Search Results - "SESNIE, J. C"

Comparative therapeutic efficacy of clinafloxacin in a Pseudomonas aeruginosa mouse renal abscess model by SHAPIRO, M. A, SESNIE, J. C, DESATY, T. M, GRIFFIN, T. J, HEIFETZ, C. L

“…A deep-seated Pseudomonas aeruginosa mouse kidney abscess model was used to compare the therapeutic efficacy of clinafloxacin, a fluoroquinolone in clinical…”
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Comparative therapeutic efficacy of clinafloxacin in leucopenic mice by SHAPIRO, M. A, DEVER, J. A, SESNIE, J. C, VANDERROEST, S. R

“…A cyclophosphamide-induced leucopenic mouse model was used to compare the therapeutic efficacy of clinafloxacin, a fluoroquinolone in clinical trials, with…”
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In vivo therapeutic efficacies of PD 138312 and PD 140248, two novel fluoronaphthyridines with outstanding gram-positive potency by SHAPIRO, M. A, DEVER, J. A, JOANNIDES, E. T, SESNIE, J. C, VANDERROEST, S. R

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New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8-fluoro group with reduced phototoxic risk by Sanchez, J. P, Bridges, A. J, Bucsh, R, Domagala, J. M, Gogliotti, R. D, Hagen, S. E, Heifetz, C. L, Joannides, E. T, Sesnie, J. C

“…A series of 8-(trifluoromethyl)-substituted quinolones has been prepared and evaluated for in vitro and in vivo antibacterial activity, and phototolerance in a…”
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Interpretive criteria and quality control limits for testing susceptibility of Neisseria gonorrhoeae to enoxacin by BARRY, A. L, COHEN, M. A, SESNIE, J. C, FUCHS, P. C, WASHINGTON, J. A, MURRAY, P. R, BAKER, C

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Synthesis and antimicrobial evaluation of a series of 7-[3-amino (or aminomethyl)-4-aryl (or cyclopropyl)-1-pyrrolidinyl]-4-quinolone and -1,8-naphthyridone-3-carboxylic acids by Bucsh, Ruth A, Domagala, John M, Laborde, Edgardo, Sesnie, Josephine C

“…A series of 6-fluoroquinolone- and 6-fluoro-1,8-naphthyridone-3-carboxylic acids possessing a [3-amino (or aminomethyl)-4-aryl (or cyclopropyl)-1-pyrrolidinyl]…”
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Comparison of microdilution and agar dilution procedures for testing antibiotic susceptibility of Neisseria gonorrhoeae by SHAPIRO, M. A, HEIFETZ, C. L, SESNIE, J. C

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In vitro evaluation of cefdinir (FK482), a new oral cephalosporin with enhanced antistaphylococcal activity and beta-lactamase stability by Cohen, M A, Joannides, E T, Roland, G E, Meservey, M A, Huband, M D, Shapiro, M A, Sesnie, J C, Heifetz, C L

“…Cefdinir (FK482), a new oral cephalosporin with enhanced beta-lactamase stability, was tested by microbroth dilution against respiratory, urogenital, and skin…”
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New "ofloxacin" type antibacterial agents. Incorporation of the spiro cyclopropyl group at N-1 by Kiely, John S, Schroeder, Mel C, Sesnie, Josephine C

“…The first example incorporating a spiro cyclopropyl group into an "ofloxacin" type of quinolone antibacterial agent has been prepared by potassium fluoride…”
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Comparative chemotherapeutic activity of new fluorinated 4-quinolones and standard agents against a variety of bacteria in a mouse infection model by Sesnie, J C, Fritsch, P W, Griffin, T J, Heifetz, C L, Leopold, E T, Malta, T E, Shapiro, M A, Vincent, P W

“…The new fluorinated 4-quinolones appear to represent orally effective alternatives to parenteral and oral agents currently in use. A number of new fluorinated…”
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5″-Amino-5″-Deoxybutirosin, a Semisynthetic Analogue of Butirosin A: Antibacterial Activity In Vitro and in Mice by Heifetz, C L, Frey, C A, Pearson, I A, Sesnie, J C

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Quinolone antibacterials: preparation and activity of bridged bicyclic analogues of the C7-piperazine by Kiely, John S, Hutt, Marland P, Culbertson, Townley P, Bucsh, Ruth A, Worth, Donald F, Lesheski, Lawrence E, Gogliotti, Rocco D, Sesnie, Josephine C, Solomon, Marjorie, Mich, Thomas F

“…A series of quinolone and naphthyridine antibacterial agents possessing as the C7-heterocycle bicyclic 2,5-diazabicyclo[n.2.m]alkanes, where n = 2, 3 and m =…”
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Enoxacin: in-vitro and animal evaluation as a parenteral and oral agent against hospital bacterial isolates by Heifetz, C L, Bien, P A, Cohen, M A, Dombrowski, M E, Griffin, T J, Malta, T E, Sesnie, J C, Shapiro, M A, Wold, S A

“…Enoxacin was evaluated in in-vitro tests and in studies of effectiveness and blood concentrations in the mouse. Enoxacin was active against both susceptible…”
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A novel rapid throughput phototolerance screen in mice by Shapiro, Martin A., Sesnie, Josephine C., Joannides, E.Themis, Malta, Thomas E., Dever, Julie A., Heifetz, Carl L.

“…A relatively simple, rapid throughput phototolerance screen in small animals would be very useful in early drug development. It could prioritize or select…”
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Comparative in-vitro activity of enoxacin against penicillinase- and non-penicillinase-producing Neisseria gonorrhoeae by Shapiro, M A, Heifetz, C L, Sesnie, J C

“…The in-vitro antigonococcal activity of enoxacin was measured by a broth microdilution method. Comparisons were made with five clinically relevant marketed…”
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Comparison of microdilution and agar dilution procedures for testing antibiotic susceptiblity of Neisseria gonorrhoeae by Shapiro, M, Heifetz, CL, Sesnie, J C

“…Studies were run in parallel to compare the broth microdilution method and the chocolate agar dilution method for testing antibiotic susceptibility of N…”
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Quinolone antibacterials: Preparation and activity of bridged bicyclic analogues of the C sub(7)-piperazine by Kiely, J S, Hutt, M P, Culbertson, T P, Bucsh, R A, Worth, D F, Lesheski, LE, Gogliotti, R D, Sesnie, J C, Solomon, M, Mich, T F

“…A series of quinolone and naphthyridine antibacterial agents possessing as the C sub(7)-heterocycle bicyclic 2,5-diazabicyclo(n.2.m)alkanes, where n = 2, 3 and…”
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