Search Results - "SETTLEMAN, J"

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer by Singh, A, Settleman, J

“…Tumors are cellularly and molecularly heterogeneous, with subsets of undifferentiated cancer cells exhibiting stem cell-like features (CSCs). Epithelial to…”
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Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors by Ducker, G S, Atreya, C E, Simko, J P, Hom, Y K, Matli, M R, Benes, C H, Hann, B, Nakakura, E K, Bergsland, E K, Donner, D B, Settleman, J, Shokat, K M, Warren, R S

“…The mammalian target of rapamycin (mTOR) regulates cell growth by integrating nutrient and growth factor signaling and is strongly implicated in cancer. But…”
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The Drosophila Pkn protein kinase is a Rho/Rac effector target required for dorsal closure during embryogenesis by Lu, Y, Settleman, J

“…The PKN family of PKC-related protein kinases constitutes the major Rho GTPase-associated protein kinase activities detected in mammalian tissues. However, the…”
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Chromatin Condensation Mediated by EGFR and Aurora B Protects KRAS-Mutant Lung Cancer Cells Against Ionizing Radiation by Willers, H, Wang, M, Han, J, Kern, A, Hülskötter, M, Krause, M, Baumann, M, Benes, C, Efstathiou, J, Settleman, J

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The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development by Brouns, M R, Matheson, S F, Hu, K Q, Delalle, I, Caviness, V S, Silver, J, Bronson, R T, Settleman, J

“…Rho GTPases direct actin rearrangements in response to a variety of extracellular signals. P190 RhoGAP (GTPase activating protein) is a potent Rho regulator…”
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The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization by Vincent, Sylvie, Settleman, Jeffrey

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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MC13-0075 Rapid assessment of TORC1 suppression as a functional biomarker predicting responsiveness to RAF and MEK inhibitors in BRAF-mutant melanoma patients by Corcoran, R.B, Rothenberg, M.S, Piris, A, Nazarian, R.M, Maheswaran, S, Settleman, J, Wargo, J.A, Flaherty, K.T, Haber, D.A, Engelman, J.A

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Molecular targeted therapy of lung cancer: EGFR mutations and response to EGFR inhibitors by Haber, D A, Bell, D W, Sordella, R, Kwak, E L, Godin-Heymann, N, Sharma, S V, Lynch, T J, Settleman, J

“…Somatic mutations within the kinase domain of the epidermal growth factor receptor (EGFR) are present in approximately 10% of non-small-cell lung cancer…”
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P190A RhoGAP is required for mammary gland development by Heckman-Stoddard, B.M., Vargo-Gogola, T., Herrick, M.P., Visbal, A.P., Lewis, M.T., Settleman, J., Rosen, J.M.

“…P190A and p190B Rho GTPase activating proteins (GAPs) are essential genes that have distinct, but overlapping roles in the developing nervous system. Previous…”
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149 Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS-mutant Cancer Models by Corcoran, R, Cheng, K, Hata, A, Faber, A, Singh, A, Settleman, J, Benes, C, Mino-Kenudson, M, Wong, K, Engelman, J

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Getting in shape with Rho by Settleman, Jeffrey

“…The Rho GTPases are potent regulators of the actin cytoskeleton and consequently influence many aspects of cell shape and movement. In vivo, Rho activity…”
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Identification of a human rasGAP-related protein containing calmodulin-binding motifs by WEISSBACH, L, SETTLEMAN, J, KALADY, M. F, SNIJDERS, A. J, MURTHY, A. E, YU-XIN YAN, BERNARDS, A

“…Conversion of active GTP-bound Ras to its inactive GDP-bound form is catalyzed by GTPase-activating proteins (GAPs). Two mammalian Ras-specific GAPs, p120GAP…”
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EGFR Inhibition Radiosensitizes NSCLC Cells via DNA Double-strand Break Inducible Senescence by Willers, H, Wang, M, Morsbach, F, Sander, D, Nanda, A, Kriegs, M, Krause, M, Dikomey, E, Baumann, M, Settleman, J

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Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation by Foster, Rosemary, Hu, Kang-Quan, Lu, Yu, Nolan, Katherine M., Thissen, Julia, Settleman, Jeffrey

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Role of Prenylation in the Interaction of Rho-Family Small GTPases with GTPase Activating Proteins by Molnár, Gergely, Dagher, Marie-Claire, Geiszt, Miklós, Settleman, Jeffrey, Ligeti, Erzsébet

“…The role of prenylation in the interaction of Rho-family small GTPases with their GTPase activating proteins (GAPs) was investigated. Prenylated and…”
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c-Src Regulates the Simultaneous Rearrangement of Actin Cytoskeleton, p190RhoGAP, and p120RasGAP Following Epidermal Growth Factor Stimulation by Chang, Jin-Hong, Gill, Satinder, Settleman, Jeffrey, Parsons, Sarah J.

“…Analysis of C3H10T1/2 murine fibroblasts overexpressing wild type and dominant negative variants of c-Src has demonstrated a requirement for c-Src in…”
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RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion by ZRIHAN-LICHT, S, YIGONG FU, SETTLEMAN, J, SCHINKMANN, K, SHAW, L, KEYDAR, L, AVRAHAM, S, AVRAHAM, H

“…Focal adhesions and actin cytoskeleton are involved in cell growth, shape and movement and in tumor invasion. Mitogen-induced changes in actin cytoskeleton are…”
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Differing structural requirements for GTPase-activating protein responsiveness and NADPH oxidase activation by Rac by Xu, X, Barry, D C, Settleman, J, Schwartz, M A, Bokoch, G M

“…The Rac GTP-binding proteins regulate the actin cytoskeleton and the superoxide-forming NADPH oxidase of phagocytic leukocytes. These functions of Rac are…”
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Characterization of rho GTPase family homologues in Drosophila melanogaster: overexpressing Rho1 in retinal cells causes a late developmental defect by Hariharan, I.K., Hu, K.Q., Asha, H., Quintanilla, A., Ezzell, R.M., Settleman, J.

“…The rho family of GTPases has been implicated in regulating changes in cell morphology in response to extracellular signals. We have cloned three widely…”
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The N‐terminal region of GAP regulates cytoskeletal structure and cell adhesion by McGlade, J., Brunkhorst, B., Anderson, D., Mbamalu, G., Settleman, J., Dedhar, S., Rozakis‐Adcock, M., Chen, L.B., Pawson, T.

“…Ras GTPase activating protein (GAP) possesses a C‐terminal domain that interacts with GTP‐bound Ras, and an N‐terminal region containing two SH2 domains and an…”
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