Search Results - "SEHGAL, P. B"

Repression of the Interleukin 6 Gene Promoter by p53 and the Retinoblastoma Susceptibility Gene Product by Santhanam, U, Ray, A, Sehgal, P B

“…The aberrant overexpression of interleukin 6 (IL-6) is implicated as an autocrine mechanism in the enhanced proliferation of the neoplastic cell elements in…”
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Interleukin 6 is Expressed in High Levels in Psoriatic Skin and Stimulates Proliferation of Cultured Human Keratinocytes by Grossman, Rachel M., Krueger, James, Yourish, Debra, Granelli-Piperno, Angela, Murphy, Daniel P., May, Lester T., Kupper, Thomas S., Sehgal, Pravinkumar B., Gottlieb, Alice B.

“…Psoriasis is a common papulosquamous skin disease. The histopathology is characterized by epidermal hyperplasia and inflammation. Recent studies suggest that…”
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Cytokine signaling: STATS in plasma membrane rafts by Sehgal, Pravin B, Guo, Gary G, Shah, Mehul, Kumar, Vinita, Patel, Kirit

“…STAT transcription factors signal from the plasma membrane to the nucleus in response to growth factors and cytokines. We have investigated whether plasma…”
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On the mechanism for efficient repression of the interleukin-6 promoter by glucocorticoids: enhancer, TATA box, and RNA start site (Inr motif) occlusion by RAY, A, LAFORGE, K. S, SEHGAL, P. B

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Amniotic fluid interleukin 6 in preterm labor. Association with infection by ROMERO, R, AVILA, C, SANTHANAM, U, SEHGAL, P. B

“…To evaluate whether IL-6 participates in the host response to intrauterine infection, we studied IL-6 bioactivity and isoforms in amniotic fluid (AF). Two…”
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A Mouse Model for Investigating the Molecular Pathogenesis of Adenovirus Pneumonia by Ginsberg, Harold S., Moldawer, Lyle L., Sehgal, Pravinkumar B., Redington, Miriam, Kilian, Patricia L., Chanock, Robert M., Prince, Gregory A.

“…Intranasal inoculation of type 5 adenovirus (Ad5) produced pneumonia in mice even though the virus did not replicate. To induce the pneumonia, however, a large…”
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Modulation of the human interleukin-6 promoter (IL-6) and transcription factor C/EBP beta (NF-IL6) activity by p53 species by MARGULIES, L, SEHGAL, P. B

“…Constitutive up-regulation of interleukin-6 (IL-6) gene expression is observed in many neoplastic cell lines. The contribution of mutations in p53 to the…”
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A multiple cytokine- and second messenger-responsive element in the enhancer of the human interleukin-6 gene: similarities with c-fos gene regulation by Ray, A, Sassone-Corsi, P, Sehgal, P B

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A cytokine network in human diploid fibroblasts: interactions of beta-interferons, tumor necrosis factor, platelet-derived growth factor, and interleukin-1 by KOHASE, M, MAY, L. T, TAMM, I, VILCEK, J, SEHGAL, P. B

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Interleukin-6 induces increased motility, cell-cell and cell-substrate dyshesion and epithelial-to-mesenchymal transformation in breast cancer cells by Sehgal, P B

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Interleukin 6 decreases cell-cell association and increases motility of ductal breast carcinoma cells by TAMM, I, CARDINALE, I, KRUEGER, J, MURPHY, J. S, MAY, L. T, SEHGAL, P. B

“…Treatment of transformed breast duct epithelial cells with IL-6 produces a unique cellular phenotype characterized by diminished proliferation and increased…”
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Type I IL-1 receptor blockade exacerbates murine listeriosis by Havell, EA, Moldawer, LL, Helfgott, D, Kilian, PL, Sehgal, PB

“…It was found that IL-1 is produced in livers and spleens of mice shortly after the i.v. injection of a sublethal or lethal Listeria monocytogenes inoculum. In…”
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High levels of "complexed" interleukin-6 in human blood by MAY, L. T, VIGUET, H, KENNEY, J. S, IDA, N, ALLISON, A. C, SEHGAL, P. B

“…The biochemical nature of endogenous interleukin-6 (IL-6) as it exists in human serum or plasma was investigated. Serum from a patient following bone marrow…”
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Interleukin 6 in infection and cancer by Sehgal, P B

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Interleukin-6: Molecular Pathophysiology by Sehgal, Pravinkumar B

“…The cytokine interleukin-6 (IL-6) has emerged as a major systemic alarm signal which appears to be produced by essentially every injured tissue. Recent…”
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STAT-signalling through the cytoplasmic compartment:: Consideration of a new paradigm by Sehgal, Pravin B

“…The binding of a large number of cytokines and growth factors to their cognate receptors on the surface of mammalian-cell plasma membrane activates a…”
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Interleukin-6 immunoreactivity in human tumors by Tabibzadeh, SS, Poubouridis, D, May, LT, Sehgal, PB

“…The cytokine, interleukin-6 (IL-6), has emerged as a likely mediator of many of the systemic alterations observed in patients with cancer (fever, increased…”
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Endotoxemia elicits increased circulating beta 2-IFN/IL-6 in man by Fong, Y, Moldawer, LL, Marano, M, Wei, H, Tatter, SB, Clarick, RH, Santhanam, U, Sherris, D, May, LT, Sehgal, PB

“…beta 2-IFN/hepatocyte stimulating factor/IL-6 is a cytokine secreted by monocytes, fibroblasts, and endothelial cells in cell culture that possesses diverse…”
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Antibodies chaperone circulating IL-6. Paradoxical effects of anti-IL-6 "neutralizing" antibodies in vivo by May, LT, Neta, R, Moldawer, LL, Kenney, JS, Patel, K, Sehgal, PB

“…In the baboon or the mouse, a stimulus such as LPS, TNF, or IL-1 typically led to a rapid induction of circulating IL-6, the levels peaked by 2 to 3 h and then…”
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Interleukin-6-type cytokines in vivo: regulated bioavailability by Sehgal, P B

“…Investigators have traditionally thought of the class of inflammation- and injury-associated cytokines in large part as "free" entities in the peripheral…”
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