Search Results - "SHADDIX, S. C"

Metabolism and Metabolic Actions of 6-Methylpurine and 2-Fluoroadenine in Human Cells by Parker, William B, Allan, Paula W, Shaddix, Sue C, Rose, Lucy M, Speegle, Heath F, Gillespie, G.Yancey, Bennett, L.Lee

“…Activation of purine nucleoside analogs by Escherichia coli purine nucleoside phosphorylase (PNP) is being evaluated as a suicide gene therapy strategy for the…”
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Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase and human DNA polymerases alpha, beta, and gamma by the 5'-triphosphates of carbovir, 3'-azido-3'-deoxythymidine, 2',3'-dideoxyguanosine and 3'-deoxythymidine. A novel RNA template for the evaluation of antiretroviral drugs by W B Parker, E L White, S C Shaddix, L J Ross, R W Buckheit, Jr, J M Germany, J A Secrist, 3rd, R Vince, W M Shannon

“…Carbovir (the carbocyclic analog of 2'-3'-didehydro-2',3'-dideoxyguanosine) is a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) replication…”
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Metabolism of carbovir, a potent inhibitor of human immunodeficiency virus type 1, and its effects on cellular metabolism by PARKER, W. B, SHADDIX, S. C, BOWDON, B. J, ROSE, L. M, VINCE, R, SHANNON, W. M, BENNETT, L. L

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Effects of 2-chloro-9-(3-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate by PARKER, W. B, SHADDIX, S. C, CHI-HSIUNG CHANG, WHITE, E. L, ROSE, L. M, BROCKMAN, R. W, SHORTNACY, A. T, MONTGOMERY, J. A, SECRIST, J. A, LEE BENNETT, L. JR

“…2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-adenine (Cl-F-ara-A) has activity against the P388 tumor in mice on several different schedules…”
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Lack of mitochondrial toxicity in CEM cells treated with carbovir by Parker, William B, Shaddix, S.C, Vince, Robert, Bennett, L.Lee

“…Carbovir (CBV) is a guanine nucleoside analog with potent in vitro anti-HIV activity. A prodrug of CBV is currently being evaluated in clinical trials as a…”
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Comparison of the effect of Carbovir, AZT, and dideoxynucleoside triphosphates on the activity of human immunodeficiency virus reverse transcriptase and selected human polymerases by White, E L, Parker, W B, Macy, L J, Shaddix, S C, McCaleb, G, Secrist, 3rd, J A, Vince, R, Shannon, W M

“…Carbocylic 2',3'-didehydro-2',3'-dideoxyguanosine (Carbovir; NSC 614846) is an antiretroviral agent which may be useful in the treatment of AIDS. We have…”
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Comparison of the mechanism of cytotoxicity of 2-chloro-9-(2-deoxy-2- fluoro-beta-D-arabinofuranosyl)adenine, 2-chloro-9-(2-deoxy-2-fluoro- beta-D-ribofuranosyl)adenine, and 2-chloro-9-(2-deoxy-2,2-difluoro- beta-D-ribofuranosyl)adenine in CEM cells by Parker, W B, Shaddix, S C, Rose, L M, Shewach, D S, Hertel, L W, Secrist, 3rd, J A, Montgomery, J A, Bennett, Jr, L L

“…In an effort to understand biochemical features that are important to the selective antitumor activity of…”
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Inhibition of utilization of hypoxanthine and guanine in cells treated with the carbocyclic analog of adenosine. Phosphates of carbocyclic nucleoside analogs as inhibitors of hypoxanthine (guanine) phosphoribosyltransferase by Bennett, Jr, L L, Brockman, R W, Rose, L M, Allan, P W, Shaddix, S C, Shealy, Y F, Clayton, J D

“…In cell cultures treated with the carbocyclic analog of adenosine (C-Ado, (+/-)-aristeromycin), the utilization of hypoxanthine and guanine has been observed…”
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Enhancement of Nucleoside Cytotoxicity through Nucleotide Prodrugs by Rose, Jerry D, Parker, William B, Someya, Hitoshi, Shaddix, Sue C, Montgomery, John A, Secrist, John A

“…A common reason for the lack of cytotoxicity of certain nucleosides is thought to be their inability to be initially activated to the monophosphate level by a…”
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Metabolism of 4′-thio-β- d-arabinofuranosylcytosine in CEM cells by Parker, William B, Shaddix, Sue C, Rose, Lucy M, Waud, William R, Shewach, Donna S, Tiwari, Kamal N, Secrist, John A

“…Because of the excellent in vivo activity of 4′-thio-β- d-arabinofuranosylcytosine (T-araC) against a variety of human solid tumors, we have studied its…”
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Incorporation of the carbocyclic analog of 2'-deoxyguanosine into the DNA of herpes simplex virus and of HEp-2 cells infected with herpes simplex virus by Parker, W B, Shaddix, S C, Allan, P W, Arnett, G, Rose, L M, Shannon, W M, Shealy, Y F, Montgomery, J A, Secrist, 3rd, J A, Bennett, Jr, L L

“…The carbocyclic analog of 2'-deoxyguanosine (CdG) is active against herpes simplex virus (HSV), human cytomegalovirus, and human hepatitis-B virus. In order to…”
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Interference with HIV-1 reverse transcriptase-catalyzed DNA chain elongation by the 5'-triphosphate of the carbocyclic analog of 2'-deoxyguanosine by Parker, W B, White, E L, Shaddix, S C, Ross, L J, Shannon, W M, Secrist, 3rd, J A

“…In an effort to better understand features in nucleotide analogs that result in the inhibition of HIV-1 reverse transcriptase, we have evaluated this enzyme…”
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Metabolism of 2-methyladenosine in Mycobacterium tuberculosis by Parker, William B, Barrow, Esther W, Allan, Paula W, Shaddix, Sue C, Long, Mary C, Barrow, William W, Bansal, Namita, Maddry, Joseph A

“…2-Methyladenosine (methyl-Ado) has selective activity against Mycobacterium tuberculosis ( M. tuberculosis). In an effort to better understand its mechanism of…”
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Alterations in nucleotide pools induced by 3-deazaadenosine and related compounds. Role of adenylate deaminase by Bennett, Jr, L L, Brockman, R W, Allan, P W, Rose, L M, Shaddix, S C

“…3-Deazaadenine, 3-deazaadenosine, and the carbocyclic analog of 3-deazaadenosine produced similar effects on nucleotide pools of L1210 cells in culture: each…”
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Nitrosoureido nucleosides as potential inhibitors of nucleotide biosynthesis by Elliott, Robert D, Thomas, H. Jeanette, Shaddix, Sue C, Adamson, Doris J, Brockman, R. Wallace, Riordan, James M, Montgomery, John A

“…Several nitrosoureido nucleosides (3a, 3b, 5a, 7a, 7c, and 10a) designed as inhibitors of enzymes that metabolize pyrimidine nucleotides have been prepared and…”
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Biochemical aspects of chemotherapy of mouse colon carcinoma: fluoropyrimidines and pyrazofurin by Brockman, R W, Shaddix, S C, Rose, L M

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Metabolism and metabolic effects of 2-azahypoxanthine and 2-azaadenosine by Bennett, Jr, L L, Smithers, D, Rose, L M, Adamson, D J, Shaddix, S C, Thomas, H J

“…The metabolism and metabolic effects of 2-azahypoxanthine and 2-azaadenosine were studied to elucidate the biochemical basis for their known cytotoxicities…”
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Metabolism and metabolic actions of 4′-thiothymidine in L1210 cells by Parker, William B., Shaddix, Sue C., Rose, Lucy M., Tiwari, Kamal N., Montgomery, John A., Secrist, John A., Bennett, L.Lee

“…4′-Thiothymidine (S-dThd) is a potent inhibitor of L1210 cell growth and is active against P388 leukemia in mice. Because of these activities and its novel…”
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Comparison of the actions of 9-beta-D-arabinofuranosyl-2-fluoroadenine and 9-beta-D-arabinofuranosyladenine on target enzymes from mouse tumor cells by White, E L, Shaddix, S C, Brockman, R W, Bennett, Jr, L L

“…9-beta-D-Arabinofuranosyl-2-fluoroadenine (2-F-ara-A), a derivative of 9-beta-D-arabinofuranosyladenine (ara-A) that is resistant to deamination, selectively…”
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alpha.-(N)-Formylheteroaromatic thiosemicarbazones. Inhibition of tumor-derived ribonucleoside diphosphate reductase and correlation with in vivo antitumor activity by French, Frederic A, Blanz, Erwin J, Shaddix, Sue C, Brockman, R. Wallace

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