Search Results - "SEPKOVIC, Daniel W"

Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11 by Dhar, Madhurima, Sepkovic, Daniel W., Hirani, Vandana, Magnusson, Ronald P., Lasker, Jerome M.

“…Long-chain 3-hydroxydicarboxylic acids (3-OHDCAs) are thought to arise via β-oxidation of the corresponding dicarboxylic acids (DCAs), although long-chain DCAs…”
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Polychlorinated biphenyl exposure, diabetes and endogenous hormones: a cross-sectional study in men previously employed at a capacitor manufacturing plant by Persky, Victoria, Piorkowski, Julie, Turyk, Mary, Freels, Sally, Chatterton, Jr, Robert, Dimos, John, Bradlow, H Leon, Chary, Lin Kaatz, Burse, Virlyn, Unterman, Terry, Sepkovic, Daniel W, McCann, Kenneth

“…Studies have shown associations of diabetes and endogenous hormones with exposure to a wide variety of organochlorines. We have previously reported positive…”
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Diindolylmethane Inhibits Cervical Dysplasia, Alters Estrogen Metabolism, and Enhances Immune Response in the K14-HPV16 Transgenic Mouse Model by SEPKOVIC, Daniel W, STEIN, Johann, CARLISTE, Antoine D, KSIESKI, H. Barbara, AUBORN, Karen, BRADLOW, H. Leon

“…This study was designed to establish whether 3,3′-diindolylmethane (DIM) can inhibit cervical lesions, alter estrogen metabolism in favor of C-2 hydroxylation,…”
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Effects of A Breast-Health Herbal Formula Supplement on Estrogen Metabolism in Pre- and Post-Menopausal Women not Taking Hormonal Contraceptives or Supplements: A Randomized Controlled Trial by Laidlaw, Maggie, Cockerline, Carla A, Sepkovic, Daniel W

“…Both indole-3-carbinol and dietary lignans have beneficial effects on estrogen metabolism and breast cancer risk. There is no published literature on the…”
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Erratum for ＂Effects of a Breast-Health Herbal Formula Supplement on Estrogen Metabolism in Pre- and Post-Menopausal Women not Taking Hormonal Contraceptives or Supplements: A Randomized Controlled Trial by Laidlaw, Maggie, Cockerline, Carla A., Sepkovic, Daniel W.

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Estrogen Hydroxylation-The Good and the Bad by Sepkovic, Daniel W., Bradlow, H. Leon

“…Although estradiol itself is primarily responsible for female development, the metabolites are responsible for many of the other positive and negative…”
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Urinary Estrogen Metabolites and Their Ratio among Asian American Women by FALK, Roni T, FEARS, Thomas R, BRADLOW, H. Leon, ZIEGLER, Regina G, XIA XU, HOOVER, Robert N, PIKE, Malcolm C, WU, Anna H, NOMURA, Abraham M. Y, KOLONEL, Laurence N, WEST, Dee W, SEPKOVIC, Daniel W

“…Controversy persists regarding the role of a low ratio of 2-hydroxyestone (2-OHE 1 )/16α-hydroxyestrone (16α-OHE 1 ) as a potential estrogen metabolism marker…”
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The nutritional herb Epimedium grandiflorum inhibits the growth in a model for the Luminal A molecular subtype of breast cancer by Telang, Nitin T, Li, Gou, Katdare, Meena, Sepkovic, Daniel W, Bradlow, H Leon, Wong, George Y C

“…The Luminal A subtype of breast cancer expresses the estrogen receptor (ER)-α and progesterone receptor (PR), but not the human epidermal growth factor…”
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3,3'-diindolylmethane modulates estrogen metabolism in patients with thyroid proliferative disease: a pilot study by Rajoria, Shilpi, Suriano, Robert, Parmar, Perminder Singh, Wilson, Yushan Lisa, Megwalu, Uchechukwu, Moscatello, Augustine, Bradlow, H Leon, Sepkovic, Daniel W, Geliebter, Jan, Schantz, Stimson P, Tiwari, Raj K

“…The incidence of thyroid cancer is four to five times higher in women than in men, suggesting a role for estrogen (E₂) in the pathogenesis of thyroid…”
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Urinary Estrogen Metabolites and Mammographic Parenchymal Patterns in Postmenopausal Women by RIZA, Elena, DOS SANTOS SILVA, Isabel, DE STAVOLA, Bianca, BRADLOW, H. Leon, SEPKOVIC, Daniel W, LINOS, Dimitrios, LINOS, Athena

“…It has been hypothesized that women who metabolize their endogenous estrogens predominantly via 16 α -hydroxylation rather than via 2-hydroxylation and, as a…”
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Estrogen Metabolism and Risk of Breast Cancer: A Prospective Study of the 2:16α-Hydroxyestrone Ratio in Premenopausal and Postmenopausal Women by Muti, Paola, Bradlow, H. Leon, Micheli, Andrea, Krogh, Vittorio, Freudenheim, Jo L., Schünemann, Holger J., Stanulla, Martin, Yang, Jun, Sepkovic, Daniel W., Trevisan, Maurizio, Berrino, Franco

“…Experimental and clinical evidence suggests that 16α-hydroxylated estrogen metabolites, biologically strong estrogens, are associated with breast cancer risk,…”
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Lycium Barbarum Inhibits Growth of Estrogen Receptor Positive Human Breast Cancer Cells by Favorably Altering Estradiol Metabolism by Li, Go, Sepkovic, Daniel W, Bradlow, H. Leon, Telang, Nitin T, Wong, George Y.C

“…Selective estrogen receptor modulators represent accepted therapy for estrogen receptor positive (ER+) breast cancer, exhibit adverse side effects, and reduce…”
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Adipocyte-derived factor as a modulator of oxidative estrogen metabolism: implications for obesity and estrogen-dependent breast cancer by Bradlow, H Leon, Sepkovic, Daniel W, Telang, Nitin, Tiwari, Raj

“…The role of body fat as a risk factor for breast cancer has been well established. A decrease in the urinary 2/16α-hydroxyestrone ratio has also been shown to…”
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Placebo-Controlled Trial of Indole-3-Carbinol in the Treatment of CIN by Bell, Maria C., Crowley-Nowick, Peg, Bradlow, H.Leon, Sepkovic, Daniel W., Schmidt-Grimminger, Delf, Howell, Patti, Mayeaux, E.J., Tucker, Angela, Turbat-Herrera, Elba A., Mathis, J.Michael

“…Objective. Most precancerous lesions of the cervix are treated with surgery or ablative therapy. Chemoprevention, using natural and synthetic compounds, may…”
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Estrogen Metabolism and Breast Cancer by Kabat, Geoffrey C., O'Leary, Erin S., Gammon, Marilie D., Sepkovic, Daniel W., Teitelbaum, Susan L., Britton, Julie A., Terry, Mary B., Neugut, Alfred I., Bradlow, H. Leon

“…Background: Specific pathways involved in estrogen metabolism may play a role in the etiology of breast cancer. We used data from a large population-based…”
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3,3'-Diindolylmethane increases serum interferon-γ levels in the K14-HPV16 transgenic mouse model for cervical cancer by Sepkovic, Daniel W, Raucci, Laura, Stein, Johann, Carlisle, Antoine D, Auborn, Karen, Ksieski, H Barbara, Nyirenda, Themba, Bradlow, H Leon

“…While cervical cancer incidence and mortality rates have declined in the United States, this cancer represents a worldwide threat. Human papilloma viral…”
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Dietary seaweed modifies estrogen and phytoestrogen metabolism in healthy postmenopausal women by Teas, Jane, Hurley, Thomas G, Hebert, James R, Franke, Adrian A, Sepkovic, Daniel W, Kurzer, Mindy S

“…Seaweed and soy foods are consumed daily in Japan, where breast cancer rates for postmenopausal women are significantly lower than in the West. Likely…”
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Results from a dose-response study using 3,3'-diindolylmethane in the K14-HPV16 transgenic mouse model: cervical histology by Sepkovic, Daniel W, Stein, Johann, Carlisle, Antoine D, Ksieski, H Barbara, Auborn, Karen, Raucci, Laura, Nyirenda, Themba, Bradlow, H Leon

“…The human papilloma virus is the major cause of cervical cancer. Viral infection initiates cervical intraepithelial neoplasia, which progresses through several…”
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Effect of soy protein on endogenous hormones in postmenopausal women by PERSKY, Victoria W, TURYK, Mary E, LING WANG, FREELS, Sally, CHATTERTON, Robert, BARNES, Stephen, ERDMAN, John, SEPKOVIC, Daniel W, BRADLOW, H. Leon, POTTER, Susan

“…The long-term clinical effects of soy protein containing various concentrations of isoflavones on endogenous hormones are unknown. We examined the effects of…”
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Evaluation of 3,3'-diindolylmethane with gardasil quadrivalent HPV vaccine in K14-HPV16-transgenic mice cervical histology by Sepkovic, Daniel W, Pagan, Doris V, Stein, Johann, Carlisle, Antoine D, Ksieski, H Barbara, Auborn, Karen, Nyirenda, Themba, Bradlow, H Leon

“…The effects of 3,3'-diindolylmethane (DIM) together with the Gardasil vaccine on cervical histology were evaluated using the K14-HPV16-transgenic mouse model…”
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