Search Results - "SHACKLETT, Barbara L"

HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality by Serrano-Villar, Sergio, Sainz, Talia, Lee, Sulggi A, Hunt, Peter W, Sinclair, Elizabeth, Shacklett, Barbara L, Ferre, April L, Hayes, Timothy L, Somsouk, Ma, Hsue, Priscilla Y, Van Natta, Mark L, Meinert, Curtis L, Lederman, Michael M, Hatano, Hiroyu, Jain, Vivek, Huang, Yong, Hecht, Frederick M, Martin, Jeffrey N, McCune, Joseph M, Moreno, Santiago, Deeks, Steven G

“…A low CD4/CD8 ratio in elderly HIV-uninfected adults is associated with increased morbidity and mortality. A subset of HIV-infected adults receiving effective…”
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Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection by Leeansyah, Edwin, Ganesh, Anupama, Quigley, Máire F., Sönnerborg, Anders, Andersson, Jan, Hunt, Peter W., Somsouk, Ma, Deeks, Steven G., Martin, Jeffrey N., Moll, Markus, Shacklett, Barbara L., Sandberg, Johan K.

“…Mucosal-associated invariant T (MAIT) cells are an evolutionarily conserved antimicrobial MR1-restricted T-cell subset. MAIT cells are CD161+, express a Vα7.2…”
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Cerebrospinal fluid (CSF) neuronal biomarkers across the spectrum of HIV infection: hierarchy of injury and detection by Peterson, Julia, Gisslen, Magnus, Zetterberg, Henrik, Fuchs, Dietmar, Shacklett, Barbara L, Hagberg, Lars, Yiannoutsos, Constantin T, Spudich, Serena S, Price, Richard W

“…The character of central nervous system (CNS) HIV infection and its effects on neuronal integrity vary with evolving systemic infection. Using a…”
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Editorial: CD8+ T-cells in HIV/SIV infection, prophylaxis, and therapy by Shacklett, Barbara L, Buggert, Marcus, Dias, Joana

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Compartmentalization of cerebrospinal fluid inflammation across the spectrum of untreated HIV-1 infection, central nervous system injury and viral suppression by Gisslen, Magnus, Keating, Sheila M, Spudich, Serena, Arechiga, Victor, Stephenson, Sophie, Zetterberg, Henrik, Di Germanio, Clara, Blennow, Kaj, Fuchs, Dietmar, Hagberg, Lars, Norris, Philip J, Peterson, Julia, Shacklett, Barbara L, Yiannoutsos, Constantin T, Price, Richard W

“…To characterize the evolution of central nervous system (CNS) inflammation in HIV-1 infection applying a panel of cerebrospinal fluid (CSF) inflammatory…”
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Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection by Lal, Kerri G., Kim, Dohoon, Costanzo, Margaret C., Creegan, Matthew, Leeansyah, Edwin, Dias, Joana, Paquin-Proulx, Dominic, Eller, Leigh Anne, Schuetz, Alexandra, Phuang-ngern, Yuwadee, Krebs, Shelly J., Slike, Bonnie M., Kibuuka, Hannah, Maganga, Lucas, Nitayaphan, Sorachai, Kosgei, Josphat, Sacdalan, Carlo, Ananworanich, Jintanat, Bolton, Diane L., Michael, Nelson L., Shacklett, Barbara L., Robb, Merlin L., Eller, Michael A., Sandberg, Johan K.

“…Mucosa-associated invariant T (MAIT) cell loss in chronic HIV-1 infection is a significant insult to antimicrobial immune defenses. Here we investigate the…”
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Viral Sanctuaries during Highly Active Antiretroviral Therapy in a Nonhuman Primate Model for AIDS by NORTH, Thomas W, HIGGINS, Joanne, DEERE, Jesse D, HAYES, Timothy L, VILLALOBOS, Andradi, ADAMSON, Lourdes, SHACKLETT, Barbara L, SCHINAZI, Raymond F, LUCIW, Paul A

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Effects of the levonorgestrel-containing intrauterine device, copper intrauterine device, and levonorgestrel-containing oral contraceptive on susceptibility of immune cells from cervix, endometrium and blood to HIV-1 fusion measured ex vivo by Cavrois, Marielle, Hilton, Joan F, Roan, Nadia R, Takeda, Margaret, Seidman, Dominika, Averbach, Sarah, Chang, Eric, Raman, Nandhini, Greenblatt, Ruth, Shacklett, Barbara L, Smith-McCune, Karen

“…Globally, HIV/AIDS is a leading cause of morbidity worldwide among reproductive-aged cisgender women, highlighting the importance of understanding effects of…”
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Increased Frequency of Regulatory T Cells Accompanies Increased Immune Activation in Rectal Mucosae of HIV-Positive Noncontrollers by SHAW, Julia M, HUNT, Peter W, CRITCHFIELD, J. William, MCCONNELL, Delandy H, GARCIA, Juan Carlos, POLLARD, Richard B, SOMSOUK, Ma, DEEKS, Steven G, SHACKLETT, Barbara L

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Viral Suppression and Immune Restoration in the Gastrointestinal Mucosa of Human Immunodeficiency Virus Type 1-Infected Patients Initiating Therapy during Primary or Chronic Infection by GUADALUPE, Moraima, SANKARAN, Sumathi, GEORGE, Michael D, REAY, Elizabeth, VERHOEVEN, David, SHACKLETT, Barbara L, FLAMM, Jason, WEGELIN, Jacob, PRINDIVILLE, Thomas, DANDEKAR, Satya

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The Role of Tissue Resident Memory CD4 T Cells in Herpes Simplex Viral and HIV Infection by O'Neil, Thomas R, Hu, Kevin, Truong, Naomi R, Arshad, Sana, Shacklett, Barbara L, Cunningham, Anthony L, Nasr, Najla

“…Tissue-resident memory T cells (TRM) were first described in 2009. While initially the major focus was on CD8 TRM, there has recently been increased interest…”
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Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers by Hatano, Hiroyu, Yukl, Steven A, Ferre, April L, Graf, Erin H, Somsouk, Ma, Sinclair, Elizabeth, Abdel-Mohsen, Mohamed, Liegler, Teri, Harvill, Kara, Hoh, Rebecca, Palmer, Sarah, Bacchetti, Peter, Hunt, Peter W, Martin, Jeffrey N, McCune, Joseph M, Tracy, Russell P, Busch, Michael P, O'Doherty, Una, Shacklett, Barbara L, Wong, Joseph K, Deeks, Steven G

“…The study of HIV-infected "controllers" who are able to maintain low levels of plasma HIV RNA in the absence of antiretroviral therapy (ART) may provide…”
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HIV Controllers with HLA-DRB113 and HLA-DQB106 Alleles Have Strong, Polyfunctional Mucosal CD4+ T-Cell Responses by FERRE, April L, HUNT, Peter W, MCCONNELL, Delandy H, MORRIS, Megan M, GARCIA, Juan C, POLLARD, Richard B, YEE, Hal F, MARTIN, Jeffrey N, DEEKS, Steven G, SHACKLETT, Barbara L

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Unexpected Inflammatory Effects of Intravaginal Gels (Universal Placebo Gel and Nonoxynol-9) on the Upper Female Reproductive Tract: A Randomized Crossover Study by Smith-McCune, Karen, Chen, Joseph C, Greenblatt, Ruth M, Shanmugasundaram, Uma, Shacklett, Barbara L, Hilton, Joan F, Johnson, Brittni, Irwin, Juan C, Giudice, Linda C

“…Intravaginal anti-HIV microbicides could provide women with a self-controlled means for HIV prevention, but results from clinical trials have been largely…”
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Cryopreservation of human mucosal tissues by Hughes, Sean M, Ferre, April L, Yandura, Sarah E, Shetler, Cory, Baker, Chris A R, Calienes, Fernanda, Levy, Claire N, Astronomo, Rena D, Shu, Zhiquan, Lentz, Gretchen M, Fialkow, Michael, Kirby, Anna C, McElrath, M Juliana, Sinclair, Elizabeth, Rohan, Lisa C, Anderson, Peter L, Shacklett, Barbara L, Dezzutti, Charlene S, Gao, Dayong, Hladik, Florian

“…Cryopreservation of leukocytes isolated from the cervicovaginal and colorectal mucosa is useful for the study of cellular immunity (see Hughes SM et al. PLOS…”
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Changes in Circulating B Cell Subsets Associated with Aging and Acute SIV Infection in Rhesus Macaques by Chang, W L William, Gonzalez, Denise F, Kieu, Hung T, Castillo, Luis D, Messaoudi, Ilhem, Shen, Xiaoying, Tomaras, Georgia D, Shacklett, Barbara L, Barry, Peter A, Sparger, Ellen E

“…Aging and certain viral infections can negatively impact humoral responses in humans. To further develop the nonhuman primate (NHP) model for investigating B…”
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Immunodominant HIV-Specific CD8+ T-Cell Responses Are Common to Blood and Gastrointestinal Mucosa, and Gag-Specific Responses Dominate in Rectal Mucosa of HIV Controllers by FERRE, April L, LEMONGELLO, Donna, HUNT, Peter W, MORRIS, Megan M, GARCIA, Juan Carlos, POLLARD, Richard B, YEE, Hal F, MARTIN, Jeffrey N, DEEKS, Steven G, SHACKLETT, Barbara L

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Utilizing a TLR5-Adjuvanted Cytomegalovirus as a Lentiviral Vaccine in the Nonhuman Primate Model for AIDS by Deere, Jesse D, Chang, W L William, Castillo, Luis D, Schmidt, Kim A, Kieu, Hung T, Renzette, Nicholas, Kowalik, Timothy, Barthold, Stephen W, Shacklett, Barbara L, Barry, Peter A, Sparger, Ellen E

“…Despite tremendous progress in our understanding of human immunodeficiency virus (HIV) natural history and advances in HIV treatment, there is neither an…”
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Cryopreservation of Human Mucosal Leukocytes by Hughes, Sean M, Shu, Zhiquan, Levy, Claire N, Ferre, April L, Hartig, Heather, Fang, Cifeng, Lentz, Gretchen, Fialkow, Michael, Kirby, Anna C, Adams Waldorf, Kristina M, Veazey, Ronald S, Germann, Anja, von Briesen, Hagen, McElrath, M Juliana, Dezzutti, Charlene S, Sinclair, Elizabeth, Baker, Chris A R, Shacklett, Barbara L, Gao, Dayong, Hladik, Florian

“…Understanding how leukocytes in the cervicovaginal and colorectal mucosae respond to pathogens, and how medical interventions affect these responses, is…”
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Multifunctional Human Immunodeficiency Virus (HIV) Gag-Specific CD8+ T-Cell Responses in Rectal Mucosa and Peripheral Blood Mononuclear Cells during Chronic HIV Type 1 Infection by CRITCHFIELD, J. William, LEMONGELLO, Donna, WALKER, Digna H, GARCIA, Juan C, ASMUTH, David M, POLLARD, Richard B, SHACKLETT, Barbara L

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