Search Results - "SESSA, William C"

Endothelial NOS: perspective and recent developments by Garcia, Victor, Sessa, William C

“…Endothelial NOS (eNOS), and its product NO, are vital components of the control of vasomotor function and cardiovascular homeostasis. In the present review, we…”
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Inflammation and the blood microvascular system by Pober, Jordan S, Sessa, William C

“…Acute and chronic inflammation is associated with changes in microvascular form and function. At rest, endothelial cells maintain a nonthrombogenic,…”
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Evolving functions of endothelial cells in inflammation by Pober, Jordan S, Sessa, William C

“…Inflammation is usually analysed from the perspective of tissue-infiltrating leukocytes. Microvascular endothelial cells at a site of inflammation are both…”
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Lipid Droplet Biogenesis and Function in the Endothelium by Kuo, Andrew, Lee, Monica Y, Sessa, William C

“…RATIONALE:Fatty acids (FA) are transported across the capillary endothelium to parenchymal tissues. However, it is not known how endothelial cells (EC) from…”
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Contemporary Approaches to Modulating the Nitric Oxide–cGMP Pathway in Cardiovascular Disease by Kraehling, Jan R, Sessa, William C

“…Endothelial cells lining the vessel wall control important aspects of vascular homeostasis. In particular, the production of endothelium-derived nitric oxide…”
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MicroRNAs As Novel Regulators of Angiogenesis by Suárez, Yajaira, Sessa, William C

“…MicroRNAs are short noncoding RNAs that function as negative regulators of gene expression. Posttranscriptional regulation by miRNAs is important for many…”
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Targeting the vasculature in cardiometabolic disease by Boutagy, Nabil E, Singh, Abhishek K, Sessa, William C

“…Obesity has reached epidemic proportions and is a major contributor to insulin resistance (IR) and type 2 diabetes (T2D). Importantly, IR and T2D substantially…”
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VEGF-Induced Expression of miR-17–92 Cluster in Endothelial Cells Is Mediated by ERK/ELK1 Activation and Regulates Angiogenesis by Chamorro-Jorganes, Aránzazu, Lee, Monica Y, Araldi, Elisa, Landskroner-Eiger, Shira, Fernández-Fuertes, Marta, Sahraei, Mahnaz, Quiles del Rey, Maria, van Solingen, Coen, Yu, Jun, Fernández-Hernando, Carlos, Sessa, William C, Suárez, Yajaira

“…RATIONALE:Several lines of evidence indicate that the regulation of microRNA (miRNA) levels by different stimuli may contribute to the modulation of…”
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Cav-1 (Caveolin-1) Deficiency Increases Autophagy in the Endothelium and Attenuates Vascular Inflammation and Atherosclerosis by Zhang, Xinbo, Ramírez, Cristina M., Aryal, Binod, Madrigal-Matute, Julio, Liu, Xinran, Diaz, Antonio, Torrecilla-Parra, Marta, Suárez, Yajaira, Cuervo, Ana M., Sessa, William C., Fernández-Hernando, Carlos

“…OBJECTIVE:Endothelial Cav-1 (caveolin-1) expression plays a relevant role during atherogenesis by controlling NO production, vascular inflammation, LDL…”
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Lacteal junction zippering protects against diet-induced obesity by Zhang, Feng, Zarkada, Georgia, Han, Jinah, Li, Jinyu, Dubrac, Alexandre, Ola, Roxana, Genet, Gael, Boyé, Kevin, Michon, Pauline, Künzel, Steffen E, Camporez, Joao Paulo, Singh, Abhishek K, Fong, Guo-Hua, Simons, Michael, Tso, Patrick, Fernández-Hernando, Carlos, Shulman, Gerald I, Sessa, William C, Eichmann, Anne

“…Excess dietary lipid uptake causes obesity, a major global health problem. Enterocyte-absorbed lipids are packaged into chylomicrons, which enter the…”
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An optogenetic-phosphoproteomic study reveals dynamic Akt1 signaling profiles in endothelial cells by Zhou, Wenping, Li, Wenxue, Wang, Shisheng, Salovska, Barbora, Hu, Zhenyi, Tao, Bo, Di, Yi, Punyamurtula, Ujwal, Turk, Benjamin E., Sessa, William C., Liu, Yansheng

“…The serine/threonine kinase AKT is a central node in cell signaling. While aberrant AKT activation underlies the development of a variety of human diseases,…”
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Endothelial glucocorticoid receptor is required for protection against sepsis by Goodwin, Julie E., Feng, Yan, Velazquez, Heino, Sessa, William C.

“…The glucocorticoid receptor (GR) is ubiquitously expressed on nearly all cell types, but tissue-specific deletion of this receptor can produce dramatic whole…”
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CLOCK phosphorylation by AKT regulates its nuclear accumulation and circadian gene expression in peripheral tissues by Luciano, Amelia K., Zhou, Wenping, Santana, Jeans M., Kyriakides, Cleo, Velazquez, Heino, Sessa, William C.

“…Circadian locomotor output cycles kaput (CLOCK) is a transcription factor that activates transcription of clock-controlled genes by heterodimerizing with BMAL1…”
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Dicer Dependent MicroRNAs Regulate Gene Expression and Functions in Human Endothelial Cells by Suárez, Yajaira, Fernández-Hernando, Carlos, Pober, Jordan S, Sessa, William C

“…Dicer is a key enzyme involved in the maturation of microRNAS (miRNAs). miRNAs have been shown to be regulators of gene expression participating in the control…”
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Caveolin-1 Regulates Atherogenesis by Attenuating Low-Density Lipoprotein Transcytosis and Vascular Inflammation Independently of Endothelial Nitric Oxide Synthase Activation by Ramírez, Cristina M, Zhang, Xinbo, Bandyopadhyay, Chirosree, Rotllan, Noemi, Sugiyama, Michael G, Aryal, Binod, Liu, Xinran, He, Shun, Kraehling, Jan R, Ulrich, Victoria, Lin, Chin Sheng, Velazquez, Heino, Lasunción, Miguel A, Li, Guangxin, Suárez, Yajaira, Tellides, George, Swirski, Filip K, Lee, Warren L, Schwartz, Martin A, Sessa, William C, Fernández-Hernando, Carlos

“…BACKGROUND:Atherosclerosis is driven by synergistic interactions between pathological, biomechanical, inflammatory, and lipid metabolic factors. Our previous…”
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MicroRNAs Are Necessary for Vascular Smooth Muscle Growth, Differentiation, and Function by Albinsson, Sebastian, Suarez, Yajaira, Skoura, Athanasia, Offermanns, Stefan, Miano, Joseph M, Sessa, William C

“…OBJECTIVE—Regulation of vascular smooth muscle (VSM) proliferation and contractile differentiation is an important factor in vascular development and…”
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Ten-eleven translocation (Tet) and thymine DNA glycosylase (TDG), components of the demethylation pathway, are direct targets of miRNA-29a by Zhang, Pei, Huang, Bihui, Xu, Xiangru, Sessa, William C.

“…•Ten-eleven translocation (TET) enzymes convert 5-mC to 5-hmC.•5hmC can be repaired by thymine DNA glycosylase (TDG).•miR-29a targets to Tet1-3 and TDG mRNA…”
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Mutation of Nogo-B Receptor, a Subunit of cis-Prenyltransferase, Causes a Congenital Disorder of Glycosylation by Park, Eon Joo, Grabińska, Kariona A., Guan, Ziqiang, Stránecký, Viktor, Hartmannová, Hana, Hodaňová, Kateřina, Barešová, Veronika, Sovová, Jana, Jozsef, Levente, Ondrušková, Nina, Hansíková, Hana, Honzík, Tomáš, Zeman, Jiří, Hůlková, Helena, Wen, Rong, Kmoch, Stanislav, Sessa, William C.

“…Dolichol is an obligate carrier of glycans for N-linked protein glycosylation, O-mannosylation, and GPI anchor biosynthesis. cis-prenyltransferase (cis-PTase)…”
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Endothelial Transcytosis of Lipoproteins in Atherosclerosis by Zhang, Xinbo, Sessa, William C, Fernández-Hernando, Carlos

“…Seminal studies from Nikolai Anichckov identified the accumulation of cholesterol in the arteries as the initial event that lead to the formation of…”
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PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia by Ola, Roxana, Dubrac, Alexandre, Han, Jinah, Zhang, Feng, Fang, Jennifer S., Larrivée, Bruno, Lee, Monica, Urarte, Ana A., Kraehling, Jan R., Genet, Gael, Hirschi, Karen K., Sessa, William C., Canals, Francesc V., Graupera, Mariona, Yan, Minhong, Young, Lawrence H., Oh, Paul S., Eichmann, Anne

“…Activin receptor-like kinase 1 (ALK1) is an endothelial serine–threonine kinase receptor for bone morphogenetic proteins (BMPs) 9 and 10. Inactivating…”
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