Search Results - "SHABANA DIN"

Myocardial AKT: the omnipresent nexus by Sussman, Mark A, Völkers, Mirko, Fischer, Kimberlee, Bailey, Brandi, Cottage, Christopher T, Din, Shabana, Gude, Natalie, Avitabile, Daniele, Alvarez, Roberto, Sundararaman, Balaji, Quijada, Pearl, Mason, Matt, Konstandin, Mathias H, Malhowski, Amy, Cheng, Zhaokang, Khan, Mohsin, McGregor, Michael

“…One of the greatest examples of integrated signal transduction is revealed by examination of effects mediated by AKT kinase in myocardial biology. Positioned…”
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Enhancement of Myocardial Regeneration Through Genetic Engineering of Cardiac Progenitor Cells Expressing Pim-1 Kinase by FISCHER, Kimberlee M, COTTAGE, Christopher T, WEITAO WU, SHABANA DIN, GUDE, Natalie A, AVITABILE, Daniele, QUIJADA, Pearl, COLLINS, Brett L, FRANSIOLI, Jenna, SUSSMAN, Mark A

“…Despite numerous studies demonstrating the efficacy of cellular adoptive transfer for therapeutic myocardial regeneration, problems remain for donated cells…”
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Pim-1 preserves mitochondrial morphology by inhibiting dynamin-related protein 1 translocation by Din, Shabana, Mason, Matthew, Völkers, Mirko, Johnson, Bevan, Cottage, Christopher T., Wang, Zeping, Joyo, Anya Y., Quijada, Pearl, Erhardt, Peter, Magnuson, Nancy S., Konstandin, Mathias H., Sussman, Mark A.

“…Mitochondrial morphological dynamics affect the outcome of ischemic heart damage and pathogenesis. Recently, mitochondrial fission protein dynamin-related…”
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Mechanistic Target of Rapamycin Complex 2 Protects the Heart From Ischemic Damage by Völkers, Mirko, Konstandin, Mathias H, Doroudgar, Shirin, Toko, Haruhiro, Quijada, Pearl, Din, Shabana, Joyo, Anya, Ornelas, Luis, Samse, Kaitleen, Thuerauf, Donna J, Gude, Natalie, Glembotski, Christopher C, Sussman, Mark A

“…BACKGROUND—The mechanistic target of rapamycin (mTOR) comprises 2 structurally distinct multiprotein complexes, mTOR complexes 1 and 2 (mTORC1 and mTORC2)…”
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Fibronectin Is Essential for Reparative Cardiac Progenitor Cell Response After Myocardial Infarction by Konstandin, Mathias H, Toko, Haruhiro, Gastelum, Grady M, Quijada, Pearl, De La Torre, Andrea, Quintana, Mercedes, Collins, Brett, Din, Shabana, Avitabile, Daniele, Völkers, Mirko, Gude, Natalie, Fässler, Reinhard, Sussman, Mark A

“…RATIONALE:Adoptive transfer of cardiac progenitor cells (CPCs) has entered clinical application, despite limited mechanistic understanding of the endogenous…”
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Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1 by Völkers, Mirko, Toko, Haruhiro, Doroudgar, Shirin, Din, Shabana, Quijada, Pearl, Joyo, Anya Y., Ornelas, Luis, Joyo, Eri, Thuerauf, Donna J., Konstandin, Mathias H., Gude, Natalie, Glembotski, Christopher C., Sussman, Mark A.

“…Mechanistic target of rapamycin complex 1 (mTORC1), necessary for cellular growth, is regulated by intracellular signaling mediating inhibition of mTORC1…”
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Role of preoperative dexamethasone nebulization versus ketamine nebulization in reducing complications of nasogastric tube after laparoscopic surgery by Zakaria, Mai Mohammed, Aboulella, Sahar Kamal Mohammed, Hassanein, Sahar Mohammed Kamal, El Hennawy, Ahmed Mohammed Elsayed, Din Shabana, Tarek Samir Salah El

“…Background & objective: Nasogastric (NG) tube insertion is a frequently performed medical procedure. Most of the time, the oropharyngeal discomfort is usually…”
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PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity by Völkers, Mirko, Doroudgar, Shirin, Nguyen, Nathalie, Konstandin, Mathias H, Quijada, Pearl, Din, Shabana, Ornelas, Luis, Thuerauf, Donna J, Gude, Natalie, Friedrich, Kilian, Herzig, Stephan, Glembotski, Christopher C, Sussman, Mark A

“…Diabetes is a multi‐organ disease and diabetic cardiomyopathy can result in heart failure, which is a leading cause of morbidity and mortality in diabetic…”
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Mitochondrial translocation of Nur77 mediates cardiomyocyte apoptosis by ZHAOKANG CHENG, VÖLKERS, Mirko, MASON, Matt, FISCHER, Kimbertee M, KONSTANDIN, Mathias H, ZHANG, Xiao-Kun, BROWN, Joan Heller, SUSSMAN, Mark A, DIN, Shabana, AVITABILE, Daniele, KHAN, Mohsin, GUDE, Natalie, MOHSIN, Sadia, TAO BO, TRUFFA, Silvia, ALVAREZ, Roberto

“…The cascade of events leading to compromised mitochondrial integrity in response to stress is mediated by various combinatorial interactions of pro- and…”
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Regulation of Cardiac Hypertrophic Signaling by Prolyl Isomerase Pin1 by Toko, Haruhiro, Konstandin, Mathias H, Doroudgar, Shirin, Ormachea, Lucia, Joyo, Eri, Joyo, Anya Y, Din, Shabana, Gude, Natalie A, Collins, Brett, Völkers, Mirko, Thuerauf, Donna J, Glembotski, Christopher C, Chen, Chun-Hau, Lu, Kun Ping, Müller, Oliver J, Uchida, Takafumi, Sussman, Mark A

“…RATIONALE:Cardiac hypertrophy results from the complex interplay of differentially regulated cascades based on the phosphorylation status of involved signaling…”
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Differential Regulation of Cellular Senescence and Differentiation by Prolyl Isomerase Pin1 in Cardiac Progenitor Cells by Toko, Haruhiro, Hariharan, Nirmala, Konstandin, Mathias H., Ormachea, Lucia, McGregor, Michael, Gude, Natalie A., Sundararaman, Balaji, Joyo, Eri, Joyo, Anya Y., Collins, Brett, Din, Shabana, Mohsin, Sadia, Uchida, Takafumi, Sussman, Mark A.

“…Autologous c-kit+ cardiac progenitor cells (CPCs) are currently used in the clinic to treat heart disease. CPC-based regeneration may be further augmented by…”
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Nucleolar stress is an early response to myocardial damage involving nucleolar proteins nucleostemin and nucleophosmin by Avitabile, Daniele, Bailey, Brandi, Cottage, Christopher T, Sundararaman, Balaji, Joyo, Anya, McGregor, Michael, Gude, Natalie, Truffa, Silvia, Zarrabi, Aryan, Konstandin, Mathias, Khan, Mohsin, Mohsin, Sadia, Völkers, Mirko, Toko, Haruhiro, Mason, Matt, Cheng, Zhaokang, Din, Shabana, Alvarez, Roberto Jr, Fischer, Kimberlee, Sussman, Mark A

“…Nucleolar stress, characterized by loss of nucleolar integrity, has not been described in the cardiac context. In addition to ribosome biogenesis, nucleoli are…”
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Pim-1 Kinase Protects Mitochondrial Integrity in Cardiomyocytes by Borillo, Gwynngelle A, Mason, Matt, Quijada, Pearl, Völkers, Mirko, Cottage, Christopher, McGregor, Michael, Din, Shabana, Fischer, Kimberlee, Gude, Natalie, Avitabile, Daniele, Barlow, Steven, Alvarez, Roberto, Truffa, Silvia, Whittaker, Ross, Glassy, Matthew S, Gustafsson, Asa B, Miyamoto, Shigeki, Glembotski, Christopher C, Gottlieb, Roberta A, Brown, Joan Heller, Sussman, Mark A

“…RATIONALE:Cardioprotective signaling mediates antiapoptotic actions through multiple mechanisms including maintenance of mitochondrial integrity. Pim-1 kinase…”
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C-MORE: A high-content single-cell morphology recognition methodology for liquid biopsies toward personalized cardiovascular medicine by Furkel, Jennifer, Knoll, Maximilian, Din, Shabana, Bogert, Nicolai V., Seeger, Timon, Frey, Norbert, Abdollahi, Amir, Katus, Hugo A., Konstandin, Mathias H.

“…Cellular morphology has the capacity to serve as a surrogate for cellular state and functionality. However, primary cardiomyocytes, the standard model in…”
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Cardiac Progenitor Cell Commitment Is Inhibited by Nuclear Akt Expression by Fischer, Kimberlee M, Din, Shabana, Gude, Natalie, Konstandin, Mathias H, Wu, Weitao, Quijada, Pearl, Sussman, Mark A

“…RATIONALE:Stem cell therapies to regenerate damaged cardiac tissue represent a novel approach to treat heart disease. However, the majority of adoptively…”
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Pim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload by Muraski, John A, Fischer, Kimberlee M, Wu, Weitao, Cottage, Christopher T, Quijada, Pearl, Mason, Matt, Din, Shabana, Gude, Natalie, Alvarez, Roberto Jr, Rota, Marcello, Kajstura, Jan, Wang, Zeping, Schaefer, Erik, Chen, Xiongen, MacDonnel, Scott, Magnuson, Nancy, Houser, Stephen R, Anversa, Piero, Sussman, Mark A

“…Pim-1 kinase exerts potent cardioprotective effects in the myocardium downstream of AKT, but the participation of Pim-1 in cardiac hypertrophy requires…”
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Validation of Antibodies against Histone Modifications and Transcription Factors for ChIC/CUT&RUN Assays by Din, Shabana, Saito, Kan, Silverman, Jennifer, MilliporeSigma, Jeffrey Turner

“…Abstract only DNA‐protein interactions in the nuclei control a wide variety of biological processes such as development, differentiation, and cellular response…”
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Cellular Encapsulation and Immunostaining Using a Photo Polymerized Hydrogel by Din, Shabana, White, Laura, Saito, Kan, Desmond, Lisa, MilliporeSigma, Jeffrey Turner

“…Abstract only…”
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Macrophages amplify flecainide efficacy by Therre, Markus, Bogert, Nicolai, Din, Shabana, Zhou, Xiabo, El-Battrawy, Ibrahim, Heineke, Jörg, Schweizer, Patrick, Katus, Hugo, Frey, Norbert, Leuschner, Florian, Konstandin, Matthias

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Reactive Oxidative Species–Modulated Ca2+ Release Regulates β2 Integrin Activation on CD4+ CD28null T Cells of Acute Coronary Syndrome Patients by Samstag, Yvonne, Bogert, Nicolai V., Wabnitz, Guido H., Din, Shabana, Therre, Markus, Leuschner, Florian, Katus, Hugo A., Konstandin, Mathias H.

“…The number and activity of T cell subsets in the atherosclerotic plaques are critical for the prognosis of patients with acute coronary syndrome. β2 Integrin…”
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