Search Results - "SHARDA JHA"

Combination of the mTOR inhibitor ridaforolimus and the anti-IGF1R monoclonal antibody dalotuzumab: preclinical characterization and phase I clinical trial by Di Cosimo, Serena, Sathyanarayanan, Sriram, Bendell, Johanna C, Cervantes, Andrés, Stein, Mark N, Braña, Irene, Roda, Desamparados, Haines, Brian B, Zhang, Theresa, Winter, Christopher G, Jha, Sharda, Xu, Youyuan, Frazier, Jason, Klinghoffer, Richard A, Leighton-Swayze, Ann, Song, Yang, Ebbinghaus, Scot, Baselga, José

“…Mammalian target of rapamycin (mTOR) inhibition activates compensatory insulin-like growth factor receptor (IGFR) signaling. We evaluated the ridaforolimus…”
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Subarachnoid block in a pediatric patient with severe kyphoscoliosis by Alka Chandra, Sharda Jha, Megha Agarwal, Naresh Chandra

“…Anesthesia in pediatric patients with severe kyphoscoliosis presents a definite challenge to the anesthesiologists. Giving general anesthesia as well as…”
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Therapeutic role of TGF-β-neutralizing antibody in mouse Cyclosporin A nephropathy: Morphologic improvement associated with functional preservation by HONG LING, XUEMEI LI, SHARDA JHA, WEI WANG, KARETSKAYA, Lina, PRATT, Bruce, LEDBETTER, Steven

“…TGF-beta is believed to play a central role in the development of Cyclosporin A (CsA)-induced nephropathy. This study investigated the effects of 1D11, a…”
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Recurrent Postpartum Hemorrhage: A Case of Uterine Artery Pseudoaneurysm Probably Induced by Anticoagulants by Jha, Sangam, Jha, Sharda, Praveena, Pammy, Brightsingh, Jafeesha

“…Pseudoaneurysm formation often occurs when there is inadequate sealing at an arterial puncture site. We present the case of a 27-year-old primigravida with…”
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Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors by Morris, Erick J, Jha, Sharda, Restaino, Clifford R, Dayananth, Priya, Zhu, Hugh, Cooper, Alan, Carr, Donna, Deng, Yongi, Jin, Weihong, Black, Stuart, Long, Brian, Liu, Jenny, Dinunzio, Edward, Windsor, William, Zhang, Rumin, Zhao, Shuxia, Angagaw, Minilik H, Pinheiro, Elaine M, Desai, Jagdish, Xiao, Li, Shipps, Gerald, Hruza, Alan, Wang, James, Kelly, Joe, Paliwal, Sunil, Gao, Xiaolei, Babu, Boga Sobhana, Zhu, Liang, Daublain, Pierre, Zhang, Ling, Lutterbach, Bart A, Pelletier, Marc R, Philippar, Ulrike, Siliphaivanh, Phieng, Witter, David, Kirschmeier, Paul, Bishop, W Robert, Hicklin, Daniel, Gilliland, D Gary, Jayaraman, Lata, Zawel, Leigh, Fawell, Stephen, Samatar, Ahmed A

“…The high frequency of activating RAS or BRAF mutations in cancer provides strong rationale for targeting the mitogen-activated protein kinase (MAPK) pathway…”
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Citrobacter rodentium espB Is Necessary for Signal Transduction and for Infection of Laboratory Mice by NEWMAN, J. V, ZABEL, B. A, JHA, S. S, SCHAUER, D. B

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Dissecting Therapeutic Resistance to ERK Inhibition by Jha, Sharda, Morris, Erick J, Hruza, Alan, Mansueto, My Sam, Schroeder, Gottfried K, Arbanas, Jaren, McMasters, Daniel, Restaino, Clifford R, Dayananth, Priya, Black, Stuart, Elsen, Nathaniel L, Mannarino, Anthony, Cooper, Alan, Fawell, Stephen, Zawel, Leigh, Jayaraman, Lata, Samatar, Ahmed A

“…The MAPK pathway is frequently activated in many human cancers, particularly melanomas. A single-nucleotide mutation in BRAF resulting in the substitution of…”
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A modified model of graft‐versus‐host–induced systemic sclerosis (scleroderma) exhibits all major aspects of the human disease by Ruzek, Melanie C., Jha, Sharda, Ledbetter, Steve, Richards, Susan M., Garman, Richard D.

“…Objective Diffuse systemic sclerosis (SSc; scleroderma) is a debilitating disease characterized by excessive dermal fibrosis with later progression to internal…”
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Antibody to transforming growth factor-β ameliorates tubular apoptosis in unilateral ureteral obstruction by Miyajima, Akira, Chen, Jie, Lawrence, Cathy, Ledbetter, Steve, Soslow, Robert A., Stern, Joshua, Jha, Sharda, Pigato, Joseph, Lemer, Matthew L., Poppas, Dix P., Vaughan, E. Darracott, Felsen, Diane

“…Antibody to transforming growth factor-β ameliorates tubular apoptosis in unilateral ureteral obstruction. Unilateral ureteral obstruction (UUO) is…”
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Abstract 2343: A novel ERK inhibitor is active in models of acquired resistance to BRAF and MEK inhibitors by Samatar, Ahmed A., Morris, Erick J., Jha, Sharda, Clifford, Restaino R., Luttrerbach, Bart, Pelletier, Marc, Philippar, Ulrike, Jayaraman, Lata, Zawel, Leigh, Fawell, Steve, Gilliland, Gary

“…Abstract The high frequency of activating BRAFV600E mutations in melanoma (40-70%), thyroid (50%) and colorectal cancer (10%), or KRAS/NRAS mutations in…”
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Effect of combination therapy with enalapril and the TGF-beta antagonist 1D11 in unilateral ureteral obstruction by El Chaar, Maher, Chen, Jie, Seshan, Surya V, Jha, Sharda, Richardson, Ingride, Ledbetter, Steven R, Vaughan, Jr, E D, Poppas, Dix P, Felsen, Diane

“…In unilateral ureteral obstruction (UUO), the kidney is characterized by increased fibrosis and apoptosis. Both transforming growth factor-beta (TGF-beta) and…”
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Divergent effects of low versus high dose anti-TGF-β antibody in puromycin aminonucleoside nephropathy in rats by Ma, Li.-Jun, Jha, Sharda, Ling, Hong, Pozzi, Ambra, Ledbetter, Steve, Fogo, Agnes B.

“…Divergent effects of low versus high dose anti-TGF-β antibody in puromycin aminonucleoside nephropathy in rats. Transforming growth factor-β (TGF-β) modulates…”
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Antihypertensive effects of chronic anti-TGF-beta antibody therapy in Dahl S rats by Dahly, Annette J, Hoagland, Kimberly M, Flasch, Averia K, Jha, Sharda, Ledbetter, Steven R, Roman, Richard J

“…This study examined the role of transforming growth factor-beta (TGF-beta) in the development of hypertension and renal disease in 9-wk-old male Dahl…”
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Abstract LB-303: Anti-IGF1R therapy with dalotuzumab is efficacious in pre-clinical models of erlotinib refractory NSCLC by Xu, Youyuan, Jha, Sharda, Sykes, Kara, Paweletz, Cloud P., Nebozhyn, Michael, Feldman, Igor, Loboda, andrey, Reilly, john, Winter, Christopher, Zhang, Theresa, Sathyanarayanan, Sriram

“…Abstract Epidermal growth factor receptor (EGFR) is expressed in a majority of non-small cell lung carcinomas (NSCLC) and it has been an attractive target for…”
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Recurrent Postpartum Hemorrhage: A Case of Uterine Artery Pseudoaneurysm Probably Induced by Anticoagulants by Jha, Sangam, Jha, Sharda, Praveena, Pammy, Brightsingh, Jafeesha

“…Pseudoaneurysm formation often occurs when there is inadequate sealing at an arterial puncture site. We present the case of a 27-year-old primigravida with…”
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Divergent effects of low versus high dose anti-TGF-[beta] antibody in puromycin aminonucleoside nephropathy in rats by Li-Jun, Ma, Jha, Sharda, Ling, Hong, Pozzi, Ambra, Ledbetter, Steve, Fogo, Agnes B

“…Transforming growth factor-beta (TGF-beta) modulates immune/inflammatory cells, promotes extracellular matrix (ECM) accumulation, and is increased in fibrotic…”
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Antibody to transforming growth factor- ameliorates tubular apoptosis in unilateral ureteral obstruction by Miyajima, Akira, Chen, Jie, Lawrence, Cathy, Ledbetter, Steve, Soslow, Robert A, Stern, Joshua, Jha, Sharda, Pigato, Joseph, Lemer, Matthew L, Poppas, Dix P, E Darracott Vaughan, Felsen, Diane

“…Unilateral ureteral obstruction (UUO) is characterized by progressive renal atrophy, renal interstitial fibrosis, an increase in renal transforming growth…”
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Proliferative enterocolitis associated with dual infection with enteropathogenic Escherichia coli and Lawsonia intracellularis in rabbits by Schauer, D.B. (MIT, Cambridge, MA.), McCathey, S.N, Daft, B.M, Jha, S.S, Tatterson, L.E, Taylor, N.S, Fox, J.G

“…Both enteropathogenic Escherichia coli (EPEC) and an obligate intracellular bacterium, previously referred to as an intracellular Campylobacter-like organism…”
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Proliferative Enterocolitis Associated with Dual Infection with Enteropathogenic Escherichia coliand Lawsonia intracellularis in Rabbits by David B. Schauer, Sonya N. McCathey, Barbara M. Daft, Sharda S. Jha, Lisa E. Tatterson, Nancy S. Taylor, James G. Fox

“…Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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