Search Results - "SERGEJEW, T"

Dose proportionality study of four doses of an estradiol transdermal system, Estradot by Hossain, M., Quebe-Fehling, Erhard, Sergejew, T., Schmidt, G., Skerjanec, Andrej, Ibarra de Palacios, Patricia, Krinsky, L.

“…Objectives: To establish dose proportionality among four doses of a new estradiol transdermal system (ETS), Estradot®, in healthy postmenopausal women and to…”
Get full text

Chelator‐induced iron excretion in iron‐overloaded marmosets by Sergejew, Thomas, Forgiarini, Peter, Schnebli, Hans‐Peter

“…In order to test new orally active iron chelators in a predictive way, a primate model has been developed. This model makes use of the marmoset monkey…”
Get full text

Comparative bioequivalence studies with Estradot® and Menorest® transdermal systems by Hossain, M, Quebe-Fehling, E, Sergejew, T, Schmidt, G, Skerjanec, A, Cohen, A, Krinsky, L, Ibarra de Palacios, Patricia

“…Objectives: To compare the relative bioavailability of Estradot®, a small size, new generation estradiol transdermal system (ETS) to Menorest®, in healthy…”
Get full text

Pyridyl substituted benzocycloalkenes: new inhibitors of 17 alpha-hydroxylase/17,20-lyase (P450 17 alpha) by Sergejew, T, Hartmann, R W

“…Compounds capable of inhibiting 17 alpha-hydroxylase/17,20-lyase (P450 17 alpha) are of great interest for the therapy of prostatic cancer since they block…”
Get more information

Comparative study to evaluate skin irritation and adhesion of Estradot and Climara in healthy postmenopausal women by Ibarra de Palacios, P, Schmidt, G, Sergejew, T, Quebe-Fehling, E, Lockhart, L, Krinsky, L

“…To compare the local tolerability, adhesion and estradiol delivery of a 5-cm(2) transdermal patch (Estradot), Novartis Pharmaceuticals, Basel, Switzerland) and…”
Get full text

Effect of a diphenylethylenediamine platinum complex on steroidogenesis in rats by Sergejew, Thomas F., Hartmann, Rolf W.

“…Although less cytotoxic, the new platinum complex [meso-1,2-bis(2,6-difluoro-4-hydroxyphenyl)-ethylenediamine]sulfatoplatinum(II) (2) is equipotent to…”
Get full text

Synthesis and evaluation of azole-substituted tetrahydronaphthalenes as inhibitors of P450 arom, P450 17, and P450 TxA2 by Hartmann, R W, Frotscher, M, Ledergerber, D, Wächter, G A, Grün, G L, Sergejew, T F

“…In search of potential drugs for the treatment of estrogen- and androgen-dependent cancer as well as the prophylaxis of metastases, tetralones, tetralins, and…”
Get more information

ICL670A: preclinical profile by Nick, Hanspeter, Wong, Agnes, Acklin, Pierre, Faller, Bernard, Jin, Yi, Lattmann, René, Sergejew, Thomas, Hauffe, Suzanne, Thomas, Helmut, Schnebli, Hans Peter

Get more information

Improving the Oral Bioavailability of the Iron Chelator HBED by Breaking the Symmetry of the Intramolecular H-Bond Network by Faller, Bernard, Spanka, Carsten, Sergejew, Thomas, Tschinke, Vincenzo

“…Physicochemical analysis and Monte Carlo simulations were used to identify structural features which prevent oral absorption of HBED, a potent iron chelator…”
Get full text

Tetrahydronaphthalenes:  Influence of Heterocyclic Substituents on Inhibition of Steroidogenic Enzymes P450 arom and P450 17 by Wächter, Gerald A, Hartmann, Rolf W, Sergejew, Tom, Grün, Gertrud L, Ledergerber, Dorothea

“…In search of new leads for selective inhibition of estrogen and androgen biosynthesis, respectively, heterocyclic substituted 2-(arylmethylene)-1-tetralones (1…”
Get full text

Comparative study to evaluate skin irritation and adhesion of Estradot® and Climara® in healthy postmenopausal women by Ibarra de Palacios, P., Schmidt, G., Sergejew, T., Quebe-Fehling, E., Lockhart, L., Krinsky, L.

“…Objectives: To compare the local tolerability, adhesion and estradiol delivery of a 5-cm2 transdermal patch (Estradot®, Novartis Pharmaceuticals, Basel,…”
Get full text

Caco-2 cell permeability of a new (hydroxybenzyl)ethylenediamine oral iron chelator: correlation with physicochemical properties and oral activity by Lowther, N, Tomlinson, B, Fox, R, Faller, B, Sergejew, T, Donnelly, H

“…This study describes the transport of CGP 75254A, a novel oral iron chelator, across Caco-2 cells in an attempt to model intestinal epithelial cell…”
Get more information

Pyridyl-Substituted Tetrahydrocyclopropa[a]naphthalenes: Highly Active and Selective Inhibitors of P450 arom by Hartmann, Rolf W, Bayer, Herbert, Gruen, Gertrud, Sergejew, Tom, Bartz, Ulrike, Mitrenga, Markus

“…The synthesis and biological evaluation of substituted exo-1-(4-pyridyl)-1a,2,3,7b-tetrahydro-1H-cyclopropa[a]naphthalene s as inhibitors of estrogen…”
Get full text

In vitro and in situ permeability of a 'second generation' hydroxypyridinone oral iron chelator : Correlation with physico-chemical properties and oral activity by LOWTHER, N, FOX, R, FALLER, B, NICK, H, YI JIN, SERGEJEW, T, HIRSCHBERG, Y, OBERLE, R, DONNELLY, H

“…The in vitro and in situ transport of CGP 65015 ((+)-3-hydroxy-1-(2-hydroxyethyl)-2-hydroxyphenyl-methyl-1H-pyridin-4-on e), a novel oral iron chelator, is…”
Get full text

Tetrahydronaphthalenes: influence of heterocyclic substituents on inhibition of steroid enzymes P450 arom and P450 17 by Wächter, G A, Hartmann, R W, Sergejew, T, Grün, G L, Ledergerber, D

“…In search of new leads for selective inhibition of estrogen and androgen biosynthesis, respectively, heterocyclic substituted 2-(arylmethylene)-1-tetralones…”
Get full text

Tetrahydronaphthalenes : influence of heterocyclic substituents on inhibition of steroidogenic enzymes P450 arom and P450 17 by WÄCHTER, G. A, HARTMANN, R. W, SERGEJEW, T, GRÜN, G. L, LEDERGERBER, D

Get full text

4,5-Dihydro-3-(2-pyrazinyl)naphtho[1,2-c]pyrazole: a potent and selective inhibitor of steroid-17 alpha-hydroxylase-C17,20-lyase (P450 17) by Hartmann, R W, Wächter, G A, Sergejew, T, Würtz, R, Düerkop, J

Get more information