Search Results - "SEMENCHENKO, Anna V"

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice by Anisimov, Vladimir N., Zabezhinski, Mark A., Popovich, Irina G., Piskunova, Tatiana S., Semenchenko, Anna V., Tyndyk, Margarita L., Yurova, Maria N., Rosenfeld, Svetlana V., Blagosklonny, Mikhail V

“…The nutrient-sensing TO R (target of rapamycin) pathway is involved in cellular and organismal aging. Rapamycin, an inhibitor of TO R, extends lifespan in…”
Get full text

Metformin slows down aging and extends life span of female SHR mice by Anisimov, Vladimir N., Berstein, Lev M., Egormin, Peter A., Piskunova, Tatiana S., Popovich, Irina G., Zabezhinski, Mark A., Tyndyk, Margarita L., Yurova, Maria V., Kovalenko, Irina G., Poroshina, Tatiana E., Semenchenko, Anna V.

“…Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer. It…”
Get full text

If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice by Anisimov, Vladimir N, Berstein, Lev M, Popovich, Irina G, Zabezhinski, Mark A, Egormin, Peter A, Piskunova, Tatiana S, Semenchenko, Anna V, Tyndyk, Margarita L, Yurova, Maria N, Kovalenko, Irina G, Poroshina, Tatiana E

“…Hyperglycemia and hyperinsulinemia accelerate both aging and cancer. Antidiabetic biguanides such as metformin decrease glucose, insulin and IGF-1 level…”
Get full text

Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice by Anisimov, Vladimir N., Berstein, Lev M., Egormin, Peter A., Piskunova, Tatiana S., Popovich, Irina G., Zabezhinski, Mark A., Kovalenko, Irina G., Poroshina, Tatiana E., Semenchenko, Anna V., Provinciali, Mauro, Re, Francesca, Franceschi, Claudio

“…Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer…”
Get full text

Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice by Anisimov, Vladimir N, Zabezhinski, Mark A, Popovich, Irina G, Piskunova, Tatiana S, Semenchenko, Anna V, Tyndyk, Margarita L, Yurova, Maria N, Antoch, Marina P, Blagosklonny, Mikhail V

“…Aging is associated with obesity and cancer. Calorie restriction both slows down aging and delays cancer. Evidence has emerged that the nutrient-sensing…”
Get full text

Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin by Popovich, Irina G, Anisimov, Vladimir N, Zabezhinski, Mark A, Semenchenko, Anna V, Tyndyk, Margarita L, Yurova, Maria N, Blagosklonny, Mikhail V

“…Target of Rapamycin (TOR) is involved in cellular and organismal aging. Rapamycin extends lifespan and delays cancer in mice. It is important to determine the…”
Get full text

Sex differences in aging, life span and spontaneous tumorigenesis in 129/Sv mice neonatally exposed to metformin by Anisimov, Vladimir N, Popovich, Irina G, Zabezhinski, Mark A, Egormin, Peter A, Yurova, Maria N, Semenchenko, Anna V, Tyndyk, Margarita L, Panchenko, Andrey V, Trashkov, Alexandr P, Vasiliev, Andrey G, Khaitsev, Nikolai V

“…The perinatal (prenatal and early neonatal) period is a critical stage for hypothalamic programming of sexual differentiation as well as for the development of…”
Get full text

Central and Peripheral Effects of Insulin/IGF-1 Signaling in Aging and Cancer: Antidiabetic Drugs as Geroprotectors and Anticarcinogens by ANISIMOV, VLADIMIR N., BERSTEIN, LEV M., POPOVICH, IRINA G., ZABEZHINSKI, MARK A., EGORMIN, PETER A., TYNDYK, MARGARITA L., ANIKIN, IVAN V., SEMENCHENKO, ANNA V., YASHIN, ANATOLI I.

“…Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer…”
Get full text

Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice by Anisimov, Vladimir N, Piskunova, Tatiana S, Popovich, Irina G, Zabezhinski, Mark A, Tyndyk, Margarita L, Egormin, Peter A, Yurova, Maria V, Rosenfeld, Svetlana V, Semenchenko, Anna V, Kovalenko, Irina G, Poroshina, Tatiana E, Berstein, Lev M

“…Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer. It…”
Get full text

Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats by Vinogradova, Irina A, Anisimov, Vladimir N, Bukalev, Andrey V, Semenchenko, Anna V, Zabezhinski, Mark A

“…We evaluated the effect of various light/dark regimens on the survival, life span and tumorigenesis in rats. Two hundred eight male and 203 females LIO rats…”
Get full text

Exposure to light at night accelerates aging and spontaneous uterine carcinogenesis in female 129/Sv mice by Popovich, Irina G., Zabezhinski, Mark A., Panchenko, Andrei V., Piskunova, Tatiana S., Semenchenko, Anna V., Tyndyk, Maragriata L., Yurova, Maria N., Anisimov, Vladimir N.

“…The effect of the constant illumination on the development of spontaneous tumors in female 129/Sv mice was investigated. Forty-six female 129/Sv mice starting…”
Get full text

Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in young but not in old rats by Vinogradova, Irina A, Anisimov, Vladimir N, Bukalev, Andrey V, Ilyukha, Viktor A, Khizhkin, Evgeniy A, Lotosh, Tatiana A, Semenchenko, Anna V, Zabezhinski, Mark A

“…We evaluated the effect of exposure to constant light started at the age of 1 month and at the age of 14 months on the survival, life span, tumorigenesis and…”
Get full text

Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice by Piskunova, Tatiana S., Yurova, Maria N., Ovsyannikov, Anton I., Semenchenko, Anna V., Zabezhinski, Mark A., Popovich, Irina G., Wang, Zhao-Qi, Anisimov, Vladimir N.

“…Genetic and biochemical studies have shown that PARP-1 and poly(ADP-ribosyl)ation play an important role in DNA repair, genomic stability, cell death,…”
Get full text

Effect of exposure to light‐at‐night on life span and spontaneous carcinogenesis in female CBA mice by Anisimov, Vladimir N., Baturin, Dmitri A., Popovich, Irina G., Zabezhinski, Mark A., Manton, Kenneth G., Semenchenko, Anna V., Yashin, Anatoly I.

“…The effect of constant illumination on the development of spontaneous tumors in female CBA mice was investigated. Fifty female CBA mice starting from the age…”
Get full text

Insulin and longevity: antidiabetic biguanides as geroprotectors by Anisimov, Vladimir N, Semenchenko, Anna V, Yashin, Anatoli I

“…The results of previous experimental studies of effects of antidiabetic biguanides (phenformin and buformin) on life span and spontaneous tumor incidence in…”
Get full text

The effect of melatonin treatment regimen on mammary adenocarcinoma development in HER‐2/neu transgenic mice by Anisimov, Vladimir N., Alimova, Irina N., Baturin, Dmitri A., Popovich, Irina G., Zabezhinski, Mark A., Manton, Kenneth G., Semenchenko, Anna V., Yashin, Anatoly I.

“…The effect of various regimens of treatment with melatonin on the development of mammary tumors in HER2/neu transgenic mice was investigated. Female HER‐2/neu…”
Get full text

Rodent models for the preclinical evaluation of drugs suitable for pharmacological intervention in aging by Anisimov, Vladimir N, Zabezhinski, Mark A, Popovich, Irina G, Pliss, Gennady B, Bespalov, Vladimir G, Alexandrov, Valeri A, Stukov, Alexander N, Anikin, Ivan V, Alimova, Irina N, Egormin, Peter А, Panchenko, Andrey V, Piskunova, Tatiana S, Semenchenko, Anna V, Tyndyk, Margarita L, Yurova, Maria N

“…There is a growing scientific and public interest in the development of new antiaging drugs for the purposes of extending mean and/or maximum life span,…”
Get more information

Dose-dependent effect of melatonin on life span and spontaneous tumor incidence in female SHR mice by Anisimov, Vladimir N, Alimova, Irina N, Baturin, Dmitri A, Popovich, Irina G, Zabezhinski, Mark A, Rosenfeld, Svetlana V, Manton, Kenneth G, Semenchenko, Anna V, Yashin, Anatoli I

“…From the age of 3 months until their natural death, female Swiss-derived SHR mice were given melatonin with their drinking water (2 or 20 mg/l) for 5…”
Get full text

Insulin in aging and cancer: antidiabetic drug diabenol as geroprotector and anticarcinogen by Popovich, Irina G., Zabezhinski, Mark A., Egormin, Peter A., Tyndyk, Margarita L., Anikin, Ivan V., Spasov, Alexander A., Semenchenko, Anna V., Yashin, Anatoly I., Anisimov, Vladimir N.

“…The effects of new antidiabetic drug Diabenol ® (9-β-diethylaminoethyl-2,3-dihydroimidazo-(1,2-α)benzimidazol dihydrochloride) on life span and spontaneous…”
Get full text

Effect of delta-sleep inducing peptide-containing preparation Deltaran on biomarkers of aging, life span and spontaneous tumor incidence in female SHR mice by Popovich, Irina G., Voitenkov, Boris O., Anisimov, Vladimir N., Ivanov, Vadim T., Mikhaleva, Inessa I., Zabezhinski, Mark A., Alimova, Irina N., Baturin, Dmitri A., Zavarzina, Natalia Yu, Rosenfeld, Svetlana V., Semenchenko, Anna V., Yashin, Anatoli I.

“…From the age of 3 months until their natural deaths, female Swiss-derived SHR mice were subcutaneously injected 5 consecutive days every month with 0.1 ml of…”
Get full text