Search Results - "SHAH, Manish A"

Update on metastatic gastric and esophageal cancers by Shah, Manish A

“…Cancers of the stomach and esophagus are among the most challenging cancers of the GI tract to treat, associated with poor median survivals for metastatic…”
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Gastric cancer epidemiology and risk factors by Guggenheim, Douglas E., Shah, Manish A.

“…Gastric cancer is a prevalent yet heterogeneous disease. From diet and lifestyle to genetics and ethnicity, our appreciation of the complexity of gastric…”
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Randomized Phase III KEYNOTE-181 Study of Pembrolizumab Versus Chemotherapy in Advanced Esophageal Cancer by Kojima, Takashi, Shah, Manish A, Muro, Kei, Francois, Eric, Adenis, Antoine, Hsu, Chih-Hung, Doi, Toshihiko, Moriwaki, Toshikazu, Kim, Sung-Bae, Lee, Se-Hoon, Bennouna, Jaafar, Kato, Ken, Shen, Lin, Enzinger, Peter, Qin, Shu-Kui, Ferreira, Paula, Chen, Jia, Girotto, Gustavo, de la Fouchardiere, Christelle, Senellart, Helene, Al-Rajabi, Raed, Lordick, Florian, Wang, Ruixue, Suryawanshi, Shailaja, Bhagia, Pooja, Kang, S Peter, Metges, Jean-Philippe

“…Patients with advanced esophageal cancer have a poor prognosis and limited treatment options after first-line chemotherapy. In this open-label, phase III…”
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Treatment of Locally Advanced Esophageal Carcinoma: ASCO Guideline by Shah, Manish A, Kennedy, Erin B, Catenacci, Daniel V, Deighton, Dana C, Goodman, Karyn A, Malhotra, Narinder K, Willett, Christopher, Stiles, Brendon, Sharma, Prateek, Tang, Laura, Wijnhoven, Bas P L, Hofstetter, Wayne L

“…To develop an evidence-based clinical practice guideline to assist in clinical decision making for patients with locally advanced esophageal cancer. ASCO…”
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Zolbetuximab plus CAPOX in CLDN18.2-positive gastric or gastroesophageal junction adenocarcinoma: the randomized, phase 3 GLOW trial by Shah, Manish A., Shitara, Kohei, Ajani, Jaffer A., Bang, Yung-Jue, Enzinger, Peter, Ilson, David, Lordick, Florian, Van Cutsem, Eric, Gallego Plazas, Javier, Huang, Jing, Shen, Lin, Oh, Sang Cheul, Sunpaweravong, Patrapim, Soo Hoo, Hwoei Fen, Turk, Haci Mehmet, Oh, Mok, Park, Jung Wook, Moran, Diarmuid, Bhattacharya, Pranob, Arozullah, Ahsan, Xu, Rui-Hua

“…There is an urgent need for first-line treatment options for patients with human epidermal growth factor receptor 2 (HER2)-negative, locally advanced…”
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Bevacizumab in Combination With Chemotherapy As First-Line Therapy in Advanced Gastric Cancer: A Randomized, Double-Blind, Placebo-Controlled Phase III Study by OHTSU, Atsushi, SHAH, Manish A, STARNAWSKI, Michal, KANG, Yoon-Koo, VAN CUTSEM, Eric, SUN YOUNG RHA, SAWAKI, Akira, SOOK RYUN PARK, HO YEONG LIM, YAMADA, Yasuhide, JIAN WU, LANGER, Bernd

“…The Avastin in Gastric Cancer (AVAGAST) trial was a multinational, randomized, placebo-controlled trial designed to evaluate the efficacy of adding bevacizumab…”
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Dysregulation of ILC3s unleashes progression and immunotherapy resistance in colon cancer by Goc, Jeremy, Lv, Mengze, Bessman, Nicholas J., Flamar, Anne-Laure, Sahota, Sheena, Suzuki, Hiroaki, Teng, Fei, Putzel, Gregory G., Eberl, Gerard, Withers, David R., Arthur, Janelle C., Shah, Manish A., Sonnenberg, Gregory F.

“…Group 3 innate lymphoid cells (ILC3s) regulate immunity and inflammation, yet their role in cancer remains elusive. Here, we identify that colorectal cancer…”
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Trastuzumab emtansine versus taxane use for previously treated HER2-positive locally advanced or metastatic gastric or gastro-oesophageal junction adenocarcinoma (GATSBY): an international randomised, open-label, adaptive, phase 2/3 study by Thuss-Patience, Peter C, MD, Shah, Manish A, MD, Ohtsu, Atsushi, MD, Van Cutsem, Eric, Prof, Ajani, Jaffer A, Prof, Castro, Hugo, MD, Mansoor, Wasat, PhD, Chung, Hyun Cheol, Prof, Bodoky, Gyorgy, Prof, Shitara, Kohei, MD, Phillips, Gail D Lewis, MS, van der Horst, Tina, MSc, Harle-Yge, Marie-Laurence, MSc, Althaus, Betsy L, PharmD, Kang, Yoon-Koo, Prof

“…Summary Background Although trastuzumab plus chemotherapy is the standard of care for first-line treatment of HER2-positive advanced gastric cancer, there is…”
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Metastatic Pancreatic Cancer: ASCO Guideline Update by Sohal, Davendra P.S., Kennedy, Erin B., Cinar, Pelin, Conroy, Thierry, Copur, Mehmet S., Crane, Christopher H., Garrido-Laguna, Ignacio, Lau, Michelle W., Johnson, Tyler, Krishnamurthi, Smitha, Moravek, Cassadie, O’Reilly, Eileen M., Philip, Philip A., Pant, Shubham, Shah, Manish A., Sahai, Vaibhav, Uronis, Hope E., Zaidi, Neeha, Laheru, Daniel

“…PURPOSE The aim of this work was to provide an update to the ASCO guideline on metastatic pancreatic cancer pertaining to recommendations for therapy options…”
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Metastatic Pancreatic Cancer: ASCO Clinical Practice Guideline Update by Sohal, Davendra P S, Kennedy, Erin B, Khorana, Alok, Copur, Mehmet S, Crane, Christopher H, Garrido-Laguna, Ignacio, Krishnamurthi, Smitha, Moravek, Cassadie, O'Reilly, Eileen M, Philip, Philip A, Ramanathan, Ramesh K, Ruggiero, Joseph T, Shah, Manish A, Urba, Susan, Uronis, Hope E, Lau, Michelle W, Laheru, Daniel

“…Purpose In 2016, ASCO published a guideline to assist in clinical decision making in metastatic pancreatic cancer for initial assessment after diagnosis,…”
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Ramucirumab for the treatment of gastric or gastro-esophageal junction cancer by Khan, Uqba, Shah, Manish A

“…: Gastric cancer remains one of the most lethal malignancy, accounting for an estimated 783,000 deaths worldwide in 2018. Although there are several approved…”
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Locally Advanced, Unresectable Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline by Balaban, Edward P, Mangu, Pamela B, Khorana, Alok A, Shah, Manish A, Mukherjee, Somnath, Crane, Christopher H, Javle, Milind M, Eads, Jennifer R, Allen, Peter, Ko, Andrew H, Engebretson, Anitra, Herman, Joseph M, Strickler, John H, Benson, 3rd, Al B, Urba, Susan, Yee, Nelson S

“…To provide evidence-based recommendations to oncologists and others for treatment of patients with locally advanced, unresectable pancreatic cancer. American…”
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Metastatic Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline by Sohal, Davendra P S, Mangu, Pamela B, Khorana, Alok A, Shah, Manish A, Philip, Philip A, O'Reilly, Eileen M, Uronis, Hope E, Ramanathan, Ramesh K, Crane, Christopher H, Engebretson, Anitra, Ruggiero, Joseph T, Copur, Mehmet S, Lau, Michelle, Urba, Susan, Laheru, Daniel

“…To provide evidence-based recommendations to oncologists and others for the treatment of patients with metastatic pancreatic cancer. American Society of…”
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Targeting the Cell Cycle: A New Approach to Cancer Therapy by SCHWARTZ, Gary K, SHAH, Manish A

“…The cell cycle represents a series of tightly integrated events that allow the cell to grow and proliferate. Critical parts of the cell cycle machinery are the…”
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Gastric Cancer—An Enigmatic and Heterogeneous Disease by Shah, Manish A, Ajani, Jaffer A

“…Shah and Ajani comment on a study by the Global Advanced/Adjuvant Stomach Tumor Research International Collaboration (GASTRIC) Group that reports findings from…”
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Genomic Alterations Observed in Colitis-Associated Cancers Are Distinct From Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease by Yaeger, Rona, Shah, Manish A, Miller, Vincent A, Kelsen, Judith R, Wang, Kai, Heins, Zachary J, Ross, Jeffrey S, He, Yuting, Sanford, Eric, Yantiss, Rhonda K, Balasubramanian, Sohail, Stephens, Philip J, Schultz, Nikolaus, Oren, Moshe, Tang, Laura, Kelsen, David

“…Background & Aims Patients with inflammatory bowel diseases, such as Crohn’s disease (CD) and ulcerative colitis (UC), are at increased risk for small bowel or…”
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Bevacizumab in Combination With Chemotherapy As First-Line Therapy in Advanced Gastric Cancer: A Biomarker Evaluation From the AVAGAST Randomized Phase III Trial by VAN CUTSEM, Eric, DE HAAS, S. Anne, SHAH, Manish A, KANG, Yoon-Koo, OHTSU, Atsushi, TEBBUTT, Niall C, JIAN MING XU, WEI PENG YONG, LANGER, Bernd, DELMAR, Paul, SCHERER, Stefan J

“…The AVAGAST study showed that adding bevacizumab to chemotherapy in patients with advanced gastric cancer improves progression-free survival and tumor response…”
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First-in-Human Trial of a Novel Anti-Trop-2 Antibody-SN-38 Conjugate, Sacituzumab Govitecan, for the Treatment of Diverse Metastatic Solid Tumors by Starodub, Alexander N, Ocean, Allyson J, Shah, Manish A, Guarino, Michael J, Picozzi, Jr, Vincent J, Vahdat, Linda T, Thomas, Sajeve S, Govindan, Serengulam V, Maliakal, Pius P, Wegener, William A, Hamburger, Steven A, Sharkey, Robert M, Goldenberg, David M

“…Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2, a surface glycoprotein expressed on many epithelial tumors, for delivery…”
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Molecular Classification of Gastric Cancer: A New Paradigm by SHAH, Manish A, KHANIN, Raya, TANG, Laura, JANJIGIAN, Yelena Y, KLIMSTRA, David S, GERDES, Hans, KELSEN, David P

“…Gastric cancer may be subdivided into 3 distinct subtypes--proximal, diffuse, and distal gastric cancer--based on histopathologic and anatomic criteria. Each…”
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The RENAISSANCE (AIO-FLOT5) trial: effect of chemotherapy alone vs. chemotherapy followed by surgical resection on survival and quality of life in patients with limited-metastatic adenocarcinoma of the stomach or esophagogastric junction - a phase III trial of the German AIO/CAO-V/CAOGI by Al-Batran, Salah-Eddin, Goetze, Thorsten O, Mueller, Daniel W, Vogel, Arndt, Winkler, Michael, Lorenzen, Sylvie, Novotny, Alexander, Pauligk, Claudia, Homann, Nils, Jungbluth, Thomas, Reissfelder, Christoph, Caca, Karel, Retter, Steffen, Horndasch, Eva, Gumpp, Julia, Bolling, Claus, Fuchs, Karl-Hermann, Blau, Wolfgang, Padberg, Winfried, Pohl, Michael, Wunsch, Andreas, Michl, Patrick, Mannes, Frank, Schwarzbach, Matthias, Schmalenberg, Harald, Hohaus, Michael, Scholz, Christian, Benckert, Christoph, Knorrenschild, Jorge Riera, Kanngießer, Veit, Zander, Thomas, Alakus, Hakan, Hofheinz, Ralf-Dieter, Roedel, Claus, Shah, Manish A, Sasako, Mitsuru, Lorenz, Dietmar, Izbicki, Jakob, Bechstein, Wolf O, Lang, Hauke, Moenig, Stefan P

“…Historical data indicate that surgical resection may benefit select patients with metastatic gastric and gastroesophageal junction cancer. However, randomized…”
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