Search Results - "SERGHERAERT, Christian"

Design, synthesis and in vitro antimalarial activity of an acylhydrazone library by Melnyk, Patricia, Leroux, Virginie, Sergheraert, Christian, Grellier, Philippe

“…A library of acylhydrazone iron chelators was synthesized and tested for its ability to inhibit the growth of a chloroquine-resistant strain of Plasmodium…”
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Truncated beta‐amyloid peptide species in pre‐clinical Alzheimer's disease as new targets for the vaccination approach by Sergeant, Nicolas, Bombois, Stepanie, Ghestem, Antoine, Drobecq, Hervé, Kostanjevecki, Vesna, Missiaen, Carla, Wattez, Annick, David, Jean‐Phillipe, Vanmechelen, Eugeen, Sergheraert, Christian, Delacourte, André

“…Vaccination against human beta‐amyloid peptide (Aβ) has been shown to remove the amyloid burden produced in transgenic mice overexpressing the mutated human…”
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Synthesis, Antimalarial Activity, and Molecular Modeling of New Pyrrolo[1,2-a]quinoxalines, Bispyrrolo[1,2-a]quinoxalines, Bispyrido[3,2-e]pyrrolo[1,2-a]pyrazines, and Bispyrrolo[1,2-a]thieno[3,2-e]pyrazines by Guillon, Jean, Grellier, Philippe, Labaied, Mehdi, Sonnet, Pascal, Léger, Jean-Michel, Déprez-Poulain, Rébecca, Forfar-Bares, Isabelle, Dallemagne, Patrick, Lemaître, Nicolas, Péhourcq, Fabienne, Rochette, Jacques, Sergheraert, Christian, Jarry, Christian

“…Three pyrrolo[1,2-a]quinoxalines, 15 bispyrrolo[1,2-a]quinoxalines, bispyrido[3,2-e]pyrrolo[1,2-a]pyrazines, and bispyrrolo[1,2-a]thieno[3,2-e]pyrazines were…”
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2- and 3-Substituted 1,4-Naphthoquinone Derivatives as Subversive Substrates of Trypanothione Reductase and Lipoamide Dehydrogenase from Trypanosoma cruzi:  Synthesis and Correlation between Redox Cycling Activities and in Vitro Cytotoxicity by SALMON-CHEMIN, Laurence, BUISINE, Eric, YARDLEY, Vanessa, KOHLER, Sven, DEBREU, Marie-Ange, LANDRY, Valérie, SERGHERAERT, Christian, CROFT, Simon L., KRAUTH-SIEGEL, R. Luise, DAVIOUD-CHARVET, Elisabeth

“…Trypanothione reductase (TR) is both a valid and an attractive target for the design of new trypanocidal drugs. Starting from menadione, plumbagin, and…”
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Synthesis and biological evaluation of benzimidazole derivatives as potent AMP-activated protein kinase activators by Charton, Julie, Girault-Mizzi, Sophie, Debreu-Fontaine, Marie-Ange, Foufelle, Fabienne, Hainault, Isabelle, Bizot-Espiard, Jean-Guy, Caignard, Daniel-Henri, Sergheraert, Christian

“…Design, synthesis and structure–activity relationships of benzimidazole derivatives as activators of the AMP-activated protein kinase are presented in this…”
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Mycobacterial Heparin-Binding Hemagglutinin and Laminin-Binding Protein Share Antigenic Methyllysines That Confer Resistance to Proteolysis by Pethe, Kevin, Bifani, Pablo, Drobecq, Hervé, Sergheraert, Christian, Debrie, Anne-Sophie, Locht, Camille, Menozzi, Franco D.

“…Mycobacterium tuberculosis and Mycobacterium bovis bacillus Calmette-Guérin produce a heparin-binding hemagglutinin adhesin (HBHA) required for extrapulmonary…”
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Antimalarial, Antitrypanosomal, and Antileishmanial Activities and Cytotoxicity of Bis(9-amino-6-chloro-2-methoxyacridines):  Influence of the Linker by Girault, Sophie, Grellier, Philippe, Berecibar, Amaya, Maes, Louis, Mouray, Elisabeth, Lemière, Pascal, Debreu, Marie-Ange, Davioud-Charvet, Elisabeth, Sergheraert, Christian

“…Forty bis(9-amino-6-chloro-2-methoxyacridines), in which acridine moieties are joined by alkanediamines, polyamines, or polyamines substituted by a side chain,…”
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Trypanosoma cruzi Prolyl Oligopeptidase Tc80 Is Involved in Nonphagocytic Mammalian Cell Invasion by Trypomastigotes by Grellier, Philippe, Vendeville, Sandrine, Joyeau, Roger, Bastos, Izabela M.D., Drobecq, Hervé, Frappier, François, Teixeira, Antonio R.L., Schrével, Joseph, Davioud-Charvet, Elisabeth, Sergheraert, Christian, Santana, Jaime M.

“…Trypanosoma cruzi is an intracellular protozoan parasite able to invade a wide variety of mammalian cells. To have access to the target organs/cells, the…”
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Conversion of Sterically Hindered Diacylated 1,2-Phenylenediamines into 2-Substituted Benzimidazoles by Charton, Julie, Girault-Mizzi, Sophie, Sergheraert, Christian

“…A series of bulky 2-substituted benzimidazoles was designed in order to find new leads for several biological targets. Formation by cyclodehydration from their…”
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Glucose regulates LXRα subcellular localization and function in rat pancreatic β-cells by Helleboid-Chapman, Audrey, Helleboid, Stéphane, Jakel, Heidelinde, Timmerman, Catherine, Sergheraert, Christian, Pattou, François, Fruchart-Najib, Jamila, Fruchart, Jean-Charles

“…Liver X receptors （LXRs） are members of the nuclear receptor superfamily, which have been implicated in lipid homeostasis and more recently in glucose…”
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Novel N-(4-Piperidinyl)benzamide Antimalarials with Mammalian Protein Farnesyltransferase Inhibitory Activity by Ryckebusch, Adina, Gilleron, Pauline, Millet, Régis, Houssin, Raymond, Lemoine, Amélie, Pommery, Nicole, Grellier, Philippe, Sergheraert, Christian, Hénichart, Jean-Pierre

“…Protein farnesyltransferase of Plasmodium falciparum is a potential target in the treatment of malaria for which increased drug resistance is observed. The…”
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Synthesis and antimalarial evaluation of new 1,4-bis(3-aminopropyl)piperazine derivatives by RYCKEBUSCH, Adina, DEPREZ-POULAIN, Rébecca, DEBREU-FONTAINE, Marie-Ange, VANDAELE, Richard, MOURAY, Elisabeth, GRELLIER, Philippe, SERGHERAERT, Christian

“…Synthesis and evaluation of the activity of a new family of 1,4-bis(3-aminopropyl)piperazine derivatives against a chloroquine-resistant strain of Plasmodium…”
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Characterization of boar sperm cytoskeletal cylicin II as an actin-binding protein by Rousseaux- Prévost, Roselyne, Lécuyer, Christophe, Drobecq, Hervé, Sergheraert, Christian, Dacheux, Jean-Louis, Rousseaux, Jean

“…The presence of actin-binding proteins in the perinuclear theca of boar spermatozoa has been investigated, using stepwise extractions of proteins from sperm…”
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Trypanothione reductase inhibition/trypanocidal activity relationships in a 1,4-bis(3-aminopropyl)piperazine series by BONNET, B, SOULLEZ, D, GIRAULT, S, MAES, L, LANDRY, V, DAVIOUD-CHARVET, E, SERGHERAERT, A. C

“…A series of symmetrically substituted 1,4-bis(3-aminopropyl)piperazines was synthesized and tested towards trypanothione reductase and for its in vitro…”
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“One-Pot” Synthesis and Antimalarial Activity of Formamidine Derivatives of 4-Anilinoquinoline by DELARUE, Sandrine, GIRAULT, Sophie, ALI, Fouad DALI, MAES, Louis, GRELLIER, Philippe, SERGHERAERT, Christian

“…Amodiaquine (AQ) is an antimalarial which is effective against chloroquino-resistant strains of Plasmodium falciparum but whose clinical use is severely…”
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Different protein kinase C isozymes mediate lower esophageal sphincter tone and phasic contraction of esophageal circular smooth muscle by Sohn, U D, Zoukhri, D, Dartt, D, Sergheraert, C, Harnett, K M, Behar, J, Biancani, P

“…Circular muscle of the esophagus (ESO) is normally relaxed and contracts phasically in response to neural stimuli. In contrast, lower esophageal sphincter…”
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Conversion of Sterically Hindered Diacylated 1,2-Phenylenediamines into 2-Substituted Benzimidazoles by Julie CHARTON, Sophie GIRAULT-MIZZI, Christian SERGHERAERT

“…A series of bulky 2-substituted benzimidazoles was designed in order to find new leads for several biological targets. Formation by cyclodehydration from their…”
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Lacrimal Gland Functions Are Differentially Controlled by Protein Kinase C Isoforms by ZOUKHRI, DRISS, HODGES, ROBIN R., SERGHERAERT, CHRISTIAN, DARTT, DARLENE A.

“…Lacrimal gland protein secretion is primarily under the control of cholinergic muscarinic and alpha 1-adrenergic receptors. Cholinergic agonists are coupled to…”
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Compared Reactivities of Trypanothione and Glutathione in Conjugation Reactions by MOUTIEZ, Mireille, MEZIANE-CHERIF, Djalal, AUMERCIER, Marc, SERGHERAERT, Christian, TARTAR, Andre

“…In order to compare the non-enzymatic capacities of the xenobiotic conjugation of trypanothione (a spermidine-glutathione conjugate unique to kinetoplastidae)…”
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Protein kinase C isoforms differentially control lacrimal gland functions by Zoukhri, D, Hodges, R R, Sergheraert, C, Dartt, D A

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