Search Results - "SHAIN, H"

Daratumumab, lenalidomide, bortezomib, and dexamethasone for transplant-eligible newly diagnosed multiple myeloma: the GRIFFIN trial by Voorhees, Peter M., Kaufman, Jonathan L., Laubach, Jacob, Sborov, Douglas W., Reeves, Brandi, Rodriguez, Cesar, Chari, Ajai, Silbermann, Rebecca, Costa, Luciano J., Anderson, Larry D., Nathwani, Nitya, Shah, Nina, Efebera, Yvonne A., Holstein, Sarah A., Costello, Caitlin, Jakubowiak, Andrzej, Wildes, Tanya M., Orlowski, Robert Z., Shain, Kenneth H., Cowan, Andrew J., Murphy, Sean, Lutska, Yana, Pei, Huiling, Ukropec, Jon, Vermeulen, Jessica, de Boer, Carla, Hoehn, Daniela, Lin, Thomas S., Richardson, Paul G.

“…Lenalidomide, bortezomib, and dexamethasone (RVd) followed by autologous stem cell transplantation (ASCT) is standard frontline therapy for transplant-eligible…”
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Clonal haemopoiesis and therapy-related myeloid malignancies in elderly patients: a proof-of-concept, case-control study by Gillis, Nancy K, PharmD, Ball, Markus, PhD, Zhang, Qing, MD, Ma, Zhenjun, PhD, Zhao, YuLong, PhD, Yoder, Sean J, MS, Balasis, Maria E, BS, Mesa, Tania E, BS, Sallman, David A, MD, Lancet, Jeffrey E, Prof, Komrokji, Rami S, Prof, List, Alan F, Prof, McLeod, Howard L, Prof, Alsina, Melissa, Prof, Baz, Rachid, MD, Shain, Kenneth H, MD, Rollison, Dana E, PhD, Padron, Eric, Dr

“…Summary Background Clonal haemopoiesis of indeterminate potential (CHIP) is an age-associated genetic event linked to increased risk of primary haematological…”
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The tumor microenvironment shapes hallmarks of mature B-cell malignancies by Shain, K H, Dalton, W S, Tao, J

“…B-cell tumorigenesis results from a host of known and unknown genetic anomalies, including non-random translocations of genes that normally function as…”
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Randomized multicenter phase 2 study of pomalidomide, cyclophosphamide, and dexamethasone in relapsed refractory myeloma by Baz, Rachid C., Martin, Thomas G., Lin, Hui-Yi, Zhao, Xiuhua, Shain, Kenneth H., Cho, Hearn J., Wolf, Jeffrey L., Mahindra, Anuj, Chari, Ajai, Sullivan, Daniel M., Nardelli, Lisa A., Lau, Kenneth, Alsina, Melissa, Jagannath, Sundar

“…Pomalidomide and low-dose dexamethasone (PomDex) is standard treatment of lenalidomide refractory myeloma patients who have received >2 prior therapies. We…”
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Ibrutinib for the treatment of Bing-Neel syndrome: a multicenter study by Castillo, Jorge J., Itchaki, Gilad, Paludo, Jonas, Varettoni, Marzia, Buske, Christian, Eyre, Toby A., Chavez, Julio C., Shain, Kenneth H., Issa, Samar, Palomba, M. Lia, Pasvolsky, Oren, Simpson, David, Talaulikar, Dipti, Tam, Constantine S., Tedeschi, Alessandra, Ansell, Stephen M., Nayak, Lakshmi, Treon, Steven P.

“…The treatment of patients with Bing-Neel syndrome (BNS) is not standardized. We included patients with Waldenström macroglobulinemia (WM) and a radiologic…”
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Unification of de novo and acquired ibrutinib resistance in mantle cell lymphoma by Zhao, Xiaohong, Lwin, Tint, Silva, Ariosto, Shah, Bijal, Tao, Jiangchuan, Fang, Bin, Zhang, Liang, Fu, Kai, Bi, Chengfeng, Li, Jiannong, Jiang, Huijuan, Meads, Mark B., Jacobson, Timothy, Silva, Maria, Distler, Allison, Darville, Lancia, Zhang, Ling, Han, Ying, Rebatchouk, Dmitri, Di Liberto, Maurizio, Moscinski, Lynn C., Koomen, John M., Dalton, William S., Shain, Kenneth H., Wang, Michael, Sotomayor, Eduardo, Tao, Jianguo

“…The novel Bruton’s tyrosine kinase inhibitor ibrutinib has demonstrated high response rates in B-cell lymphomas; however, a growing number of ibrutinib-treated…”
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Disappearing Kilimanjaro snow—Are we the last generation to explore equatorial glacier biodiversity? by Zawierucha, Krzysztof, Shain, Daniel H.

“…Glaciation accompanied our human ancestors in Africa throughout the Pleistocene. Regrettably, equatorial glaciers and snow are disappearing rapidly, and we are…”
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Biocontrol of snail-borne parasites with the glossiphoniid leech, Helobdella austinensis by Saglam, Naim, Melissaratos, Diana S, Shain, Daniel H

“…Parasites in which freshwater snails are intermediate hosts pose a serious threat to human health worldwide. We show here that freshwater snails can…”
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BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models by Zhao, Xiaohong, Ren, Yuan, Lawlor, Matthew, Shah, Bijal D., Park, Paul M.C., Lwin, Tint, Wang, Xuefeng, Liu, Kenian, Wang, Michelle, Gao, Jing, Li, Tao, Xu, Mousheng, Silva, Ariosto S., Lee, Kaplan, Zhang, Tinghu, Koomen, John M., Jiang, Huijuan, Sudalagunta, Praneeth R., Meads, Mark B., Cheng, Fengdong, Bi, Chengfeng, Fu, Kai, Fan, Huitao, Dalton, William S., Moscinski, Lynn C., Shain, Kenneth H., Sotomayor, Eduardo M., Wang, Gang Greg, Gray, Nathanael S., Cleveland, John L., Qi, Jun, Tao, Jianguo

“…Drug-tolerant “persister” tumor cells underlie emergence of drug-resistant clones and contribute to relapse and disease progression. Here we report that…”
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Long-distance dispersal, ice sheet dynamics and mountaintop isolation underlie the genetic structure of glacier ice worms by Hotaling, Scott, Shain, Daniel H, Lang, Shirley A, Bagley, Robin K, Tronstad, Lusha M, Weisrock, David W, Kelley, Joanna L

“…Disentangling the contemporary and historical factors underlying the spatial distributions of species is a central goal of biogeography. For species with broad…”
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The bone ecosystem facilitates multiple myeloma relapse and the evolution of heterogeneous drug resistant disease by Bishop, Ryan T., Miller, Anna K., Froid, Matthew, Nerlakanti, Niveditha, Li, Tao, Frieling, Jeremy S., Nasr, Mostafa M., Nyman, Karl J., Sudalagunta, Praneeth R., Canevarolo, Rafael R., Silva, Ariosto Siqueira, Shain, Kenneth H., Lynch, Conor C., Basanta, David

“…Multiple myeloma (MM) is an osteolytic malignancy that is incurable due to the emergence of treatment resistant disease. Defining how, when and where myeloma…”
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Five animal phyla in glacier ice reveal unprecedented biodiversity in New Zealand's Southern Alps by Shain, Daniel H., Novis, Philip M., Cridge, Andrew G., Zawierucha, Krzysztof, Geneva, Anthony J., Dearden, Peter K.

“…Glacier ice is an extreme environment in which most animals cannot survive. Here we report the colonization of high elevation, climate-threatened glaciers…”
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β1 Integrin Adhesion Enhances IL-6―Mediated STAT3 Signaling in Myeloma Cells: Implications for Microenvironment Influence on Tumor Survival and Proliferation by SHAIN, Kenneth H, YARDE, Danielle N, MEADS, Mark B, MEI HUANG, JOVE, Richard, HAZLEHURST, Lori A, DALTON, William S

“…The bone marrow microenvironmental components interleukin (IL)-6 and fibronectin (FN) individually influence the proliferation and survival of multiple myeloma…”
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Response and resistance to CDK12 inhibition in aggressive B-cell lymphomas by Gao, Jing, Wang, Michelle Y, Ren, Yuan, Lwin, Tint, Li, Tao, Yan, Joy C, Sotomayor, Eduardo M, Duckett, Derek R, Shah, Bijal D, Shain, Kenneth H, Zhao, Xiaohong, Tao, Jianguo

“…Despite significant progress in the treatment of patients with diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL), the prognosis of patients…”
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A comparison of salvage infusional chemotherapy regimens for recurrent/refractory multiple myeloma by Griffin, Patrick T., Ho, Viet Q., Fulp, William, Nishihori, Taiga, Shain, Kenneth H., Alsina, Melissa, Baz, Rachid C.

“…BACKGROUND Despite the impact of proteasome inhibitors and immunomodulatory agents, infusional chemotherapy regimens continue to be used for patients with…”
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Hepatocellular neoplasms with loss of liver fatty acid binding protein: Clinicopathologic features and molecular profiling by Joseph, Nancy M., Blank, Annika, Shain, Alan H., Gill, Ryan M., Umetsu, Sarah E., Shafizadeh, Nafis, Torbenson, Michael S., Kakar, Sanjay

“…HNF1A-inactivated hepatocellular adenomas (H-HCA) show steatosis, no atypia and loss of liver fatty acid binding protein (LFABP). LFABP loss also occurs in…”
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Recurrent cardiotoxicity potentiated by the interaction of proteasome inhibitor and immunomodulatory therapy for the treatment of multiple myeloma by Fradley, Michael G., Groarke, John D., Laubach, Jacob, Alsina, Melissa, Lenihan, Daniel J., Cornell, Robert F., Maglio, Michelle, Shain, Kenneth H., Richardson, Paul G., Moslehi, Javid

“…Summary Patients with multiple myeloma (MM) have improved treatment options, including immunomodulatory drugs (IMiDs) and proteasome inhibitors (PIs). Despite…”
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The Glacier Ice Worm, Mesenchytraeus solifugus , Elevates Mitochondrial Inorganic Polyphosphate (PolyP) Levels in Response to Stress by Osorio, Teresa, Scoma, Ernest R, Shain, Daniel H, Melissaratos, Diana S, Riggs, Lindsey M, Hambardikar, Vedangi, Solesio, Maria E

“…The inorganic polymer, polyphosphate (polyP), is present in all organisms examined to date with putative functions ranging from the maintenance of…”
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Treatment of acquired drug resistance in multiple myeloma by combination therapy with XPO1 and topoisomerase II inhibitors by Turner, Joel G, Dawson, Jana L, Grant, Steven, Shain, Kenneth H, Dalton, William S, Dai, Yun, Meads, Mark, Baz, Rachid, Kauffman, Michael, Shacham, Sharon, Sullivan, Daniel M

“…Acquired drug resistance is the greatest obstacle to the successful treatment of multiple myeloma (MM). Despite recent advanced treatment options such as…”
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Whole-Exome sequencing analysis identified TMSB10/TRABD2A locus to be associated with carfilzomib-related cardiotoxicity among patients with multiple myeloma by Tantawy, Marwa, Yang, Guang, Algubelli, Raghunandan Reddy, DeAvila, Gabriel, Rubinstein, Samuel M, Cornell, Robert F, Fradley, Michael G, Siegel, Erin M, Hampton, Oliver A, Silva, Ariosto S, Lenihan, Daniel, Shain, Kenneth H, Baz, Rachid C, Gong, Yan

“…Proteasome inhibitor Carfilzomib (CFZ) is effective in treating patients with refractory or relapsed multiple myeloma (MM) but has been associated with…”
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