Search Results - "SGARAGLI, G. P"

Potentiation of mitochondrial Ca2+ sequestration by taurine by PALMI, M, YOUMBI, G. T, FUSI, F, SGARAGLI, G. P, DIXON, H. B. F, FROSINI, M, TIPTON, K. F

“…The effects of taurine (2-aminoethanesulphonic acid) and its analogues, 2-aminoethylarsonic acid, 2-hydroxyethanesulphonic (isethionic) acid,…”
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Characterization of voltage-gated calcium currents in freshly isolated smooth muscle cells from rat tail main artery by Petkov, G. V., Fusi, F., Saponara, S., Gagov, H. S., Sgaragli, G. P., Boev, K. K.

“…The aim of the present study was to characterize voltage‐gated Ca2+ currents in smooth muscle cells freshly isolated from rat tail main artery in the presence…”
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Calcium antagonist and antiperoxidant properties of some hindered phenols by Sgaragli, G.P., Valoti, M., Gorelli, B., Fusi, F., Palmi, M., Mantovani, P.

“…1 The calcium antagonist and antioxidant activities of certain synthetic and natural phenols, related to BHA (2‐t‐butyl‐4‐methoxyphenol), were evaluated in rat…”
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Cytochrome P450-dependent n-dealkylation of l-deprenyl in C57BL mouse liver microsomes: effects of in vivo pretreatment with ethanol, phenobarbital, β-naphthoflavone and l-deprenyl by Valoti, Massimo, Fusi, Fabio, Frosini, Maria, Pessina, Federica, Tipton, Keith F, Sgaragli, Gian P

“…The monoamine oxidase inhibitor l-deprenyl [(−)-deprenyl, selegiline] is an effective therapeutic agent for improving early symptoms of idiopathic Parkinson's…”
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2,5-Di- t-butyl-1,4-benzohydroquinone induces endothelium-dependent relaxation of rat thoracic aorta by Fusi, Fabio, Valoti, Massimo, Frosini, Maria, Sgaragli, Gian P.

“…The aim of this work was to clarify the mechanism by which 2,5-di- t-butyl-1,4-benzohydroquinone (BHQ) induces relaxation of rat thoracic aorta. In particular,…”
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Increase of extracellular brain calcium involved in interleukin‐1β‐induced pyresis in the rabbit: antagonism by dexamethasone by Palmi, M., Frosini, M., Becherucci, C., Sgaragli, G.P., Parente, L.

“…1 This study investigates the role of extracellular brain calcium in the hyperthermia induced by interleukin‐1β (IL‐1β). 2 Intracerebroventricular (i.c.v.)…”
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Effects of 2,5-di- t-butyl-1,4-benzohydroquinone (BHQ) on rat aorta smooth muscle by Fusi, Fabio, Gorelli, Beatrice, Valoti, Massimo, Marazova, Katia, Sgaragli, Gian P

“…To characterise the pharmacological activity of 2,5-di- t-butyl-1,4-benzohydroquinone (BHQ) on vascular smooth muscle, the different effects of BHQ on rat…”
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Myorelaxant activity of 2- t-butyl-4-methoxyphenol (BHA) in guinea pig gastric fundus by Fusi, Fabio, Valoti, Massimo, Petkov, Georgi V., Boev, Kiril K., Sgaragli, Gian P.

“…This study investigates the mechanism whereby the antioxidant 2- t-butyl-4-methoxyphenol (BHA) relaxes guinea pig gastric fundus smooth muscle. In circular…”
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Inhibition of interleukin-1β-induced pyresis in the rabbit by peptide 204–212 of lipocortin 5 by Palmi, Mitri, Frosini, Maria, Sgaragli, Gian Pietro, Becherucci, Cristina, Perretti, Mauro, Parente, Luca

“…The intracerebroventricular administration of interleukin-1β (12.5 ng/kg) in rabbits caused a prompt rise of prostaglandin E 2 concentration (+632.6 ± 243.9%)…”
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Pharmacokinetics of chlorimipramine, chlorpromazine and their N-dealkylated metabolites in plasma of healthy volunteers after a single oral dose of the parent compounds by Della Corte, L, Valoti, M, Palmi, M, Giovannini, M G, Sgaragli, G P

“…A single oral dose of 0.7 mg kg-1 chlorimipramine (n = 18) and chlorpromazine (n = 16) was given to each subject 45 days apart and plasma concentrations of…”
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Rat tissue concentrations of chlorimipramine, chlorpromazine and their N-demethylated metabolites after a single oral dose of the parent compounds by Sgaragli, G P, Valoti, M, Palmi, M, Frosini, M, Giovannini, M G, Bianchi, L, Della Corte, L

“…A single oral dose of 90 mg kg-1 chlorimipramine or chlorpromazine, corresponding to 54.5 or 55.9 mumol, respectively, was given to male Sprague-Dawley rats…”
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Oxidative ring-coupling of tyrosine and its derivatives by purified rat intestinal peroxidase by Valoti, M, Tipton, K F, Sgaragli, G P

“…Intestinal peroxidase was shown to catalyse the oxidative ring-coupling of tyrosine, alpha-methyltyrosine, tyramine and morphine whereas amphetamine was not…”
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Toxic injury to rat gut musculature following intraperitoneal administration of 2-t-butyl-4-methoxyphenol by Sgaragli, G P, Valoti, M, Fusi, F, Palmi, M, Mantovani, P, De Santi, M M, Lorenzini, L, Tosi, P

“…The 100-fold increase in toxicity of intraperitoneal (i.p.) rather than orally administered 2-t-butyl-4-methoxyphenol (BHA) is adduced to the depressive effect…”
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Effects of bacterial endotoxin, interleukin-1 and prostaglandins on thermoregulation and cerebrospinal fluid-calcium concentration in rabbits by Palmi, M, Frosini, M, Sgaragli, G P

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Dehalogenation and N-dealkylation of chlorpromazine as revealed by plasma concentrations of metabolites in a population of chronically medicated schizophrenics by Valoti, M, Palmi, M, Della Corte, L, Nardini, M, Corti, P, Sgaragli, G P

“…Dehalogenaton and N-demethylation of chlorpromazine (CPZ) were studied in twelve psychotic inpatients orally treated for four weeks with a daily CPZ dose of…”
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Interactions between substituted tryptamine analogues, MAO inhibitors and cytochrome P-450 by Valoti, M, Costanzo, M, Perez, V, Unzeta, M, Sgaragli, G P

“…The effects of some MAO inhibitors, N-acetylenic analogues of tryptamine, on rat liver microsomal cytochrome P-450 (cyt P-450) have been investigated. All the…”
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Measurement of synthetic phenolic antioxidants in human tissues by high-performance liquid chromatography with coulometric electrochemical detection by Bianchi, L, Colivicchi, M.A, Della Corte, L, Valoti, M, Sgaragli, G.P, Bechi, P

“…The antioxidants, 2- tert.-butyl-4-methoxyphenol (BHA) and its oxidative peroxidation product 2,2′-dihydroxy-3,3′-di- tert.-butyl-5,5′-dimethoxybiphenyl…”
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Clinical response and tricyclic plasma levels during treatment with clomipramine by Della Corte, L, Broadhurst, A D, Sgaragli, G P, Filippini, S, Heeley, A F, James, H D, Faravelli, C, Pazzagli, A

“…Fifty depressed in-patients at two psychiatric units, one in Italy the other in England, were treated with clomipramine, either orally, or intravenously and…”
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Homotaurine and muscimol mimic taurine and GABA effects on muscle tone and temperature regulation by Sgaragli, G P, Carlà, V, Magnani, M, Giotti, A

“…Taurine, homotaurine, GABA and muscimol, given intraventricularly to the conscious, unrestrained rabbit cause hypothermia and a reduction in skeletal muscle…”
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Tissue distribution of chlorimipramine and its demethylated metabolite after a single dose in the rat by Della Corte, L, Sgaragli, G P

“…The pattern of distribution of chlorimipramine (CI) and of its demethyl-derivative (DMCI) in different organs (lung, liver, kidney, heart and spleen) 24 h…”
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