Search Results - "SELZER, P"

Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties by Ertl, Peter, Rohde, Bernhard, Selzer, Paul

“…Molecular polar surface area (PSA), i.e., surface belonging to polar atoms, is a descriptor that was shown to correlate well with passive molecular transport…”
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A combined bioinformatics and chemoinformatics approach for the development of new antiparasitic drugs by Krasky, A., Rohwer, A., Schroeder, J., Selzer, P.M.

“…A modern concept for the development of novel antiparasitic drugs is the combination of bioinformatics and chemoinformatics approaches. This covers, for…”
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A compendium of antibiotic-induced transcription profiles reveals broad regulation of Pasteurella multocida virulence genes by Melnikow, E., Schoenfeld, C., Spehr, V., Warrass, R., Gunkel, N., Duszenko, M., Selzer, P.M., Ullrich, H.J.

“…The transcriptional responses of Pasteurella multocida to eight antibiotics with known mode of actions (MoAs) and one novel antibiotic compound with an unknown…”
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A hidden beneficial: biology of the tick-wasp Ixodiphagus hookeri in Germany by Collatz, J., Selzer, P., Fuhrmann, A., Oehme, R. M., Mackenstedt, U., Kahl, O., Steidle, J. L. M.

“…The parasitic wasp Ixodiphagus hookeri parasitizes hard ticks and is therefore considered as a potential candidate for biological control of ticks. However,…”
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The ecology of ticks, tick-borne diseases and biological tick control in Baden-Württemberg by Sebastian, P, Mackenstedt, U, Wassermann, M, Wurst, E, Hartelt, K, Petney, T, Pfäffle, M, Littwin, N, Steidle, J L M, Selzer, P, Norra, S, Böhnke, D, Gebhardt, R, Kahl, O, Dautel, H, Oehme, R

“…Ticks and tick-borne diseases are of great significance for the health of humans and animals. However, the factors influencing their distribution and dynamics…”
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Antibiotic resistance patterns of enterococci isolated from estuarine waters by Baldini, M, Selzer, P

“…The introduction of antibiotic-resistant bacteria to the environment, affects its hygienic-sanitary quality. The objective of this work is to study the…”
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Virtual screening by high-throughput docking using hydrogen bonding constraints for targeting a protein-protein interface in M. tuberculosis by Koch, Oliver, Jäger, T, Flohé, L, Selzer, PM

“…Doc number: P24…”
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Web-based cheminformatics and molecular property prediction tools supporting drug design and development at Novartis by Ertl, P., Mühlbacher, J., Rohde, B., Selzer, P.

“…Web-based tools offer many advantages for processing chemical information, most notably ease of use and high interactivity. Therefore more and more…”
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Cysteine Protease Inhibitors as Chemotherapy: Lessons from a Parasite Target by Selzer, P M, Pingel, S, Hsieh, I, Ugele, B, Chan, V J, Engel, J C, Bogyo, M, Russell, D G, Sakanari, J A, McKerrow, J H

“…Papain family cysteine proteases are key factors in the pathogenesis of cancer invasion, arthritis, osteoporosis, and microbial infections. Targeting this…”
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Femoral capital osteonecrosis: MR finding of diffuse marrow abnormalities without focal lesions by Turner, D A, Templeton, A C, Selzer, P M, Rosenberg, A G, Petasnick, J P

“…Six painful hips in five patients were examined with magnetic resonance (MR) imaging and were found to have diffuse signal abnormalities in the marrow of the…”
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Ökologie von Zecken als Überträger von Krankheitserregern in Baden-Württemberg und biologische Zeckenbekämpfung by Sebastian, P., Mackenstedt, U., Wassermann, M., Wurst, E., Hartelt, K., Petney, T., Pfäffle, M., Littwin, N., Steidle, J.L.M., Selzer, P., Norra, S., Böhnke, D., Gebhardt, R., Kahl, O., Dautel, H., Oehme, R.

“…Zusammenfassung Zecken und von Zecken übertragene Krankheitserreger sind von großer Bedeutung für die Gesundheit von Mensch und Tier. Über die Faktoren, die…”
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Dissection of the external iliac artery in highly trained athletes by Cook, Philip S., Erdoes, Luke S., Selzer, Peter M., Rivera, Frank J., Palmaz, Julio C.

“…We report a series of four acute external iliac artery dissections occurring in three patients within days of completion of ultraendurance athletic events…”
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Target-based drug discovery for the development of novel antiinfectives by Selzer, Paul M., Brutsche, Sandra, Wiesner, Petra, Schmid, Peter, Müllner, Hubert

“…In the 20 th century and especially during the last 50 years, antiinfectives have been increasingly used to control and prevent infectious diseases…”
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Patrones de resistencia a antibióticos de enterococos aislados de aguas estuarinas by M. BALDINI, P. SELZER

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Structure-based design, synthesis and evaluation of conformationally constrained cysteine protease inhibitors by Scheidt, Karl A., Roush, William R., McKerrow, James H., Selzer, Paul M., Hansell, Elizabeth, Rosenthal, Philip J.

“…The inhibition of cysteine proteases is being studied as a strategy to combat parasitic diseases such as Chagas' disease, leishmaniasis, and malaria. Cruzain…”
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Eimeria tenella: Identification of secretory and surface proteins from expressed sequence tags by Klotz, Christian, Marhöfer, Richard J., Selzer, Paul M., Lucius, Richard, Pogonka, Thomas

“…To identify new vaccine candidates, Eimeria tenella expressed sequence tags (ESTs) from public databases were analysed for secretory molecules with an…”
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Structure-based design of parasitic protease inhibitors by Li, Rongshi, Chen, Xiaowu, Gong, Baoqing, Selzer, Paul M., Li, Zhe, Davidson, Eugene, Kurzban, Gary, Miller, Robert E., Nuzum, Edwin O., McKerrow, James H., Fletterick, Robert J., Gillmor, Sarah A., Craik, Charles S., Kuntz, Irwin D., Cohen, Fred E., Kenyon, George L.

“…To streamline the preclinical phase of pharmaceutical development, we have explored the utility of structural data on the molecular target and synergy between…”
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The second largest subunit of Trypanosoma brucei’s multifunctional RNA polymerase I has a unique N-terminal extension domain by Schimanski, Bernd, Klumpp, Birgit, Laufer, Gabriele, Marhöfer, Richard J., Selzer, Paul M., Günzl, Arthur

“…In the protist parasite Trypanosoma brucei, RNA polymerase (pol) I transcribes the large ribosomal RNA gene unit and, in addition, variant surface glycoprotein…”
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Decision support systems for chemical structure representation, reaction modeling, and spectra simulation by Gasteiger, J., Bauerschmidt, S., Burkard, U., Hemmer, M.C., Herwig, A., von Homeyer, A., Höllering, R., Kleinöder, T., Kostka, T., Schwab, C., Selzer, P., Steinhauer, L.

“…The choice of an appropriate structure coding scheme is the secret to success in QSAR studies. Depending on the problem at hand, 2D or 3D descriptors have to…”
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Characterisation of Tc-cpl-1, a cathepsin L-like cysteine protease from Toxocara canis infective larvae by Loukas, Alex, Selzer, Paul M, Maizels, Rick M

“…Cysteine proteases play vital biological roles in both intracellular and extracellular environments. A cysteine protease migrating at 30 kDa was identified in…”
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