Search Results - "SEPETOV, N. F"

Enzyme-Mediated Spatial Segregation on Individual Polymeric Support Beads: Application to Generation and Screening of Encoded Combinatorial Libraries by Vágner, Josef, Barany, George, Lam, Kit S., Krchn̆ák, Viktor, Sepetov, Nikolai F., Ostrem, James A., Strop, Peter, Lebl, Michal

“…Proteolysis of short Nα-protected peptide substrates bound to polyoxyethylene-polystyrene beads releases selectively free amino sites in the enzyme-accessible…”
Get full text

The flexible region of protein L12 from bacterial ribosomes studied by proton nuclear magnetic resonance by Bushuev, V N, Gudkov, A T, Liljas, A, Sepetov, N F

“…The dimeric protein L7/L12 from bacterial ribosomes has a highly elongated and flexible structure. We have, using 1H NMR methods, analyzed the extent of the…”
Get full text

Library of Libraries: Approach to Synthetic Combinatorial Library Design and Screening of "Pharmacophore" Motifs by Sepetov, Nikolai F., Krchnak, Viktor, Stankova, Magda, Wade, Shelly, Lam, Kit S., Lebl, Michal

“…Construction of synthetic combinatorial libraries is described that allows for the generation of a library of motifs rather than a library of compounds…”
Get full text

The use of hydrogen-deuterium exchange to facilitate peptide sequencing by electrospray tandem mass spectrometry by Sepetov, N F, Issakova, O L, Lebl, M, Swiderek, K, Stahl, D C, Lee, T D

“…The utility of hydrogen-deuterium exchange for sequencing peptides by mass spectrometry is demonstrated. The number of exchangeable hydrogens in a peptide is…”
Get more information

One-bead-one-structure combinatorial libraries by Lebl, M, Krchnák, V, Sepetov, N F, Seligmann, B, Strop, P, Felder, S, Lam, K S

“…Combinatorial libraries employing the one-bead-one-compound technique are reviewed. Two distinguishing features characterize this technique. First, each…”
Get more information

Spontaneous chemical degradation of substance P in the solid phase and in solution by Kertscher, U, Bienert, M, Krause, E, Sepetov, N F, Mehlis, B

“…The instability of the undecapeptide substance P (SP), a neuropeptide implicated in several physiological processes, was occasionally observed when the peptide…”
Get more information

Sequence-dependent modification of Trp by the Pmc protecting group of Arg during TFA deprotection by Stierandová, A, Sepetov, N F, Nikiforovich, G V, Lebl, M

“…The extent of transfer of the Pmc protecting group from the guanidino group of arginine to the side chain of tryptophan depends on the spacial distance of…”
Get more information

Symmetrical structure of the L7 protein dimer by Bushuev, V.N., Sepetov, N.F., Gudkov, A.T.

“…500 MHz NMR studies of the L7 monomer (oxidized protein) and of the dimer (intact protein) show that its N-terminal sequence takes part in the dimer formation…”
Get full text

A comparative study of structural properties of fibronectin and its 180 kDa fragment by Bushuev, V.N., Metsis, M.L., Morozkin, A.D., Ruuge, E.K., Sepetov, N.F., Koteliansky, V.E.

“…Fibronectin from human plasma and its 180 kDa fragment which retained collagen-binding, cell-attachment and heparin-binding activities, were studied by…”
Get full text

Rearrangement, racemization and decomposition of peptides in aqueous solution by Sepetov, N F, Krymsky, M A, Ovchinnikov, M V, Bespalova, Z D, Isakova, O L, Soucek, M, Lebl, M

“…We reported earlier that peptides containing glycine as the third amino acid from the amino end undergo sequence rearrangement of the first two amino acid…”
Get more information

Preparation and characterization of new analogues of dalargin by POSPISEK, J, BARTH, T, BESPALOVA, Z. D, TITOV, M. I, MASKOVA, H. P, MOLOKOEDOV, A. S, SEPETOV, N. F

“…Tert-butyloxycarbonyl-O-tert-butyloxycarbonyl-L-tyrosyl-D-alanyl-glycyl-L-phenylalanyl-DL-neopentylglycyl-L-arginine was prepared by means of fragment…”
Get full text

Behavioral and electrophysiological characteristics of L-pyroglutamyl-D-alanine amide, a pyracetam analog by Ostrovskaya, R. U., Gudasheva, T. A., Trofimov, S. S., Romanova, G. A., Dobrynin, V. P., Sepetov, N. F., Isakova, O. L., Skoldinov, A. P.

Get full text

Synthesis and evaluation of antigenic properties of peptides of the HIV-1 protein GP 41 by BESPALOVA, Z. D, PEKELIS, B. L, DEIGIN, V. I, YAROVA, E. P, SAKS, T. P, OVCHINIKOV, M. V, EFREMOV, E. E, SEPETOV, N. F, KOROTKOV, A. M, MOLOKOEDOV, A. S

“…Scheme is described for the synthesis of 19- and 21-member peptides which constitute a part of the domain (sequence 584-609) from the conservative region of…”
Get full text

Kemp's Triacid Scaffolding for Synthesis of Combinatorial Nonpeptide Uncoded Libraries by Kocis, P

Get full text

Direction of carbonium ion rearrangements during acylation of propyne by stereoisomers of 4-tert-butyl-1-methylcyclohexanoylcarbonyl cation by Kanishchev, M. I., Shchegolev, A. A., Smit, V. A., Caple, R., Sepetov, N. F.

Get full text

Identification of signals in overlapping NMR spectra of proteins by the differential spin echo method by Sepetov, N F, Bushuev, V N

“…A novel method for identification of the spin systems of Thr and Ala amino acid residues in H--NMR spectra of proteins is proposed…”
Get more information

A One-Bead One-Peptide Combinatorial Library Method for B-Cell Epitope Mapping by Lam, Kit S., Lake, Douglas, Salmon, Sydney E., Smith, John, Chen, Man-Ling, Wade, Shelly, Abdul-Latif, Farid, Knapp, Richard J., Leblova, Zuzana, Ferguson, Ronald D., Krchnak, Viktor, Sepetov, Nikolai F., Lebl, Michal

“…The one-bead one-peptide combinatorial library method represents a powerful approach to the discovery of binding peptides for various macromolecular targets…”
Get full text

1H-NMR study of protein L7/L12 from bacterial ribosomes by Sepetov, N F, Bushuev, V N, Gudkov, A T

“…The 500 MHz 1H-NMR spectra of dimeric protein L12 from ribosomes shows a limited number of unusually sharp signals at room temperature. This is interpreted as…”
Get more information

Use of super(1)H NMR spectroscopy for investigation of peptide degradation by angiotensin-converting enzymes by Sakharov, I Y, Isakova, O L, Sepetov, N F, Bespalova, Z D, Ruuge, E K

“…A new method for continuous recording of the enzymatic hydrolysis of peptides using super(1)H NMR spectroscopy has been developed. The advantages of this…”
Get full text

Atrial natriuretic peptides. IV. Synthesis and study of shortened analogs by Ovchinnikov, M V, Bespalova, Zh D, Zhukovskiĭ, S V, Sepetov, N F, Revenko, I V

“…New analogues of atrial peptides of rat were synthesized by classical methods of peptide chemistry in solution. They contain a D-amino acid residue in the…”
Get more information