Search Results - "SEPPÄLÄ, T. T"

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender by Seppälä, T T, Latchford, A, Negoi, I, Sampaio Soares, A, Jimenez-Rodriguez, R, Sánchez-Guillén, L, Evans, D G, Ryan, N, Crosbie, E J, Dominguez-Valentin, M, Burn, J, Kloor, M, Knebel Doeberitz, M von, Duijnhoven, F J B van, Quirke, P, Sampson, J R, Møller, P, Möslein, G

“…Lynch syndrome is the most common genetic predisposition for hereditary cancer but remains underdiagnosed. Large prospective observational studies have…”
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Lynch Syndrome Genetics and Clinical Implications by Peltomäki, Päivi, Nyström, Minna, Mecklin, Jukka-Pekka, Seppälä, Toni T.

“…Lynch syndrome (LS) is one of the most prevalent hereditary cancer syndromes in humans and accounts for some 3% of unselected patients with colorectal or…”
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Pretibial lacerations among elderly patients: A province-wide study from Kymenlaakso, Finland, 2015–2019 by Seppälä, T., Grünthal, V., Koljonen, V.

“…In this retrospective cohort study, we analysed treatment and outcomes among ≥65-year-old patients who experienced a traumatic pretibial laceration in the…”
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CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings by SEPPÄLÄ, T. T, NERG, O, JÄÄSKELÄINEN, J. E, RINNE, J, SOININEN, H, LEINONEN, V, HERUKKA, S.-K, KOIVISTO, A. M, RUMMUKAINEN, J, PULI, L, ZETTERBERG, H, PYYKKÖ, O. T, HELISALMI, S, ALAFUZOFF, I, HILTUNEN, M

“…To assess the relationship between Alzheimer disease (AD)-related pathologic changes in frontal cortical brain biopsy and AD biomarkers in ventricular vs…”
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Indoor air problems and experiences of injustice in the workplace: A quantitative and a qualitative study by Finell, E., Seppälä, T.

“…This study explores subjective injustice experiences of individuals suffering from suspected or observed indoor air problems in their workplaces in two…”
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Cerebrospinal fluid biomarker and brain biopsy findings in idiopathic normal pressure hydrocephalus by Pyykkö, Okko T, Lumela, Miikka, Rummukainen, Jaana, Nerg, Ossi, Seppälä, Toni T, Herukka, Sanna-Kaisa, Koivisto, Anne M, Alafuzoff, Irina, Puli, Lakshman, Savolainen, Sakari, Soininen, Hilkka, Jääskeläinen, Juha E, Hiltunen, Mikko, Zetterberg, Henrik, Leinonen, Ville

“…The significance of amyloid precursor protein (APP) and neuroinflammation in idiopathic normal pressure hydrocephalus (iNPH) and Alzheimer's disease (AD) is…”
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Editorial: Identification, risk stratification, and optimized management for Lynch Syndrome by Bernstein, Inge, Therkildsen, Christina, Seppälä, Toni T

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Epidemiological, clinical and molecular characterization of Lynch‐like syndrome: A population‐based study by Porkka, Noora, Lahtinen, Laura, Ahtiainen, Maarit, Böhm, Jan P., Kuopio, Teijo, Eldfors, Samuli, Mecklin, Jukka‐Pekka, Seppälä, Toni T., Peltomäki, Päivi

“…Colorectal carcinomas that are mismatch repair (MMR)‐deficient in the absence of MLH1 promoter methylation or germline mutations represent Lynch‐like syndrome…”
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Genetic and Epigenetic Characteristics of Inflammatory Bowel Disease–Associated Colorectal Cancer by Rajamäki, Kristiina, Taira, Aurora, Katainen, Riku, Välimäki, Niko, Kuosmanen, Anna, Plaketti, Roosa-Maria, Seppälä, Toni T., Ahtiainen, Maarit, Wirta, Erkki-Ville, Vartiainen, Emilia, Sulo, Päivi, Ravantti, Janne, Lehtipuro, Suvi, Granberg, Kirsi J., Nykter, Matti, Tanskanen, Tomas, Ristimäki, Ari, Koskensalo, Selja, Renkonen-Sinisalo, Laura, Lepistö, Anna, Böhm, Jan, Taipale, Jussi, Mecklin, Jukka-Pekka, Aavikko, Mervi, Palin, Kimmo, Aaltonen, Lauri A.

“…Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder associated with an elevated risk of colorectal cancer (CRC). IBD-associated CRC…”
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Subtotal Colectomy for Colon Cancer Reduces the Need for Subsequent Surgery in Lynch Syndrome by Renkonen-Sinisalo, Laura, Seppälä, Toni T, Järvinen, Heikki J, Mecklin, Jukka-Pekka

“…BACKGROUND:The risk of metachronous colorectal cancer is high after surgical resection for first colon cancer in Lynch syndrome. OBJECTIVE:This study aimed to…”
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National learning curve for laparoscopic hysterectomy and trends in hysterectomy in Finland 2000–2005 by Brummer, Tea H.I., Seppälä, Tomi T., Härkki, Päivi S.M.

“…BACKGROUND Complications of laparoscopic hysterectomy (LH) have been evaluated with particular focus on quantities of urinary tract injuries. An earlier survey…”
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Clinical characteristics of pancreatic and biliary tract cancers in Lynch syndrome: A retrospective analysis from the Finnish National Lynch Syndrome Research Registry by Zalevskaja, Kristina, Mecklin, Jukka-Pekka, Seppälä, Toni T

“…Patients with Lynch syndrome (LS) have an increased lifetime risk of pancreatic cancer (PC) and biliary tract cancer (BTC). These cancers have a notoriously…”
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Patient-derived Organoid Pharmacotyping is a Clinically Tractable Strategy for Precision Medicine in Pancreatic Cancer by Seppälä, Toni T., Zimmerman, Jacquelyn W., Sereni, Elisabetta, Plenker, Dennis, Suri, Reecha, Rozich, Noah, Blair, Alex, Thomas, Dwayne L., Teinor, Jonathan, Javed, Ammar, Patel, Hardik, Cameron, John L., Burns, William R., He, Jin, Tuveson, David A., Jaffee, Elizabeth M., Eshleman, James, Szabolcs, Annamaria, Ryan, David P., Ting, David T., Wolfgang, Christopher L., Burkhart, Richard A.

“…OBJECTIVE:PDAC patients who undergo surgical resection and receive effective chemotherapy have the best chance of long-term survival. Unfortunately, we lack…”
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Mortality and Length of Stay of Very Low Birth Weight and Very Preterm Infants: A EuroHOPE Study by Numerato, Dino, Fattore, Giovanni, Tediosi, Fabrizio, Zanini, Rinaldo, Peltola, Mikko, Banks, Helen, Mihalicza, Péter, Lehtonen, Liisa, Sveréus, Sofia, Heijink, Richard, Klitkou, Søren Toksvig, Fletcher, Eilidh, Heijden, Amber van der, Lundberg, Fredrik, Over, Eelco, Häkkinen, Unto, Seppälä, Timo T

“…The objective of this paper was to compare health outcomes and hospital care use of very low birth weight (VLBW), and very preterm (VLGA) infants in seven…”
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Precision Medicine in Pancreatic Cancer: Patient-Derived Organoid Pharmacotyping Is a Predictive Biomarker of Clinical Treatment Response by Seppälä, Toni T, Zimmerman, Jacquelyn W, Suri, Reecha, Zlomke, Haley, Ivey, Gabriel D, Szabolcs, Annamaria, Shubert, Christopher R, Cameron, John L, Burns, William R, Lafaro, Kelly J, He, Jin, Wolfgang, Christopher L, Zou, Ying S, Zheng, Lei, Tuveson, David A, Eshlemann, James R, Ryan, David P, Kimmelman, Alec C, Hong, Theodore S, Ting, David T, Jaffee, Elizabeth M, Burkhart, Richard A

“…Patient-derived organoids (PDO) are a promising technology to support precision medicine initiatives for patients with pancreatic ductal adenocarcinoma (PDAC)…”
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Pretibial hematomas – A real-world single-center study by Seppälä, T., Grünthal, V., Koljonen, V.

“…We analyzed treatment, outcome, and risk factors for skin necrosis of 60 patients aged ≥65 years treated for a pretibial hematoma in the province of…”
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The “unnatural” history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance by Ahadova, Aysel, Seppälä, Toni T., Engel, Christoph, Gallon, Richard, Burn, John, Holinski‐Feder, Elke, Steinke‐Lange, Verena, Möslein, Gabriela, Nielsen, Maartje, Broeke, Sanne W., Laghi, Luigi, Dominguez‐Valentin, Mev, Capella, Gabriel, Macrae, Finlay, Scott, Rodney, Hüneburg, Robert, Nattermann, Jacob, Hoffmeister, Michael, Brenner, Hermann, Bläker, Hendrik, Knebel Doeberitz, Magnus, Sampson, Julian R., Vasen, Hans, Mecklin, Jukka‐Pekka, Møller, Pål, Kloor, Matthias

“…Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at increased risk of developing malignancies, in particular…”
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Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer by Elomaa, Hanna, Ahtiainen, Maarit, Väyrynen, Sara A., Ogino, Shuji, Nowak, Jonathan A., Friman, Marjukka, Helminen, Olli, Wirta, Erkki-Ville, Seppälä, Toni T., Böhm, Jan, Mäkinen, Markus J., Mecklin, Jukka-Pekka, Kuopio, Teijo, Väyrynen, Juha P.

“…Background Although high T cell density is a strong favourable prognostic factor in colorectal cancer, the significance of the spatial distribution of T cells…”
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Associations of Pathogenic Variants in MLH1, MSH2, and MSH6 With Risk of Colorectal Adenomas and Tumors and With Somatic Mutations in Patients With Lynch Syndrome by Engel, Christoph, Ahadova, Aysel, Seppälä, Toni T., Aretz, Stefan, Bigirwamungu-Bargeman, Marloes, Bläker, Hendrik, Bucksch, Karolin, Büttner, Reinhard, de Vos tot Nederveen Cappel, Wouter T., Endris, Volker, Holinski-Feder, Elke, Holzapfel, Stefanie, Hüneburg, Robert, Jacobs, Maarten A.J.M., Koornstra, Jan J., Langers, Alexandra M., Lepistö, Anna, Morak, Monika, Möslein, Gabriela, Peltomäki, Päivi, Pylvänäinen, Kirsi, Rahner, Nils, Renkonen-Sinisalo, Laura, Schulmann, Karsten, Steinke-Lange, Verena, Stenzinger, Albrecht, Strassburg, Christian P., van de Meeberg, Paul C., van Kouwen, Mariette, van Leerdam, Monique, Vangala, Deepak B., Vecht, Juda, Verhulst, Marie-Louise, von Knebel Doeberitz, Magnus, Weitz, Jürgen, Zachariae, Silke, Loeffler, Markus, Mecklin, Jukka-Pekka, Kloor, Matthias, Vasen, Hans F.

“…Lynch syndrome is caused by variants in DNA mismatch repair (MMR) genes and associated with an increased risk of colorectal cancer (CRC). In patients with…”
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The Different Immune Profiles of Normal Colonic Mucosa in Cancer-Free Lynch Syndrome Carriers and Lynch Syndrome Colorectal Cancer Patients by Bohaumilitzky, Lena, Kluck, Klaus, Hüneburg, Robert, Gallon, Richard, Nattermann, Jacob, Kirchner, Martina, Kristiansen, Glen, Hommerding, Oliver, Pfuderer, Pauline L., Wagner, Lelia, Echterdiek, Fabian, Kösegi, Svenja, Müller, Nico, Fischer, Konstantin, Nelius, Nina, Hartog, Ben, Borthwick, Gillian, Busch, Elena, Haag, Georg Martin, Bläker, Hendrik, Möslein, Gabriela, von Knebel Doeberitz, Magnus, Seppälä, Toni T., Ahtiainen, Maarit, Mecklin, Jukka-Pekka, Bishop, D. Timothy, Burn, John, Stenzinger, Albrecht, Budczies, Jan, Kloor, Matthias, Ahadova, Aysel

“…Owing to the high load of immunogenic frameshift neoantigens, tumors arising in individuals with Lynch syndrome (LS), the most common inherited colorectal…”
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