Search Results - "SESHADRI, Mukund"

TMEM16A/ANO1 Inhibits Apoptosis Via Downregulation of Bim Expression by Godse, Neal R, Khan, Nayel, Yochum, Zachary A, Gomez-Casal, Roberto, Kemp, Carolyn, Shiwarski, Daniel J, Seethala, Raja S, Kulich, Scott, Seshadri, Mukund, Burns, Timothy F, Duvvuri, Umamaheswar

“…TMEM16A is a calcium-activated chloride channel that is amplified in a variety of cancers, including 30% of head and neck squamous cell carcinomas (HNSCCs),…”
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EZH2 Modifies Sunitinib Resistance in Renal Cell Carcinoma by Kinome Reprogramming by Adelaiye-Ogala, Remi, Budka, Justin, Damayanti, Nur P, Arrington, Justine, Ferris, Mary, Hsu, Chuan-Chih, Chintala, Sreenivasulu, Orillion, Ashley, Miles, Kiersten Marie, Shen, Li, Elbanna, May, Ciamporcero, Eric, Arisa, Sreevani, Pettazzoni, Piergiorgio, Draetta, Giulio F, Seshadri, Mukund, Hancock, Bradley, Radovich, Milan, Kota, Janaiah, Buck, Michael, Keilhack, Heike, McCarthy, Brian P, Persohn, Scott A, Territo, Paul R, Zang, Yong, Irudayaraj, Joseph, Tao, W Andy, Hollenhorst, Peter, Pili, Roberto

“…Acquired and intrinsic resistance to receptor tyrosine kinase inhibitors (RTKi) represents a major hurdle in improving the management of clear cell renal cell…”
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Targeting CXCL12/CXCR4 signaling with oncolytic virotherapy disrupts tumor vasculature and inhibits breast cancer metastases by Gil, Margaret, Seshadri, Mukund, Komorowski, Marcin P, Abrams, Scott I, Kozbor, Danuta

“…Oncolytic viruses hold promise for the treatment of cancer, but their interaction with the tumor microenvironment needs to be elucidated for optimal tumor cell…”
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Current Understanding of the Molecular Biology of Pancreatic Neuroendocrine Tumors by JIANLIANG ZHANG, FRANCOIS, Rony, IYER, Renuka, SESHADRI, Mukund, ZAJAC-KAYE, Maria, HOCHWALD, Steven N

“…Pancreatic neuroendocrine tumors (PanNETs) are complicated and often deadly neoplasms. A recent increased understanding of their molecular biology has…”
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Delivery of anti-microRNA-21 by lung-targeted liposomes for pulmonary fibrosis treatment by Yan, Lingyue, Su, Yafei, Hsia, Isaac, Xu, Ying, Vincent-Chong, Vui King, Mojica, Wilfrido, Seshadri, Mukund, Zhao, Ruogang, Wu, Yun

“…Idiopathic pulmonary fibrosis (IPF) is a chronic lung disorder with a low survival rate. Pulmonary fibrosis is one of the complications of COVID-19 and has a…”
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Impact of dietary vitamin D on initiation and progression of oral cancer by Verma, Aparajita, Vincent-Chong, Vui King, DeJong, Hendrik, Hershberger, Pamela A., Seshadri, Mukund

“…•Malignant transformation and disease progression of oral lesions is critically impacted by host vitamin D status.•Dietary supplementation of 100 IU vitamin D…”
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Survival rates and prognostic factors for infiltrating salivary duct carcinoma: Analysis of 228 cases from the Surveillance, Epidemiology, and End Results database by Jayaprakash, Vijayvel, Merzianu, Mihai, Warren, Graham W., Arshad, Hassan, Hicks Jr, Wesley L., Rigual, Nestor R., Sullivan, Maureen A., Seshadri, Mukund, Marshall, James R., Cohan, David M., Zhao, Yujie, Singh, Anurag K.

“…Background The survival rates and prognostic factors for salivary duct carcinoma (SDC) are not clear. Methods Survival estimates and prognostic factors were…”
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Preclinical Prevention Trial of Calcitriol: Impact of Stage of Intervention and Duration of Treatment on Oral Carcinogenesis by Vincent-Chong, Vui King, DeJong, Hendrik, Attwood, Kristopher, Hershberger, Pamela A., Seshadri, Mukund

“…The anticancer activity of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3 or calcitriol) has been widely reported in preclinical models. However, systematic…”
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Role of Vitamin D Receptor in the Antiproliferative Effects of Calcitriol in Tumor-Derived Endothelial Cells and Tumor Angiogenesis In vivo by CHUNG, Ivy, GUANGZHOU HAN, SESHADRI, Mukund, GILLARD, Bryan M, YU, Wei-Dong, FOSTER, Barbara A, TRUMP, Donald L, JOHNSON, Candace S

“…Calcitriol (1,25-dihydroxycholecalciferol), the major active form of vitamin D, is antiproliferative in tumor cells and tumor-derived endothelial cells (TDEC)…”
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Association of pre-treatment lymphocyte-monocyte ratio with survival outcome in patients with head and neck cancer treated with chemoradiation by Yu, Brian, Ma, Sung Jun, Khan, Michael, Gill, Jasmin, Iovoli, Austin, Fekrmandi, Fatemeh, Farrugia, Mark K, Wooten, Kimberly, Gupta, Vishal, McSpadden, Ryan, Kuriakose, Moni A, Markiewicz, Michael R, Al-Afif, Ayham, Hicks, Jr, Wesley L, Seshadri, Mukund, Ray, Andrew D, Repasky, Elizabeth A, Singh, Anurag K

“…Given the role of systematic inflammation in cancer progression, lymphocyte-monocyte ratio (LMR) from peripheral blood has been suggested as a biomarker to…”
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Dll4 blockade potentiates the anti-tumor effects of VEGF inhibition in renal cell carcinoma patient-derived xenografts by Miles, Kiersten Marie, Seshadri, Mukund, Ciamporcero, Eric, Adelaiye, Remi, Gillard, Bryan, Sotomayor, Paula, Attwood, Kristopher, Shen, Li, Conroy, Dylan, Kuhnert, Frank, Lalani, Alshad S, Thurston, Gavin, Pili, Roberto

“…The Notch ligand Delta-like 4 (Dll4) is highly expressed in vascular endothelium and has been shown to play a pivotal role in regulating tumor angiogenesis…”
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Protocol to detect and quantify tumor hypoxia in mice using photoacoustic imaging by Dai, Tao, Rich, Laurie J., Seshadri, Mukund, Dasgupta, Subhamoy

“…Photoacoustic imaging (PAI) with co-registered ultrasound (US) is a hybrid non-invasive imaging modality that enables visualization and quantification of tumor…”
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Adrenergic-Angiogenic Crosstalk in Head and Neck Cancer: Mechanisms and Therapeutic Implications by Vincent-Chong, Vui King, Seshadri, Mukund

“…Head and neck squamous cell carcinomas (HNSCC) are loco-regionally aggressive tumors that often lead to debilitating changes in appearance, speech, swallowing…”
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Tumor-derived thymic stromal lymphopoietin enhances lung metastasis through an alveolar macrophage-dependent mechanism by Burkard-Mandel, Lauren, O'Neill, Rachel, Colligan, Sean, Seshadri, Mukund, Abrams, Scott I.

“…It is well-recognized that macrophages, which arise from circulating precursors, enhance tumor progression in patients and animal models. However, less is…”
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Manganese-enhanced MRI of salivary glands and head and neck tumors in living subjects by Seshadri, Mukund, Hoy, Allison

“…Manganese‐enhanced MRI has previously been used for visualization of brain architecture and functional mapping of neural pathways. The present work…”
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Adjuvant intraoperative photodynamic therapy in head and neck cancer by Rigual, Nestor R, Shafirstein, Gal, Frustino, Jennifer, Seshadri, Mukund, Cooper, Michele, Wilding, Gregory, Sullivan, Maureen A, Henderson, Barbara

“…There is an immediate need to develop local intraoperative adjuvant treatment strategies to improve outcomes in patients with cancer who undergo head and neck…”
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Oncolytic Maraba virus armed with tumor antigen boosts vaccine priming and reveals diverse therapeutic response patterns when combined with checkpoint blockade in ovarian cancer by McGray, A J Robert, Huang, Ruea-Yea, Battaglia, Sebastiano, Eppolito, Cheryl, Miliotto, Anthony, Stephenson, Kyle B, Lugade, Amit A, Webster, Gill, Lichty, Brian D, Seshadri, Mukund, Kozbor, Danuta, Odunsi, Kunle

“…Cancer immunotherapies are emerging as promising treatment strategies for ovarian cancer patients that experience disease relapse following first line therapy…”
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Ultrasound-Guided Photoacoustic Imaging of Salivary Gland Hemodynamics in Rabbits by Bolookat, Eftekhar Rajab, Vincent-Chong, Vui King, Rich, Laurie J., Singh, Anurag K., Seshadri, Mukund

“…Xerostomia (severe dry mouth) is a debilitating and often permanent side effect experienced by head and neck cancer patients due to radiation injury to…”
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Excretable, ultrasmall hexagonal NaGdF4:Yb50% nanoparticles for bimodal imaging and radiosensitization by Damasco, Jossana A., Ohulchanskyy, Tymish Y., Mahajan, Supriya, Chen, Guanying, Singh, Ajay, Kutscher, Hilliard L., Huang, Haoyuan, Turowski, Steven G., Spernyak, Joseph A., Singh, Anurag K., Lovell, Jonathan F., Seshadri, Mukund, Prasad, Paras N.

“…Background In this study, we report on the synthesis, imaging, and radiosensitizing properties of ultrasmall β-NaGdF 4 :Yb50% nanoparticles as a…”
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Dynamic photoacoustic imaging of neurovascular coupling in salivary glands by Rich, Laurie J., Bolookat, Eftekhar Rajab, Seshadri, Mukund

“…The purpose of this study was to apply photoacoustic imaging (PAI), a relatively new imaging method, to non-invasively map neurovascular dynamics in salivary…”
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