Search Results - "SEVERS, N. J"

Gap junctions and connexin expression in human suburothelial interstitial cells by Sui, G.P., Rothery, S., Dupont, E., Fry, C.H., Severs, N.J.

“…Objective  To determine whether suburothelial interstitial cells of the human bladder express gap junctions, and if so, to establish their extent and…”
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Distinct patterns of dystrophin organization in myocyte sarcolemma and transverse tubules of normal and diseased human myocardium by Kaprielian, R R, Stevenson, S, Rothery, S M, Cullen, M J, Severs, N J

“…Genetic mutations of dystrophin and associated glycoproteins underlie cell degeneration in several inherited cardiomyopathies, although the precise…”
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Reduced content of connexin43 gap junctions in ventricular myocardium from hypertrophied and ischemic human hearts by PETERS, N. S, GREEN, C. R, POOLE-WILSON, P. A, SEVERS, N. J

“…Gap junctions are a determinant of myocardial conduction. Disturbances of gap-junctional content may account for abnormalities of impulse propagation,…”
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Disturbed connexin43 gap junction distribution correlates with the location of reentrant circuits in the epicardial border zone of healing canine infarcts that cause ventricular tachycardia by PETERS, N. S, COROMILAS, J, SEVERS, N. J, WIT, A. L

“…Slow, nonuniform conduction caused by abnormal gap-junctional coupling of infarct-related myocardium is thought to be a component of the arrhythmogenic…”
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Loss of desmoplakin isoform I causes early onset cardiomyopathy and heart failure in a Naxos-like syndrome by Uzumcu, A, Norgett, E E, Dindar, A, Uyguner, O, Nisli, K, Kayserili, H, Sahin, S E, Dupont, E, Severs, N J, Leigh, I M, Yuksel-Apak, M, Kelsell, D P, Wollnik, B

“…Background: Desmosomes are cellular junctions important for intercellular adhesion and anchoring the intermediate filament (IF) cytoskeleton to the cell…”
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Altered patterns of cardiac intercellular junction distribution in hypertrophic cardiomyopathy by Sepp, R., Severs, N. J., Gourdie, R. G.

“…OBJECTIVE: To examine the distribution pattern of intercellular junctions (the mechanically coupling desmosomes and the electrically coupling gap junctions) in…”
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Connexin45 Expression Is Preferentially Associated With the Ventricular Conduction System in Mouse and Rat Heart by Coppen, Steven R, Dupont, Emmanuel, Rothery, Stephen, Severs, Nicholas J

“…Cardiac myocytes are electrically coupled by gap junctions, clusters of low-resistance intercellular channels composed of connexins. Variations in the…”
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The extra- and intracellular barriers to lipid and adenovirus-mediated pulmonary gene transfer in native sheep airway epithelium by KITSON, C, ANGEL, B, ALTON, E. W. F. W, JUDD, D, ROTHERY, S, SEVERS, N. J, DEWAR, A, HUANG, L, WADSWORTH, S. C, CHENG, S. H, GEDDES, D. M

“…Gene transfer to the respiratory epithelium is currently suboptimal and may be helped by the identification of limiting biological barriers. We have,…”
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The cardiac muscle cell by Severs, Nicholas J.

“…The cardiac myocyte is the most physically energetic cell in the body, contracting constantly, without tiring, 3 billion times or more in an average human…”
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Upregulation of Connexin43 Gap Junctions Between Smooth Muscle Cells After Balloon Catheter Injury in the Rat Carotid Artery by Yeh, Hung-I, Lupu, Florea, Dupont, Emmanuel, Severs, Nicholas J

“…Phenotypic transformation of smooth muscle cells (SMCs) to the synthetic state in vitro and in human coronary atherosclerosis is reported to be associated with…”
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Remodeling of Gap Junctional Coupling in Hypertrophied Right Ventricles of Rats With Monocrotaline-Induced Pulmonary Hypertension by Uzzaman, Mahmud, Honjo, Haruo, Takagishi, Yoshiko, Emdad, Luni, Magee, Anthony I, Severs, Nicholas J, Kodama, Itsuo

“…The present study investigates the remodeling of gap junctional organization in relation to changes in anisotropic conduction properties in hypertrophied right…”
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Impedance measurements and connexin expression in human detrusor muscle from stable and unstable bladders by Sui, G.P., Coppen, S.R., Dupont, E., Rothery, S., Gillespie, J., Newgreen, D., Severs, N.J., Fry, C.H.

“…Three of this month's Scientific Discovery papers highlight the importance of collaboration in delivering high quality scientific research. As scientific…”
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Individual Gap Junction Plaques Contain Multiple Connexins in Arterial Endothelium by Yeh, Hung-I, Rothery, Stephen, Dupont, Emmanuel, Coppen, Steven R, Severs, Nicholas J

“…Gap-junctional intercellular communication in endothelial cells is implicated in the coordination of growth, migration, and vasomotor responses. Up to 3…”
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Spatiotemporal relation between gap junctions and fascia adherens junctions during postnatal development of human ventricular myocardium by PETERS, N. S, SEVERS, N. J, ROTHERY, S. M, LINCOLN, C, YACOUB, M. H, GREEN, C. R

“…The growing postnatal human heart maintains electromechanical function while undergoing substantial changes of cellular topology and myocardial architecture…”
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Downregulation of immunodetectable connexin43 and decreased gap junction size in the pathogenesis of chronic hibernation in the human left ventricle by KAPRIELIAN, R. R, GUNNING, M, SEVERS, N. J, DUPONT, E, SHEPPARD, M. N, ROTHERY, S. M, UNDERWOOD, R, PENNELL, D. J, FOX, K, PEPPER, J, POOLE-WILSON, P. A

“…The regional wall motion impairment and predisposition to arrhythmias in human ventricular hibernation may plausibly result from abnormal intercellular…”
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Altered patterns of gap junction distribution in ischemic heart disease. An immunohistochemical study of human myocardium using laser scanning confocal microscopy by Smith, JH, Green, CR, Peters, NS, Rothery, S, Severs, NJ

“…Arrhythmias are a common and potentially life-threatening complication of myocardial ischemia and infarction in humans. The structural pathways for the rapid…”
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Expression, Localization, and Activity of Tissue Factor Pathway Inhibitor in Normal and Atherosclerotic Human Vessels by Crawley, James, Lupu, Florea, Westmuckett, Andrew D, Severs, Nicholas J, Kakkar, Vijay V, Lupu, Cristina

“…Tissue factor (TF) pathway inhibitor (TFPI) is the major downregulator of the procoagulant activity of the TF–factor VIIa (FVIIa) complex (TF · FVII). The…”
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Upregulation of Connexin43 Gap Junctions During Early Stages of Human Coronary Atherosclerosis by Blackburn, J.P, Peters, N.S, Yeh, H.-I, Rothery, S, Green, C.R, Severs, N.J

“…Interactions between cells form the framework for understanding the pathogenesis of atherosclerosis, but little information is available on the role of direct…”
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Dissociated Spatial Patterning of Gap Junctions and Cell Adhesion Junctions During Postnatal Differentiation of Ventricular Myocardium by Angst, Brigitt D, Khan, Laeeq U.R, Severs, Nicholas J, Whitely, Kate, Rothery, Stephen, Thompson, Robert P, Magee, Anthony I, Gourdie, Robert G

“…Nonuniformity in the spatial patterning of gap junctions between heart muscle cells is now recognized as an important determinant of electromechanical function…”
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CONNEXIN EXPRESSION IN HUNTINGTON'S DISEASED HUMAN BRAIN by Vis, J.C., Nicholson, L.F.B., Faull, R.L.M., Evans, W.H., Severs, N.J., Green, C.R.

“…In Huntington's diseased human brain, it is in the caudate nucleus (CN) and globus pallidus (GP) of the basal ganglia where nerve cell death is seen most…”
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