Search Results - "SETALURI, Vijayasaradhi"

Role of dual specificity phosphatases (DUSPs) in melanoma cellular plasticity and drug resistance by Singh, Mithalesh K., Altameemi, Sarah, Lares, Marcos, Newton, Michael A., Setaluri, Vijayasaradhi

“…Melanoma cells exhibit phenotypic plasticity that allows transition from a proliferative and differentiated phenotype to a more invasive and undifferentiated…”
Get full text

Advances in Microengineered Platforms for Skin Research by Teertam, Sireesh Kumar, Setaluri, Vijayasaradhi, Ayuso, Jose M.

“…The skin plays a critical role in human physiology, acting both as a barrier to environmental insults and as a window to environmental stimuli. Disruption of…”
Get full text

microRNA-340 as a modulator of RAS–RAF–MAPK signaling in melanoma by Poenitzsch Strong, Ashley M., Setaluri, Vijayasaradhi, Spiegelman, Vladimir S.

“…•miR-340 is a novel inhibitor of tumorigenic phenotype in melanoma cells.•miR-340 inhibits RAS–RAF–MAPK signaling pathway.•miR-340 targets multiple components…”
Get full text

Microtubule-Associated Proteins as Targets in Cancer Chemotherapy by BHAT, Kumar M. R, SETALURI, Vijayasaradhi

“…Natural and synthetic compounds that disrupt microtubule dynamics are among the most successful and widely used cancer chemotherapeutic agents. However, lack…”
Get full text

Microfluidic Tumor-on-a-Chip Model to Study Tumor Metabolic Vulnerability by Ayuso, Jose M, Rehman, Shujah, Farooqui, Mehtab, Virumbrales-Muñoz, María, Setaluri, Vijayasaradhi, Skala, Melissa C, Beebe, David J

“…Tumor-specific metabolic adaptations offer an interesting therapeutic opportunity to selectively destroy cancer cells. However, solid tumors also present…”
Get full text

Evidence for a retroviral insertion in TRPM1 as the cause of congenital stationary night blindness and leopard complex spotting in the horse by Bellone, Rebecca R, Holl, Heather, Setaluri, Vijayasaradhi, Devi, Sulochana, Maddodi, Nityanand, Archer, Sheila, Sandmeyer, Lynne, Ludwig, Arne, Foerster, Daniel, Pruvost, Melanie, Reissmann, Monika, Bortfeldt, Ralf, Adelson, David L, Lim, Sim Lin, Nelson, Janelle, Haase, Bianca, Engensteiner, Martina, Leeb, Tosso, Forsyth, George, Mienaltowski, Michael J, Mahadevan, Padmanabhan, Hofreiter, Michael, Paijmans, Johanna L A, Gonzalez-Fortes, Gloria, Grahn, Bruce, Brooks, Samantha A

“…Leopard complex spotting is a group of white spotting patterns in horses caused by an incompletely dominant gene (LP) where homozygotes (LP/LP) are also…”
Get full text

Targeted Knockdown of Notch1 Inhibits Invasion of Human Prostate Cancer Cells Concomitant with Inhibition of Matrix Metalloproteinase-9 and Urokinase Plasminogen Activator by Bin Hafeez, Bilal, Adhami, Vaqar Mustafa, Asim, Mohammad, Siddiqui, Imtiaz A, Bhat, Kumar M, Zhong, Weixiong, Saleem, Mohammad, Din, Maria, Setaluri, Vijayasaradhi, Mukhtar, Hasan

“…Purpose: Notch , a type 1 transmembrane protein, plays a key role in the development of many tissues and organ types. Aberrant Notch signaling, found in a wide…”
Get full text

EPAC-RAP1 Axis-Mediated Switch in the Response of Primary and Metastatic Melanoma to Cyclic AMP by Rodríguez, Carlos I, Castro-Pérez, Edgardo, Prabhakar, Kirthana, Block, Laura, Longley, B Jack, Wisinski, Jaclyn A, Kimple, Michelle E, Setaluri, Vijayasaradhi

“…Cyclic AMP (cAMP) is an important second messenger that regulates a wide range of physiologic processes. In mammalian cutaneous melanocytes, cAMP-mediated…”
Get full text

MicroRNA-340-mediated Degradation of Microphthalmia-associated Transcription Factor mRNA Is Inhibited by the Coding Region Determinant-binding Protein by Goswami, Srikanta, Tarapore, Rohinton S., TeSlaa, Jessica J., Grinblat, Yevgenya, Setaluri, Vijayasaradhi, Spiegelman, Vladimir S.

“…Alternative cleavage and polyadenylation generate multiple transcript variants of mRNA isoforms with different length of 3′-untranslated region (UTR)…”
Get full text

Induction of Autophagy and Inhibition of Melanoma Growth In Vitro and In Vivo by Hyperactivation of Oncogenic BRAF by Maddodi, Nityanand, Huang, Wei, Havighurst, Thomas, Kim, KyungMann, Jack Longley, B., Setaluri, Vijayasaradhi

“…Activating mutations in NRAS and BRAF are found frequently in cutaneous melanomas. Because concurrent mutations of both BRAF and RAS are extremely rare, it is…”
Get full text

Lupeol Inhibits Growth of Highly Aggressive Human Metastatic Melanoma Cells In vitro and In vivo by Inducing Apoptosis by SALEEM, Mohammad, MADDODI, Nityanand, MOHAMMAD ABU ZAID, KHAN, Naghma, BIN HAFEEZ, Bilal, ASIM, Mohammad, SUH, Yewseok, YUN, Jung-Mi, SETALURI, Vijayasaradhi, MUKHTAR, Hasan

“…Purpose: Poor prognosis of metastatic melanoma mandates the development of novel strategies for its treatment and prevention. In this study, the effect of…”
Get full text

Bromodomain and extra-terminal domain (BET) proteins regulate melanocyte differentiation by Trivedi, Archit, Mehrotra, Aanchal, Baum, Caitlin E, Lewis, Brandon, Basuroy, Tupa, Blomquist, Thomas, Trumbly, Robert, Filipp, Fabian V, Setaluri, Vijayasaradhi, de la Serna, Ivana L

“…Pharmacologic inhibition of bromodomain and extra-terminal (BET) proteins is currently being explored as a new therapeutic approach in cancer. Some studies…”
Get full text

Numb Regulates Stability and Localization of the Mitotic Kinase PLK1 and Is Required for Transit through Mitosis by SCHMIT, Travis L, NIHAL, Minakshi, NDIAYE, Mary, SETALURI, Vijayasaradhi, SPIEGELMAN, Vladimir S, AHMAD, Nihal

“…Numb functions in progenitor cell fate determination and early development, but it is also expressed in postdevelopmental tissues and cancers where its role is…”
Get full text

S100A4 Accelerates Tumorigenesis and Invasion of Human Prostate Cancer through the Transcriptional Regulation of Matrix Metalloproteinase 9 by Saleem, Mohammad, Kweon, Mee-Hyang, Johnson, Jeremy James, Adhami, Vaqar Mustafa, Elcheva, Irina, Khan, Naghma, Hafeez, Bilal Bin, Bhat, Kumar M. R., Sarfaraz, Sami, Reagan-Shaw, Shannon, Spiegelman, Vladimir S., Setaluri, Vijayasaradhi, Mukhtar, Hasan

“…We previously showed that the calcium-binding protein S100A4 is overexpressed during the progression of prostate cancer (CaP) in humans and in the TRAMP…”
Get full text

Metabotropic glutamate receptor 6 signaling enhances TRPM1 calcium channel function and increases melanin content in human melanocytes by Devi, Sulochana, Markandeya, Yogananda, Maddodi, Nityanand, Dhingra, Anuradha, Vardi, Noga, Balijepalli, Ravi C., Setaluri, Vijayasaradhi

“…Summary Mutations in TRPM1, a calcium channel expressed in retinal bipolar cells and epidermal melanocytes, cause complete congenital stationary night…”
Get full text

Calcium homeostasis in human melanocytes: role of transient receptor potential melastatin 1 (TRPM1) and its regulation by ultraviolet light by Devi, Sulochana, Kedlaya, Rajendra, Maddodi, Nityanand, Bhat, Kumar M R, Weber, Craig S, Valdivia, Hector, Setaluri, Vijayasaradhi

“…Transient receptor potential melastatin (TRPM) is a subfamily of ion channels that are involved in sensing taste, ambient temperature, low pH, osmolarity, and…”
Get more information

Melanoma Progression Inhibits Pluripotency and Differentiation of Melanoma-Derived iPSCs Produces Cells with Neural-like Mixed Dysplastic Phenotype by Castro-Pérez, Edgardo, Rodríguez, Carlos I., Mikheil, Dareen, Siddique, Shakir, McCarthy, Alexandra, Newton, Michael A., Setaluri, Vijayasaradhi

“…Melanomas are known to exhibit phenotypic plasticity. However, the role cellular plasticity plays in melanoma tumor progression and drug resistance is not…”
Get full text

Mutation in archain 1, a subunit of COPI coatomer complex, causes diluted coat color and Purkinje cell degeneration by Xu, Xinjie, Kedlaya, Rajendra, Higuchi, Hitoshi, Ikeda, Sakae, Justice, Monica J, Setaluri, Vijayasaradhi, Ikeda, Akihiro

“…Intracellular trafficking is critical for delivering molecules and organelles to their proper destinations to carry out normal cellular functions. Disruption…”
Get full text

Delphinidin inhibits cell proliferation and invasion via modulation of Met receptor phosphorylation by Syed, Deeba N., Afaq, Farrukh, Sarfaraz, Sami, Khan, Naghma, Kedlaya, Rajendra, Setaluri, Vijayasaradhi, Mukhtar, Hasan

“…The HGF/Met signaling pathway is deregulated in majority of cancers and is associated with poor prognosis in breast cancer. Delphinidin, present in pigmented…”
Get full text

Pandemic and the PCMR by Setaluri, Vijayasaradhi

Get full text