Search Results - "SEVIGNY, J. J"

Specificity of the ecto‐ATPase inhibitor ARL 67156 on human and mouse ectonucleotidases by Lévesque, S A, Lavoie, É G, Lecka, J, Bigonnesse, F, Sévigny, J

“…Background and purpose: ARL 67156, 6‐N,N‐Diethyl‐D‐β‐γ‐dibromomethylene adenosine triphosphate, originally named FPL 67156, is the only commercially available…”
Get full text

Evaluation of HIV RNA and markers of immune activation as predictors of HIV-associated dementia by SEVIGNY, J. J, ALBERT, S. M, PALUMBO, D, KIEBURTZ, K, RIGGS, G, COHEN, B, EPSTEIN, L. G, MARDER, K, MCDERMOTT, M. P, MCARTHUR, J. C, SACKTOR, N, CONANT, K, SCHIFITTO, G, SELNES, O. A, STERN, Y, MCCLERNON, D. R

“…To evaluate whether baseline levels of plasma and CSF HIV RNA, tumor necrosis factor alpha (TNFalpha), monocyte chemoattractant protein-1 (MCP-1), matrix…”
Get full text

Nasal Administration of Cationic Nanoemulsions as CD73-siRNA Delivery System for Glioblastoma Treatment: a New Therapeutical Approach by Azambuja, J. H., Schuh, R. S., Michels, L. R., Gelsleichter, N. E., Beckenkamp, L. R., Iser, I. C., Lenz, G. S., de Oliveira, F. H., Venturin, G., Greggio, S., daCosta, J. C., Wink, M. R., Sevigny, J., Stefani, M. A., Battastini, A. M. O., Teixeira, H. F., Braganhol, E.

“…Glioblastoma is the most devastating primary brain tumor. Effective therapies are not available, mainly due to high tumor heterogeneity, chemoresistance, and…”
Get full text

Ecto-5'-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions by Augusto, Elisabete, Matos, Marco, Sévigny, Jean, El-Tayeb, Ali, Bynoe, Margaret S, Müller, Christa E, Cunha, Rodrigo A, Chen, Jiang-Fan

“…Adenosine is a neuromodulator acting through inhibitory A1 receptors (A1Rs) and facilitatory A2ARs, which have similar affinities for adenosine. It has been…”
Get full text

Adaptive behavior in autism: Minimal clinically important differences on the Vineland‐II by Chatham, C. H., Taylor, K. I., Charman, T., Liogier D'ardhuy, X., Eule, E., Fedele, A., Hardan, A. Y., Loth, E., Murtagh, L., del Valle Rubido, M., San Jose Caceres, A., Sevigny, J., Sikich, L., Snyder, L., Tillmann, J. E., Ventola, P. E., Walton‐Bowen, K. L., Wang, P. P., Willgoss, T., Bolognani, F.

“…Autism Spectrum Disorder (ASD) is associated with persistent impairments in adaptive abilities across multiple domains. These social, personal, and…”
Get full text

Optimizing Central Nervous System Drug Development Using Molecular Imaging by Hargreaves, RJ, Hoppin, J, Sevigny, J, Patel, S, Chiao, P, Klimas, M, Verma, A

“…Advances in multimodality fusion imaging technologies promise to accelerate the understanding of the systems biology of disease and help in the development of…”
Get full text

Growth hormone secretagogue MK-677 : No clinical effect on AD progression in a randomized trial by SEVIGNY, J. J, RYAN, J. M, VAN DYCK, C. H, PENG, Y, LINES, C. R, NESSLY, M. L

“…In animals, insulin-like growth factor-1 (IGF-1) increases clearance of beta-amyloid, a pathologic hallmark of Alzheimer disease (AD), from the CNS. Serum…”
Get full text

17 beta -Estradiol upregulates ecto-5'-nucleotidase (CD73) in hippocampal synaptosomes of female rats through action mediated by estrogen receptor- alpha and - beta by Mitrovic, N, Zaric, M, Drakulic, D, Martinovic, J, Stanojlovic, M, Sevigny, J, Horvat, A, Nedeljkovic, N, Grkovic, I

“…17 beta -Estradiol (E2) crucially affects several processes in the hippocampus of both sexes. E2 acts upon estradiol receptors ER alpha and ER beta ,…”
Get full text

Attenuated allergic airway inflammation in Cd39 null mice by Idzko, M., K. Ayata, C., Müller, T., Dürk, T., Grimm, M., Baudiß, K., Vieira, R. P., Cicko, S., Boehlke, C., Zech, A., Sorichter, S., Pelletier, J., Sévigny, J., Robson, S. C.

“…Background Extracellular Adenosine‐5′‐Triphosphate (ATP) is known to accumulate in the lung, following allergen challenge, and contributes via activation of…”
Get full text

Genetic structure of deep-water redfish, Sebastes mentella, populations across the North Atlantic by ROQUES, S, SEVIGNY, J.-M, BERNATCHEZ, L

“…Patterns of genetic diversity of the marine deep-water redfish, Sebastes mentella Travin, from 21 sampling locations (n = 46 per sample, from 1995 to 1998)…”
Get full text

Carbon Monoxide Generated by Heme Oxygenase-1 Suppresses the Rejection of Mouse-to-Rat Cardiac Transplants by Sato, Koichiro, Balla, Jozsef, Otterbein, Leo, Smith, R. Neal, Brouard, Sophie, Lin, Yuan, Csizmadia, Eva, Sevigny, Jean, Robson, Simon C, Vercellotti, Gregory, Choi, Augustine M, Bach, Fritz H, Soares, Miguel P

“…Mouse-to-rat cardiac transplants survive long term after transient complement depletion by cobra venom factor and T cell immunosuppression by cyclosporin A…”
Get full text

Randomized, placebo-controlled, phase 1b study of anti-beta-amyloid antibody aducanumab (biib037) in prodromal ad/mild ad dementia: Interim results by patient subgroup by Sevigny, J, Chiao, P, Williams, L, Chen, T, Ling, Y, O’Gorman, J, Hock, C, Nitsch, R, Sandrock, A

Get full text

Probing the Radial Chemistry of Getter Components in Light Water Reactors via Controlled Electrochemical Dissolution by Chatterjee, Sayandev, Fujimoto, Meghan S, Canfield, Nathan L, Elmore, Monte R, Varga, Tamas, Sevigny, Gary J, Senor, David J

“…Getters are among the key functional components in the tritium-producing burnable absorber rods (TPBARs) of light water reactors (LWRs) and are used to capture…”
Get full text

Targeted disruption of cd39 /ATP diphosphohydrolase results in disordered hemostasis and thromboregulation by Rosenberg, Robert D, Enjyoji, Keiichi, Sévigny, Jean, Lin, Yuan, Frenette, Paul S, Christie, Patricia D, Esch, Jan Schulte Am, Imai, Masato, Edelberg, Jay M, Rayburn, Helen, Lech, Miroslaw, Beeler, David L, Csizmadia, Eva, Wagner, Denisa D, Robson, Simon C

“…CD39, or vascular adenosine triphosphate diphosphohydrolase, has been considered an important inhibitor of platelet activation. Unexpectedly, cd39-deficient…”
Get full text

Evidence for broadscale introgressive hybridization between two redfish (genus Sebastes) in the North-west Atlantic: a rare marine example by Roques, SÉverine, SÉvigny, Jean-Marie, Bernatchez, Louis

“…The evolutionary importance of introgressive hybridization has long been recognized by plant evolutionists, and there is now a growing recognition for its…”
Get full text

Blockade of CD73 delays glioblastoma growth by modulating the immune environment by Azambuja, J. H., Schuh, R. S., Michels, L. R., Iser, I. C., Beckenkamp, L. R., Roliano, G. G., Lenz, G. S., Scholl, J. N., Sévigny, J., Wink, M. R., Stefani, M. A., Battastini, A. M. O., Figueiró, F., Teixeira, H. F., Braganhol, E.

“…Immunotherapy as an approach for cancer treatment is clinically promising. CD73, which is the enzyme that produces extracellular adenosine, favors cancer…”
Get full text

Motor, cognitive, and functional declines contribute to a single progressive factor in early HD by Schobel, Scott A, Palermo, Giuseppe, Auinger, Peggy, Long, Jeffrey D, Ma, Shiyang, Khwaja, Omar S, Trundell, Dylan, Cudkowicz, Merit, Hersch, Steven, Sampaio, Cristina, Dorsey, E Ray, Leavitt, Blair R, Kieburtz, Karl D, Sevigny, Jeffrey J, Langbehn, Douglas R, Tabrizi, Sarah J

“…OBJECTIVE:To identify an improved measure of clinical progression in early Huntington disease (HD) using data from prospective observational cohort studies and…”
Get full text

Arching effect on fish body shape in geometric morphometric studies by Valentin, A. E., Penin, X., Chanut, J.-P., Sévigny, J.-M., Rohlf, F. J.

“…Upward and downward arching of the body was observed during a study on redfishes Sebastes sp. population structure in the north‐west Atlantic Ocean. The…”
Get full text

Distribution of ecto-nucleotidases in mouse sensory circuits suggests roles for nucleoside triphosphate diphosphohydrolase-3 in nociception and mechanoreception by Vongtau, H.O, Lavoie, E.G, Sévigny, J, Molliver, D.C

“…Abstract Nucleotide-activated P2X channels and P2Y metabotropic receptors participate in nociceptive signaling. Agonist availability is regulated by nucleoside…”
Get full text

Diacylhydrazine Derivatives of 2-(5-(Pyridin-3-yl)-2H-Tetrazol-2-yl)Acetohydrazide and 2-(5-(Pyridin-4-yl)-2H-Tetrazol-2-yl)Acetohydrazide as Potential Inhibitors of Nucleotide Pyrophosphatase by Arif, M., Shabir, G., Ejaz, S. A., Saeed, A., Khan, S. U., Lecka, J., Sévigny, J., Iqbal, J.

“…Nucleotide Pyrophosphatases (NPPs) i.e. NPP1 and 3 are responsible for maintaining the extracellular level of nucleotides and nucleosides and are also involve…”
Get full text