Search Results - "SHANGJIN YANG"

Microstructures and thermodynamic properties of high-entropy alloys CoCrCuFeNi by Wu, Bo, Xie, Zheyu, Huang, Jinchang, Lin, Jinwei, Yang, Yixu, Jiang, Linqiao, Huang, Jianglin, Ye, Guoxin, Zhao, Chunfeng, Yang, Shangjin, Sa, Baisheng

“…The high entropy alloys (HEAs) is a kind of innovative alloy design conception. However, seldom quantitative thermodynamics descriptions were reported in the…”
Get full text

Mechanism of Action and Preclinical Antitumor Activity of the Novel Hypoxia-Activated DNA Cross-Linking Agent PR-104 by PATTERSON, Adam V, FERRY, Dianne M, SHANGJIN YANG, DENNY, William A, WILSON, William R, EDMUNDS, Shelley J, YONGCHUAN GU, SINGLETON, Rachelle S, PATEL, Kashyap, PULLEN, Susan M, HICKS, Kevin O, SYDDALL, Sophie P, ATWELL, Graham J

“…Purpose: Hypoxia is a characteristic of solid tumors and a potentially important therapeutic target. Here, we characterize the mechanism of action and…”
Get full text

Hypoxia-Activated Prodrugs: Substituent Effects on the Properties of Nitro seco-1,2,9,9a-Tetrahydrocyclopropa[c]benz[e]indol-4-one (nitroCBI) Prodrugs of DNA Minor Groove Alkylating Agents by Tercel, Moana, Atwell, Graham J, Yang, Shangjin, Stevenson, Ralph J, Botting, K. Jane, Boyd, Maruta, Smith, Eileen, Anderson, Robert F, Denny, William A, Wilson, William R, Pruijn, Frederik B

“…Nitrochloromethylbenzindolines (nitroCBIs) are a new class of hypoxia-activated prodrugs for antitumor therapy. The recently reported prototypes undergo…”
Get full text

Synthesis and Structure−Activity Relationships for 2,4-Dinitrobenzamide-5-mustards as Prodrugs for the Escherichia coli nfsB Nitroreductase in Gene Therapy by Atwell, Graham J, Yang, Shangjin, Pruijn, Frederik B, Pullen, Susan M, Hogg, Alison, Patterson, Adam V, Wilson, William R, Denny, William A

“…A series of 2,4-dinitrobenzamide mustards were prepared from 5-chloro-2,4-dinitrobenzoic acid or the corresponding 5-dimesylate mustard as potential prodrugs…”
Get full text

Hypoxic selectivity and solubility—investigating the properties of A-ring substituted nitro seco-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-ones (nitroCBIs) as hypoxia-activated prodrugs for antitumor therapy by Tercel, Moana, Yang, Shangjin, Atwell, Graham J., Smith, Eileen, Gu, Yongchuan, Anderson, Robert F., Denny, William A., Wilson, William R., Pruijn, Frederik B.

“…Nitro seco-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-ones (nitroCBIs) are a new class of prodrugs for antitumor therapy that undergo hypoxia-selective…”
Get full text

A New Short Synthesis of 3-Substituted 5-Amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indoles (Amino-CBIs) by Yang, Shangjin, Denny, William A

“…A new short synthesis of 3-substituted 5-amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indoles from Martius Yellow is disclosed. The key steps of the synthesis…”
Get full text

Synthesis and cytotoxic activity of N-[(alkylamino)alkyl]carboxamide derivatives of 7-oxo-7H-benz[de]anthracene, 7-oxo-7H-naphtho[1,2,3-de]quinoline, and 7-oxo-7H-benzo[e]perimidine by Bu, Xianyong, Chen, Junjie, Deady, Leslie W., Smith, Clare L., Baguley, Bruce C., Greenhalgh, Debra, Yang, Shangjin, Denny, William A.

“…We discuss the synthesis and structure–cytotoxicity relationships of GC-selective naphthoquinoline-11-carboxamides and analogues. Examples showed high activity…”
Get full text

Aziridinyldinitrobenzamides:  Synthesis and Structure−Activity Relationships for Activation by E. coli Nitroreductase by Helsby, Nuala A, Atwell, Graham J, Yang, Shangjin, Palmer, Brian D, Anderson, Robert F, Pullen, Susan M, Ferry, Dianne M, Hogg, Alison, Wilson, William R, Denny, William A

“…The 5-aziridinyl-2,4-dinitrobenzamide CB 1954 is a substrate for the oxygen-insensitive nitroreductase (NTR) from E. coli and is in clinical trial in…”
Get full text

An improved synthesis of 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by Atwell, Graham J, Yang, Shangjin, Denny, William A

“…5,6-Dimethylxanthenone-4-acetic acid (DMXAA) is a novel anticancer agent with a number of unique activities, and is in clinical trial. The current synthesis of…”
Get full text

Soil-moisture-dependent nocturnal water use strategy and its responses to meteorological factors in a seasonal-arid poplar plantation by Di, Nan, Yang, Shangjin, Liu, Yang, Fan, Yunxiang, Duan, Jie, Nadezhdina, Nadezhda, Li, Ximeng, Xi, Benye

“…Nocturnal water uses (Qn) significantly affect global water budgets and diurnal water cycles, which are currently suffering from restrictions of soil drought…”
Get full text

Radial force cancellation method and experimental analysis of BTA deep hole drilling under cutting fluid rheology by Chen, Zhenya, Yang, Shangjin, Li, Xiang, Ma, Zhuoqiang, Bai, Yuxin, Suo, Chao, Yan, Shoujun

“…The generating conditions and affecting elements of oil film pressure of deep hole drilling are investigated based on the idea of hydrodynamic lubrication. A…”
Get full text

A short conversion of cyclohexanones to cycloheptenones by Yang, Shangjin, Hungerhoff, Benno, Metz, Peter

“…Cycloheptenones are efficiently prepared from cyclohexanones via organoaluminum-promoted ring enlargement with trimethylsilydiazomethane and subsequent…”
Get full text

Optimised synthesis of a nitroCBI hypoxia-activated prodrug with substantial anticancer activity by Lee, Ho H., Dickson, Benjamin D., Stevenson, Ralph J., Yang, Shangjin, Tercel, Moana

“…An optimised synthesis of a hypoxia-activated anticancer prodrug related to the duocarmycin family of natural products is described. The improved 10-step…”
Get full text

Structural, half-metallic and elastic properties of the half-Heusler compounds NiMnM (M = Sb, As and Si) and IrMnAs from first-principles calculations by Wu, Yufeng, Wu, Bo, Wei, Zhenyi, Zhou, Zeyou, Zhao, Chunfeng, Xiong, Yuanpeng, Tou, Shushi, Yang, Shangjin, Zhou, Baiyang, Shao, Yanqun

“…The structural, half-metallic and elastic properties of the half-Heusler compounds NiMnM (M = Sb, As and Si) and IrMnAs were investigated using…”
Get full text

A new short synthesis of 5,6-dimethylxanthenone-4-acetic acid (ASA404, DMXAA) by Yang, Shangjin, Denny, William A.

“…A new four-step synthesis (>50% overall yield) of the drug ASA404 via 2,5-dibromo-3,4-dimethylbenzoic acid is described. A new short synthesis of…”
Get full text

Thermodynamic Properties of Elements and Compounds in Al-Sc Binary System from Ab Initio Calculations Based on Density Functional Theory by Zhou, Zeyou, Wu, Bo, Dou, Shushi, Zhao, Chunfeng, Xiong, Yuanpeng, Wu, Yufeng, Yang, Shangjin, Wei, Zhenyi

“…The thermodynamic properties of FCC Al, HCP Sc, B2 AlSc, C15 Al 2 Sc, B8 2 AlSc 2 , and L1 2 Al 3 Sc were studied using ab initio calculations based on density…”
Get full text

Selective Treatment of Hypoxic Tumor Cells In Vivo: Phosphate Pre-Prodrugs of Nitro Analogues of the Duocarmycins by Tercel, Moana, Atwell, Graham J, Yang, Shangjin, Ashoorzadeh, Amir, Stevenson, Ralph J, Botting, K. Jane, Gu, Yongchuan, Mehta, Sunali Y, Denny, William A, Wilson, William R, Pruijn, Frederik B

“…Hitting the hypoxic target: Combining a nitro prodrug with a water‐soluble phosphate converts duocarmycin analogues from highly toxic DNA‐alkylating agents to…”
Get full text

Synthesis of asymmetric halomesylate mustards with aziridineethanol/alkali metal halides: application to an improved synthesis of the hypoxia prodrug PR-104 by Yang, Shangjin, Atwell, Graham J., Denny, William A.

“…Aromatic asymmetric halomesylate mustards are efficiently prepared by reaction of activated aromatic chlorides with aziridineethanol/alkali metal halides,…”
Get full text

[O9]Thermodynamic properties and phase diagram revisit of Al-Sc binary system from ab initio calculations and calphad assessment by Wu, Bo, Zhou, Zeyou, Peng, Qiong, Dou, Shushi, Fang, Yuan, Wu, Yufeng, Yang, Shangjin, Wei, Zhenyi, Chen, Zuhua

Get full text

基于潮流及短路计算的电力系统Ward等值实现方法 by 许海, 杨尚瑾, 金雪芬, 汪扬

Get full text