Search Results - "SERIE, Daniel J"

Determining the genetic basis of anthracycline-cardiotoxicity by molecular response QTL mapping in induced cardiomyocytes by Knowles, David A, Burrows, Courtney K, Blischak, John D, Patterson, Kristen M, Serie, Daniel J, Norton, Nadine, Ober, Carole, Pritchard, Jonathan K, Gilad, Yoav

“…Anthracycline-induced cardiotoxicity (ACT) is a key limiting factor in setting optimal chemotherapy regimes, with almost half of patients expected to develop…”
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Clear Cell Type A and B Molecular Subtypes in Metastatic Clear Cell Renal Cell Carcinoma: Tumor Heterogeneity and Aggressiveness by Serie, Daniel J, Joseph, Richard W, Cheville, John C, Ho, Thai H, Parasramka, Mansi, Hilton, Tracy, Thompson, R. Houston, Leibovich, Bradley C, Parker, Alexander S, Eckel-Passow, Jeanette E

“…Abstract Background Intratumor molecular heterogeneity has been reported for primary clear cell renal cell carcinoma (ccRCC) tumors; however, heterogeneity in…”
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Transcriptomic analysis to identify genes associated with selective hippocampal vulnerability in Alzheimer’s disease by Crist, Angela M., Hinkle, Kelly M., Wang, Xue, Moloney, Christina M., Matchett, Billie J., Labuzan, Sydney A., Frankenhauser, Isabelle, Azu, Nkem O., Liesinger, Amanda M., Lesser, Elizabeth R., Serie, Daniel J., Quicksall, Zachary S., Patel, Tulsi A., Carnwath, Troy P., DeTure, Michael, Tang, Xiaojia, Petersen, Ronald C., Duara, Ranjan, Graff-Radford, Neill R., Allen, Mariet, Carrasquillo, Minerva M., Li, Hu, Ross, Owen A., Ertekin-Taner, Nilüfer, Dickson, Dennis W., Asmann, Yan W., Carter, Rickey E., Murray, Melissa E.

“…Selective vulnerability of different brain regions is seen in many neurodegenerative disorders. The hippocampus and cortex are selectively vulnerable in…”
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Folate receptor-α (FOLR1) expression and function in triple negative tumors by Necela, Brian M, Crozier, Jennifer A, Andorfer, Cathy A, Lewis-Tuffin, Laura, Kachergus, Jennifer M, Geiger, Xochiquetzal J, Kalari, Krishna R, Serie, Daniel J, Sun, Zhifu, Moreno-Aspitia, Alvaro, Aspita, Alvaro Moreno, O'Shannessy, Daniel J, Maltzman, Julia D, McCullough, Ann E, Pockaj, Barbara A, Cunliffe, Heather E, Ballman, Karla V, Thompson, E Aubrey, Perez, Edith A

“…Folate receptor alpha (FOLR1) has been identified as a potential prognostic and therapeutic target in a number of cancers. A correlation has been shown between…”
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Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases by Allen, Mariet, Wang, Xue, Burgess, Jeremy D., Watzlawik, Jens, Serie, Daniel J., Younkin, Curtis S., Nguyen, Thuy, Malphrus, Kimberly G., Lincoln, Sarah, Carrasquillo, Minerva M., Ho, Charlotte, Chakrabarty, Paramita, Strickland, Samantha, Murray, Melissa E., Swarup, Vivek, Geschwind, Daniel H., Seyfried, Nicholas T., Dammer, Eric B., Lah, James J., Levey, Allan I., Golde, Todd E., Funk, Cory, Li, Hongdong, Price, Nathan D., Petersen, Ronald C., Graff-Radford, Neill R., Younkin, Steven G., Dickson, Dennis W., Crook, Julia R., Asmann, Yan W., Ertekin-Taner, Nilüfer

“…Comparative transcriptome analyses in Alzheimer's disease (AD) and other neurodegenerative proteinopathies can uncover both shared and distinct disease…”
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Genome-wide association study of cardiotoxicity in the NCCTG N9831 (Alliance) adjuvant trastuzumab trial by Serie, Daniel J, Crook, Julia E, Necela, Brian M, Dockter, Travis J, Wang, Xue, Asmann, Yan W, Fairweather, DeLisa, Bruno, Katelyn A, Colon-Otero, Gerardo, Perez, Edith A, Thompson, E Aubrey, Norton, Nadine

“…The major clinical side effect of the ERBB2-targeted breast cancer therapy, trastuzumab, is a decline in the left ventricular ejection fraction (LVEF)…”
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Replication of progressive supranuclear palsy genome-wide association study identifies SLCO1A2 and DUSP10 as new susceptibility loci by Sanchez-Contreras, Monica Y, Kouri, Naomi, Cook, Casey N, Serie, Daniel J, Heckman, Michael G, Finch, NiCole A, Caselli, Richard J, Uitti, Ryan J, Wszolek, Zbigniew K, Graff-Radford, Neill, Petrucelli, Leonard, Wang, Li-San, Schellenberg, Gerard D, Dickson, Dennis W, Rademakers, Rosa, Ross, Owen A

“…Progressive supranuclear palsy (PSP) is a parkinsonian neurodegenerative tauopathy affecting brain regions involved in motor function, including the basal…”
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RNA Sequencing Identifies Multiple Fusion Transcripts, Differentially Expressed Genes, and Reduced Expression of Immune Function Genes in BRAF (V600E) Mutant vs BRAF Wild-Type Papillary Thyroid Carcinoma by Smallridge, Robert C, Chindris, Ana-Maria, Asmann, Yan W, Casler, John D, Serie, Daniel J, Reddi, Honey V, Cradic, Kendall W, Rivera, Michael, Grebe, Stefan K, Necela, Brian M, Eberhardt, Norman L, Carr, Jennifer M, McIver, Bryan, Copland, John A, Thompson, E. Aubrey

“…Context: The BRAF V600E mutation (BRAF-MUT) confers an aggressive phenotype in papillary thyroid carcinoma, but unidentified additional genomic abnormalities…”
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Alcohol consumption, variability in alcohol dehydrogenase genes and risk of renal cell carcinoma by Antwi, Samuel O., Eckel‐Passow, Jeanette E., Diehl, Nancy D., Serie, Daniel J., Custer, Kaitlynn M., Wu, Kevin J., Cheville, John C., Thiel, David D, Leibovich, Bradley C., Parker, Alexander S.

“…Alcohol consumption has been associated inversely with renal cell carcinoma (RCC) risk; however, no study has examined effect modification by germline…”
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Assessment of Tumor Heterogeneity, as Evidenced by Gene Expression Profiles, Pathway Activation, and Gene Copy Number, in Patients with Multifocal Invasive Lobular Breast Tumors by Norton, Nadine, Advani, Pooja P, Serie, Daniel J, Geiger, Xochiquetzal J, Necela, Brian M, Axenfeld, Bianca C, Kachergus, Jennifer M, Feathers, Ryan W, Carr, Jennifer M, Crook, Julia E, Moreno-Aspitia, Alvaro, Anastasiadis, Panos Z, Perez, Edith A, Thompson, E Aubrey

“…Invasive lobular carcinoma (ILC) comprises approximately ~10-20% of breast cancers. In general, multifocal/multicentric (MF/MC) breast cancer has been…”
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Gene expression, single nucleotide variant and fusion transcript discovery in archival material from breast tumors by Norton, Nadine, Sun, Zhifu, Asmann, Yan W, Serie, Daniel J, Necela, Brian M, Bhagwate, Aditya, Jen, Jin, Eckloff, Bruce W, Kalari, Krishna R, Thompson, Kevin J, Carr, Jennifer M, Kachergus, Jennifer M, Geiger, Xochiquetzal J, Perez, Edith A, Thompson, E Aubrey

“…Advantages of RNA-Seq over array based platforms are quantitative gene expression and discovery of expressed single nucleotide variants (eSNVs) and fusion…”
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Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia by Slager, Susan L., Skibola, Christine F., Di Bernardo, Maria Chiara, Conde, Lucia, Broderick, Peter, McDonnell, Shannon K., Goldin, Lynn R., Croft, Naomi, Holroyd, Amy, Harris, Shelley, Riby, Jacques, Serie, Daniel J., Kay, Neil E., Call, Timothy G., Bracci, Paige M., Halperin, Eran, Lanasa, Mark C., Cunningham, Julie M., Leis, Jose F., Morrison, Vicki A., Spector, Logan G., Vachon, Celine M., Shanafelt, Tait D., Strom, Sara S., Camp, Nicola J., Weinberg, J. Brice, Matutes, Estella, Caporaso, Neil E., Wade, Rachel, Dyer, Martin J.S., Dearden, Claire, Cerhan, James R., Catovsky, Daniel, Houlston, Richard S.

“…We performed a meta-analysis of 3 genome-wide association studies to identify additional common variants influencing chronic lymphocytic leukemia (CLL) risk…”
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Chromoanasynthesis is a common mechanism that leads to ERBB2 amplifications in a cohort of early stage HER2 + breast cancer samples by Vasmatzis, George, Wang, Xue, Smadbeck, James B, Murphy, Stephen J, Geiersbach, Katherine B, Johnson, Sarah H, Gaitatzes, Athanasios G, Asmann, Yan W, Kosari, Farhad, Borad, Mitesh J, Serie, Daniel J, McLaughlin, Sarah A, Kachergus, Jennifer M, Necela, Brian M, Thompson, E Aubrey

“…HER2 positive (HER2+) breast cancers involve chromosomal structural alterations that act as oncogenic driver events. We interrogated the genomic structure of…”
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The antineoplastic drug, trastuzumab, dysregulates metabolism in iPSC-derived cardiomyocytes by Necela, Brian M., Axenfeld, Bianca C., Serie, Daniel J., Kachergus, Jennifer M., Perez, Edith A., Thompson, E. Aubrey, Norton, Nadine

“…Background The targeted ERBB2 therapy, trastuzumab, has had a tremendous impact on management of patients with HER2+ breast cancer, leading to development and…”
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Loss of PBRM1 and BAP1 expression is less common in non–clear cell renal cell carcinoma than in clear cell renal cell carcinoma by Ho, Thai H., M.D., Ph.D, Kapur, Payal, M.D, Joseph, Richard W., M.D, Serie, Daniel J., B.S, Eckel-Passow, Jeanette E., Ph.D, Parasramka, Mansi, Ph.D, Cheville, John C., M.D, Wu, Kevin J., M.D, Frenkel, Eugene, M.D, Rakheja, Dinesh, M.D, Stefanius, Karoliina, Ph.D, Brugarolas, James, M.D., Ph.D, Parker, Alexander S., Ph.D

“…Abstract Background Recurrent mutations in polybromo-1 ( PBRM1 , ~40%) and BRCA1-associated protein-1 ( BAP1 , ~10%) occur in clear cell renal cell carcinoma…”
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NOTCH3 variants and risk of ischemic stroke by Ross, Owen A, Soto-Ortolaza, Alexandra I, Heckman, Michael G, Verbeeck, Christophe, Serie, Daniel J, Rayaprolu, Sruti, Rich, Stephen S, Nalls, Michael A, Singleton, Andrew, Guerreiro, Rita, Kinsella, Emma, Wszolek, Zbigniew K, Brott, Thomas G, Brown, Jr, Robert D, Worrall, Bradford B, Meschia, James F

“…Mutations within the NOTCH3 gene cause cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). CADASIL mutations…”
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Concordance of PD‐1 and PD‐L1 (B7‐H1) in paired primary and metastatic clear cell renal cell carcinoma by Eckel‐Passow, Jeanette E., Ho, Thai H., Serie, Daniel J., Cheville, John C., Houston Thompson, R., Costello, Brian A., Dong, Haidong, Kwon, Eugene D., Leibovich, Bradley C., Parker, Alexander S.

“…Objectives Previous studies noted discordance of programmed death‐1 (PD‐1) and one of its ligands (PD‐L1) across patient‐matched primary and metastatic clear…”
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Adaptive immune signature in HER2-positive breast cancer in NCCTG (Alliance) N9831 and NeoALTTO trials by Chumsri, Saranya, Li, Zhuo, Serie, Daniel J., Norton, Nadine, Mashadi-Hossein, Afshin, Tenner, Kathleen, Brauer, Heather Ann, Warren, Sarah, Danaher, Patrick, Colon-Otero, Gerardo, Partridge, Ann H., Carey, Lisa A., Hilbers, Florentine, Van Dooren, Veerle, Holmes, Eileen, Di Cosimo, Serena, Werner, Olena, Huober, Jens Bodo, Dueck, Amylou C., Sotiriou, Christos, Saura, Cristina, Moreno-Aspitia, Alvaro, Knutson, Keith L., Perez, Edith A., Thompson, E. Aubrey

“…Trastuzumab acts in part through the adaptive immune system. Previous studies showed that enrichment of immune-related gene expression was associated with…”
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Correction: Folate receptor-α (FOLR1) expression and function in triple negative tumors by Necela, Brian M, Crozier, Jennifer A, Andorfer, Cathy A, Lewis-Tuffin, Laura, Kachergus, Jennifer M, Geiger, Xochiquetzal J, Kalari, Krishna R, Serie, Daniel J, Sun, Zhifu, Moreno-Aspitia, Alvaro, O'Shannessy, Daniel J, Maltzman, Julia D, McCullough, Ann E, Pockaj, Barbara A, Cunliffe, Heather E, Ballman, Karla V, Thompson, E Aubrey, Perez, Edith A

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Association of Genetic Variants at TRPC6 With Chemotherapy-Related Heart Failure by Norton, Nadine, Crook, Julia E, Wang, Liwei, Olson, Janet E, Kachergus, Jennifer M, Serie, Daniel J, Necela, Brian M, Borgman, Paul G, Advani, Pooja P, Ray, Jordan C, Landolfo, Carolyn, Di Florio, Damian N, Hill, Anneliese R, Bruno, Katelyn A, Fairweather, DeLisa

“…Our previous GWAS identified genetic variants at six novel loci that were associated with a decline in left ventricular ejection fraction (LVEF), < 1 × 10 in…”
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