Search Results - "SHAKARJIAN, Michael P"

Tetramethylenedisulfotetramine neurotoxicity: What have we learned in the past 70 years? by Lauková, Marcela, Velíšková, Jana, Velíšek, Libor, Shakarjian, Michael P.

“…Tetramethylenedisulfotetramine (tetramine, TETS, TMDT) is a seizure-producing neurotoxic chemical formed by the condensation of sulfamide and formaldehyde…”
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Mechanisms Mediating the Vesicant Actions of Sulfur Mustard after Cutaneous Exposure by Shakarjian, Michael P., Heck, Diane E., Gray, Joshua P., Sinko, Patrick J., Gordon, Marion K., Casillas, Robert P., Heindel, Ned D., Gerecke, Donald R., Laskin, Debra L., Laskin, Jeffrey D.

“…Sulfur mustard (SM), a chemical weapon first employed during World War I, targets the skin, eyes, and lung. It remains a significant military and civilian…”
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Nrf2 Regulates the Sensitivity of Mouse Keratinocytes to Nitrogen Mustard via Multidrug Resistance-Associated Protein 1 (Mrp1) by Udasin, Ronald G, Wen, Xia, Bircsak, Kristin M, Aleksunes, Lauren M, Shakarjian, Michael P, Kong, Ah-Ng Tony, Heck, Diane E, Laskin, Debra L, Laskin, Jeffrey D

“…Sulfur mustard and nitrogen mustard (mechlorethamine, HN2) are potent vesicants developed as chemical warfare agents. These electrophilic, bifunctional…”
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Induction of heme oxygenase-1 (HO-1) and NAD[P]H : Quinone oxidoreductase 1 (NQO1) by a phenolic antioxidant, butylated hydroxyanisole (BHA) and its metabolite, tert -butylhydroquinone (tBHQ) in primary-cultured human and rat hepatocytes by KEUM, Young-Sam, HAN, Yong-Hae, LIEW, Celine, KIM, Jung-Hwan, CHANGJIANG XU, XIAOLING YUAN, SHAKARJIAN, Michael P, CHONG, Saeho, KONG, Ah-Ng

“…This study was aimed to investigate the effects of a phenolic antioxidant, butylated hydroxyanisole (BHA) and its metabolite, tert-butylhydroquinone (tBHQ) on…”
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UVB light upregulates prostaglandin synthases and prostaglandin receptors in mouse keratinocytes by Black, Adrienne T., Gray, Joshua P., Shakarjian, Michael P., Mishin, Vladimir, Laskin, Debra L., Heck, Diane E., Laskin, Jeffrey D.

“…Prostaglandins belong to a class of cyclic lipid-derived mediators synthesized from arachidonic acid via COX-1, COX-2 and various prostaglandin synthases…”
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Developmental and sex differences in tetramethylenedisulfotetramine (TMDT)‐induced syndrome in rats by Lauková, Marcela, Velíšková, Jana, Velíšek, Libor, Shakarjian, Michael P.

“…ABSTRACT Tetramethylenedisulfotetramine (TMDT) is a synthetic neurotoxic rodenticide considered a chemical threat agent. Symptoms of intoxication include…”
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Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms by Chern, Chian-Ru, Lauková, Marcela, Schonwald, Antonia, Kudová, Eva, Chodounská, Hana, Chern, Chian-Jiang, Shakarjian, Michael P, Velíšková, Jana, Velíšek, Libor

“…Neurosteroids are investigated as effective antidotes for the poisoning induced by tetramethylenedisulfotetramine (TMDT) as well as treatments for epileptic…”
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Mouse model of human poisonings with tetramethylenedisulfotetramine: Characterization of the effect of exposure route on syndrome outcomes by Lauková, Marcela, Pervez, Sundas, Rosman, Rebekah, Velíšková, Jana, Velíšek, Libor, Shakarjian, Michael P

“…•Onset and potency of tetramethylenedisulfotetramine effect varies by exposure route.•Oral delivery via adulterated cereal mirrors toxicity via subcutaneous…”
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Tetramethylenedisulfotetramine: pest control gone awry by Shakarjian, Michael P., Laukova, Marcela, Velíšková, Jana, Stanton, Patric K., Heck, Diane E., Velíšek, Libor

“…Incidences of pesticide poisonings are a significant cause of morbidity and mortality worldwide. The seizure‐inducing rodenticide…”
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Differential antagonism of tetramethylenedisulfotetramine-induced seizures by agents acting at NMDA and GABAA receptors by Shakarjian, Michael P., Velíšková, Jana, Stanton, Patric K., Velíšek, Libor

“…Tetramethylenedisulfotetramine (TMDT) is a highly lethal neuroactive rodenticide responsible for many accidental and intentional poisonings in mainland China…”
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Acceleration of cutaneous wound healing by brassinosteroids by Esposito, Debora, Rathinasabapathy, Thirumurugan, Schmidt, Barbara, Shakarjian, Michael P., Komarnytsky, Slavko, Raskin, Ilya

“…Brassinosteroids are plant growth hormones involved in cell growth, division, and differentiation. Their effects in animals are largely unknown, although…”
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Combined diazepam and MK-801 therapy provides synergistic protection from tetramethylenedisulfotetramine-induced tonic-clonic seizures and lethality in mice by Shakarjian, Michael P, Ali, Mahil S, Velíšková, Jana, Stanton, Patric K, Heck, Diane E, Velíšek, Libor

“…The synthetic rodenticide, tetramethylenedisulfotetramine (TMDT), is a persistent and highly lethal GABA-gated Cl(-) channel blocker. TMDT is clandestinely…”
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Modulation of keratinocyte expression of antioxidants by 4-hydroxynonenal, a lipid peroxidation end product by Zheng, Ruijin, Heck, Diane E., Mishin, Vladimir, Black, Adrienne T., Shakarjian, Michael P., Kong, Ah-Ng Tony, Laskin, Debra L., Laskin, Jeffrey D.

“…4-Hydroxynonenal (4-HNE) is a lipid peroxidation end product generated in response to oxidative stress in the skin. Keratinocytes contain an array of…”
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Differential antagonism of tetramethylenedisulfotetramine-induced seizures by agents acting at NMDA and GABA(A) receptors by Shakarjian, Michael P, Velíšková, Jana, Stanton, Patric K, Velíšek, Libor

“…Tetramethylenedisulfotetramine (TMDT) is a highly lethal neuroactive rodenticide responsible for many accidental and intentional poisonings in mainland China…”
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Increased oxidative stress and antioxidant expression in mouse keratinocytes following exposure to paraquat by Black, Adrienne T., Gray, Joshua P., Shakarjian, Michael P., Laskin, Debra L., Heck, Diane E., Laskin, Jeffrey D.

“…Paraquat (1,1′-dimethyl-4,4′-bipyridinium) is a widely used herbicide known to induce skin toxicity. This is thought to be due to oxidative stress resulting…”
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Distinct effects of ultraviolet B light on antioxidant expression in undifferentiated and differentiated mouse keratinocytes by Black, Adrienne T., Gray, Joshua P., Shakarjian, Michael P., Laskin, Debra L., Heck, Diane E., Laskin, Jeffrey D.

“…Ultraviolet (UV) B causes oxidative stress, which has been implicated in carcinogenesis. We determined if the sensitivity of keratinocytes to UVB-induced…”
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Preferential expression of matrix metalloproteinase-9 in mouse skin after sulfur mustard exposure by Shakarjian, Michael P., Bhatt, Pinaki, Gordon, Marion K., Chang, Yoke-Chen, Casbohm, Stacy L., Rudge, Thomas L., Kiser, Robyn C., Sabourin, Carol L., Casillas, Robert P., Ohman-Strickland, Pamela, Riley, David J., Gerecke, Donald R.

“…Matrix metalloproteinases (MMPs), a class of enzymes responsible for the degradation of extracellular matrix proteins, play important roles in inflammatory and…”
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Abstract 1034: Induction of miR183 and miR21 is associated with down regulation of cellular signaling in nitrogen mustard mediated inhibition of tumor cell proliferation by Kim, Hong Duck, Shakarjian, Michael P., Vetrano, Anna M., Laskin, Jeffrey D., Heck, Diane E.

“…Abstract Nitrogen mustard (HN2) is a chemotherapeutic agent used to treat skin cancers and lymphomas including squamous cell carcinomas (SCC) and cutaneous T…”
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Upregulation of the Gamma‐2 Chain of Laminin‐332 (Laminin‐5) in Wounded Mouse Ears by Chang, Yoke‐Chen, Gordon, Marion K, Shakarjian, Michael P, Riley, David J, Gerecke, Donald R

“…Laminins, extracellular matrix components found in the basement membranes of tissues, are formed from combinations of α, β, and γ polypeptide chains that are…”
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Erratum to “Recombinant human relaxin reduces hypoxic pulmonary hypertension in the rat” [Pulmonary Pharmacology & Therapeutics 18 (2005) 346–353] by Tozzi, Carol A., Poiani, George J., McHugh, Nansie A., Shakarjian, Michael P., Grove, Beverly H., Samuel, Chrishan S., Unemori, Elaine N., Riley, David J.

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