Search Results - "SENARIS, Rosa"

Expression of the cold thermoreceptor TRPM8 in rodent brain thermoregulatory circuits by Ordás, Purificación, Hernández‐Ortego, Pablo, Vara, Hugo, Fernández‐Peña, Carlos, Reimúndez, Alfonso, Morenilla‐Palao, Cruz, Guadaño‐Ferraz, Ana, Gomis, Ana, Hoon, Mark, Viana, Félix, Señarís, Rosa

“…The cold‐ and menthol‐activated ion channel transient receptor potential channel subfamily M member 8 (TRPM8) is the principal detector of environmental cold…”
Get full text

Deletion of the Cold Thermoreceptor TRPM8 Increases Heat Loss and Food Intake Leading to Reduced Body Temperature and Obesity in Mice by Reimúndez, Alfonso, Fernández-Peña, Carlos, García, Guillermo, Fernández, Rubén, Ordás, Purificación, Gallego, Rosalía, Pardo-Vazquez, Jose L, Arce, Victor, Viana, Félix, Señarís, Rosa

“…The coupling of energy homeostasis to thermoregulation is essential to maintain homeothermy in changing external environments. We studied the role of the cold…”
Get full text

TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins by Meseguer, Victor, Alpizar, Yeranddy A., Luis, Enoch, Tajada, Sendoa, Denlinger, Bristol, Fajardo, Otto, Manenschijn, Jan-Albert, Fernández-Peña, Carlos, Talavera, Arturo, Kichko, Tatiana, Navia, Belén, Sánchez, Alicia, Señarís, Rosa, Reeh, Peter, Pérez-García, María Teresa, López-López, José Ramón, Voets, Thomas, Belmonte, Carlos, Talavera, Karel, Viana, Félix

“…Gram-negative bacterial infections are accompanied by inflammation and somatic or visceral pain. These symptoms are generally attributed to sensitization of…”
Get full text

Muscle-specific interleukin-6 deletion influences body weight and body fat in a sex-dependent manner by Ferrer, Beatriz, Navia, Belén, Giralt, Mercedes, Comes, Gemma, Carrasco, Javier, Molinero, Amalia, Quintana, Albert, Señarís, Rosa M, Hidalgo, Juan

“…Highlight • Muscle interleukin-6 (IL-6) influences body weight and behaviour in a sex-dependent manner…”
Get full text

Pregnancy Induces Resistance to the Anorectic Effect of Hypothalamic Malonyl-CoA and the Thermogenic Effect of Hypothalamic AMPK Inhibition in Female Rats by Martínez de Morentin, Pablo B, Lage, Ricardo, González-García, Ismael, Ruíz-Pino, Francisco, Martins, Luís, Fernández-Mallo, Diana, Gallego, Rosalía, Fernø, Johan, Señarís, Rosa, Saha, Asish K, Tovar, Sulay, Diéguez, Carlos, Nogueiras, Rubén, Tena-Sempere, Manuel, López, Miguel

“…During gestation, hyperphagia is necessary to cope with the metabolic demands of embryonic development. There were three main aims of this study: Firstly, to…”
Get full text

Agouti-Related Peptide, Neuropeptide Y, and Somatostatin-Producing Neurons Are Targets for Ghrelin Actions in the Rat Hypothalamus by Seoane, Luisa M, López, Miguel, Tovar, Sulay, Casanueva, Felipe F, Señarís, Rosa, Diéguez, Carlos

“…Ghrelin, the endogenous ligand of the GH secretagogue receptor, acts at central level to elicit GH release and regulate food intake. To elucidate the neural…”
Get full text

The cold‐sensing ion channel TRPM8 regulates central and peripheral clockwork and the circadian oscillations of body temperature by Reimúndez, Alfonso, Fernández‐Peña, Carlos, Ordás, Purificación, Hernández‐Ortego, Pablo, Gallego, Rosalía, Morenilla‐Palao, Cruz, Navarro, Juan, Martín‐Cora, Francisco, Pardo‐Vázquez, José Luís, Schwarz, Lindsay A., Arce, Victor, Viana, Félix, Señarís, Rosa

“…Aim Physiological functions in mammals show circadian oscillations, synchronized by daily cycles of light and temperature. Central and peripheral clocks…”
Get full text

Fas/CD95 Ligation Induces Proliferation of Primary Fetal Astrocytes Through a Mechanism Involving Caspase 8-Mediated ERK Activation by Barca, Olga, Seoane, Marcos, Señarís, Rosa Mª, Arce, Víctor M.

“…Background: Fas/CD95 is the best-studied member of the death receptor (DR) superfamily in the central nervous system where it can trigger cellular responses…”
Get full text

Resistance of neonatal primary astrocytes against Fas-induced apoptosis depends on silencing of caspase 8 by Barca, Olga, Carneiro, Carmen, Costoya, José A., Señarís, Rosa Mª, Arce, Víctor M.

“…In the present report, we have found that primary fetal astrocytes express caspase 8 and undergo apoptosis in response to Fas ligation. In contrast, neonatal…”
Get full text

Interferon-β protects astrocytes against tumour necrosis factor-induced apoptosis via activation of p38 mitogen-activated protein kinase by Barca, Olga, Costoya, José A., Señarís, Rosa M., Arce, Víctor M.

“…Several large clinical trials have demonstrated that interferon-β (IFN-β) therapy is effective in the treatment of multiple sclerosis (MS) patients. However,…”
Get full text

Hypothalamic levels of NPY, MCH, and prepro‐orexin mRNA during pregnancy and lactation in the rat: role of prolactin by García, M. C., López, M., Gualillo, O., Seoane, L. M., Diéguez, C., Señarís, Rosa Maria

“…ABSTRACT Pregnancy and lactation provide excellent models of physiological hyperphagia and hyper‐prolactinemia. To identify possible factors associated with…”
Get full text

AMPK Activation by Oncogenesis Is Required to Maintain Cancer Cell Proliferation in Astrocytic Tumors by RIOS, Marcos, FORETZ, Marc, VIOLLET, Benoit, PRIETO, Angel, FRAGA, Máximo, COSTOYA, Jose A, SENARIS, Rosa

“…5'-AMP-activated protein kinase (AMPK) is an energy sensor that controls cell metabolism, and it has been related to apoptosis and cell-cycle arrest. Although…”
Get full text

Mammalian cold TRP channels: impact on thermoregulation and energy homeostasis by Señarís, Rosa, Ordás, Purificación, Reimúndez, Alfonso, Viana, Félix

“…Body temperature regulation is a fundamental homeostatic function in homeothermic animals. It is governed by the central nervous system that integrates…”
Get full text

Sex differences in thermoregulation in mammals: Implications for energy homeostasis by Fernández-Peña, Carlos, Reimúndez, Alfonso, Viana, Félix, Arce, Victor M, Señarís, Rosa

“…Thermal homeostasis is a fundamental process in mammals, which allows the maintenance of a constant internal body temperature to ensure an efficient function…”
Get full text

Leptin resistance during pregnancy is also exerted at the periphery by Trujillo-Güiza, Martha Liliana, Señarís, Rosa

“…Pregnancy is a physiological state with a great demand of energy and nutrients in mammals and is characterized by hyperphagia, increase in fat mass,…”
Get full text

Cellular localization of orexin receptors in human pituitary by BLANCO, Montserrat, LOPEZ, Miguel, GARCIA-CABALLERO, Tomas, GALLEGO, Rosalia, VAZQUEZ-BOQUETE, Angel, MOREL, Gerard, SENARIS, Rosa, CASANUEVA, Felipe, DIEGUEZ, Carlos, BEIRAS, Andrés

“…Orexins-A and -B are hypothalamic peptides derived from a precursor called prepro-orexin and relationated with the stimulation of food intake. They act on G…”
Get full text

Thyroid status regulates CART but not AgRP mRNA levels in the rat hypothalamus by López, Miguel, Seoane, Luisa, Tovar, Sulay, Señarís, Rosa M, Diéguez, Carlos

“…We examined the effects of thyroid status on cocaine- and amphetamine-regulated transcript and agouti-related peptide expression in the rat hypothalamus. Hypo-…”
Get full text

Orexins (hypocretins) and energy balance: More than feeding by Fernø, Johan, Señarís, Rosa, Diéguez, Carlos, Tena-Sempere, Manuel, López, Miguel

“…Initially implicated in the regulation of feeding, orexins/hypocretins are now acknowledged to play a major role in the control of a wide variety of biological…”
Get full text

Hepatic steatosis induced in C57BL/6 mice by a non-ß oxidizable fatty acid analogue is associated with reduced plasma kynurenine metabolites and a modified hepatic NAD + /NADH ratio by Berge, Rolf K, Cacabelos, Daniel, Señarís, Rosa, Nordrehaug, Jan Erik, Nygård, Ottar, Skorve, Jon, Bjørndal, Bodil

“…Non-alcoholic fatty liver disease is often associated with obesity, insulin resistance, dyslipidemia, and the metabolic syndrome in addition to mitochondrial…”
Get full text

TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins by Meseguer, Victor, Alpizar, Yeranddy A., Luis, Enoch, Tajada, Sendoa, Denlinger, Bristol, Fajardo, Otto, Manenschijn, Jan-Albert, Fernández-Peña, Carlos, Talavera, Arturo, Kichko, Tatiana, Navia, Belén, Sánchez, Alicia, Señarís, Rosa, Reeh, Peter, Pérez-García, María Teresa, López-López, José Ramón, Voets, Thomas, Belmonte, Carlos, Talavera, Karel, Viana, Félix

Get full text