Search Results - "SHANTZ, Lisa M"

Molecular signaling cascades involved in nonmelanoma skin carcinogenesis by Feehan, Robert P, Shantz, Lisa M

“…Nonmelanoma skin cancer (NMSC) is the most common cancer worldwide and the incidence continues to rise, in part due to increasing numbers in high-risk groups…”
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mTORC2 confers neuroprotection and potentiates immunity during virus infection by Suryawanshi, Rahul K., Patil, Chandrashekhar D., Agelidis, Alex, Koganti, Raghuram, Ames, Joshua M., Koujah, Lulia, Yadavalli, Tejabhiram, Madavaraju, Krishnaraju, Shantz, Lisa M., Shukla, Deepak

“…Herpes simplex virus type-1 (HSV-1) causes ocular and orofacial infections. In rare cases, HSV-1 can cause encephalitis, which leads to permanent brain…”
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Hypermethylation of FOXA1 and allelic loss of PTEN drive squamous differentiation and promote heterogeneity in bladder cancer by Osei-Amponsa, Vasty, Buckwalter, Jenna M., Shuman, Lauren, Zheng, Zongyu, Yamashita, Hironobu, Walter, Vonn, Wildermuth, Thomas, Ellis-Mohl, Justine, Liu, Chang, Warrick, Joshua I., Shantz, Lisa M., Feehan, Robert P., Al-Ahmadie, Hikmat, Mendelsohn, Cathy, Raman, Jay D., Kaestner, Klaus H., Wu, Xue-Ru, DeGraff, David J.

“…Intratumoral heterogeneity in bladder cancer is a barrier to accurate molecular sub-classification and treatment efficacy. However, individual cellular and…”
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Ornithine decarboxylase mRNA is stabilized in an mTORC1-dependent manner in Ras-transformed cells by Origanti, Sofia, Nowotarski, Shannon L, Carr, Theresa D, Sass-Kuhn, Suzanne, Xiao, Lan, Wang, Jian-Ying, Shantz, Lisa M

“…Upon Ras activation, ODC (ornithine decarboxylase) is markedly induced, and numerous studies suggest that ODC expression is controlled by Ras effector…”
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Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors by Carr, Theresa D, Feehan, Robert P, Hall, Michael N, Rüegg, Markus A, Shantz, Lisa M

“…Activation of signaling dependent on the mammalian target of rapamycin (mTOR) has been demonstrated in a variety of human malignancies, and our previous work…”
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The ODC 3'-Untranslated Region and 5'-Untranslated Region Contain cis-Regulatory Elements: Implications for Carcinogenesis by Nowotarski, Shannon L, Shantz, Lisa M

“…It has been hypothesized that both the 3'-untranslated region (3'UTR) and the 5'-untranslated region (5'UTR) of the ornithine decarboxylase (ODC) mRNA…”
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Skin Carcinogenesis Studies Using Mouse Models with Altered Polyamines by Nowotarski, Shannon L., Feith, David J., Shantz, Lisa M.

“…Nonmelanoma skin cancer (NMSC) is a major health concern worldwide. With increasing numbers in high-risk groups such as organ transplant recipients and…”
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Overexpression of ornithine decarboxylase increases myogenic potential of H9c2 rat myoblasts by Govoni, Marco, Bonavita, Francesca, Shantz, Lisa M, Guarnieri, Carlo, Giordano, Emanuele

“…Myoblast differentiation into multinuclear myotubes implies the slow-down of their proliferative drive and the expression of myogenin, an early marker of…”
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REDD1 interacts with AIF and regulates mitochondrial reactive oxygen species generation in the keratinocyte response to UVB by Feehan, Robert P., Coleman, Catherine S., Ebanks, Shauna, Lang, Charles H., Shantz, Lisa M.

“…Non-melanoma skin cancer (NMSC) incidence is rising, especially in high-risk, immunocompromised groups such as organ transplant patients, who often develop…”
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Negative regulation of the FOXO3a transcription factor by mTORC2 induces a pro-survival response following exposure to ultraviolet-B irradiation by Feehan, Robert P., Shantz, Lisa M.

“…Exposure to ultraviolet-B (UVB) irradiation, the principal cause of non-melanoma skin cancer (NMSC), activates both the rapamycin-sensitive mammalian target of…”
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Knockout of Raptor destabilizes ornithine decarboxylase mRNA and decreases binding of HuR to the ODC transcript in cells exposed to ultraviolet-B irradiation by Nowotarski, Shannon L., Feehan, Robert P., Presloid, Christopher, Shantz, Lisa M.

“…Non-melanoma skin cancer (NMSC) is the most commonly diagnosed cancer in the United States. Ultraviolet-B (UVB) irradiation is the primary carcinogen…”
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Tumor suppressor activity of ODC antizyme in MEK-driven skin tumorigenesis by Feith, David J., Origanti, Sofia, Shoop, Paula L., Sass-Kuhn, Suzanne, Shantz, Lisa M.

“…To test the hypothesis that suppression of ornithine decarboxylase (ODC) activity blocks the promotion of target cells in the outer root sheath of the hair…”
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Inhibition of mTORC2 enhances UVB-induced apoptosis in keratinocytes through a mechanism dependent on the FOXO3a transcriptional target NOXA but independent of TRAIL by Feehan, Robert P., Nelson, Amanda M., Shantz, Lisa M.

“…The primary cause of non-melanoma skin cancer (NMSC) is ultraviolet B (UVB) radiation. We have shown previously that mTORC2 inhibition sensitizes keratinocytes…”
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Induction of ornithine decarboxylase activity is a necessary step for mitogen-activated protein kinase kinase-induced skin tumorigenesis by FEITH, David J, BOL, David K, CARBONI, Joan M, LYNCH, Mark J, SASS-KUHN, Suzanne, SHOOP, Paula L, SHANTZ, Lisa M

“…A transgenic mouse line overexpressing a constitutively active mutant of MEK1, a downstream effector of Ras, driven by the keratin 14 (K14) promoter, has been…”
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Polyamine homeostasis in arginase knockout mice by Deignan, Joshua L, Livesay, Justin C, Shantz, Lisa M, Pegg, Anthony E, O'Brien, William E, Iyer, Ramaswamy K, Cederbaum, Stephen D, Grody, Wayne W

“…The role of ornithine decarboxylase (ODC) in polyamine metabolism has long been established, but the exact source of ornithine has always been unclear. The…”
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Characterization of transgenic mice with widespread overexpression of spermine synthase by Ikeguchi, Yoshihiko, Wang, Xiaojing, McCloskey, Diane E, Coleman, Catherine S, Nelson, Paul, Hu, Guirong, Shantz, Lisa M, Pegg, Anthony E

“…A widespread increase in SpmS (spermine synthase) activity has been produced in transgenic mice using a construct in which the human SpmS cDNA was placed under…”
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Knocking down raptor in human keratinocytes affects ornithine decarboxylase in a post-transcriptional Manner following ultraviolet B exposure by Stump, Coryn L., Feehan, Robert P., Jordan, Torey, Shantz, Lisa M., Nowotarski, Shannon L.

“…Non-melanoma skin cancer (NMSC) is the most common form of cancer. Ultraviolet-B (UVB) radiation has been shown to be a complete carcinogen in the development…”
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Inhibition of mTOR suppresses UVB-induced keratinocyte proliferation and survival by Carr, Theresa D, DiGiovanni, John, Lynch, Christopher J, Shantz, Lisa M

“…UV radiation is the major risk factor for developing skin cancer, the most prevalent cancer worldwide. Several studies indicate that mTOR signaling is…”
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Overproduction of cardiac S-adenosylmethionine decarboxylase in transgenic mice by Nisenberg, Oleg, Pegg, Anthony E, Welsh, Patricia A, Keefer, Kerry, Shantz, Lisa M

“…The present study was designed to provide a better understanding of the role played by AdoMetDC (S-adenosylmethionine decarboxylase), the key rate-controlling…”
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Mouse skin chemical carcinogenesis is inhibited by antizyme in promotion-sensitive and promotion-resistant genetic backgrounds by Feith, David J., Shantz, Lisa M., Shoop, Paula L., Keefer, Kerry A., Prakashagowda, Chethana, Pegg, Anthony E.

“…Elevated polyamine content and increased ornithine decarboxylase (ODC) activity have been associated with neoplastic growth in numerous animal models and human…”
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