Search Results - "SEWALD, K"

A toxicological evaluation of inhaled solid lipid nanoparticles used as a potential drug delivery system for the lung by Nassimi, M., Schleh, C., Lauenstein, H.D., Hussein, R., Hoymann, H.G., Koch, W., Pohlmann, G., Krug, N., Sewald, K., Rittinghausen, S., Braun, A., Müller-Goymann, C.

“…Inhalation is a non-invasive approach for both local and systemic drug delivery. This study aimed to define the therapeutic window for solid lipid…”
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Assessment of immunotoxicity induced by chemicals in human precision-cut lung slices (PCLS) by Lauenstein, L., Switalla, S., Prenzler, F., Seehase, S., Pfennig, O., Förster, C., Fieguth, H., Braun, A., Sewald, K.

“…•Human PCLS were exposed to 4 respiratory, 11 contact allergens, and 5 irritants.•Tissue injury and inflammation was assessed by analysis of toxicity and…”
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Ex vivo testing of immune responses in precision-cut lung slices by Henjakovic, M., Sewald, K., Switalla, S., Kaiser, D., Müller, M., Veres, T.Z., Martin, C., Uhlig, S., Krug, N., Braun, A.

“…The aim of this study was the establishment of precision-cut lung slices (PCLS) as a suitable ex vivo alternative approach to animal experiments for…”
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Prevalidation of the ex-vivo model PCLS for prediction of respiratory toxicity by Hess, A., Wang-Lauenstein, L., Braun, A., Kolle, S.N., Landsiedel, R., Liebsch, M., Ma-Hock, L., Pirow, R., Schneider, X., Steinfath, M., Vogel, S., Martin, C., Sewald, K.

“…In acute inhalation toxicity studies, animals inhale substances at given concentrations. Without additional information, however, appropriate starting…”
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Natural innate cytokine response to immunomodulators and adjuvants in human precision-cut lung slices by Switalla, S., Lauenstein, L., Prenzler, F., Knothe, S., Förster, C., Fieguth, H.-G., Pfennig, O., Schaumann, F., Martin, C., Guzman, C.A., Ebensen, T., Müller, M., Hohlfeld, J.M., Krug, N., Braun, A., Sewald, K.

“…Prediction of lung innate immune responses is critical for developing new drugs. Well-established immune modulators like lipopolysaccharides (LPS) can elicit a…”
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Effects of acute in vitro exposure of murine precision-cut lung slices to gaseous nitrogen dioxide and ozone in an air–liquid interface (ALI) culture by Switalla, S., Knebel, J., Ritter, D., Krug, N., Braun, A., Sewald, K.

“…The aim of this study was to establish an air–liquid interface (ALI) culture of precision-cut lung slices (PCLS) for direct exposure of lung cells to gaseous…”
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Bronchoconstriction in nonhuman primates: a species comparison by SEEHASE, S, SCHLEPÜTZ, M, KUEHL, A. R, UHLIG, S, BRAUN, A, SEWALD, K, MARTIN, C, SWITALLA, S, MÄTZ-RENSING, K, KAUP, F. J, ZÖLLER, M, SCHLUMBOHM, C, FUCHS, E, LAUENSTEIN, H.-D, WINKLER, C

“…Bronchoconstriction is a characteristic symptom of various chronic obstructive respiratory diseases such as chronic obstructive pulmonary disease and asthma…”
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Ex Vivo Lung Function Measurements in Precision-Cut Lung Slices (PCLS) from Chemical Allergen–Sensitized Mice Represent a Suitable Alternative to In Vivo Studies by Henjakovic, M., Martin, C., Hoymann, H. G., Sewald, K., Ressmeyer, A. R., Dassow, C., Pohlmann, G., Krug, N., Uhlig, S., Braun, A.

“…A wide range of industrial chemicals can induce respiratory allergic reactions. Hence, there is an urgent need for methods identifying and characterizing the…”
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Determination of genotoxicity by the Comet assay applied to murine precision-cut lung slices by Switalla, S., Knebel, J., Ritter, D., Dasenbrock, C., Krug, N., Braun, A., Sewald, K.

“…► The Comet assay was applied for measuring DNA damage in precision-cut lung slices to study genotoxic effects of xenobiotics. ► EMS induced dose-dependent…”
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The use of surface plasmon resonance (SPR) and fluorescence resonance energy transfer (FRET) to monitor the interaction of the plant G-proteins Ms-Rac1 and Ms-Rac4 with GTP by Brecht, Martina, Sewald, Katherina, Schiene, Karin, Keen, Gunnar, Fricke, Matthias, Sauer, Markus, Niehaus, Karsten

“…Using an RT-PCR approach a cDNA clone, designated Ms-Rac4 and putatively coding for a small GTPase was isolated from Medicago sativa. Ms-Rac4 and the earlier…”
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OS02-03 Using a systems biology approach to construct adverse outcome pathway networks aligned with the FAIR principles by Ladeira, L., Mazein, A., Ostaszewski, M., Verhoeven, A., Kuchovská, E., Sanz-Serrano, J., Drees, A., Reiche, K., Sewald, K., Fritsche, E., Vinken, M., Geris, L., Staumont, B.

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Childhood Leukemia - Influence of Extremely Low Frequency Magnetic Fields on the Development of the Disease by Sachno, D., Carstensen, S., Dahlmann, F., Tillmann, T., Sewald, K., Müller, M., Dasenbrock, C., Bitsch, A.

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P13-09: Influence of Extremely Low Frequency Magnetic Fields on the Developing Immune System – An Experimental Study in a Leukemia-Prone Mouse Model by Sachno, D., Dahlmann, F., Carstensen, S., Müller, M., Sewald, K., Schaudien, D., Rittinghausen, S., Wagner, A., Tillmann, T., Kellner, R., Bahr, A., Wleklinski, M., Dasenbrock, C., Bitsch, A.

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P06-18 Influence of extremely low frequency magnetic fields on the development of childhood leukemia – an experimental study in a susceptible mouse model by Sachno, D., Carstensen, S., Dahlmann, F., Kellner, R., Müller, M., Sewald, K., Tillmann, T., Bahr, A., Wleklinski, M., Dasenbrock, C., Bitsch, A.

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Immunotherapy: NOVEL STRATEGIES TO ENHANCE THE SAFETY OF CAR T CELL IMMUNOTHERAPY: THE IMSAVAR PROJECT by Alb, M., Einsele, H., Loskill, P., van der Meer, A., Sewald, K., Reiche, K., Köhl, U., Hudecek, M.

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C29 SENSATIONS IN THE LUNG: COUGHING AND CONSTRICTING: Peripheral Sensory Nerves Stimulation Lead To Bronchoconstriction-Augment In Passive Sensitized Human Precision-Cut Lung Slices And Is Histamine 1 Receptor Dependent by Delgado, S M Jimenez, Schindler, S, Sewald, K, Braun, A

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D29 UNRAVELING THE EXTRACELLULAR MATRIX: Comparison Of Bleomycin Models Of Pulmonary Fibrosis In Rats And Mice by Walter, D, Schaudien, D, Sewald, K, Braun, A, Hoymann, H-G

“…Higher amounts of hydroxyproline were found in lung tissues of bleomycin-treated mice and rats (mice: 298.6 vs. 206.12 pg/right lung, p<0.01; rats: 2.07 vs…”
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Beyond chemicals: Opportunities and challenges of integrating non-chemical stressors in adverse outcome pathways by Clerbaux, Laure-Alix, Filipovska, Julija, Nymark, Penny, Chauhan, Vinita, Sewald, Katherina, Alb, Miriam, Sachana, Madgalini, Beronius, Anna, Amorim, Maria-Joao, Wittwehr, Clemens

“…Adverse outcome pathways (AOPs) were developed to accelerate evidence-based chemical risk assessment by leveraging data from new approach methodologies. Thanks…”
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D36 SEPSIS, ACUTE RESPIRATORY DISTRESS SYNDROME, AND ACUTE LUNG INJURY: Precision-Cut Lung Slices As Alternative To Mimic Inflammation, Lung Injury And Bronchoconstriction After Short And Long-Term Maintenance In Culture by Neuhaus, V, Schaudien, D, Sewald, K, Braun, A

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A51 NEW INSIGHTS INTO PATHOGENS AND HOST DEFENSE: Rhinovirus Infection In Human And Mouse Precision Cut Lung Slices by Rochlitzer, S, Muller, M, Sewald, K, Braun, A

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