Nicolay, Nils H, Middleton, Mark R, Sharma, Ricky A

“…Highlights ► Some of the greatest advances in the treatment of solid malignancies have resulted from the combination of chemotherapy and radiotherapy. ►…”
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How rapid advances in imaging are defining the future of precision radiation oncology by Beaton, Laura, Bandula, Steve, Gaze, Mark N., Sharma, Ricky A.

“…Imaging has an essential role in the planning and delivery of radiotherapy. Recent advances in imaging have led to the development of advanced radiotherapy…”
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XPF protein levels determine sensitivity of malignant melanoma cells to oxaliplatin chemotherapy: Suitability as a biomarker for patient selection by Hatch, Stephanie B., Swift, Lonnie P., Caporali, Simona, Carter, Rebecca, Hill, Esme J., MacGregor, Thomas P., D'Atri, Stefania, Middleton, Mark R., McHugh, Peter J., Sharma, Ricky A.

“…As the options for systemic treatment of malignant melanoma (MM) increase, the need to develop biomarkers to identify patients who might benefit from cytotoxic…”
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Biological Relevance of Adduct Detection to the Chemoprevention of Cancer by SHARMA, Ricky A, FARMER, Peter B

“…Adducts arise from the chemical modification of bases in DNA or amino acids in proteins by toxic chemicals. Many chemicals known to be carcinogenic in humans…”
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Chemopreventive Efficacy and Pharmacokinetics of Curcumin in the Min/+ Mouse, a Model of Familial Adenomatous Polyposis by PERKINS, Sarah, VERSCHOYLE, Richard D, HILL, Kirsti, PARVEEN, Ifat, THREADGILL, Michael D, SHARMA, Ricky A, WILLIAMS, Marion L, STEWARD, William P, GESCHER, Andreas J

“…Curcumin, the major yellow pigment in turmeric, prevents the development of adenomas in the intestinal tract of the C57Bl/6J Min/+ mouse, a model of human…”
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FLASH Proton Pencil Beam Scanning Irradiation Minimizes Radiation-Induced Leg Contracture and Skin Toxicity in Mice by Cunningham, Shannon, McCauley, Shelby, Vairamani, Kanimozhi, Speth, Joseph, Girdhani, Swati, Abel, Eric, Sharma, Ricky A, Perentesis, John P, Wells, Susanne I, Mascia, Anthony, Sertorio, Mathieu

“…Ultra-high dose rate radiation has been reported to produce a more favorable toxicity and tumor control profile compared to conventional dose rates that are…”
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Impact of Multiple Beams on the FLASH Effect in Soft Tissue and Skin in Mice by Mascia, Anthony, McCauley, Shelby, Speth, Joseph, Nunez, Stefanno Alarcon, Boivin, Gael, Vilalta, Marta, Sharma, Ricky A, Perentesis, John P, Sertorio, Mathieu

“…FLASH proton pencil-beam-scanning (p-PBS) showed a reduction in mouse skin toxicity and fibrosis when delivered as a single uninterrupted high dose fraction…”
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