Search Results - "SHALINSKY, D. R"

Phase I trial of SU14813 in patients with advanced solid malignancies by Fiedler, W., Giaccone, G., Lasch, P., van der Horst, I., Brega, N., Courtney, R., Abbattista, A., Shalinsky, D.R., Bokemeyer, C., Boven, E.

“…Background: This phase I, open-label, dose-escalation study investigated SU14813, an oral multitargeted tyrosine kinase inhibitor, in adults with solid tumors…”
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Broad Antitumor and Antiangiogenic Activities of AG3340, a Potent and Selective MMP Inhibitor Undergoing Advanced Oncology Clinical Trials by SHALINSKY, D. R., BREKKEN, J., ZOU, H., MCDERMOTT, C. D., FORSYTH, P., EDWARDS, D., MARGOSIAK, S., BENDER, S., TRUITT, G., WOOD, A., VARKI, N. M., APPELT, K.

“…We studied AG3340, a potent metalloproteinase (MMP) inhibitor with pM affinities for inhibiting gelatinases (MMP‐2 and ‐9), MT‐MMP‐1 (MMP‐14), and…”
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Ventilator-Induced Lung Injury Upregulates and Activates Gelatinases and EMMPRIN . Attenuation by the Synthetic Matrix Metalloproteinase Inhibitor, Prinomastat (AG3340) by Foda, Hussein D, Rollo, Ellen E, Drews, Michelle, Conner, Cathleen, Appelt, Krzysztof, Shalinsky, David R, Zucker, Stanley

“…Mechanical ventilation has become an indispensable therapeutic modality for patients with respiratory failure. However, a serious potential complication of MV…”
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Rapid vascular regrowth in tumors after reversal of VEGF inhibition by Mancuso, Michael R, Davis, Rachel, Norberg, Scott M, O'Brien, Shaun, Sennino, Barbara, Nakahara, Tsutomu, Yao, Virginia J, Inai, Tetsuichiro, Brooks, Peter, Freimark, Bruce, Shalinsky, David R, Hu-Lowe, Dana D, McDonald, Donald M

“…Inhibitors of VEGF signaling can block angiogenesis and reduce tumor vascularity, but little is known about the reversibility of these changes after treatment…”
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Synergistic interaction between cisplatin and taxol in human ovarian carcinoma cells in vitro by JEKUNEN, A. P, CHRISTEN, R. D, SHALINSKY, D. R, HOWELL, S. B

“…Taxol, a unique tubulin active agent, was found to demonstrate a marked schedule-dependent synergistic interaction with cisplatin (DDP) in the killing of human…”
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Marked Antiangiogenic and Antitumor Efficacy of AG3340 in Chemoresistant Human Non-Small Cell Lung Cancer Tumors: Single Agent and Combination Chemotherapy Studies by SHALINSKY, D. R, BREKKEN, J, ZOU, H, BLOOM, L. A, MCDERMOTT, C. D, ZOOK, S, VARKI, N. M, APPELT, K

“…Effective therapy is needed to improve the survival of patients with advanced lung cancers. We studied the effects of a selective metalloprotease inhibitor,…”
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Enhanced antitumor efficacy of cisplatin in combination with ALRT1057 (9-cis retinoic acid) in human oral squamous carcinoma xenografts in nude mice by SHALINSKY, D. R, BISCHOFF, E. D, GREGORY, M. L, LAMPH, W. W, HEYMAN, R. A, HAYES, J. S, THOMAZY, V, DAVIES, P. J. A

“…Cisplatin (DDP) is commonly used to treat head and neck tumors. Therapy frequently fails due to development of DDP resistance or toxicities associated with DDP…”
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Retinoid-induced suppression of squamous cell differentiation in human oral squamous cell carcinoma xenografts (Line 1483) in athymic nude mice by SHALINSKY, D. R, BISCHOFF, E. D, THOMAZY, V, GREGORY, M. L, GOTTARDIS, M. M, HAYES, J. S, LAMPH, W. W, HEYMAN, R. A, SHIRLEY, M. A, COOKE, T. A, DAVIES, P. J. A

“…Retinoids are promising agents for therapy of squamous cancers. In vitro, retinoids decrease expression of differentiation markers in head and neck squamous…”
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Regulation of initial vinblastine influx by P-glycoprotein by SHALINSKY, D. R, JEKUNEN, A. P, ALCAREZ, J. E, CHRISTEN, R. D, KIM, S, KHATIBI, S, HOWELL, S. B

“…P-glycoprotein (PGP) is an energy-dependent efflux pump that serves to protect cells against the cytotoxicity of many natural product drugs including…”
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The efficacy of 9-cis retinoic acid in experimental models of cancer by GOTTARDIS, M. M, LAMPH, W. W, SHALINSKY, D. R, WELLSTEIN, A, HEYMAN, R. A

“…9-cis retinoic acid (9-cis RA) is a retinoid receptor pan-agonist that binds with high affinity to both retinoic acid receptors (RARs) and retinoid X receptors…”
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A novel retinoic acid receptor-selective retinoid, ALRT1550, has potent antitumor activity against human oral squamous carcinoma xenografts in nude mice by SHALINSKY, D. R, BISCHOFF, E. D, LAMPH, W. W, ZHANG, L, BOEHM, M. F, DAVIES, P. J. A, NADZAN, A. M, HEYMAN, R. A

“…We have identified a novel retinoid, ALRT1550, that potently and selectively activates retinoic acid receptors (RARs). ALRT1550 binds RARs with Kd values of…”
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Antitumor efficacy of AG3340 associated with maintenance of minimum effective plasma concentrations and not total daily dose, exposure or peak plasma concentrations by SHALINSKY, D. R, BREKKEN, J, ZOU, H, KOLIS, S, WOOD, A, WEBBER, S, APPELT, K

“…Oral administration of AG3340, a novel metalloprotease (MMP) inhibitor, suppresses the growth of human colon adenocarcinoma (COLO-320DM) tumors in vivo (Proc…”
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Phase I/pharmacokinetic study of high-dose progesterone and doxorubicin by Christen, R D, McClay, E F, Plaxe, S C, Yen, S S, Kim, S, Kirmani, S, Wilgus, L L, Heath, D D, Shalinsky, D R, Freddo, J L

“…We developed a new formulation of progesterone that permits administration of up to 10 g of progesterone as a continuous intravenous infusion over 24 hours and…”
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In vitro modulation of cisplatin accumulation in human ovarian carcinoma cells by pharmacologic alteration of microtubules by CHRISTEN, R. D, JEKUNEN, A. P, JONES, J. A, THIEBAUT, F, SHALINSKY, D. R, HOWELL, S. B

“…We have previously shown that forskolin and 3-isobutyl-1-methylxanthine (IBMX) increased accumulation of cisplatin (DDP) in DDP-sensitive 2008 human ovarian…”
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HIV-1 Tat neurotoxicity is prevented by matrix metalloproteinase inhibitors by Johnston, James B., Zhang, Kunyan, Silva, Claudia, Shalinsky, David R., Conant, Katherine, Ni, Weimin, Corbett, Dale, Yong, Voon Wee, Power, Christopher

“…The release of potentially neurotoxic molecules by HIV‐infected brain macrophages is accompanied by neuronal injury and death that results in the development…”
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Modulation of vinblastine sensitivity by dipyridamole in multidrug resistant fibrosarcoma cells lacking mdr1 expression by SHALINSKY, D. R, SLOVAK, M. L, HOWELL, S. B

“…We examined the ability of dipyridamole (DPM) to act synergistically with vinblastine (VBL) in HT1080 fibrosarcoma cells and a drug-resistant variant,…”
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Selective modulation of vinblastine sensitivity by 1,9-dideoxyforskolin and related diterpenes in multidrug resistant tumour cells by SHALINSKY, D. R, HEATH, D. D, JEKUNEN, A. P, ALCARAZ, J. E, HOWELL, S. B

“…The ability of 1,9-dideoxyforskolin (DDF), 1-deoxyforskolin (DF) and forskolin to modulate cellular sensitivity to vinblastine (VBL) was examined in…”
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Inhibition of GSH-dependent PGH2 isomerase in mammary adenocarcinoma cells by allicin by Shalinsky, D R, McNamara, D B, Agrawal, K C

“…We have reported that allicin, a constituent of garlic oil, has no effect on the activities of platelet cyclooxygenase or thromboxane synthase, or vascular…”
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Regional lymphatic drug exposure following intraperitoneal administration of 5-fluorouracil, carboplatin, and etoposide by Lindnér, P, Heath, D D, Shalinsky, D R, Howell, S B, Naredi, P, Hafström, L

“…Intraperitoneal (i.p.) administration of chemoterapeutic agents results in greater total drug exposures in the peritoneal cavity than in plasma. A study on the…”
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Modulation of prostaglandin biosynthesis in hypoxic murine mammary adenocarcinoma cells by misonidazole by SHALINSKY, D. R, MCNAMARA, D. B, AGRAWAL, K. C

“…Resistance of hypoxic cells to radiation and chemotherapy remains a major limitation to effective therapy of solid tumors. Misonidazole, a 2-nitroimidazole…”
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