Search Results - "SERRUTO, Davide"

The role of vaccines in combatting antimicrobial resistance by Micoli, Francesca, Bagnoli, Fabio, Rappuoli, Rino, Serruto, Davide

“…The use of antibiotics has enabled the successful treatment of bacterial infections, saving the lives and improving the health of many patients worldwide…”
Get full text

The new multicomponent vaccine against meningococcal serogroup B, 4CMenB: Immunological, functional and structural characterization of the antigens by Serruto, Davide, Bottomley, Matthew J, Ram, Sanjay, Giuliani, Marzia M, Rappuoli, Rino

“…Abstract Neisseria meningitidis is a major cause of endemic cases and epidemics of meningitis and devastating septicemia. Although effective vaccines exist for…”
Get full text

Post-genomic vaccine development by Serruto, Davide, Rappuoli, Rino

“…For over a century, vaccines were developed according to Pasteur’s principles of isolating, inactivating and injecting the causative agent of an infectious…”
Get full text

Staphylococcal Esx proteins modulate apoptosis and release of intracellular Staphylococcus aureus during infection in epithelial cells by Korea, Charalampia G, Balsamo, Giuliana, Pezzicoli, Alfredo, Merakou, Christina, Tavarini, Simona, Bagnoli, Fabio, Serruto, Davide, Unnikrishnan, Meera

“…The opportunistic pathogen Staphylococcus aureus is one of the major causes of health care-associated infections. S. aureus is primarily an extracellular…”
Get full text

Multiple Factors Modulate Biofilm Formation by the Anaerobic Pathogen Clostridium difficile by Ðapa, Tanja, Leuzzi, Rosanna, Ng, Yen K, Baban, Soza T, Adamo, Roberto, Kuehne, Sarah A, Scarselli, Maria, Minton, Nigel P, Serruto, Davide, Unnikrishnan, Meera

“…Bacteria within biofilms are protected from multiple stresses, including immune responses and antimicrobial agents. The biofilm-forming ability of bacterial…”
Get full text

Neisseria meningitidis NalP cleaves human complement C3, facilitating degradation of C3b and survival in human serum by Del Tordello, Elena, Vacca, Irene, Ram, Sanjay, Rappuoli, Rino, Serruto, Davide

“…The complement system is a crucial component of the innate immune response against invading bacterial pathogens. The human pathogen Neisseria meningitidis (Nm)…”
Get full text

Qualitative and quantitative assessment of meningococcal antigens to evaluate the potential strain coverage of protein-based vaccines by Donnelly, John, Medini, Duccio, Boccadifuoco, Giuseppe, Biolchi, Alessia, Ward, Joel, Frasch, Carl, Moxon, E. Richard, Stella, Maria, Comanducci, Maurizio, Bambini, Stefania, Muzzi, Alessandro, Andrews, William, Chen, Jie, Santos, George, Santini, Laura, Boucher, Philip, Serruto, Davide, Pizza, Mariagrazia, Rappuoli, Rino, Giuliani, Marzia Monica

“…A uniquemulticomponent vaccine against serogroup B meningococci incorporates the novel genome-derived proteins fHbp, NHBA, and NadA that may vary in sequence…”
Get full text

Neisseria meningitidis is structured in clades associated with restriction modification systems that modulate homologous recombination by Budroni, Sonia, Siena, Emilio, Hotopp, Julie C. Dunning, Seib, Kate L., Serruto, Davide, Nofroni, Chiara, Comanducci, Maurizio, Riley, David R., Daugherty, Sean C., Angiuoli, Samuel V., Covacci, Antonello, Pizza, Mariagrazia, Rappuoli, Rino, Moxon, E. Richard, Tettelin, Hervé, Medini, Duccio

“…Molecular data on a limited number of chromosomal loci have shown that the population of Neisseria meningitidis (Nm), a deadly human pathogen, is structured in…”
Get full text

Transcriptome analysis of Neisseria meningitidis in human whole blood and mutagenesis studies identify virulence factors involved in blood survival by Echenique-Rivera, Hebert, Muzzi, Alessandro, Del Tordello, Elena, Seib, Kate L, Francois, Patrice, Rappuoli, Rino, Pizza, Mariagrazia, Serruto, Davide

“…During infection Neisseria meningitidis (Nm) encounters multiple environments within the host, which makes rapid adaptation a crucial factor for meningococcal…”
Get full text

A Universal Vaccine for Serogroup B Meningococcus by Giuliani, Marzia M., Adu-Bobie, Jeannette, Comanducci, Maurizio, Aricò, Beatrice, Savino, Silvana, Santini, Laura, Brunelli, Brunella, Bambini, Stefania, Biolchi, Alessia, Capecchi, Barbara, Cartocci, Elena, Ciucchi, Laura, Di Marcello, Federica, Ferlicca, Francesca, Galli, Barbara, Luzzi, Enrico, Masignani, Vega, Serruto, Davide, Veggi, Daniele, Contorni, Mario, Morandi, Maurizio, Bartalesi, Alessandro, Cinotti, Vanda, Mannucci, Donatella, Titta, Francesca, Ovidi, Elisa, Welsch, Jo Anne, Granoff, Dan, Rappuoli, Rino, Pizza, Mariagrazia

“…Meningitis and sepsis caused by serogroup B meningococcus are two severe diseases that still cause significant mortality. To date there is no universal vaccine…”
Get full text

Identification of a novel zinc metalloprotease through a global analysis of Clostridium difficile extracellular proteins by Cafardi, Valeria, Biagini, Massimiliano, Martinelli, Manuele, Leuzzi, Rosanna, Rubino, Jeffrey T, Cantini, Francesca, Norais, Nathalie, Scarselli, Maria, Serruto, Davide, Unnikrishnan, Meera

“…Clostridium difficile is a major cause of infectious diarrhea worldwide. Although the cell surface proteins are recognized to be important in clostridial…”
Get full text

Lung mucosal immunity to NTHi vaccine antigens: Antibodies in sputum of chronic obstructive pulmonary disease patients by Baffetta, Federica, Buonsanti, Cecilia, Moraschini, Luca, Aprea, Susanna, Canè, Martina, Lombardi, Stefano, Contorni, Mario, Rondini, Simona, Arora, Ashwani Kumar, Bardelli, Monia, Finco, Oretta, Serruto, Davide, Paccani, Silvia Rossi

“…Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory illness in older adults. A major cause of COPD-related morbidity and mortality is…”
Get full text

Neisseria meningitidis GNA2132, a heparin-binding protein that induces protective immunity in humans by Serruto, Davide, Spadafina, Tiziana, Ciucchi, Laura, Lewis, Lisa A, Ram, Sanjay, Tontini, Marta, Santini, Laura, Biolchi, Alessia, Seib, Kate L, Giuliani, Marzia M, Donnelly, John J, Berti, Francesco, Savino, Silvana, Scarselli, Maria, Costantino, Paolo, Kroll, J. Simon, O'Dwyer, Clíona, Qiu, Jiazhou, Plaut, Andrew G, Moxon, Richard, Rappuoli, Rino, Pizza, Mariagrazia, Aricò, Beatrice

“…GNA2132 is a Neisseria meningitidis antigen of unknown function, discovered by reverse vaccinology, which has been shown to induce bactericidal antibodies in…”
Get full text

Neisserial Heparin Binding Antigen (NHBA) Contributes to the Adhesion of Neisseria meningitidis to Human Epithelial Cells by Vacca, Irene, Del Tordello, Elena, Gasperini, Gianmarco, Pezzicoli, Alfredo, Di Fede, Martina, Rossi Paccani, Silvia, Marchi, Sara, Mubaiwa, Tsisti D, Hartley-Tassell, Lauren E, Jennings, Michael P, Seib, Kate L, Masignani, Vega, Pizza, Mariagrazia, Serruto, Davide, Aricò, Beatrice, Delany, Isabel

“…Neisserial Heparin Binding Antigen (NHBA) is a surface-exposed lipoprotein ubiquitously expressed by Neisseria meningitidis strains and an antigen of the…”
Get full text

Analysis of the Regulated Transcriptome of Neisseria meningitidis in Human Blood Using a Tiling Array by Del Tordello, Elena, Bottini, Silvia, Muzzi, Alessandro, Serruto, Davide

“…Neisseria meningitidis is the major cause of septicemia and meningococcal meningitis. During the course of infection, the bacterium must adapt to different…”
Get full text

A type III secretion system in Vibrio cholerae translocates a formin/spire hybrid-like actin nucleator to promote intestinal colonization by Tam, Vincent C, Serruto, Davide, Dziejman, Michelle, Brieher, William, Mekalanos, John J

“…We have previously characterized a non-O1, non-O139 Vibrio cholerae strain, AM-19226, that lacks the known virulence factors but contains components of a type…”
Get full text

Global transcriptome analysis reveals small RNAs affecting Neisseria meningitidis bacteremia by Fagnocchi, Luca, Bottini, Silvia, Golfieri, Giacomo, Fantappiè, Laura, Ferlicca, Francesca, Antunes, Ana, Guadagnuolo, Serafina, Del Tordello, Elena, Siena, Emilio, Serruto, Davide, Scarlato, Vincenzo, Muzzi, Alessandro, Delany, Isabel

“…Most bacterial small RNAs (sRNAs) are post-transcriptional regulators involved in adaptive responses, controlling gene expression by modulating translation or…”
Get full text

High coverage of diverse invasive meningococcal serogroup B strains by the 4-component vaccine 4CMenB in Australia, 2007-2011: Concordant predictions between MATS and genetic MATS by Tozer, Sarah J., Smith, Helen V., Whiley, David M., Borrow, Ray, Boccadifuoco, Giuseppe, Medini, Duccio, Serruto, Davide, Giuliani, Marzia Monica, Stella, Maria, De Paola, Rosita, Muzzi, Alessandro, Pizza, Mariagrazia, Sloots, Theo P., Nissen, Michael D.

“…Meningococcal serogroup B (MenB) accounts for an important proportion of invasive meningococcal disease (IMD). The 4-component vaccine against MenB (4CMenB) is…”
Get full text

Streptococcus pyogenes SpyCEP influences host-pathogen interactions during infection in a murine air pouch model by Chiappini, Nico, Seubert, Anja, Telford, John L, Grandi, Guido, Serruto, Davide, Margarit, Immaculada, Janulczyk, Robert

“…Streptococcus pyogenes is a major human pathogen worldwide, responsible for both local and systemic infections. These bacteria express the subtilisin-like…”
Get full text

Genomic Characterization of Non-O1, Non-O139 Vibrio cholerae Reveals Genes for a Type III Secretion System by Dziejman, Michelle, Serruto, Davide, Tam, Vincent C., Sturtevant, Derek, Diraphat, Pornphan, Faruque, Shah M., Rahman, M. Hasibur, Heidelberg, John F., Decker, Jeremy, Li Li, Montgomery, Kate T., Grills, George, Kucherlapati, Raju, Mekalanos, John J.

“…Non-O1, non-O139 Vibrio cholerae can cause gastroenteritis and extraintestinal infections, but, unlike O1 and O139 strains of V. cholerae, little is known…”
Get full text