Search Results - "SHANGDE CAI"

Fluorine-18-Labeled Fluoromisonidazole Positron Emission and Computed Tomography-Guided Intensity-Modulated Radiotherapy for Head and Neck Cancer: A Feasibility Study by Lee, Nancy Y., M.D, Mechalakos, James G., Ph.D, Nehmeh, Sadek, Ph.D, Lin, Zhixiong, M.D, Squire, Olivia D., R.N, Cai, Shangde, Ph.D, Chan, Kelvin, B.A, Zanzonico, Pasquale B., Ph.D, Greco, Carlo, M.D, Ling, Clifton C., Ph.D, Humm, John L., Ph.D, Schöder, Heiko, M.D

“…Purpose Hypoxia renders tumor cells radioresistant, limiting locoregional control from radiotherapy (RT). Intensity-modulated RT (IMRT) allows for targeting of…”
Get full text

Molecular imaging of temporal dynamics and spatial heterogeneity of hypoxia-inducible factor-1 signal transduction activity in tumors in living mice by SERGANOVA, Inna, DOUBROVIN, Michael, BLASBERG, Ronald, GELOVANI, Juri, VIDER, Jelena, PONOMAREV, Vladimir, SOGHOMONYAN, Suren, BERESTEN, Tatiana, AGEYEVA, Ludmila, SERGANOV, Alexander, CAI, Shangde, BALATONI, Julius

“…Tumor hypoxia is a spatially and temporally heterogeneous phenomenon, which results from several tumor and host tissue-specific processes. To study the…”
Get full text

Escherichia coli Nissle 1917 Facilitates Tumor Detection by Positron Emission Tomography and Optical Imaging by BRADER, Peter, STRITZKER, Jochen, BLASBERG, Ronald, RIEDL, Christopher C, ZANZONICO, Pat, SHANGDE CAI, BURNAZI, Eva M, RASHID GHANI, E, HRICAK, Hedvig, SZALAY, Aladar A, YUMAN FONG

“…Purpose: Bacteria-based tumor-targeted therapy is a modality of growing interest in anticancer strategies. Imaging bacteria specifically targeting and…”
Get full text

Imaging Colon Cancer Response Following Treatment with AZD1152: A Preclinical Analysis of [18F]Fluoro-2-deoxyglucose and 3'-deoxy-3'-[18F]Fluorothymidine Imaging by MOROZ, Maxim A, KOCHETKOV, Tatiana, BERTINO, Joseph R, BLASBERG, Ronald G, SHANGDE CAI, JIYUAN WU, SHAMIS, Mikhail, NAIR, Jayasree, DE STANCHINA, Elisa, SERGANOVA, Inna, SCHWARTZ, Gary K, BANERJEE, Debabrata

“…To determine whether treatment response to the Aurora B kinase inhibitor, AZD1152, could be monitored early in the course of therapy by noninvasive…”
Get full text

3'-Deoxy-3'-[18F]Fluorothymidine Positron Emission Tomography Is a Sensitive Method for Imaging the Response of BRAF-Dependent Tumors to MEK Inhibition by SOLIT, David B, SANTOS, Elmer, PRATILAS, Christine A, LOBO, Jose, MOROZ, Maxim, SHANGDE CAI, BLASBERG, Ronald, SEBOLT-LEOPOLD, Judith, LARSON, Steven, ROSEN, Neal

“…Activating mutations of BRAF occur in approximately 7% of all human tumors and in the majority of melanomas. These tumors are very sensitive to pharmacologic…”
Get full text

Imaging of HSV-tk Reporter Gene Expression: Comparison Between [18F]FEAU, [18F]FFEAU, and Other Imaging Probes by Miyagawa, Tadashi, Gogiberidze, George, Serganova, Inna, Cai, Shangde, Balatoni, Julius A, Thaler, Howard T, Ageyeva, Lyudmila, Pillarsetty, Nagavarakishore, Finn, Ronald D, Blasberg, Ronald G

“…Herpes virus type 1 thymidine kinase (HSV1-tk) and the mutant HSV1-sr39tk are the 2 most widely used "reporter genes" for radiotracer-based imaging. Two…”
Get full text

An improved strategy for the synthesis of [18 F]-labeled arabinofuranosyl nucleosides by Zhang, Hanwen, Cantorias, Melchor V, Pillarsetty, NagaVaraKishore, Burnazi, Eva M, Cai, Shangde, Lewis, Jason S

“…Abstract The expression of the herpes simplex virus type-1 thymidine kinase (HSV1-tk) gene can be imaged efficaciously using a variety of 2′-[18…”
Get full text

Synthesis and Evaluation of [18F] Labeled Pyrimidine Nucleosides for Positron Emission Tomography Imaging of Herpes Simplex Virus 1 Thymidine Kinase Gene Expression by Pillarsetty, Nagavarakishore, Cai, Shangde, Ageyeva, Lyudmila, Finn, Ronald D, Blasberg, Ronald G

“…Synthesis of three novel 2‘-deoxy-2‘-[18F]fluoro-1-β-d-arabinofuranosyluracil derivatives [18F]FPAU, [18F]FBrVAU, and [18F]FTMAU is reported. The compounds…”
Get full text

Imaging of hypoxia-driven gene expression in an orthotopic liver tumor model by Brader, Peter, Riedl, Christopher Cesare, Woo, Yanghee, Ponomarev, Vladimir, Zanzonico, Pat, Wen, Bixiu, Cai, Shangde, Hricak, Hedvig, Fong, Yuman, Blasberg, Ronald, Serganova, Inna

“…The purpose of this study was to monitor hypoxia in an orthotopic liver tumor model using a hypoxia-sensitive reporter imaging system and to image enhanced…”
Get full text

Molecular imaging reveals skeletal engraftment sites of transplanted bone marrow cells by Mayer-Kuckuk, Philipp, Doubrovin, Mikhail, Bidaut, Luc, Budak-Alpdogan, Tulin, Cai, Shangde, Hubbard, Vanessa, Alpdogan, Onder, van den Brink, Marcel, Bertino, Joseph R, Blasberg, Ronald G, Banerjee, Debabrata, Gelovani, Juri

“…Molecular imaging holds great promise for the in vivo study of cell therapy. Our hypothesis was that multimodality molecular imaging can identify the initial…”
Get full text

Assessment of regional tumor hypoxia using 18F-fluoromisonidazole and 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone) positron emission tomography: Comparative study featuring microPET imaging, Po2 probe measurement, autoradiography, and fluorescent microscopy in the R3327-AT and FaDu rat tumor models by O'Donoghue, Joseph A, Zanzonico, Pat, Pugachev, Andrei, Wen, Bixiu, Smith-Jones, Peter, Cai, Shangde, Burnazi, Eva, Finn, Ronald D, Burgman, Paul, Ruan, Shutian, Lewis, Jason S, Welch, Michael J, Ling, C Clifton, Humm, John L

“…To compare two potential positron emission tomography (PET) tracers of tumor hypoxia in an animal model. The purported hypoxia imaging agents…”
Get more information

Combined 18F-FDG and 11C-Methionine PET Scans in Patients with Newly Progressive Metastatic Prostate Cancer by Nunez, Rodolfo, Macapinlac, Homer A, Yeung, Henry W.D, Akhurst, Tim, Cai, Shangde, Osman, Iman, Gonen, Mithat, Riedel, Elyn, Scher, Howard I, Larson, Steven M

“…Metastatic prostate cancer may respond initially to hormone suppression, with involution of tumor sites, but ultimate tumor progression is inevitable. Our aim…”
Get full text

Monitoring the Efficacy of Adoptively Transferred Prostate Cancer-Targeted Human T Lymphocytes with PET and Bioluminescence Imaging by Dobrenkov, Konstantin, Olszewska, Malgorzata, Likar, Yury, Shenker, Larissa, Gunset, Gertrude, Cai, Shangde, Pillarsetty, Nagavarakishore, Hricak, Hedvig, Sadelain, Michel, Ponomarev, Vladimir

“…Noninvasive imaging technologies have the potential to enhance the monitoring and improvement of adoptive therapy with tumor-targeted T lymphocytes. We…”
Get full text

A new pyrimidine-specific reporter gene: a mutated human deoxycytidine kinase suitable for PET during treatment with acycloguanosine-based cytotoxic drugs by Likar, Yury, Zurita, Juan, Dobrenkov, Konstantin, Shenker, Larissa, Cai, Shangde, Neschadim, Anton, Medin, Jeffrey A, Sadelain, Michel, Hricak, Hedvig, Ponomarev, Vladimir

“…In this article, we describe a series of new human-derived reporter genes based on human deoxycytidine kinase (dCK) suitable for clinical PET. Native dCK and…”
Get full text

Comparison of Radiolabeled Nucleoside Probes (FIAU, FHBG, and FHPG) for PET Imaging of HSV1-tk Gene Expression by Tjuvajev, Juri Gelovani, Doubrovin, Mikhail, Akhurst, Timothy, Cai, Shangde, Balatoni, Julius, Alauddin, Mian M, Finn, Ronald, Bornmann, William, Thaler, Howard, Conti, Peter S, Blasberg, Ronald G

“…The efficacy of 3 radiolabeled probes of current interest for imaging herpes simplex virus type 1 thymidine kinase (HSV1-tk) expression in vivo with PET,…”
Get full text

PET imaging of HSV1-tk mutants with acquired specificity toward pyrimidine- and acycloguanosine-based radiotracers by Likar, Yury, Dobrenkov, Konstantin, Olszewska, Malgorzata, Shenker, Larissa, Cai, Shangde, Hricak, Hedvig, Ponomarev, Vladimir

“…Purpose The aim of this study was to create an alternative mutant of the herpes simplex virus type 1 thymidine kinase (HSV1-tk) reporter gene with reduced…”
Get full text

Combined (18)F-FDG and (11)C-methionine PET scans in patients with newly progressive metastatic prostate cancer by Nunez, Rodolfo, Macapinlac, Homer A, Yeung, Henry W D, Akhurst, Tim

“…Metastatic prostate cancer may respond initially to hormone suppression, with involution of tumor sites, but ultimate tumor progression is inevitable. Our aim…”
Get full text

Initial results with (11)C-acetate positron emission tomography/computed tomography (PET/CT) in the staging of urinary bladder cancer by Schöder, Heiko, Ong, Seng C, Reuter, Victor E, Cai, Shangde, Burnazi, Eva, Dalbagni, Guido, Larson, Steven M, Bochner, Bernard H

“…To investigate the utility of (11)C-acetate positron emission tomography/computed tomography (PET/CT) for staging of bladder cancer and response assessment…”
Get full text

A New Acycloguanosine-Specific Supermutant of Herpes Simplex Virus Type 1 Thymidine Kinase Suitable for PET Imaging and Suicide Gene Therapy for Potential Use in Patients Treated with Pyrimidine-Based Cytotoxic Drugs by Likar, Yury, Dobrenkov, Konstantin, Olszewska, Malgorzata, Vider, Elena, Shenker, Larissa, Cai, Shangde, Pillarsetty, Nagavarakishore, Hricak, Hedvig, Ponomarev, Vladimir

“…The herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene is widely used as a suicide gene in combination with ganciclovir (GCV) and as a nuclear imaging…”
Get full text

An improved strategy for the synthesis of [18F]-labeled arabinofuranosyl nuclosides by Zhang, Hanwen, Cantorias, Melchor V., Pillarsetty, NagaVaraKishore, Burnazi, Eva M., Cai, Shangde, Lewis, Jason S.

“…The expression of the herpes simplex virus type-1 thymidine kinase (HSV1-tk) gene can be imaged efficaciously using a variety of 2′-[ 18…”
Get full text