Search Results - "SEMENZA, G"

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics by Semenza, G L

“…Adaptation of cancer cells to their microenvironment is an important driving force in the clonal selection that leads to invasive and metastatic disease. O 2…”
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Regulation of metabolism by hypoxia-inducible factor 1 by Semenza, G L

“…The maintenance of oxygen homeostasis is critical for survival, and the master regulator of this process in metazoan species is hypoxia-inducible factor 1…”
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HIF-1 inhibitors for cancer therapy: from gene expression to drug discovery by Semenza, G L

“…Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric protein composed of HIF-1alpha and HIF-1alpha subunits, which is activated in response to reduced O2…”
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Cancer–stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis by Semenza, G L

“…Interactions between cancer cells and stromal cells, including blood vessel endothelial cells (BECs), lymphatic vessel endothelial cells (LECs), bone…”
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Targeting HIF-1 for cancer therapy by Semenza, Gregg L

“…Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes that are involved in crucial aspects of cancer biology, including angiogenesis, cell…”
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Evaluation of HIF-1 inhibitors as anticancer agents by Semenza, Gregg L.

“…Hypoxia-inducible factor 1 (HIF-1) regulates the transcription of many genes involved in key aspects of cancer biology, including immortalization, maintenance…”
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HIF-1 and mechanisms of hypoxia sensing by Semenza, Gregg L

“…Hypoxia-inducible factor 1 (HIF-1) is an oxygen-regulated transcriptional activator that plays essential roles in mammalian development, physiology and disease…”
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HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs by Zhang, H, Wong, C C L, Wei, H, Gilkes, D M, Korangath, P, Chaturvedi, P, Schito, L, Chen, J, Krishnamachary, B, Winnard, Jr, P T, Raman, V, Zhen, L, Mitzner, W A, Sukumar, S, Semenza, G L

“…Most cases of breast cancer (BrCa) mortality are due to vascular metastasis. BrCa cells must intravasate through endothelial cells (ECs) to enter a blood…”
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HIF-1 and human disease: one highly involved factor by Semenza, G L

“…Vascular endothelial growth factor (VEGF) plays an essential role in angiogenesis. The regulation of VEGF expression illustrates how reduced O sub(2)…”
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REGULATION OF MAMMALIAN O2 HOMEOSTASIS BY HYPOXIA-INDUCIBLE FACTOR 1 by Semenza, Gregg L

“…Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic-helix-loop-helix-PAS transcription factor consisting of HIF-1α and HIF-1β subunits. HIF-1α…”
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HIF-1: mediator of physiological and pathophysiological responses to hypoxia by Semenza, Gregg L

“…Institute of Genetic Medicine, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-3914 All…”
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Retraction Note: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs by Zhang, H., Wong, C. C. L., Wei, H., Gilkes, D. M., Korangath, P., Chaturvedi, P., Schito, L., Chen, J., Krishnamachary, B., Winnard, P. T., Raman, V., Zhen, L., Mitzner, W. A., Sukumar, S., Semenza, G. L.

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FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity by Mahon, Patrick C., Hirota, Kiichi, Semenza, Gregg L.

“…Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls angiogenesis, erythropoiesis, and glycolysis via transcriptional…”
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Expression of hypoxia-inducible factor 1: mechanisms and consequences by Semenza, Gregg L

“…Hypoxia-inducible factor 1 (HIF-1) is a basic-helix-loop-helix transcription factor that plays essential roles in mammalian development and physiology. HIF-1…”
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Correction: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs by Zhang, H., Wong, C. C. L., Wei, H., Gilkes, D. M., Korangath, P., Chaturvedi, P., Schito, L., Chen, J., Krishnamachary, B., Winnard, P. T., Raman, V., Zhen, L., Mitzner, W. A., Sukumar, S., Semenza, G. L.

“…A Correction to this paper has been published: https://doi.org/10.1038/s41388-020-01618-z…”
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Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells : Implications for tumor angiogenesis and therapeutics by HUA ZHONG, CHILES, K, FELDSER, D, LAUGHNER, E, HANRAHAN, C, GEORGESCU, M.-M, SIMONS, J. W, SEMENZA, G. L

“…Dysregulated signal transduction from receptor tyrosine kinases to phosphatidylinositol 3-kinase (PI3K), AKT (protein kinase B), and its effector…”
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Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1) by Greijer, AE, van der Groep, P, Kemming, D, Shvarts, A, Semenza, GL, Meijer, GA, van de Wiel, MA, Belien, JAM, van Diest, PJ, van der Wall, E

“…The hypoxia‐inducible factor 1 (HIF‐1) plays a critical role in cellular responses to hypoxia. The aim of the present study was to evaluate which genes are…”
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Oxygen sensing in the body by Lahiri, S., Roy, A., Baby, S.M., Hoshi, T., Semenza, G.L., Prabhakar, N.R.

“…This review is divided into three parts: (a) The primary site of oxygen sensing is the carotid body which instantaneously respond to hypoxia without involving…”
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SAG ROC2 RBX2 is a HIF-1 target gene that promotes HIF-1α ubiquitination and degradation by Tan, M, Gu, Q, He, H, Pamarthy, D, Semenza, G L, Sun, Y

“…SAG (sensitive to apoptosis gene) or ROC2/RBX2 is the second family member of ROC1/RBX1, a component of SCF (Skp1, Cullin, F-box protein) and VCB (von…”
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HIF-1: using two hands to flip the angiogenic switch by Semenza, G L

“…In brain, breast, and other common human tumors there is a correlation between expression of the transcriptional activator hypoxia-inducible factor 1 (HIF-1)…”
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