Search Results - "SELLMAN, Bret"

Antibacterial monoclonal antibodies: the next generation? by DiGiandomenico, Antonio, Sellman, Bret R

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Moving toward endotypes in atopic dermatitis: Identification of patient clusters based on serum biomarker analysis by Thijs, Judith L., MD, Strickland, Ian, PhD, Bruijnzeel-Koomen, Carla A.F.M., MD, PhD, Nierkens, Stefan, PhD, Giovannone, Barbara, PhD, Csomor, Eszter, PhD, Sellman, Bret R., PhD, Mustelin, Tomas, MD, PhD, Sleeman, Matthew A., PhD, de Bruin-Weller, Marjolein S., MD, PhD, Herath, Athula, PhD, Drylewicz, Julia, PhD, May, Richard D., PhD, Hijnen, DirkJan, MD, PhD

“…Background Atopic dermatitis (AD) is a complex, chronic, inflammatory skin disease with a diverse clinical presentation. However, it is unclear whether this…”
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Microbial burden and viral exacerbations in a longitudinal multicenter COPD cohort by Bouquet, Jerome, Tabor, David E, Silver, Jonathan S, Nair, Varsha, Tovchigrechko, Andrey, Griffin, M Pamela, Esser, Mark T, Sellman, Bret R, Jin, Hong

“…Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by frequent exacerbation phenotypes independent of disease stage…”
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Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source by Boland, Michelle L, Oró, Denise, Tølbøl, Kirstine S, Thrane, Sebastian T, Nielsen, Jens Christian, Cohen, Taylor S, Tabor, David E, Fernandes, Fiona, Tovchigrechko, Andrey, Veidal, Sanne S, Warrener, Paul, Sellman, Bret R, Jelsing, Jacob, Feigh, Michael, Vrang, Niels, Trevaskis, James L, Hansen, Henrik H

“…The trans-fat containing AMLN (amylin liver non-alcoholic steatohepatitis, NASH) diet has been extensively validated in C57BL/6J mice with or without the Lep…”
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Differential expression and roles of Staphylococcus aureus virulence determinants during colonization and disease by Jenkins, Amy, Diep, Binh An, Mai, Thuy T, Vo, Nhung H, Warrener, Paul, Suzich, Joann, Stover, C Kendall, Sellman, Bret R

“…Staphylococcus aureus is a Gram-positive, commensal bacterium known to asymptomatically colonize the human skin, nares, and gastrointestinal tract. Colonized…”
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Bispecific antibody targets multiple Pseudomonas aeruginosa evasion mechanisms in the lung vasculature by Thanabalasuriar, Ajitha, Surewaard, Bas Gj, Willson, Michelle E, Neupane, Arpan S, Stover, Charles K, Warrener, Paul, Wilson, George, Keller, Ashley E, Sellman, Bret R, DiGiandomenico, Antonio, Kubes, Paul

“…Pseudomonas aeruginosa is a major cause of severe infections that lead to bacteremia and high patient mortality. P. aeruginosa has evolved numerous evasion and…”
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α-Toxin Induces Platelet Aggregation and Liver Injury during Staphylococcus aureus Sepsis by Surewaard, Bas G.J., Thanabalasuriar, Ajitha, Zeng, Zhutian, Tkaczyk, Christine, Cohen, Taylor S., Bardoel, Bart W., Jorch, Selina K., Deppermann, Carsten, Bubeck Wardenburg, Juliane, Davis, Rachelle P., Jenne, Craig N., Stover, Kendall C., Sellman, Bret R., Kubes, Paul

“…During sepsis, small blood vessels can become occluded by large platelet aggregates of poorly understood etiology. During Staphylococcal aureus infection,…”
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Alpha-Toxin Contributes to Biofilm Formation among Staphylococcus aureus Wound Isolates by Anderson, Michele J, Schaaf, Emily, Breshears, Laura M, Wallis, Heidi W, Johnson, James R, Tkaczyk, Christine, Sellman, Bret R, Sun, Jisun, Peterson, Marnie L

“…Biofilms complicate treatment of (SA) wound infections. Previously, we determined alpha-toxin (AT)-promoted SA biofilm formation on mucosal tissue. Therefore,…”
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A multifunctional bispecific antibody protects against Pseudomonas aeruginosa by DiGiandomenico, Antonio, Keller, Ashley E, Gao, Cuihua, Rainey, Godfrey J, Warrener, Paul, Camara, Mareia M, Bonnell, Jessica, Fleming, Ryan, Bezabeh, Binyam, Dimasi, Nazzareno, Sellman, Bret R, Hilliard, Jamese, Guenther, Caitlin M, Datta, Vivekananda, Zhao, Wei, Gao, Changshou, Yu, Xiang-Qing, Suzich, JoAnn A, Stover, C Kendall

“…Widespread drug resistance due to empiric use of broad-spectrum antibiotics has stimulated development of bacteria-specific strategies for prophylaxis and…”
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A fungal metabolic regulator underlies infectious synergism during Candida albicans-Staphylococcus aureus intra-abdominal co-infection by Paul, Saikat, Todd, Olivia A, Eichelberger, Kara R, Tkaczyk, Christine, Sellman, Bret R, Noverr, Mairi C, Cassat, James E, Fidel, Jr, Paul L, Peters, Brian M

“…Candida albicans and Staphylococcus aureus are two commonly associated pathogens that cause nosocomial infections with high morbidity and mortality. Our prior…”
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Staphylococcus aureus alpha toxin suppresses effective innate and adaptive immune responses in a murine dermonecrosis model by Tkaczyk, Christine, Hamilton, Melissa M, Datta, Vivekananda, Yang, Xiang Ping, Hilliard, Jamese J, Stephens, Geoffrey L, Sadowska, Agnieszka, Hua, Lei, O'Day, Terrence, Suzich, JoAnn, Stover, Charles Kendall, Sellman, Bret R

“…An optimal host response against Staphylococcus aureus skin and soft tissue infections (SSTI) is dependent on IL-1β and IL-17 mediated abscess formation. Alpha…”
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Antibiotics and Immunotherapy: Too Much of Anything is Bad by Gopalakrishnan, Vancheswaran, Sellman, Bret R., Cohen, Taylor S., Dennis, Phillip A.

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Candida albicans Augments Staphylococcus aureus Virulence by Engaging the Staphylococcal agr Quorum Sensing System by Todd, Olivia A, Fidel, Jr, Paul L, Harro, Janette M, Hilliard, Jamese J, Tkaczyk, Christine, Sellman, Bret R, Noverr, Mairi C, Peters, Brian M

“…and are among the most prevalent nosocomial pathogens that are responsible for severe morbidity and mortality, even with appropriate treatment. Using a murine…”
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Mechanisms of Neutralization of a Human Anti-α-toxin Antibody by Oganesyan, Vaheh, Peng, Li, Damschroder, Melissa M., Cheng, Li, Sadowska, Agnieszka, Tkaczyk, Christine, Sellman, Bret R., Wu, Herren, Dall'Acqua, William F.

“…MEDI4893 is a neutralizing human monoclonal antibody that targets α-toxin (AT) and is currently undergoing evaluation in the field of Staphylococcus…”
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S. aureus Evades Macrophage Killing through NLRP3-Dependent Effects on Mitochondrial Trafficking by Cohen, Taylor S., Boland, Michelle L., Boland, Brandon B., Takahashi, Virginia, Tovchigrechko, Andrey, Lee, Young, Wilde, Aimee D., Mazaitis, Mark J., Jones-Nelson, Omari, Tkaczyk, Christine, Raja, Rajiv, Stover, C. Kendall, Sellman, Bret R.

“…Clinical severity of Staphylococcus aureus respiratory infection correlates with alpha toxin (AT) expression. AT activates the NLRP3 inflammasome; deletion of…”
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A protein-free vaccine stimulates innate immunity and protects against nosocomial pathogens by Yan, Jun, Nielsen, Travis B, Lu, Peggy, Talyansky, Yuli, Slarve, Matt, Reza, Hernan, Novakovic, Boris, Netea, Mihai G, Keller, Ashley E, Warren, Troy, DiGiandomenico, Antonio, Sellman, Bret R, Luna, Brian M, Spellberg, Brad

“…Traditional vaccines are difficult to deploy against the diverse antimicrobial-resistant, nosocomial pathogens that cause health care-associated infections. We…”
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Staphylococcus aureus α toxin potentiates opportunistic bacterial lung infections by Cohen, Taylor S, Hilliard, Jamese J, Jones-Nelson, Omari, Keller, Ashley E, O'Day, Terrence, Tkaczyk, Christine, DiGiandomenico, Antonio, Hamilton, Melissa, Pelletier, Mark, Wang, Qun, Diep, Binh An, Le, Vien T M, Cheng, Lily, Suzich, JoAnn, Stover, C Kendall, Sellman, Bret R

“…Broad-spectrum antibiotic use may adversely affect a patient's beneficial microbiome and fuel cross-species spread of drug resistance. Although alternative…”
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Neutralizing Alpha-Toxin Accelerates Healing of Staphylococcus aureus-Infected Wounds in Nondiabetic and Diabetic Mice by Ortines, Roger V, Liu, Haiyun, Cheng, Lily I, Cohen, Taylor S, Lawlor, Heather, Gami, Abhishek, Wang, Yu, Dillen, Carly A, Archer, Nathan K, Miller, Robert J, Ashbaugh, Alyssa G, Pinsker, Bret L, Marchitto, Mark C, Tkaczyk, Christine, Stover, C Kendall, Sellman, Bret R, Miller, Lloyd S

“…wound infections delay healing and result in invasive complications such as osteomyelitis, especially in the setting of diabetic foot ulcers. In preclinical…”
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Restoring polyamine levels by supplementation of spermidine modulates hepatic immune landscape in murine model of NASH by Szydlowska, Marta, Lasky, Ginger, Oldham, Stephanie, Rivera, Cristian, Ford, Michael, Sellman, Bret R, Rhodes, Christopher J, Cohen, Taylor S

“…To determine if changes in polyamines metabolism occur during non-alcoholic steatohepatitis (NASH) in human patients and mice, as well as to assess systemic…”
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Staphylococcus aureus Alpha-Toxin Is Conserved among Diverse Hospital Respiratory Isolates Collected from a Global Surveillance Study and Is Neutralized by Monoclonal Antibody MEDI4893 by Tabor, David E, Yu, Li, Mok, Hoyin, Tkaczyk, Christine, Sellman, Bret R, Wu, Yuling, Oganesyan, Vaheh, Slidel, Tim, Jafri, Hasan, McCarthy, Michael, Bradford, Patricia, Esser, Mark T

“…Staphylococcus aureus infections lead to an array of illnesses ranging from mild skin infections to serious diseases, such endocarditis, osteomyelitis, and…”
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