Search Results - "SEYMOUR, Len"

Deregulation of HLA-I in cancer and its central importance for immunotherapy by Hazini, Ahmet, Fisher, Kerry, Seymour, Len

“…It is now well accepted that many tumors undergo a process of clonal selection which means that tumor antigens arising at various stages of tumor progression…”
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The role of cancer metabolism in defining the success of oncolytic viro-immunotherapy by Dyer, Arthur, Frost, Sally, Fisher, Kerry D., Seymour, Len W.

“…[Display omitted] •Each oncolytic virus type has essential nutrients required for optimal oncolysis.•In vitro work often uses conditions that do not reflect…”
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Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial by MacLaren, Robert E, Prof, Groppe, Markus, PhD, Barnard, Alun R, PhD, Cottriall, Charles L, PhD, Tolmachova, Tanya, PhD, Seymour, Len, Prof, Clark, K Reed, PhD, During, Matthew J, Prof, Cremers, Frans P M, Prof, Black, Graeme C M, Prof, Lotery, Andrew J, Prof, Downes, Susan M, FRCOphth, Webster, Andrew R, Prof, Seabra, Miguel C, Prof

“…Summary Background Choroideremia is an X-linked recessive disease that leads to blindness due to mutations in the CHM gene, which encodes the Rab escort…”
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Making Oncolytic Virotherapy a Clinical Reality: The European Contribution by Duffy, Margaret R, Fisher, Kerry D, Seymour, Len W

“…Oncolytic viruses (OVs) are quickly moving toward the forefront of modern medicines. The reward for the decades of research invested into developing viral…”
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Phase 1 study of intravenous administration of the chimeric adenovirus enadenotucirev in patients undergoing primary tumor resection by Garcia-Carbonero, Rocio, Salazar, Ramon, Duran, Ignacio, Osman-Garcia, Ignacio, Paz-Ares, Luis, Bozada, Juan M, Boni, Valentina, Blanc, Christine, Seymour, Len, Beadle, John, Alvis, Simon, Champion, Brian, Calvo, Emiliano, Fisher, Kerry

“…Enadenotucirev (formerly ColoAd1) is a tumor-selective chimeric adenovirus with demonstrated preclinical activity. This phase 1 Mechanism of Action study…”
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Use of Liquid Patient Ascites Fluids as a Preclinical Model for Oncolytic Virus Activity by Scott, Eleanor M, Frost, Sally, Khalique, Hena, Freedman, Joshua D, Seymour, Len W, Lei-Rossmann, Janet

“…The translational success of oncolytic virotherapies would benefit from the widespread use of clinically relevant ex vivo models. Malignant ascites, an…”
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Bi- and tri-valent T cell engagers deplete tumour-associated macrophages in cancer patient samples by Scott, Eleanor M., Jacobus, Egon J., Lyons, Brian, Frost, Sally, Freedman, Joshua D., Dyer, Arthur, Khalique, Hena, Taverner, William K., Carr, Alison, Champion, Brian R., Fisher, Kerry D., Seymour, Len W., Duffy, Margaret R.

“…BackgroundTumour-associated macrophages (TAMs) are often implicated in cancer progression but can also exert anti-tumour activities. Selective eradication of…”
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Attenuation of the Hypoxia Inducible Factor Pathway after Oncolytic Adenovirus Infection Coincides with Decreased Vessel Perfusion by Yousaf, Iris, Kaeppler, Jakob, Frost, Sally, Seymour, Len W, Jacobus, Egon J

“…The interplay between oncolytic virus infection and tumour hypoxia is particularly unexplored in vivo, although hypoxia is present in virtually all solid…”
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Inertial cavitation to non-invasively trigger and monitor intratumoral release of drug from intravenously delivered liposomes by Graham, Susan M., Carlisle, Robert, Choi, James J., Stevenson, Mark, Shah, Apurva R., Myers, Rachel S., Fisher, Kerry, Peregrino, Miriam-Bazan, Seymour, Len, Coussios, Constantin C.

“…The encapsulation of cytotoxic drugs within liposomes enhances pharmacokinetics and allows passive accumulation within tumors. However, liposomes designed to…”
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Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1 by Benlahrech, Adel, Harris, Julian, Meiser, Andrea, Papagatsias, Timos, Hornig, Julia, Hayes, Peter, Lieber, Andre, Athanasopoulos, Takis, Bachy, Veronique, Csomor, Eszter, Daniels, Rod, Fisher, Kerry, Gotch, Frances, Seymour, Len, Logan, Karen, Barbagallo, Romina, Klavinskis, Linda, Dickson, George, Patterson, Steven

“…In the recently halted HIV type 1 (HIV-1) vaccine STEP trial, individuals that were seropositive for adenovirus serotype 5 (Ad5) showed increased rates of…”
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Turning cold tumours hot: oncolytic virotherapy gets up close and personal with other therapeutics at the 11th Oncolytic Virus Conference by Dyer, Arthur, Baugh, Richard, Chia, Suet Lin, Frost, Sally, Iris, Jacobus, Egon J., Khalique, Hena, Pokrovska, Tzveta D., Scott, Eleanor M., Taverner, William K., Seymour, Len W., Lei, Janet

“…The 11th International Oncolytic Virus Conference (IOVC) was held from April 9–12, 2018 in Oxford, UK. This is part of the high-profile academic-led series of…”
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Directed evolution generates a novel oncolytic virus for the treatment of colon cancer by Kuhn, Irene, Harden, Paul, Bauzon, Maxine, Chartier, Cecile, Nye, Julie, Thorne, Steve, Reid, Tony, Ni, Shaoheng, Lieber, Andre, Fisher, Kerry, Seymour, Len, Rubanyi, Gabor M, Harkins, Richard N, Hermiston, Terry W

“…Viral-mediated oncolysis is a novel cancer therapeutic approach with the potential to be more effective and less toxic than current therapies due to the agents…”
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Preclinical Safety Studies of Enadenotucirev, a Chimeric Group B Human-Specific Oncolytic Adenovirus by Illingworth, Sam, Di, Ying, Bauzon, Maxine, Lei, Janet, Duffy, Margaret R., Alvis, Simon, Champion, Brian, Lieber, André, Hermiston, Terry, Seymour, Len W., Beadle, John, Fisher, Kerry

“…Enadenotucirev is an oncolytic group B adenovirus identified by a process of bio-selection for the ability to selectively propagate in and rapidly kill…”
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External Beam Radiation Therapy and Enadenotucirev: Inhibition of the DDR and Mechanisms of Radiation-Mediated Virus Increase by Pokrovska, Tzveta D, Jacobus, Egon J, Puliyadi, Rathi, Prevo, Remko, Frost, Sally, Dyer, Arthur, Baugh, Richard, Rodriguez-Berriguete, Gonzalo, Fisher, Kerry, Granata, Giovanna, Herbert, Katharine, Taverner, William K, Champion, Brian R, Higgins, Geoff S, Seymour, Len W, Lei-Rossmann, Janet

“…Ionising radiation causes cell death through the induction of DNA damage, particularly double-stranded DNA (dsDNA) breaks. Evidence suggests that adenoviruses…”
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Polymer stealthing and mucin-1 retargeting for enhanced pharmacokinetics of an oncolytic vaccinia virus by Hill, Claudia, Grundy, Megan, Bau, Luca, Wallington, Sheena, Balkaran, Joel, Ramos, Victor, Fisher, Kerry, Seymour, Len, Coussios, Constantin, Carlisle, Robert

“…Vaccinia virus (VV) is a powerful tool for cancer treatment with the potential for tumor tropism, efficient cell-to-cell spread, rapid replication in cancer…”
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Polymer coatings for delivery of nucleic acid therapeutics by Laga, Richard, Carlisle, Robert, Tangney, Mark, Ulbrich, Karel, Seymour, Len W.

“…Gene delivery remains the greatest challenge in applying nucleic acid therapeutic for a broad range of diseases. Combining stability during the delivery phase…”
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Calcium Influx Caused by ER Stress Inducers Enhances Oncolytic Adenovirus Enadenotucirev Replication and Killing through PKCα Activation by Taverner, William K., Jacobus, Egon J., Christianson, John, Champion, Brian, Paton, Adrienne W., Paton, James C., Su, Weiheng, Cawood, Ryan, Seymour, Len W., Lei-Rossmann, Janet

“…Oncolytic viruses represent an emerging approach to cancer therapy. However, better understanding of their interaction with the host cancer cell and approaches…”
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Expression of human CD46 and trans-complementation by murine adenovirus 1 fails to allow productive infection by a group B oncolytic adenovirus in murine cancer cells by Lei, Janet, Jacobus, Egon J, Taverner, William K, Fisher, Kerry D, Hemmi, Silvio, West, Katy, Slater, Lorna, Lilley, Fred, Brown, Alice, Champion, Brian, Duffy, Margaret R, Seymour, Len W

“…Oncolytic viruses are currently experiencing accelerated development in several laboratories worldwide, with some forty-seven clinical trials currently…”
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Virotherapy – cancer targeted pharmacology by Tedcastle, Alison, Cawood, Ryan, Di, Ying, Fisher, Kerry D., Seymour, Len W.

“…Building on their success in vaccination, many groups are now exploring the use of viruses as anticancer agents. In general, viral therapeutics provide the…”
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OvAd1, a Novel, Potent, and Selective Chimeric Oncolytic Virus Developed for Ovarian Cancer by 3D-Directed Evolution by Kuhn, Irene, Bauzon, Maxine, Green, Nicola, Seymour, Len, Fisher, Kerry, Hermiston, Terry

“…Effective therapeutics for ovarian cancer continue to be urgently needed, particularly for chemotherapy-resistant cases. Here we present both a 3D-Matrigel…”
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