Search Results - "SELLERI, Silvia"
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Efficient and Robust NK-Cell Transduction With Baboon Envelope Pseudotyped Lentivector
Published in Frontiers in immunology (16-12-2019)“…NK-cell resistance to transduction is a major technical hurdle for developing NK-cell immunotherapy. By using Baboon envelope pseudotyped lentiviral vectors…”
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2
Thiosemicarbazide-Substituted Coumarins as Selective Inhibitors of the Tumor Associated Human Carbonic Anhydrases IX and XII
Published in Molecules (Basel, Switzerland) (19-07-2022)“…A novel series of thiosemicarbazide-substituted coumarins was synthesized and the inhibitory effects against four physiologically relevant carbonic anhydrase…”
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3
DPA-714, a New Translocator Protein-Specific Ligand: Synthesis, Radiofluorination, and Pharmacologic Characterization
Published in Journal of Nuclear Medicine (01-05-2008)“…The translocator protein (18 kDa) (TSPO), formerly known as the peripheral benzodiazepine receptor, is dramatically upregulated under pathologic conditions…”
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4
Heterologous expression and biochemical characterisation of the recombinant β-carbonic anhydrase (MpaCA) from the warm-blooded vertebrate pathogen malassezia pachydermatis
Published in Journal of enzyme inhibition and medicinal chemistry (01-12-2022)“…Warm-blooded animals may have Malassezia pachydermatis on healthy skin, but changes in the skin microenvironment or host defences induce this opportunistic…”
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5
Rapamycin as an Adjunctive Therapy for NLRC4 Associated Macrophage Activation Syndrome
Published in Frontiers in immunology (24-09-2018)“…Gain of function (GOF) mutations affecting the inflammasome component NLRC4 are known to cause early-onset macrophage activation syndrome (MAS) and neonatal…”
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6
Editorial: Toll-Like Receptors Throughout Life: From Controlling Physiological Processes to Determinants of Disease
Published in Frontiers in cell and developmental biology (04-04-2022)Get full text
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7
Inhibitory Effects of Sulfonamide Derivatives on the β -Carbonic Anhydrase (MpaCA) from Malassezia pachydermatis , a Commensal, Pathogenic Fungus Present in Domestic Animals
Published in International journal of molecular sciences (22-11-2021)“…Fungi are exposed to various environmental variables during their life cycle, including changes in CO concentration. CO has the potential to act as an…”
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8
Carbonic Anhydrase Inhibitors of Different Structures Dilate Pre-Contracted Porcine Retinal Arteries
Published in International journal of molecular sciences (22-01-2019)“…Carbonic anhydrase inhibitors (CAIs), such as dorzolamide (DZA), are used as anti-glaucoma drugs to lower intraocular pressure, but it has been found that some…”
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9
Leveraging interacting signaling pathways to robustly improve the quality and yield of human pluripotent stem cell-derived hepatoblasts and hepatocytes
Published in Stem cell reports (08-03-2022)“…Pluripotent stem cell (PSC)-derived hepatocyte-like cells (HLCs) have shown great potential as an alternative to primary human hepatocytes (PHHs) for in vitro…”
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10
β3-Adrenoreceptor Activity Limits Apigenin Efficacy in Ewing Sarcoma Cells: A Dual Approach to Prevent Cell Survival
Published in International journal of molecular sciences (30-04-2019)“…Ewing Sarcoma (ES) is an aggressive paediatric tumour where oxidative stress and antioxidants play a central role in cancer therapy response. Inhibiting…”
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11
Development of ligands for the peripheral benzodiazepine receptor
Published in Current medicinal chemistry (01-07-2006)“…The peripheral benzodiazepine receptor (PBR) initially characterised as a high affinity binding site for diazepam, is densely distributed in most peripheral…”
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12
Activation of Enteroendocrine Cells via TLRs Induces Hormone, Chemokine, and Defensin Secretion
Published in Journal of Immunology (01-04-2007)“…Enteroendocrine cells are known primarily for their production of hormones that affect digestion, but they might also be implicated in sensing and neutralizing…”
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13
Induction of pro-inflammatory programs in enteroendocrine cells by the Toll-like receptor agonists flagellin and bacterial LPS
Published in International immunology (01-08-2008)“…Enteroendocrine cells are hormone-secreting cells spread along the intestinal epithelium. Their principal function is to promote the digestion of food…”
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14
Human mesenchymal stromal cell-secreted lactate induces M2-macrophage differentiation by metabolic reprogramming
Published in Oncotarget (24-05-2016)Get full text
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15
Therapeutic efficacy of cord blood-derived mesenchymal stromal cells for the prevention of acute graft-versus-host disease in a xenogenic mouse model
Published in Stem cells and development (01-07-2012)“…Human mesenchymal stromal cells (MSCs) have been successfully utilized for the treatment of refractory graft-versus-host disease (GvHD). Despite the large…”
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16
Gene therapy of experimental brain tumors using neural progenitor cells
Published in Nature medicine (01-04-2000)“…Glioblastomas, the most frequent and malignant of primary brain tumors, have a very poor prognosis. Gene therapy of glioblastomas is limited by the short…”
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17
Cross-talk among Toll-like receptors and their ligands
Published in International immunology (01-05-2008)“…Toll-like receptors (TLRs) 4, 5, 7 and 9 belong to a family of proteins that recognize mainly conserved microbial motifs. Though each TLR has a highly specific…”
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18
Conservation of Genetic Alterations in Recurrent Melanoma Supports the Melanoma Stem Cell Hypothesis
Published in Cancer research (Chicago, Ill.) (2008)“…It is generally accepted that human cancers derive from a mutated single cell. However, the genetic steps characterizing various stages of progression remain…”
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19
CMV pp65 and IE-1 T cell epitopes recognized by healthy subjects
Published in Journal of translational medicine (28-03-2007)“…Adoptive immune and vaccine therapies have been used to prevent cytomegalovirus (CMV) disease in recipients of hematopoietic progenitor cell transplants, but…”
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The requirements for CTL-mediated rejection of cancer in humans: NKG2D and its role in the immune responsiveness of melanoma
Published in Clinical cancer research (15-12-2007)Get full text
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