Search Results - "SHANNON, H. E"

Increased anxiety-related behavior in mice deficient for metabotropic glutamate 8 (mGlu8) receptor by Linden, A.-M, Johnson, B.G, Peters, S.C, Shannon, H.E, Tian, M, Wang, Y, Yu, J.L, Köster, A, Baez, M, Schoepp, D.D

“…Pre-synaptic metabotropic glutamate (mGlu) receptors modulate neuronal excitability by controlling glutamate and gamma-aminobutyric acid (GABA) release. The…”
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A non-spatial, stimulus-comparison working memory task in rats and disruption by scopolamine by Shannon, H.E, Yang, L

“…Abstract Working memory is a theoretical concept referring to a set of cognitive processes that provide temporary maintenance and manipulation of the…”
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The seizure-related phenotype of brain-derived neurotrophic factor knockdown mice by Barton, M.E., Shannon, H.E.

“…The present investigation focused on the seizure-related phenotype of mice lacking one allele of brain-derived neurotrophic factor. Thresholds for producing…”
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Muscarinic cholinergic modulation of prepulse inhibition of the acoustic startle reflex by Jones, C K, Shannon, H E

“…The purpose of the present study was to determine the effects of muscarinic cholinergic receptor antagonists and agonists on prepulse inhibition (PPI) of the…”
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Blockade of phencyclidine-induced hyperlocomotion by olanzapine, clozapine and serotonin receptor subtype selective antagonists in mice by GLEASON, S. D, SHANNON, H. E

“…In humans, phencyclidine (PCP) is known to produce a syndrome of behavioral effects which have many characteristics in common with schizophrenia. Therefore,…”
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Comparative behavioral and neurochemical activities of cholinergic antagonists in rats by Bymaster, F P, Heath, I, Hendrix, J C, Shannon, H E

“…The comparative behavioral and neurochemical activities of the muscarinic cholinergic antagonists scopolamine, trihexyphenidyl and pirenzepine, and the…”
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The selective muscarinic agonist xanomeline improves both the cognitive deficits and behavioral symptoms of Alzheimer disease by Bodick, N C, Offen, W W, Shannon, H E, Satterwhite, J, Lucas, R, van Lier, R, Paul, S M

“…The therapeutic effects of selective cholinergic replacement using oral xanomeline, an m1/m4 receptor agonist, were assessed in a multicenter study of 343…”
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Effects of scopolamine in comparison with apomorphine and phencyclidine on prepulse inhibition in rats by Jones, Carrie K, Shannon, Harlan E

“…The potential involvement of the muscarinic cholinergic system in the underlying mechanisms of prepulse inhibition of the acoustic startle reflex was evaluated…”
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Characterization of small intestinal submucosa regenerated canine detrusor: assessment of reinnervation, in vitro compliance and contractility by Kropp, B P, Sawyer, B D, Shannon, H E, Rippy, M K, Badylak, S F, Adams, M C, Keating, M A, Rink, R C, Thor, K B

“…We characterized small intestinal submucosa regenerated canine bladder. We subjected 15-month small intestinal submucosa regenerated canine bladder strips to…”
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Xanomeline: a novel muscarinic receptor agonist with functional selectivity for M1 receptors by Shannon, H E, Bymaster, F P, Calligaro, D O, Greenwood, B, Mitch, C H, Sawyer, B D, Ward, J S, Wong, D T, Olesen, P H, Sheardown, M J, Swedberg, M D, Suzdak, P D, Sauerberg, P

“…Xanomeline [3(3-hexyloxy-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1- methylpyridine] has been evaluated as a muscarinic receptor agonist. In vitro, xanomeline…”
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Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease by Bodick, N C, Offen, W W, Levey, A I, Cutler, N R, Gauthier, S G, Satlin, A, Shannon, H E, Tollefson, G D, Rasmussen, K, Bymaster, F P, Hurley, D J, Potter, W Z, Paul, S M

“…To evaluate the therapeutic effects of selective cholinergic replacement with xanomeline tartrate, an m1 and m4 selective muscarinic receptor (mAChR) agonist…”
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Intrathecal pertussis toxin produces hyperalgesia and allodynia in mice by Womer, D E, DeLapp, N W, Shannon, H E

“…Pertussis toxin (PTX), which causes the ADP-ribosylation and thereby inactivation of Gi-proteins, has been employed in analgesia testing to elucidate receptors…”
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Detrusor regeneration in the rat using porcine small intestinal submucosal grafts: functional innervation and receptor expression by Vaught, J D, Kropp, B P, Sawyer, B D, Rippy, M K, Badylak, S F, Shannon, H E, Thor, K B

“…To evaluate functional characteristics of regenerated bladder induced by small intestinal submucosa (SIS). Strips from bladder regenerated from SIS and normal…”
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Pharmacologic reversal of pertussis toxin-induced thermal allodynia in mice by Womer, Daniel E, Shannon, Harlan E

“…We have previously demonstrated that the intrathecal administration of pertussis toxin produces a long-lasting thermal allodynia in mice. The purpose of the…”
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Glutamate receptors of the N-methyl-D-aspartate subtype in the myenteric plexus of the guinea pig ileum by Shannon, H E, Sawyer, B D

“…The excitatory amino acids L-glutamate and N-methyl-D-aspartate (NMDA) produced contractions of the myenteric plexus-longitudinal muscle preparation of the…”
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A comparison of the effects of cholinergic and dopaminergic agents on scopolamine-induced hyperactivity in mice by Shannon, H E, Peters, S C

“…The effects of cholinesterase inhibitors, cholinergic agonists, dopaminergic agonists and dopaminergic antagonists on the hyperactivity produced by the…”
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Neurochemical effects of the M1 muscarinic agonist xanomeline (LY246708/NNC11-0232) by Bymaster, F P, Wong, D T, Mitch, C H, Ward, J S, Calligaro, D O, Schoepp, D D, Shannon, H E, Sheardown, M J, Olesen, P H, Suzdak, P D, Swedberg, M D, Sauerberg, P

“…Xanomeline [3(3-hexyloxy-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-me thylpyridine)] was evaluated in vivo in rat brain for effects on neurotransmitter…”
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Reversal of pertussis toxin-induced thermal allodynia by muscarinic cholinergic agonists in mice by Womer, Daniel E, Shannon, Harlan E

“…The intrathecal administration of pertussis toxin (PTX) not only blocks the antinociceptive effects of the muscarinic cholinergic receptor agonist oxotremorine…”
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Meta-chlorophenylpiperazine induced changes in locomotor activity are mediated by 5-HT1 as well as 5-HT2C receptors in mice by GLEASON, S. D, SHANNON, H. E

“…1-(Meta-chloro)phenylpiperazine (m-CPP) is a 5-HT receptor agonist which has been purported to be relatively selective for the 5-HT2C receptor. In particular,…”
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Xanomeline compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects by Bymaster, Frank P., Carter, Petra A., Peters, Steven C., Zhang, Wei, Ward, John S., Mitch, Charles H., Calligaro, David O., Whitesitt, Celia A., DeLapp, Neil, Shannon, Harlan E., Rimvall, Karin, Jeppesen, Lone, Sheardown, Malcolm J., Fink-Jensen, Anders, Sauerberg, Per

“…Activation of muscarinic m1 receptors which are coupled to the phosphoinositide (PI) second messenger transduction system is the initial objective of…”
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