Search Results - "SEWELL, W. A"

Clinical uses of intravenous immunoglobulin by Jolles, S., Sewell, W. A. C., Misbah, S. A.

Get full text

Is dosing of therapeutic immunoglobulins optimal? A review of a three-decade long debate in europe by Kerr, Jacqueline, Quinti, Isabella, Eibl, Martha, Chapel, Helen, Späth, Peter J, Sewell, W A Carrock, Salama, Abdulgabar, van Schaik, Ivo N, Kuijpers, Taco W, Peter, Hans-Hartmut

“…The consumption of immunoglobulins (Ig) is increasing due to better recognition of antibody deficiencies, an aging population, and new indications. This review…”
Get full text

CD200 is a useful diagnostic marker for identifying atypical chronic lymphocytic leukemia by flow cytometry by Ting, Y. S., Smith, S. A. B. C., Brown, D. A., Dodds, A. J., Fay, K. C., Ma, D. D. F., Milliken, S., Moore, J. J., Sewell, W. A.

“…Introduction Immunophenotyping by flow cytometry is routinely employed in distinguishing between chronic lymphocytic leukemia (CLL) and mantle cell lymphoma…”
Get full text

European consensus proposal for immunoglobulin therapies by Sewell, W. A. Carrock, Kerr, Jacqueline, Behr‐Gross, Marie‐Emmanuelle, Peter, Hans‐Hartmut

“…The use of immunoglobulin (Ig) preparations (intravenous, IVIg, subcutaneous, SCIg) for replacement and immunomodulation therapy worldwide has tripled in the…”
Get full text

Transitional B cell subsets in human bone marrow by Agrawal, S., Smith, S. A. B. C., Tangye, S. G., Sewell, W. A.

“…Summary B cells originate from precursors in the bone marrow, and the first cells which migrate to the peripheral blood have been classified as ‘transitional B…”
Get full text

Do ribosomopathies explain some cases of common variable immunodeficiency by Khan, S, Pereira, J, Darbyshire, P.J, Holding, S, Doré, P.C, Sewell, W.A.C, Huissoon, A

“…The considerable clinical heterogeneity of patients with common variable immunodeficiency disorders (CVID) shares some similarity with bone-marrow failure…”
Get full text

Antibody deficiency by Herriot, R, Sewell, W A C

“…Antibody deficiencies may arise as primary disorders or secondary to a variety of diseases, drugs and other environmental/iatrogenic factors. Significant…”
Get more information

Clinical Immunology Review Series: An approach to the use of the immunology laboratory in the diagnosis of clinical allergy by Williams, P, Sewell, W.A.C, Bunn, C, Pumphrey, R, Read, G, Jolles, S

“…In the last 10 years UK immunology laboratories have seen a dramatic increase in the number and range of allergy tests performed. The reasons for this have…”
Get full text

Limited value of testing for intrinsic factor antibodies with negative gastric parietal cell antibodies in pernicious anaemia by Khan, S, Del-Duca, C, Fenton, E, Holding, S, Hirst, J, Doré, P C, Sewell, W A C

“…The appropriate testing strategy for diagnosing pernicious anaemia using gastric parietal cell (GPC) and/or intrinsic factor antibodies (IFA) is controversial…”
Get more information

IgE Sequences in Individuals Living in an Area of Endemic Parasitism Show Little Mutational Evidence of Antigen Selection by Wang, Y., Jackson, K. J. L., Chen, Z., Gaëta, B. A., Siba, P. M., Pomat, W., Walpole, E., Rimmer, J., Sewell, W. A., Collins, A. M.

“…Patterns of somatic mutation in IgE genes from allergic individuals have been a focus of study for many years, but IgE sequences have never been reported from…”
Get full text

Dominant Mutations in the Autoimmune Regulator AIRE Are Associated with Common Organ-Specific Autoimmune Diseases by Oftedal, Bergithe E., Hellesen, Alexander, Erichsen, Martina M., Bratland, Eirik, Vardi, Ayelet, Perheentupa, Jaakko, Kemp, E. Helen, Fiskerstrand, Torunn, Viken, Marte K., Weetman, Anthony P., Fleishman, Sarel J., Banka, Siddharth, Newman, William G., Sewell, W.A.C., Sozaeva, Leila S., Zayats, Tetyana, Haugarvoll, Kristoffer, Orlova, Elizaveta M., Haavik, Jan, Johansson, Stefan, Knappskog, Per M., Løvås, Kristian, Wolff, Anette S.B., Abramson, Jakub, Husebye, Eystein S.

“…The autoimmune regulator (AIRE) gene is crucial for establishing central immunological tolerance and preventing autoimmunity. Mutations in AIRE cause a rare…”
Get full text

British Association of Dermatologists guidelines for the management of people with chronic urticaria 2021 by Sabroe, R.A., Lawlor, F., Grattan, C.E.H., Ardern‐Jones, M.R., Bewley, A., Campbell, L., Flohr, C., Leslie, T.A., Marsland, A.M., Ogg, G., Sewell, W.A.C., Hashme, M., Exton, L.S., Mohd Mustapa, M.F., Ezejimofor, M.C.

“…Plain language summary available online…”
Get full text

Secondary systemic lupus erythematosus: An analysis of 4 cases of uncontrolled hereditary angioedema by Khan, Sujoy, Tarzi, Michael D, Doré, Philip C, Sewell, W.A.C, Longhurst, Hilary J

“…Abstract The association of systemic lupus erythematosus and hereditary angioedema (HAE) has formed the basis of numerous case reports and is hypothesised to…”
Get full text

Deficiency in circulating natural killer (NK) cell subsets in common variable immunodeficiency and X‐linked agammaglobulinaemia by Aspalter, R. M., Sewell, W. A. C., Dolman, K., Farrant, J., Webster, A. D. B.

“…Absolute and relative NK cell numbers were determined in peripheral whole blood by flow cytometry in patients with common variable immunodeficiency (CVID) (n =…”
Get full text

Some cases of common variable immunodeficiency may be due to a mutation in the SBDS gene of Shwachman-Diamond syndrome by Khan, S, Hinks, J, Shorto, J, Schwarz, M.J, Sewell, W.A.C

“…Known genetic defects currently account for only a small proportion of patients meeting criteria for 'probable' or 'possible' common variable immunodeficiency…”
Get full text

The clinical significance of antinucleolar antibodies by Khan, S, Alvi, A, Holding, S, Kemp, M L, Raine, D, Doré, P C, Sewell, W A C

“…The importance of antinucleolar antibodies seen by indirect immunofluorescence on HEp-2 cells, although associated with systemic sclerosis (SSc), in unselected…”
Get more information

A two-phase pathogenesis of graft-versus-host disease in mice by VAN LEEUWEN, L, GUIFFRE, A, ATKINSON, K, RAINER, S. P, SEWELL, W. A

“…Activation of donor T cells is required for the development of graft-versus-host disease (GVHD), a major complication of bone marrow transplantation. We…”
Get full text

Therapeutic strategies in common variable immunodeficiency by SEWELL, W. A, BUCKLAND, Matthew S, JOLLES, Stephen R. A

“…The treatment of common variable immunodeficiency (CVID) is currently based on the early recognition of the condition and replacement immunoglobulin combined…”
Get full text

Oral immunosuppressive drugs by Khan, Sujoy, Carrock Sewell, WA

Get full text

Immunomodulatory action of intravenous immunoglobulin by Sewell, W. A. C., Jolles, S.

“…Intravenous immunoglobulin (IVIg) is a blood product prepared from the serum of between 1000 and 15 000 donors per batch. It is the treatment of choice for…”
Get full text