Search Results - "SHALAEV, Evgenyi Y"

Glassy dynamics of sorbitol solutions at terahertz frequencies by Sibik, Juraj, Shalaev, Evgenyi Y, Zeitler, J Axel

“…The absorption spectra of D-sorbitol and a range of its concentrated aqueous solutions were studied by terahertz spectroscopy over the temperature interval of…”
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Investigation of Design Space for Freeze-Drying: Use of Modeling for Primary Drying Segment of a Freeze-Drying Cycle by Koganti, Venkat Rao, Shalaev, Evgenyi Y., Berry, Mark R., Osterberg, Thomas, Youssef, Maickel, Hiebert, David N., Kanka, Frank A., Nolan, Martin, Barrett, Rosemary, Scalzo, Gioval, Fitzpatrick, Gillian, Fitzgibbon, Niall, Luthra, Sumit, Zhang, Liling

“…In this work, we explore the idea of using mathematical models to build design space for the primary drying portion of freeze-drying process. We start by…”
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Optimization of a Raman microscopy technique to efficiently detect amorphous-amorphous phase separation in freeze-dried protein formulations by Forney-Stevens, Kelly M, Pelletier, Michael J, Shalaev, Evgenyi Y, Pikal, Michael J, Bogner, Robin H

“…A confocal Raman microscopic technique was optimized to more efficiently detect amorphous-amorphous phase separation in freeze-dried protein formulations. A…”
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Occurrence of Glass Transitions in Long-Chain Phosphatidylcholine Mesophases by Shalaev, Evgenyi Y, Zografi, George, Steponkus, Peter L

“…Several phosphatidylcholine (PC) species were studied by differential scanning calorimetry at different levels of hydration. A glass transition was observed in…”
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The importance of individual protein molecule dynamics in developing and assessing solid state protein preparations by Hill, John J, Shalaev, Evgenyi Y, Zografi, George

“…Processing protein solutions into the solid state is a common approach for generating stable amorphous protein mixtures that are suitable for long-term…”
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Surface Acidity and Solid-State Compatibility of Excipients with an Acid-Sensitive API: Case Study of Atorvastatin Calcium by Govindarajan, Ramprakash, Landis, Margaret, Hancock, Bruno, Gatlin, Larry A., Suryanarayanan, Raj, Shalaev, Evgenyi Y.

“…The objectives of this study were to measure the apparent surface acidity of common excipients and to correlate the acidity with the chemical stability of an…”
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Water clusters in amorphous pharmaceuticals by Authelin, Jean-Rene, MacKenzie, Alan P, Rasmussen, Don H, Shalaev, Evgenyi Y

“…Amorphous materials, although lacking the long-range translational and rotational order of crystalline and liquid crystalline materials, possess certain local…”
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Biopolymer mediated trehalose uptake for enhanced erythrocyte cryosurvival by Lynch, Andrew L, Chen, Rongjun, Dominowski, Paul J, Shalaev, Evgenyi Y, Yancey, Robert J, Slater, Nigel K.H

“…Abstract A biopolymer has been shown to facilitate efficient delivery of trehalose, a bioprotectant normally impermeable to the phospholipid bilayer, into…”
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Impact of sertraline salt form on the oxidative stability in powder blends by Hsieh, Yi-Ling, Yu, Weili, Xiang, Yanqiao, Pan, Weitao, Waterman, Kenneth C., Shalaev, Evgenyi Y., Shamblin, Sheri L., Taylor, Lynne S.

“…Oxidation of active pharmaceutical ingredients is a common chemical degradation process occurring in solid dosage forms. The aim of this study was to…”
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Pronounced Microheterogeneity in a Sorbitol–Water Mixture Observed through Variable Temperature Neutron Scattering by Chou, Shin G, Soper, Alan K, Khodadadi, Sheila, Curtis, Joseph E, Krueger, Susan, Cicerone, Marcus T, Fitch, Andrew N, Shalaev, Evgenyi Y

“…In this study, the structure of concentrated d-sorbitol–water mixtures is studied by wide- and small-angle neutron scattering (WANS and SANS) as a function of…”
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Chemical stability of amorphous materials: specific and general media effects in the role of water in the degradation of freeze-dried zoniporide by Luthra, Suman A, Shalaev, Evgenyi Y, Medek, Ales, Hong, Jinyang, Pikal, Michael J

“…The objective of the present work was to determine whether hydrolysis in a model lyophile was influenced by general media effects with water-changing…”
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Thermodynamic and dynamic factors involved in the stability of native protein structure in amorphous solids in relation to levels of hydration by Hill, John J, Shalaev, Evgenyi Y, Zografi, George

“…The internal, dynamical fluctuations of protein molecules exhibit many of the features typical of polymeric and bulk small molecule glass forming systems. The…”
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Impact of freeze-drying on ionization of sulfonephthalein probe molecules in trehalose-citrate systems by Govindarajan, Ramprakash, Chatterjee, Koustuv, Gatlin, Larry, Suryanarayanan, Raj, Shalaev, Evgenyi Y

“…"pH memory," i.e., correlation between pH of solution before freeze-drying and chemical reactivity in the freeze-dried state, has been reported in many…”
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Investigation of PEG crystallization in frozen PEG-sucrose-water solutions: II. Characterization of the equilibrium behavior during freeze-thawing by Bhatnagar, Bakul S, Martin, Susan M, Teagarden, Dirk L, Shalaev, Evgenyi Y, Suryanarayanan, Raj

“…Our objective was to characterize, by DSC and XRD, the equilibrium thermal behavior of frozen aqueous solutions containing polyethylene glycol (PEG) and…”
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Synchrotron X-ray Diffraction Investigation of the Anomalous Behavior of Ice During Freezing of Aqueous Systems by Varshney, Dushyant B, Elliott, James A, Gatlin, Larry A, Kumar, Satyendra, Suryanarayanan, Raj, Shalaev, Evgenyi Y

“…Simple aqueous systems, i.e., phosphate−glycine buffers and pure water, were studied at subambient temperatures by X-ray difractometry using a high-intensity…”
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Glycine crystallization in frozen and freeze-dried systems : Effect of pH and buffer concentration by VARSHNEY, Dushyant B, KUMAR, Satyendra, SHALAEV, Evgenyi Y, SUNDARAMURTHI, Prakash, KANG, Shin-Woong, GATLIN, Larry A, SRYANARAYANAN, Raj

“…(1) To determine the effect of solution pH before lyophilization, over the range of 1.5 to 10, on the salt and polymorphic forms of glycine crystallizing in…”
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Investigation of PEG crystallization in frozen PEG-sucrose-water solutions. I. Characterization of the nonequilibrium behavior during freeze-thawing by Bhatnagar, Bakul S, Martin, Susan M, Teagarden, Dirk L, Shalaev, Evgenyi Y, Suryanarayanan, Raj

“…Our objective was to characterize the nonequilibrium thermal behavior of frozen aqueous solutions containing PEG and sucrose. Aqueous solutions of (i) sucrose…”
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Correlation between chemical reactivity and the Hammett acidity function in amorphous solids using inversion of sucrose as a model reaction by Chatterjee, Koustuv, Shalaev, Evgenyi Y, Suryanarayanan, Raj, Govindarajan, Ramprakash

“…The goal was to evaluate the effects of acidity, expressed as the Hammett acidity function, on chemical reactivity in freeze-dried materials (lyophiles)…”
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Crystalline, liquid crystalline, and isotropic phases of sodium deoxycholate in water by Su, Ziyang, Luthra, Suman, Krzyzaniak, Joseph F, Agra-Kooijman, Dena M, Kumar, Satyendra, Byrn, Stephen R, Shalaev, Evgenyi Y

“…Sodium deoxycholate (NaDC) is an important example of bile salts, representing systems with complex phase behavior involving both crystalline and mesophase…”
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Partially crystalline systems in lyophilization: II. Withstanding collapse at high primary drying temperatures and impact on protein activity recovery by Chatterjee, Koustuv, Shalaev, Evgenyi Y, Suryanarayanan, Raj

“…In an accompanying article we have described the construction of the water-rich sections of raffinose-glycine-water and trehalose-glycine-water state diagrams…”
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