Search Results - "SEIZER, PETER"

Histopathological and Immunological Characteristics of Tachycardia-Induced Cardiomyopathy by Mueller, Karin A.L., MD, Heinzmann, David, MD, Klingel, Karin, MD, Fallier-Becker, Petra, PhD, Kandolf, Reinhard, MD, Kilias, Antonios, MD, Walker-Allgaier, Britta, PhD, Borst, Oliver, MD, Kumbrink, Jörg, PhD, Kirchner, Thomas, MD, Langer, Harald, MD, Geisler, Tobias, MD, Schreieck, Jürgen, MD, Gramlich, Michael, MD, Gawaz, Meinrad, MD, Seizer, Peter, MD

“…Abstract Background Tachycardiomyopathy or tachycardia-induced cardiomyopathy (TCM) has been known for decades as a reversible form of nonischemic…”
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Cyclophilin A and EMMPRIN (CD147) in cardiovascular diseases by Seizer, Peter, Gawaz, Meinrad, May, Andreas E

“…Cyclophilin A (CyPA) is an abundantly expressed intracellular protein. It exerts a variety of functions due to its peptidyl-prolyl cis-trans isomerase (PPIase)…”
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Platelets and matrix metalloproteinases by Seizer, P, May, A E

“…Matrix metalloproteinases (MMPs) and their inhibitors essentially contribute to a variety of pathophysiologies by modulating cell migration, tissue degradation…”
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Platelets: Inflammatory Firebugs of Vascular Walls by May, Andreas E, Seizer, Peter, Gawaz, Meinrad

“…Atherosclerosis is an inflammatory disease. Platelets can “inflame” the vascular wall by various mechanisms and thereby initiate and support the development of…”
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Sex differences in overweight and obese patients undergoing high-power short-duration pulmonary vein isolation for atrial fibrillation: an observational cohort study by Weyand, Sebastian, Adam, Viola, Biehler, Paloma, Hägele, Patricia, Hanger, Simon, Löbig, Stephanie, Pinchuk, Andrei, Ausbuettel, Felix, Waechter, Christian, Seizer, Peter

“…Atrial fibrillation (AF) is the most common heart rhythm disorder worldwide. As treatment methods evolve, optimizing personalized therapy based on patient…”
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Novel anti-bacterial activities of β-defensin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation by Kraemer, Bjoern F, Campbell, Robert A, Schwertz, Hansjörg, Cody, Mark J, Franks, Zechariah, Tolley, Neal D, Kahr, Walter H A, Lindemann, Stephan, Seizer, Peter, Yost, Christian C, Zimmerman, Guy A, Weyrich, Andrew S

“…Human β-defensins (hBD) are antimicrobial peptides that curb microbial activity. Although hBD's are primarily expressed by epithelial cells, we show that human…”
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Extracellular Matrix Metalloproteinase Inducer EMMPRIN (CD147) in Cardiovascular Disease by von Ungern-Sternberg, Saskia N I, Zernecke, Alma, Seizer, Peter

“…The receptor EMMPRIN is involved in the development and progression of cardiovascular diseases and in the pathogenesis of myocardial infarction. There are…”
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The Inflammatory Chemokine CXC Motif Ligand 16 Triggers Platelet Activation and Adhesion Via CXC Motif Receptor 6–Dependent Phosphatidylinositide 3-Kinase/Akt Signaling by Borst, Oliver, Münzer, Patrick, Gatidis, Sergios, Schmidt, Eva-Maria, Schönberger, Tanja, Schmid, Evi, Towhid, Syeda T, Stellos, Konstantinos, Seizer, Peter, May, Andreas E, Lang, Florian, Gawaz, Meinrad

“…RATIONALE:The recently discovered chemokine CXC motif ligand 16 (CXCL16) is highly expressed in atherosclerotic lesions and is a potential pathogenic mediator…”
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Predictors of Mortality in Patients With Biopsy-Proven Viral Myocarditis: 10-Year Outcome Data by Greulich, Simon, Seitz, Andreas, Müller, Karin A L, Grün, Stefan, Ong, Peter, Ebadi, Nawid, Kreisselmeier, Klaus Peter, Seizer, Peter, Bekeredjian, Raffi, Zwadlo, Carolin, Gräni, Christoph, Klingel, Karin, Gawaz, Meinrad, Sechtem, Udo, Mahrholdt, Heiko

“…Background There is scarce data about the long-term mortality as well as the prognostic value of cardiovascular magnetic resonance and late gadolinium…”
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Clinical and histopathological features of patients with systemic sclerosis undergoing endomyocardial biopsy by Mueller, Karin A L, Mueller, Iris I, Eppler, David, Zuern, Christine S, Seizer, Peter, Kramer, Ulrich, Koetter, Ina, Roecken, Martin, Kandolf, Reinhard, Gawaz, Meinrad, Geisler, Tobias, Henes, Joerg C, Klingel, Karin

“…Cardiac involvement in systemic sclerosis (SSc) is associated with a variable phenotype including heart failure, arrhythmias and pulmonary hypertension. The…”
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Elevated Mitral Valve Pressure Gradient Is Predictive of Long-Term Outcome After Percutaneous Edge-to-Edge Mitral Valve Repair in Patients With Degenerative Mitral Regurgitation ( MR ), But Not in Functional MR by Patzelt, Johannes, Zhang, Wenzhong, Sauter, Reinhard, Mezger, Matthias, Nording, Henry, Ulrich, Miriam, Becker, Annika, Patzelt, Tara, Rudolph, Volker, Eitel, Ingo, Saad, Mohammed, Bamberg, Fabian, Schlensak, Christian, Gawaz, Meinrad, Boekstegers, Peter, Schreieck, Juergen, Seizer, Peter, Langer, Harald F

“…Background This study analyzed the effects on long-term outcome of residual mitral regurgitation ( MR ) and mean mitral valve pressure gradient ( MVPG ) after…”
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Extracorporeal life support prior to left ventricular assist device implantation leads to improvement of the patients INTERMACS levels and outcome by Schibilsky, David, Haller, Christoph, Lange, Bruno, Schibilsky, Barbara, Haeberle, Helene, Seizer, Peter, Gawaz, Meinrad, Rosenberger, Peter, Walker, Tobias, Schlensak, Christian

“…The objective of this study was to evaluate the outcome of left ventricular assist device (LVAD) implantation after initial extracorporeal life support (ECLS)…”
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Platelet-Derived Stromal Cell-Derived Factor-1 Regulates Adhesion and Promotes Differentiation of Human CD34+ Cells to Endothelial Progenitor Cells by STELLOS, Konstantinos, LANGER, Harald, SEIZER, Peter, KRAEMER, Bjoern F, SIEGEL-AXEL, Dorothea, MAY, Andreas E, LINDEMANN, Stephan, GAWAZ, Meinrad, DAUB, Karin, SCHOENBERGER, Tanja, GAUSS, Alexandra, GEISLER, Tobias, BIGALKE, Boris, MUELLER, Iris, SCHUMM, Michael, SCHAEFER, Iris

“…Peripheral homing of progenitor cells in areas of diseased organs is critical for tissue regeneration. The chemokine stromal cell-derived factor-1 (SDF-1)…”
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Sympathetic activity-associated periodic repolarization dynamics predict mortality following myocardial infarction by Rizas, Konstantinos D, Nieminen, Tuomo, Barthel, Petra, Zürn, Christine S, Kähönen, Mika, Viik, Jari, Lehtimäki, Terho, Nikus, Kjell, Eick, Christian, Greiner, Tim O, Wendel, Hans P, Seizer, Peter, Schreieck, Jürgen, Gawaz, Meinrad, Schmidt, Georg, Bauer, Axel

“…Enhanced sympathetic activity at the ventricular myocardium can destabilize repolarization, increasing the risk of death. Sympathetic activity is known to…”
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Extracellular Cyclophilin A Activates Platelets Via EMMPRIN (CD147) and PI3K/Akt Signaling, Which Promotes Platelet Adhesion and Thrombus Formation In Vitro and In Vivo by Seizer, Peter, Ungern-Sternberg, Saskia N.I.v, Schönberger, Tanja, Borst, Oliver, Münzer, Patrick, Schmidt, Eva-Maria, Mack, Andreas F, Heinzmann, David, Chatterjee, Madhumita, Langer, Harald, Malešević, Miroslav, Lang, Florian, Gawaz, Meinrad, Fischer, Gunter, May, Andreas E

“…OBJECTIVE—Cyclophilin A (CyPA) is secreted under inflammatory conditions by various cell types. Whereas the important role of intracellular CyPA for platelet…”
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Cyclophilin A Is Not Acetylated at Lysine-82 and Lysine-125 in Resting and Stimulated Platelets by Rosa, Annabelle, Butt, Elke, Hopper, Christopher P, Loroch, Stefan, Bender, Markus, Schulze, Harald, Sickmann, Albert, Vorlova, Sandra, Seizer, Peter, Heinzmann, David, Zernecke, Alma

“…Cyclophilin A (CyPA) is widely expressed by all prokaryotic and eukaryotic cells. Upon activation, CyPA can be released into the extracellular space to engage…”
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Disrupting the EMMPRIN (CD147)–Cyclophilin A Interaction Reduces Infarct Size and Preserves Systolic Function After Myocardial Ischemia and Reperfusion by Seizer, Peter, Ochmann, Carmen, Schönberger, Tanja, Zach, Sebastian, Rose, Melanie, Borst, Oliver, Klingel, Karin, Kandolf, Reinhard, MacDonald, H Robson, Nowak, Romana A, Engelhardt, Stefan, Lang, Florian, Gawaz, Meinrad, May, Andreas E

“…OBJECTIVE—Inflammation and proteolysis crucially contribute to myocardial ischemia and reperfusion injury. The extracellular matrix metalloproteinase inducer…”
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The aged hematopoietic system promotes hippocampal‐dependent cognitive decline by Smith, Lucas K., Verovskaya, Evgenia, Bieri, Gregor, Horowitz, Alana M., von Ungern‐Sternberg, Saskia N. I., Lin, Karin, Seizer, Peter, Passegué, Emmanuelle, Villeda, Saul A.

“…The aged systemic milieu promotes cellular and cognitive impairments in the hippocampus. Here, we report that aging of the hematopoietic system directly…”
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Pivotal Role of Serum- and Glucocorticoid-Inducible Kinase 1 in Vascular Inflammation and Atherogenesis by Borst, Oliver, Schaub, Malte, Walker, Britta, Schmid, Evi, Münzer, Patrick, Voelkl, Jakob, Alesutan, Ioana, Rodríguez, José M, Vogel, Sebastian, Schoenberger, Tanja, Metzger, Katja, Rath, Dominik, Umbach, Anja, Kuhl, Dietmar, Müller, Iris I, Seizer, Peter, Geisler, Tobias, Gawaz, Meinrad, Lang, Florian

“…OBJECTIVE—Atherosclerosis, an inflammatory disease of arterial vessel walls, requires migration and matrix metalloproteinase (MMP)-9–dependent invasion of…”
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Time-Dependent Myocardial Necrosis in Patients With ST-Segment-Elevation Myocardial Infarction Without Angiographic Collateral Flow Visualized by Cardiac Magnetic Resonance Imaging: Results From the Multicenter STEMI-SCAR Project by Greulich, Simon, Mayr, Agnes, Gloekler, Steffen, Seitz, Andreas, Birkmeier, Stefan, Schäufele, Tim, Bekeredjian, Raffi, Zuern, Christine S, Seizer, Peter, Geisler, Tobias, Müller, Karin A L, Krumm, Patrick, Nikolaou, Konstantin, Klug, Gert, Reinstadler, Sebastian, Pamminger, Mathias, Reindl, Martin, Wahl, Andreas, Traupe, Tobias, Seiler, Christian, Metzler, Bernhard, Gawaz, Meinrad, Windecker, Stephan, Mahrholdt, Heiko

“…Background Acute complete occlusion of a coronary artery results in progressive ischemia, moving from the endocardium to the epicardium (ie, wavefront)…”
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