Search Results - "SENTZ, D. L"

Plasma pharmacokinetics of butyrate after intravenous administration of sodium butyrate or oral administration of tributyrin or sodium butyrate to mice and rats by EGORIN, M. J, YUAN, Z.-M, SENTZ, D. L, PLAISANCE, K, EISEMAN, J. L

“…To define the plasma concentrations of butyrate achieved and the profile of plasma butyrate concentrations versus time in mice and rats treated with tributyrin…”
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Pharmacokinetics and antitumor properties in tumor-bearing mice of an enediol analogue inhibitor of glyoxalase I by SHARKEY, E. M, O'NEILL, H. B, KAVARANA, M. J, HAIBO WANG, CREIGHTON, D. J, SENTZ, D. L, EISEMAN, J. L

“…The enediol analogue S-(N-p-chlorophenyl-N-hydroxycarbamoyl)glutathione (CHG) is a powerful, mechanism-based, competitive inhibitor of the…”
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Plasma pharmacokinetics and tissue distribution of paclitaxel in CD2F1 mice by EISEMAN, J. L, EDDINGTON, N. D, LESLIE, J, MACAULEY, C, SENTZ, D. L, ZUHOWSKI, M, KUJAWA, J. M, YOUNG, D, EGORIN, M. J

“…We defined the pharmacokinetics of paclitaxel after i.v., i.p., p.o., and s.c. administration of 22.5 mg/kg to CD2F1 mice. Additional mice were studied after…”
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Tumor-targeted apoptosis by a novel spermine analogue, 1,12-diaziridinyl-4,9-diazadodecane, results in therapeutic efficacy and enhanced radiosensitivity of human prostate cancer by EISEMAN, J. L, ROGERS, F. A, YANPING GUO, KAUFFMAN, J, SENTZ, D. L, KLINGER, M. F, CALLERY, P. S, KYPRIANOU, N

“…Interference with polyamine transport and biosynthesis has emerged as an important anticancer strategy involving polyamine analogues and specific inhibitors of…”
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Plasma pharmacokinetics and tissue distribution in CD2F1 mice of Pc4 (NSC 676418), a silicone phthalocyanine photodynamic sensitizing agent by EGORIN, M. J, ZUHOWSKI, E. G, SENTZ, D. L, DOBSON, J. M, CALLERY, P. S, EISEMAN, J. L

“…Pc4 is a silicone phthalocyanine photosensitizing agent that is entering clinical trials. Studies were undertaken in mice to develop a suitable formulation and…”
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Antitumor activity, distribution, and metabolism of 13-cis-retinoic acid as a single agent or in combination with tamoxifen in established human MCF-7 xenografts in mice by CONLEY, B. A, RAMSLAND, T. S, SENTZ, D. L, SUHLAN WU, ROSEN, D. M, WOLLMAN, M, EISEMAN, J. L

“…The efficacy of 13-cis-retinoic acid (13-CRA) given as a single agent or in combination with tamoxifen (TAM) was determined in athymic nude mice bearing…”
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Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) in CD2F1 mice1 by EGORIN, Merrill J, ZUHOWSKI, Eleanor G, ROSEN, D. Marc, SENTZ, Dorothy L, COVEY, Joseph M, EISEMAN, Julie L

“…17-(Allylamino)-17-demethoxygeldanamycin (17AAG) is a benzoquinone ansamycin compound agent that has entered clinical trials. Studies were performed in mice…”
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Synthesis and Antitumor Evaluation of a Highly Potent Cytotoxic DNA Cross-Linking Polyamine Analogue, 1,12-Diaziridinyl-4,9-diazadodecane by Li, Yanlong, Eiseman, Julie L, Sentz, Dorothy L, Rogers, Faye A, Pan, Su-Shu, Hu, Li-Tai, Egorin, Merrill J, Callery, Patrick S

“…A diaziridinylspermine analogue, 1,12-diaziridinyl-4,9-diazadodecane (NSC-667005), was synthesized as a bisalkylating agent with a polyamine backbone. DNA…”
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In vitro metabolism by mouse and human liver preparations of halomon, an antitumor halogenated monoterpene by EGORIN, M. J, ROSEN, D. M, BENJAMIN, S. E, CALLERY, P. S, SENTZ, D. L, EISEMAN, J. L

“…To characterize the enzymes responsible for and metabolites produced from the metabolism of halomon, a halogenated monoterpene that is isolated from the red…”
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Plasma pharmacokinetics, bioavailability, and tissue distribution in CD2F1 mice of halomon, and antitumor halogenated monoterpene isolated from the red algae Portieria hornemannii by EGORIN, M. J, SENTZ, D. L, ROSEN, D. M, BALLESTEROS, M. F, KEARNS, C. M, CALLERY, P. S, EISEMAN, J. L

“…The purpose of the present study was to define the plasma pharmacokinetics, bioavailability, and tissue distribution in mice of halomon, a halogenated…”
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Plasma pharmacokinetics and urinary excretion of the polyamine analogue 1, 19-bis(ethylamino)-5, 10, 15-triazanonadecane in CD2F1 mice by EISEMAN, J. L, YUAN, Z.-M, EDDINGTON, N. D, SENTZ, D. L, CALLERY, P. S, EGORIN, M. J

“…The pharmacokinetics of 1, 19-bis(ethylamino)-5, 10, 15-triazanonadecane (BE-4-4-4-4) were determined in CD2F1 female mice after administration of i.v. bolus…”
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