Search Results - "SERGINA, Natalia"

Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3 by Moasser, Mark M, Sergina, Natalia V, Rausch, Megan, Wang, Donghui, Blair, Jimmy, Hann, Byron, Shokat, Kevan M

“…Oncogenic tyrosine kinases have proved to be promising targets for the development of highly effective anticancer drugs. However, tyrosine kinase inhibitors…”
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The HER family and cancer: emerging molecular mechanisms and therapeutic targets by Sergina, Natalia V, Moasser, Mark M

“…The human epidermal growth factor receptor (HER) family of transmembrane tyrosine kinases regulates diverse cellular functions in response to extracellular…”
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Resiliency and vulnerability in the HER2-HER3 tumorigenic driver by Amin, Dhara N, Sergina, Natalia, Ahuja, Deepika, McMahon, Martin, Blair, Jimmy A, Wang, Donghui, Hann, Byron, Koch, Kevin M, Shokat, Kevan M, Moasser, Mark M

“…About 25% of breast cancers harbor the amplified oncogene human epidermal growth factor receptor 2 (HER2) and are dependent on HER2 kinase function,…”
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Problems of protection of urban ambient air pollution from industrial dust emissions by Azarov, Valeriy, Sergina, Natalia, Kondratenko, Tatyana

“…The development of large cities accompanied by the development of the industry hashistorically led to the fact that now residential areas are located side by…”
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Phosphorylation of Trask by Src Kinases Inhibits Integrin Clustering and Functions in Exclusion with Focal Adhesion Signaling by Spassov, Danislav S., Wong, Ching Hang, Sergina, Natalia, Ahuja, Deepika, Fried, Michael, Sheppard, Dean, Moasser, Mark M.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Reorganization of ErbB Family and Cell Survival Signaling after Knock-down of ErbB2 in Colon Cancer Cells by Hu, Yi Peter, Venkateswarlu, Srinivas, Sergina, Natalia, Howell, Gillian, Clair, Patricia St, Humphrey, Lisa E., Li, Wenhui, Hauser, Jennie, Zborowska, Elizabeth, Willson, James K.V., Brattain, Michael G.

“…The role of the ErbB family in supporting the malignant phenotype was characterized by stable transfection of a single chain antibody (ScFv5R) against ErbB2…”
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HER3 signalling is regulated through a multitude of redundant mechanisms in HER2-driven tumour cells by Amin, Dhara N, Sergina, Natalia, Lim, Lionel, Goga, Andrei, Moasser, Mark M

“…HER2 (human epidermal growth factor receptor-2)-amplified tumours are characterized by constitutive signalling via the HER2-HER3 co-receptor complex. Although…”
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Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells by Tilghman, Robert W, Slack-Davis, Jill K, Sergina, Natalia, Martin, Karen H, Iwanicki, Marcin, Hershey, E. Daniel, Beggs, Hilary E, Reichardt, Louis F, Parsons, J. Thomas

“…The process of cell migration is initiated by protrusion at the leading edge of the cell, the formation of peripheral adhesions, the exertion of force on these…”
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Abstract 1653: Highly effective treatment of HER2-amplified breast cancers through the complete inactivation of the HER2-HER3 tumorigenic driver by Amin, Dhara N., Sergina, Natalia, Ahuja, Deepika, McMahon, Martin, Wang, Donghui, Hann, Byron, Shokat, Kevan, Moasser, Mark M.

“…Abstract Approximately 25% of breast cancers are driven by amplification of the HER2 oncogene and over-activity of the HER2-HER3 signaling complex. It is a…”
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Autocrine and Exogenous Transforming Growth Factor β Control Cell Cycle Inhibition through Pathways with Different Sensitivity by Wang, Jing, Sergina, Natalia, Ko, Tien C., Gong, Jiangeng, Brattain, Michael G.

“…Human colon carcinoma cells HCT116 that lack transforming growth factor β (TGF-β) type II receptor (RII) demonstrated restoration of autocrine TGF-β activity…”
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Autocrine and Exogenous Transforming Growth Factor β Control Cell Cycle Inhibition through Pathways with Different Sensitivity by Jing Wang, Natalia Sergina, Tien C. Ko, Jiangeng Gong, Michael G. Brattain

“…Human colon carcinoma cells HCT116 that lack transforming growth factor β (TGF-β) type II receptor (RII) demonstrated restoration of autocrine TGF-β…”
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The role of transforming growth factor α in determining growth factor independence by AWWAD, Rana A, SERGINA, Natalia, HOWELL, Gillian M, HAISU YANG, ZIOBER, Barry, WILLSON, James K. V, ZBOROWSKA, Elizabeth, HUMPHREY, Lisa E, FAN, Robert, KO, Tien C, BRATTAIN, Michael G

“…Growth factor independence is a hallmark of malignancy that is attributed to the development of autocrine growth factor loops in cancer cells. However, growth…”
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Autocrine vs. exogenous growth factors: Downstream signaling and biological significance by Sergina, Natalia Vladimirovna

“…To elucidate the mechanism of cross-talk between exogenous insulin and autocrine transforming growth factor-α (TGF-α) in the control of proliferation, we have…”
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