Search Results - "SHAOGUANG WU"

Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells by Chung, Liam, Thiele Orberg, Erik, Geis, Abby L., Chan, June L., Fu, Kai, DeStefano Shields, Christina E., Dejea, Christine M., Fathi, Payam, Chen, Jie, Finard, Benjamin B., Tam, Ada J., McAllister, Florencia, Fan, Hongni, Wu, Xinqun, Ganguly, Sudipto, Lebid, Andriana, Metz, Paul, Van Meerbeke, Sara W., Huso, David L., Wick, Elizabeth C., Pardoll, Drew M., Wan, Fengyi, Wu, Shaoguang, Sears, Cynthia L., Housseau, Franck

“…Pro-carcinogenic bacteria have the potential to initiate and/or promote colon cancer, in part via immune mechanisms that are incompletely understood. Using…”
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Human colon mucosal biofilms from healthy or colon cancer hosts are carcinogenic by Tomkovich, Sarah, Dejea, Christine M, Winglee, Kathryn, Drewes, Julia L, Chung, Liam, Housseau, Franck, Pope, Jillian L, Gauthier, Josee, Sun, Xiaolun, Mühlbauer, Marcus, Liu, Xiuli, Fathi, Payam, Anders, Robert A, Besharati, Sepideh, Perez-Chanona, Ernesto, Yang, Ye, Ding, Hua, Wu, Xinqun, Wu, Shaoguang, White, James R, Gharaibeh, Raad Z, Fodor, Anthony A, Wang, Hao, Pardoll, Drew M, Jobin, Christian, Sears, Cynthia L

“…Mucus-invasive bacterial biofilms are identified on the colon mucosa of approximately 50% of colorectal cancer (CRC) patients and approximately 13% of healthy…”
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Microbiota organization is a distinct feature of proximal colorectal cancers by Dejea, Christine M., Wick, Elizabeth C., Hechenbleikner, Elizabeth M., White, James R., Welch, Jessica L. Mark, Rossetti, Blair J., Peterson, Scott N., Snesrud, Erik C., Borisy, Gary G., Lazarev, Mark, Stein, Ellen, Vadivelu, Jamuna, Roslani, April C., Malik, Ausuma A., Wanyiri, Jane W., Goh, Khean L., Thevambiga, Iyadorai, Fu, Kai, Wan, Fengyi, Llosa, Nicolas, Housseau, Franck, Romans, Katharine, Wu, XinQun, McAllister, Florencia M., Wu, Shaoguang, Vogelstein, Bert, Kinzler, Kenneth W., Pardoll, Drew M., Sears, Cynthia L.

“…Environmental factors clearly affect colorectal cancer (CRC) incidence, but the mechanisms through which these factors function are unknown. One prime…”
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Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis by Goodwin, Andrew C, Shields, Christina E. Destefano, Wu, Shaoguang, Huso, David L, Wu, XinQun, Murray-Stewart, Tracy R, Hacker-Prietz, Amy, Rabizadeh, Shervin, Woster, Patrick M, Sears, Cynthia L, Casero, Robert A. Jr

“…It is estimated that the etiology of 20–30% of epithelial cancers is directly associated with inflammation, although the direct molecular events linking…”
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Benzo[d]imidazole-functionalized triazatruxenes as the emitting materials for solution-processed non-doped OLEDs by Zhou, Yang, Li, Yanmei, Wu, Shaoguang, Zhao, Yuling, Yu, Tianzhi, Su, Wenming, Ma, Hailin, Qian, Long, Wang, Ruidong

“…Two benzo[d]imidazole/triazatruxene hybrid compounds,…”
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Redundant Innate and Adaptive Sources of IL17 Production Drive Colon Tumorigenesis by Housseau, Franck, Wu, Shaoguang, Wick, Elizabeth C, Fan, Hongni, Wu, Xinqun, Llosa, Nicolas J, Smith, Kellie N, Tam, Ada, Ganguly, Sudipto, Wanyiri, Jane W, Iyadorai, Thevambiga, Malik, Ausama A, Roslani, April C, Vadivelu, Jamunarani S, Van Meerbeke, Sara, Huso, David L, Pardoll, Drew M, Sears, Cynthia L

“…IL17-producing Th17 cells, generated through a STAT3-dependent mechanism, have been shown to promote carcinogenesis in many systems, including microbe-driven…”
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High-speed, ultrahigh-resolution distal scanning OCT endoscopy at 800 nm for in vivo imaging of colon tumorigenesis on murine models by Mavadia-Shukla, Jessica, Fathi, Payam, Liang, Wenxuan, Wu, Shaoguang, Sears, Cynthia, Li, Xingde

“…We present the first, most compact, ultrahigh-resolution, high-speed, distal scanning optical coherence tomography (OCT) endoscope operating at 800 nm…”
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Comparative Analysis of Colon Cancer-Derived Fusobacterium nucleatum Subspecies: Inflammation and Colon Tumorigenesis in Murine Models by Queen, Jessica, Domingue, Jada C, White, James Robert, Stevens, Courtney, Udayasuryan, Barath, Nguyen, Tam T D, Wu, Shaoguang, Ding, Hua, Fan, Hongni, McMann, Madison, Corona, Alina, Larman, Tatianna C, Verbridge, Scott S, Housseau, Franck, Slade, Daniel J, Drewes, Julia L, Sears, Cynthia L

“…Fusobacteria are commonly associated with human colorectal cancer (CRC), but investigations are hampered by the absence of a stably colonized murine model…”
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Gut colonization with an obesity-associated enteropathogenic microbe modulates the premetastatic niches to promote breast cancer lung and liver metastasis by Parida, Sheetal, Siddharth, Sumit, Gatla, Himavanth R, Wu, Shaoguang, Wang, Guannan, Gabrielson, Kathleen, Sears, Cynthia L, Ladle, Brian H, Sharma, Dipali

“…Obesity, an independent risk factor for breast cancer growth and metastatic progression, is also closely intertwined with gut dysbiosis; and both obese state…”
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Streptococcus gallolyticus Increases Expression and Activity of Aryl Hydrocarbon Receptor-Dependent CYP1 Biotransformation Capacity in Colorectal Epithelial Cells by Taddese, Rahwa, Roelofs, Rian, Draper, Derk, Wu, Xinqun, Wu, Shaoguang, Swinkels, Dorine W, Tjalsma, Harold, Boleij, Annemarie

“…The opportunistic pathogen is one of the few intestinal bacteria that has been consistently linked to colorectal cancer (CRC). This study aimed to identify…”
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Induction of Persistent Colitis by a Human Commensal, Enterotoxigenic Bacteroides fragilis, in Wild-Type C57BL/6 Mice by Rhee, Ki-Jong, Wu, Shaoguang, Wu, XinQun, Huso, David L, Karim, Baktiar, Franco, Augusto A, Rabizadeh, Shervin, Golub, Jonathan E, Mathews, Lauren E, Shin, Jai, Sartor, R. Balfour, Golenbock, Douglas, Hamad, Abdel R, Gan, Christine M, Housseau, Franck, Sears, Cynthia L

“…Enterotoxigenic Bacteroides fragilis (ETBF) causes diarrhea and is implicated in inflammatory bowel diseases and colorectal cancer. The only known ETBF…”
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Colon Tumors in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized Mice Do Not Display a Unique Mutational Signature but Instead Possess Host-Dependent Alterations in the APC Gene by Allen, Jawara, Rosendahl Huber, Axel, Pleguezuelos-Manzano, Cayetano, Puschhof, Jens, Wu, Shaoguang, Wu, Xinqun, Boot, Charelle, Saftien, Aurelia, O'Hagan, Heather M, Wang, Hao, van Boxtel, Ruben, Clevers, Hans, Sears, Cynthia L

“…Enterotoxigenic Bacteroides fragilis (ETBF) is consistently found at higher frequency in individuals with sporadic and hereditary colorectal cancer (CRC) and…”
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Pleiotropic ZIP8 A391T implicates abnormal manganese homeostasis in complex human disease by Sunuwar, Laxmi, Frkatović, Azra, Sharapov, Sodbo, Wang, Qinchuan, Neu, Heather M, Wu, Xinqun, Haritunians, Talin, Wan, Fengyi, Michel, Sarah, Wu, Shaoguang, Donowitz, Mark, McGovern, Dermot, Lauc, Gordan, Sears, Cynthia, Melia, Joanna

“…ZIP8 is a metal transporter with a role in manganese (Mn) homeostasis. A common genetic variant in ZIP8 (rs13107325; A391T) ranks in the top 10 of pleiotropic…”
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Bacteroides fragilis enterotoxin induces c-Myc expression and cellular proliferation by Wu, Shaoguang, Morin, Patrice J., Maouyo, Djik, Sears, Cynthia L.

“…Background & Aims: Enterotoxigenic Bacteroides fragilis that secrete a zinc-dependent metalloprotease toxin termed the B. fragilis toxin (BFT) have been…”
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Fecal transplant from vaginally seeded infants decreases intraabdominal adiposity in mice by Namasivayam, Sivaranjani, Tilves, Curtis, Ding, Hua, Wu, Shaoguang, Domingue, Jada C, Ruiz-Bedoya, Camilo, Shah, Ankit, Bohrnsen, Eric, Schwarz, Benjamin, Bacorn, Mickayla, Chen, Qing, Levy, Shira, Dominguez Bello, Maria Gloria, Jain, Sanjay K, Sears, Cynthia L, Mueller, Noel T, Hourigan, Suchitra K

“…Exposing C-section infants to the maternal vaginal microbiome, coined "vaginal seeding", partially restores microbial colonization. However, whether vaginal…”
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Drug Discovery and Repurposing Inhibits a Major Gut Pathogen-Derived Oncogenic Toxin by Metz, Paul, Tjan, Martijn J H, Wu, Shaoguang, Pervaiz, Mehrosh, Hermans, Susanne, Shettigar, Aishwarya, Sears, Cynthia L, Ritschel, Tina, Dutilh, Bas E, Boleij, Annemarie

“…The human intestinal microbiome plays an important role in inflammatory bowel disease (IBD) and colorectal cancer (CRC) development. One of the first…”
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G-protein coupled receptor 35 (GPR35) regulates the colonic epithelial cell response to enterotoxigenic Bacteroides fragilis by Boleij, Annemarie, Fathi, Payam, Dalton, William, Park, Ben, Wu, Xinqun, Huso, David, Allen, Jawara, Besharati, Sepideh, Anders, Robert A., Housseau, Franck, Mackenzie, Amanda E., Jenkins, Laura, Milligan, Graeme, Wu, Shaoguang, Sears, Cynthia L.

“…G protein-coupled receptor (GPR)35 is highly expressed in the gastro-intestinal tract, predominantly in colon epithelial cells (CEC), and has been associated…”
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Bacteroides fragilis Enterotoxin Induces Intestinal Epithelial Cell Secretion of Interleukin-8 through Mitogen-Activated Protein Kinases and a Tyrosine Kinase-Regulated Nuclear Factor-κB Pathway by SHAOGUANG WU, POWELL, Jan, MATHIOUDAKIS, Nes, KANE, Sheryl, FERNANDEZ, Ellen, SEARS, Cynthia L

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Bacteroides fragilis Toxin Binds to a Specific Intestinal Epithelial Cell Receptor by Wu, Shaoguang, Shin, Jai, Zhang, Guangming, Cohen, Mitchell, Franco, Augusto, Sears, Cynthia L

“…The Bacteroides fragilis toxin (BFT) is the only known virulence factor of enterotoxigenic B. fragilis. BFT has previously been shown to act, at least in part,…”
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Bacteroides fragilis Enterotoxin Cleaves the Zonula Adherens Protein, E-cadherin by Wu, Shaoguang, Lim, Kuei-Cheng, Huang, Julie, Saidi, Roxan F., Sears, Cynthia L.

“…Strains of Bacteroides fragilis associated with diarrheal disease (enterotoxigenic B. fragilis) produce a 20-kDa zinc-dependent metalloprotease toxin (B…”
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