Search Results - "SHAPIRO, A. M. J"

Optimal implantation site for pancreatic islet transplantation by Merani, S., Toso, C., Emamaullee, J., Shapiro, A. M. J.

“…Background: Since the first report of successful pancreatic islet transplantation to reverse hyperglycaemia in diabetic rodents, there has been great interest…”
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role of macrophage migration inhibitory factor on glucose metabolism and diabetes by Toso, C, Emamaullee, J. A, Merani, S, Shapiro, A. M. J

“…Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine involved in many inflammatory reactions and disorders, and it has become evident…”
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impact of the mTOR inhibitor sirolimus on the proliferation and function of pancreatic islets and ductal cells by Bussiere, C. T, Lakey, J. R. T, Shapiro, A. M. J, Korbutt, G. S

“…Aims/hypothesis The Edmonton Protocol for islet transplantation has provided hope for type 1 diabetic patients. However, this protocol requires lifelong…”
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The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function by Dai, X. Q., Manning Fox, J. E., Chikvashvili, D., Casimir, M., Plummer, G., Hajmrle, C., Spigelman, A. F., Kin, T., Singer-Lahat, D., Kang, Y., Shapiro, A. M. J., Gaisano, H. Y., Lotan, I., MacDonald, P. E.

“…Aims/hypothesis It is thought that the voltage-dependent potassium channel subunit Kv2.1 (Kv2.1) regulates insulin secretion by controlling beta cell…”
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Long-Term Follow-Up of the Edmonton Protocol of Islet Transplantation in the United States by Brennan, D.C., Kopetskie, H.A., Sayre, P.H., Alejandro, R., Cagliero, E., Shapiro, A.M.J., Goldstein, J.S., DesMarais, M.R., Booher, S., Bianchine, P.J.

“…We report the long-term follow-up of the efficacy and safety of islet transplantation in seven type 1 diabetic subjects from the United States enrolled in the…”
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Validation of the BETA‐2 Score: An Improved Tool to Estimate Beta Cell Function After Clinical Islet Transplantation Using a Single Fasting Blood Sample by Forbes, S., Oram, R. A., Smith, A., Lam, A., Olateju, T., Imes, S., Malcolm, A. J., Shapiro, A. M. J., Senior, P. A.

“…The beta score, a composite measure of beta cell function after islet transplantation, has limited sensitivity because of its categorical nature and requires a…”
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The Clinical Impact of Islet Transplantation by Fiorina, P., Shapiro, A. M. J., Ricordi, C., Secchi, A.

“…Islet cell transplantation has recently emerged as one of the most promising therapeutic approaches to improving glycometabolic control in diabetic patients…”
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Portal Vein Thrombosis Is a Potentially Preventable Complication in Clinical Islet Transplantation by Kawahara, T., Kin, T., Kashkoush, S., Gala‐Lopez, B., Bigam, D. L., Kneteman, N. M., Koh, A., Senior, P. A., Shapiro, A. M. J.

“…Percutaneous transhepatic portal access avoids surgery but is rarely associated with bleeding or portal venous thrombosis (PVT). We herein report our large,…”
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Chemical Basis for Qualitative and Quantitative Differences Between ABO Blood Groups and Subgroups: Implications for Organ Transplantation by Jeyakanthan, M., Tao, K., Zou, L., Meloncelli, P. J., Lowary, T. L., Suzuki, K., Boland, D., Larsen, I., Burch, M., Shaw, N., Beddows, K., Addonizio, L., Zuckerman, W., Afzali, B., Kim, D. H., Mengel, M., Shapiro, A. M. J., West, L. J.

“…Blood group ABH(O) carbohydrate antigens are carried by precursor structures denoted type I–IV chains, creating unique antigen epitopes that may differ in…”
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High Risk of Sensitization After Failed Islet Transplantation by Campbell, P. M., Senior, P. A., Salam, A., LaBranche, K., Bigam, D. L., Kneteman, N. M., Imes, S., Halpin, A., Ryan, E. A., Shapiro, A. M. J.

“…Human Leukocyte Antigen (HLA) antibodies posttransplant have been associated with an increased risk of early graft failure in kidney transplants. Whether this…”
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The Combination of Anti‐NKG2D and CTLA‐4 Ig Therapy Prolongs Islet Allograft Survival in a Murine Model by Pawlick, R., Gala‐Lopez, B., Pepper, A. R., McCall, M., Ziff, O., Shapiro, A. M. J.

“…Islet transplantation is an effective means of treating severe type 1 diabetes in patients with life‐threatening hypoglycemia. Improvements in glycemic control…”
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Liraglutide, a Long-Acting Human Glucagon-Like Peptide 1 Analog, Improves Glucose Homeostasis in Marginal Mass Islet Transplantation in Mice by Merani, S, Truong, W, Emamaullee, J. A, Toso, C, Knudsen, L. B, Shapiro, A. M. J

“…The current scarcity of high-quality deceased pancreas donors prevents widespread application of islet transplantation for treatment of labile type 1 diabetes…”
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Autologous Islet Transplantation After Total Pancreatectomy for Renal Cell Carcinoma Metastases by Gala‐Lopez, B. L., Semlacher, E., Manouchehri, N., Kin, T., Shapiro, A. M. J.

“…Pancreatic metastases from renal cell carcinoma (RCC) may have a chronic and highly indolent course, and may be resected for cure after considerable delay…”
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Pretransplant HLA Antibodies Are Associated with Reduced Graft Survival After Clinical Islet Transplantation by Campbell, P. M., Salam, A., Ryan, E. A., Senior, P., Paty, B. W., Bigam, D., McCready, T., Halpin, A., Imes, S., Al Saif, F., Lakey, J. R. T., Shapiro, A. M. J.

“…Despite significant improvements in islet transplantation, long‐term graft function is still not optimal. It is likely that both immune and nonimmune factors…”
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Distinct and opposing roles for the phosphatidylinositol 3-OH kinase catalytic subunits p110α and p110β in the regulation of insulin secretion from rodent and human beta cells by Kolic, J., Spigelman, A. F., Plummer, G., Leung, E., Hajmrle, C., Kin, T., Shapiro, A. M. J., Manning Fox, J. E., MacDonald, P. E.

“…Aims/hypothesis Phosphatidylinositol 3-OH kinases (PI3Ks) regulate beta cell mass, gene transcription, and function, although the contribution of the specific…”
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Late Cytomegalovirus Transmission and Impact of T‐Depletion in Clinical Islet Transplantation by Gala‐Lopez, B. L., Senior, P. A., Koh, A., Kashkoush, S. M., Kawahara, T., Kin, T., Humar, A., Shapiro, A. M. J.

“…The epidemiology of cytomegalovirus infection (CMV) in islet transplantation (IT) is not well defined. This study defines incidence, transmission and clinical…”
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Combined Coinhibitory and Costimulatory Modulation with Anti‐BTLA and CTLA4Ig Facilitates Tolerance in Murine Islet Allografts by Truong, W., Plester, J. C., Hancock, W. W., Merani, S., Murphy, T. L., Murphy, K. M., Kaye, J., Anderson, C. C., Shapiro, A. M. J.

“…Complex interactions between positive and negative cosignaling receptors ultimately determine the fate of the immune response. The recently identified…”
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Targeting Cells Causing Split Tolerance Allows Fully Allogeneic Islet Survival With Minimal Conditioning in NOD Mixed Chimeras by Al‐Adra, D. P., Pawlick, R., Shapiro, A. M. J., Anderson, C. C.

“…Donor‐specific tolerance induced by mixed chimerism is one approach that may eliminate the need for long‐term immunosuppressive therapy, while preventing…”
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Preliminary Single‐Center Canadian Experience of Human Normothermic Ex Vivo Liver Perfusion: Results of a Clinical Trial by Bral, M., Gala‐Lopez, B., Bigam, D., Kneteman, N., Malcolm, A., Livingstone, S., Andres, A., Emamaullee, J., Russell, L., Coussios, C., West, L. J., Friend, P. J., Shapiro, A. M. J.

“…After extensive experimentation, outcomes of a first clinical normothermic machine perfusion (NMP) liver trial in the United Kingdom demonstrated feasibility…”
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Three Cases of Alopecia Following Clinical Islet Transplantation by Zuk, D. M., Koh, A., Imes, S., Shapiro, A. M. J., Senior, P. A.

“…Successful clinical islet allotransplantation requires control of both allo‐ and autoimmunity by using immunosuppressant drugs which have a number of side…”
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