Search Results - "SHAPIRO, G"

Focused ultrasound excites cortical neurons via mechanosensitive calcium accumulation and ion channel amplification by Yoo, Sangjin, Mittelstein, David R., Hurt, Robert C., Lacroix, Jerome, Shapiro, Mikhail G.

“…Ultrasonic neuromodulation has the unique potential to provide non-invasive control of neural activity in deep brain regions with high spatial precision and…”
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Detection of BRAF Mutation in Urine DNA as a Molecular Diagnostic for Canine Urothelial and Prostatic Carcinoma by Mochizuki, Hiroyuki, Shapiro, Susan G, Breen, Matthew

“…Urothelial carcinoma (UC) of the lower urinary tract and prostatic carcinoma (PC) are aggressive genitourinary cancers in dogs, characterized by invasion to…”
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Crizotinib in ROS1-rearranged advanced non-small-cell lung cancer (NSCLC): updated results, including overall survival, from PROFILE 1001 by Shaw, A.T., Riely, G.J., Bang, Y.-J., Kim, D.-W., Camidge, D.R., Solomon, B.J., Varella-Garcia, M., Iafrate, A.J., Shapiro, G.I., Usari, T., Wang, S.C., Wilner, K.D., Clark, J.W., Ou, S.-H.I.

“…In the ongoing phase I PROFILE 1001 study, crizotinib showed antitumor activity in patients with ROS1-rearranged advanced non-small-cell lung cancer (NSCLC)…”
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Ultrasound imaging of gene expression in mammalian cells by Farhadi, Arash, Ho, Gabrielle H, Sawyer, Daniel P, Bourdeau, Raymond W, Shapiro, Mikhail G

“…The study of cellular processes occurring inside intact organisms requires methods to visualize cellular functions such as gene expression in deep tissues…”
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Detection and classification of cancer in whole slide breast histopathology images using deep convolutional networks by Gecer, Baris, Aksoy, Selim, Mercan, Ezgi, Shapiro, Linda G., Weaver, Donald L., Elmore, Joann G.

“…•Commonly studied scenario considers only binary cancer vs. no cancer classification.•Our system classifies whole slide breast biopsies into five diagnostic…”
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Ultrasound Technologies for Imaging and Modulating Neural Activity by Rabut, Claire, Yoo, Sangjin, Hurt, Robert C., Jin, Zhiyang, Li, Hongyi, Guo, Hongsun, Ling, Bill, Shapiro, Mikhail G.

“…Visualizing and perturbing neural activity on a brain-wide scale in model animals and humans is a major goal of neuroscience technology development…”
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Acoustic reporter genes for noninvasive imaging of microorganisms in mammalian hosts by Bourdeau, Raymond W., Lee-Gosselin, Audrey, Lakshmanan, Anupama, Farhadi, Arash, Kumar, Sripriya Ravindra, Nety, Suchita P., Shapiro, Mikhail G.

“…Heterologous expression of engineered gas vesicles allows noninvasive, deep-tissue ultrasound visualization of engineered bacteria in vivo in mouse tumour…”
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Multi-Instance Multi-Label Learning for Multi-Class Classification of Whole Slide Breast Histopathology Images by Mercan, Caner, Aksoy, Selim, Mercan, Ezgi, Shapiro, Linda G., Weaver, Donald L., Elmore, Joann G.

“…Digital pathology has entered a new era with the availability of whole slide scanners that create the high-resolution images of full biopsy slides…”
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Ultrasound-controllable engineered bacteria for cancer immunotherapy by Abedi, Mohamad H., Yao, Michael S., Mittelstein, David R., Bar-Zion, Avinoam, Swift, Margaret B., Lee-Gosselin, Audrey, Barturen-Larrea, Pierina, Buss, Marjorie T., Shapiro, Mikhail G.

“…Rapid advances in synthetic biology are driving the development of genetically engineered microbes as therapeutic agents for a multitude of human diseases,…”
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Tunable thermal bioswitches for in vivo control of microbial therapeutics by Piraner, Dan I, Abedi, Mohamad H, Moser, Brittany A, Lee-Gosselin, Audrey, Shapiro, Mikhail G

“…Engineering of temperature-sensitive DNA repressors led to thermal bioswitches, allowing Escherichia coli to respond sharply to temperature at tunable set…”
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BRAF Mutations in Canine Cancers by Mochizuki, Hiroyuki, Kennedy, Katherine, Shapiro, Susan G, Breen, Matthew

“…Activating mutations of the BRAF gene lead to constitutive activation of the MAPK pathway. Although many human cancers carry the mutated BRAF gene, this…”
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Mapping the microscale origins of magnetic resonance image contrast with subcellular diamond magnetometry by Davis, Hunter C., Ramesh, Pradeep, Bhatnagar, Aadyot, Lee-Gosselin, Audrey, Barry, John F., Glenn, David R., Walsworth, Ronald L., Shapiro, Mikhail G.

“…Magnetic resonance imaging (MRI) is a widely used biomedical imaging modality that derives much of its contrast from microscale magnetic field patterns in…”
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Non-invasive imaging using reporter genes altering cellular water permeability by Mukherjee, Arnab, Wu, Di, Davis, Hunter C., Shapiro, Mikhail G.

“…Non-invasive imaging of gene expression in live, optically opaque animals is important for multiple applications, including monitoring of genetic circuits and…”
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Editorial Expression of Concern: Pre-clinical evaluation of cyclin-dependent kinase 2 and 1 inhibition in anti-estrogen-sensitive and resistant breast cancer cells by Johnson, N., Bentley, J., Wang, L-Z, Newell, D. R., Robson, C. N., Shapiro, G. I., Curtin, N. J.

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Acoustically modulated magnetic resonance imaging of gas-filled protein nanostructures by Lu, George J., Farhadi, Arash, Szablowski, Jerzy O., Lee-Gosselin, Audrey, Barnes, Samuel R., Lakshmanan, Anupama, Bourdeau, Raymond W., Shapiro, Mikhail G.

“…Non-invasive biological imaging requires materials capable of interacting with deeply penetrant forms of energy such as magnetic fields and sound waves. Here,…”
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Molecular Engineering of Acoustic Protein Nanostructures by Lakshmanan, Anupama, Farhadi, Arash, Nety, Suchita P, Lee-Gosselin, Audrey, Bourdeau, Raymond W, Maresca, David, Shapiro, Mikhail G

“…Ultrasound is among the most widely used biomedical imaging modalities, but has limited ability to image specific molecular targets due to the lack of suitable…”
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Preparation of biogenic gas vesicle nanostructures for use as contrast agents for ultrasound and MRI by Lakshmanan, Anupama, Lu, George J, Farhadi, Arash, Nety, Suchita P, Kunth, Martin, Lee-Gosselin, Audrey, Maresca, David, Bourdeau, Raymond W, Yin, Melissa, Yan, Judy, Witte, Christopher, Malounda, Dina, Foster, F Stuart, Schröder, Leif, Shapiro, Mikhail G

“…This protocol describes the isolation of gas-filled protein nanostructures, called gas vesicles, their functionalization with moieties for targeting and…”
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Biomolecular Ultrasound and Sonogenetics by Maresca, David, Lakshmanan, Anupama, Abedi, Mohamad, Bar-Zion, Avinoam, Farhadi, Arash, Lu, George J, Szablowski, Jerzy O, Wu, Di, Yoo, Sangjin, Shapiro, Mikhail G

“…Visualizing and modulating molecular and cellular processes occurring deep within living organisms is fundamental to our study of basic biology and disease…”
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Eye movements as an index of pathologist visual expertise: a pilot study by Brunyé, Tad T, Carney, Patricia A, Allison, Kimberly H, Shapiro, Linda G, Weaver, Donald L, Elmore, Joann G

“…A pilot study examined the extent to which eye movements occurring during interpretation of digitized breast biopsy whole slide images (WSI) can distinguish…”
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Phase I safety, pharmacokinetic, and pharmacodynamic study of the oral phosphatidylinositol-3-kinase and mTOR inhibitor BGT226 in patients with advanced solid tumors by Markman, B., Tabernero, J., Krop, I., Shapiro, G.I., Siu, L., Chen, L.C., Mita, M., Melendez Cuero, M., Stutvoet, S., Birle, D., Anak, Ö., Hackl, W., Baselga, J.

“…This phase I dose-escalation study investigated the maximum tolerated dose (MTD), safety, pharmacokinetics, pharmacodynamics (PDs), and preliminary antitumor…”
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