Search Results - "SEILER, S. M"

Development of Potent Thrombin Receptor Antagonist Peptides by Bernatowicz, Michael S, Klimas, Clifford E, Hartl, Karen S, Peluso, Marianne, Allegretto, Nick J, Seiler, Steven M

“…A peptide-based structure−activity study is reported leading to the discovery of novel potent thrombin receptor antagonists. Systematic substitution of…”
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Growth and population size of crayfish in headwater streams: individual- and higher-level consequences of acidification by Seiler, Steven M., Turner, Andrew M.

“…Summary 1. Environmental stress may have indirect positive effects on population size through modification of food‐web interactions, despite having negative…”
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1,2-Benzisothiazol-3-one 1,1-Dioxide Inhibitors of Human Mast Cell Tryptase by Combrink, Keith D, Gülgeze, H. Belgin, Meanwell, Nicholas A, Pearce, Bradley C, Zulan, Pi, Bisacchi, Gregory S, Roberts, Daniel G. M, Stanley, Paul, Seiler, Steven M

“…A library of compounds were prepared by reacting 2-(bromomethyl)-1,2-benzisothiazol-3(2H)-one 1,1-dioxide (5) with commercially available carboxylic acids in…”
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Tuberculin Skin Testing of Physicians at a Midwestern Teaching Hospital: A 6-Year Prospective Study by Warren, David K., Foley, Kristin M., Polish, Louis B., Seiler, Sondra M., Fraser, Victoria J.

“…The epidemiology of tuberculin reactivity among physicians practicing in regions of moderate tuberculosis prevalence is unknown. We prospectively assessed the…”
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Active site-directed synthetic thrombin inhibitors: synthesis, in vitro and in vivo activity profile of BMY 44621 and analogs. An examination of the role of the amino group in the D-Phe-Pro-Arg-H series by Balasubramanian, N, St. Laurent, D. R, Federici, M. E, Meanwell, N. A, Wright, J. J, Schumacher, W. A, Seiler, S. M

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Comparison of thrombin active site and exosite inhibitors and heparin in experimental models of arterial and venous thrombosis and bleeding by Schumacher, W A, Steinbacher, T E, Heran, C L, Seiler, S M, Michel, I M, Ogletree, M L

“…Different pharmacological approaches to thrombin inhibition were compared for their effects on thrombosis and bleeding time in anesthetized rats. Thrombosis…”
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Solid-phase synthesis of benzisothiazolones as serine protease inhibitors by Yu, Kuo-Long, Civiello, Rita, Roberts, Daniel G.M., Seiler, Steven M., Meanwell, Nicholas A.

“…An efficient solid-phase synthesis of benzisothiazolone-1,1-dioxide-based serine protease inhibitors involving alkylation of carboxylic acids with…”
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High Molecular Weight Proteins Purified From Cardiac Junctional Sarcoplasmic Reticulum Vesicles Are Ryanodine-Sensitive Calcium Channels by Rardon, David P, Cefali, Dominic C, Mitchell, Robert D, Seiler, Steven M, Jones, Larry R

“…The cardiac high molecular weight proteins/ryanodine receptors were purified to homogeneity from junctional sarcoplasmic reticulum membranes and shown to…”
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Thrombin receptor activation by thrombin and receptor-derived peptides in platelet and CHRF-288 cell membranes: receptor-stimulated GTPase and evaluation of agonists and partial agonists by Seiler, S M, Peluso, M, Tuttle, J G, Pryor, K, Klimas, C, Matsueda, G R, Bernatowicz, M S

“…Thrombin receptor activation, by thrombin or SFLLR-containing peptides, stimulates GTPase activity in platelet and CHRF-288 membranes. Polyclonal antibodies to…”
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Thrombin receptor antagonists by Seiler, S M

“…Thrombin's proteolytically activated "tethered-ligand" receptor is widely expressed and mediates many of thrombin's actions on cells. Its central role in…”
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Management and Outcome of Tuberculosis in Two St Louis Hospitals, 1988 to 1994 by L'Ecuyer, Paul B., Woeltje, Keith F., Seiler, Sondra M., Fraser, Victoria J.

“…Objective: To describe management and outcome of tuberculosis (TB) and current practices for isolation in two urban hospitals in the Midwest. Design:…”
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Involvement of the "tethered-ligand" receptor in thrombin inhibition of platelet adenylate cyclase by Seiler, S M, Michel, I M, Fenton, 2nd, J W

“…Thrombin is thought to activate platelets through multiple signaling pathways. Recently a new thrombin receptor was identified (Vu et al., Cell 64:1057-1068,…”
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Demonstration of a Na+/H+ exchange activity in purified canine cardiac sarcolemmal vesicles by Seiler, S M, Cragoe, E J, Jones, L R

“…Purified canine cardiac sarcolemmal membrane vesicles exhibit a sodium ion for proton exchange activity (Na+/H+ exchange). Na+/H+ exchange was demonstrated…”
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Multiple pathways of thrombin-induced platelet activation differentiated by desensitization and a thrombin exosite inhibitor by Seiler, S M, Goldenberg, H J, Michel, I M, Hunt, J T, Zavoico, G B

“…Recently a thrombin receptor with a unique mechanism of activation was cloned from a megakaryocyte-like cell line (Vu et al., Cell 64:1057-1068, 1991)…”
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Effect of a novel thrombin active-site inhibitor on arterial and venous thrombosis by Schumacher, W A, Balasubramanian, N, St Laurent, D R, Seiler, S M

“…The effects of a thrombin active-site inhibitor on arterial and venous thrombosis, and thrombin-induced thrombocytopenia were determined in anesthetized rats…”
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Azetidin-2-one derivatives as inhibitors of thrombin by Han, William T., Trehan, Ashok K., Kim Wright, J.J., Federici, Marianne E., Seiler, Steven M., Meanwell, Nicholas A.

“…A series of 3-(3-guanidinopropyl)-azetidin-2-one derivatives was prepared and evaluated as inhibitors of cleavage of synthetic substrates in vitro by the…”
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Structure-activity relationships associated with 3,4,5-triphenyl-1H-pyrazole-1-nonanoic acid, a nonprostanoid prostacyclin mimetic by Meanwell, Nicholas A, Rosenfeld, Michael J, Wright, J. J. Kim, Brassard, Catherine L, Buchanan, John O, Federici, Marianne E, Fleming, J. Stuart, Seiler, Steven M

“…A series of phenylated pyrazoloalkanoic acid derivatives were synthesized and evaluated as inhibitors of ADP-induced human platelet aggregation…”
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Prevalence and Risk Factors for Asymptomatic Clostridium difficile Carriage by Alasmari, Faisal, Seiler, Sondra M., Hink, Tiffany, Burnham, Carey-Ann D., Dubberke, Erik R.

“…Background. Clostridium difficile infection (CDI) incidence has increased dramatically over the last decade. Recent studies suggest that asymptomatic carriers…”
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Antithrombotic activity of BMY-43351, a new imidazoquinoline with enhanced aqueous solubility by Fleming, J S, Buchanan, J O, Seiler, S M, Meanwell, N A

“…BMY-43351 is a new broad-spectrum inhibitor of platelet aggregation with greater aqueous solubility than earlier analogs from the imidazoquinoline series. This…”
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Pharmacology of a potent, new antithrombotic agent, 1,3-dihydro-7,8-dimethyl-2H-imidazo[4,5-b]quinolin-2-one (BMY-20844) by Buchanan, J O, Fleming, J S, Cornish, B T, Baryla, U M, Gillespie, E, Stanton, H C, Seiler, S M, Keely, S L

“…The effects of 1,3-dihydro-7,8-dimethyl-2H-imidazo[4,5-b]quinolin-2-one (BMY-20844) on platelet function and experimental thrombosis were evaluated in a series…”
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