Search Results - "SEGALL, Jeffrey E"

Tumor cell intravasation by Chiang, Serena P H, Cabrera, Ramon M, Segall, Jeffrey E

“…The process of entering the bloodstream, intravasation, is a necessary step in the development of distant metastases. The focus of this review is on the…”
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Microglial-stimulation of glioma invasion involves the EGFR ligand amphiregulin by Coniglio, Salvatore J, Segall, Jeffrey E

“…High grade glioma is one of the deadliest human cancers with a median survival rate of only one year following diagnosis. The highly motile and invasive nature…”
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Review: Molecular mechanism of microglia stimulated glioblastoma invasion by Coniglio, Salvatore J., Segall, Jeffrey E.

“…Glioblastoma multiforme is one of the deadliest human cancers and is characterized by a high degree of microglia and macrophage infiltration. The role of these…”
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Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling by Coniglio, Salvatore J, Eugenin, Eliseo, Dobrenis, Kostantin, Stanley, E Richard, West, Brian L, Symons, Marc H, Segall, Jeffrey E

“…Glioblastoma multiforme is a deadly cancer for which current treatment options are limited. The ability of glioblastoma tumor cells to infiltrate the…”
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Dormancy signatures and metastasis in estrogen receptor positive and negative breast cancer by Kim, Ryung S, Avivar-Valderas, Alvaro, Estrada, Yeriel, Bragado, Paloma, Sosa, Maria Soledad, Aguirre-Ghiso, Julio A, Segall, Jeffrey E

“…Breast cancers can recur after removal of the primary tumor and treatment to eliminate remaining tumor cells. Recurrence may occur after long periods of time…”
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Intravital imaging of metastatic behavior through a mammary imaging window by Condeelis, John, Segall, Jeffrey E, van Rheenen, Jacco, Kedrin, Dmitriy, Gligorijevic, Bojana, Wyckoff, Jeffrey, Verkhusha, Vladislav V

“…We report a technique to evaluate the same tumor microenvironment over multiple intravital imaging sessions in living mice. We optically marked individual…”
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Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation by Donnelly, Sara K, Cabrera, Ramon, Mao, Serena P H, Christin, John R, Wu, Bin, Guo, Wenjun, Bravo-Cordero, Jose Javier, Condeelis, John S, Segall, Jeffrey E, Hodgson, Louis

“…The initial step of metastasis is the local invasion of tumor cells into the surrounding tissue. Invadopodia are actin-based protrusions that mediate the…”
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Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors by WYCKOFF, Jeffrey B, YARONG WANG, LIN, Elaine Y, LI, Jiu-Feng, GOSWAMI, Sumanta, STANLEY, E. Richard, SEGALL, Jeffrey E, POLLARD, Jeffrey W, CONDEELIS, John

“…Although the presence of macrophages in tumors has been correlated with poor prognosis, until now there was no direct observation of how macrophages are…”
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Mechanisms of Invasion in Head and Neck Cancer by Jimenez, Lizandra, Jayakar, Sangeeta K, Ow, Thomas J, Segall, Jeffrey E

“…The highly invasive properties demonstrated by head and neck squamous cell carcinoma (HNSCC) are often associated with locoregional recurrence and lymph node…”
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Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer by Roussos, Evanthia T, Balsamo, Michele, Alford, Shannon K, Wyckoff, Jeffrey B, Gligorijevic, Bojana, Wang, Yarong, Pozzuto, Maria, Stobezki, Robert, Goswami, Sumanta, Segall, Jeffrey E, Lauffenburger, Douglas A, Bresnick, Anne R, Gertler, Frank B, Condeelis, John S

“…We have shown previously that distinct Mena isoforms are expressed in invasive and migratory tumor cells in vivo and that the invasion isoform (Mena(INV))…”
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Monomeric red fluorescent proteins with a large Stokes shift by Piatkevich, Kiryl D., Hulit, James, Subach, Oksana M., Wu, Bin, Abdulla, Arian, Segall, Jeffrey E., Verkhusha, Vladislav V., Lippincott-Schwartz, Jennifer

“…Two-photon microscopy has advanced fluorescence imaging of cellular processes in living animals. Fluorescent proteins in the blue-green wavelength range are…”
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The great escape: when cancer cells hijack the genes for chemotaxis and motility by Condeelis, John, Singer, Robert H, Segall, Jeffrey E

“…The combined use of the new technologies of multiphoton-based intravital imaging, the chemotaxis-mediated collection of invasive cells, and high sensitivity…”
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Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis by Hernandez, Lorena, Magalhaes, Marco A O, Coniglio, Salvatore J, Condeelis, John S, Segall, Jeffrey E

“…CXCL12-CXCR4 signaling has been shown to play a role in breast cancer progression by enhancing tumor growth, angiogenesis, triggering cancer cell invasion in…”
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Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop by GOSWAMI, Sumanta, SAHAI, Erik, WYCKOFF, Jeffrey B, CAMMER, Michael, COX, Dianne, PIXLEY, Fiona J, STANLEY, E. Richard, SEGALL, Jeffrey E, CONDEELIS, John S

“…Previous studies have shown that macrophages and tumor cells are comigratory in mammary tumors and that these cell types are mutually dependent for invasion…”
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A novel neuregulin - jagged1 paracrine loop in breast cancer transendothelial migration by Cabrera, Ramon M, Mao, Serena P H, Surve, Chinmay R, Condeelis, John S, Segall, Jeffrey E

“…The interaction of breast cancer cells with other cells in the tumor microenvironment plays an important role in metastasis. Invasion and intravasation, two…”
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Wiskott-Aldrich Syndrome Protein Regulates Leukocyte-Dependent Breast Cancer Metastasis by Ishihara, Dan, Dovas, Athanassios, Hernandez, Lorena, Pozzuto, Maria, Wyckoff, Jeffrey, Segall, Jeffrey E., Condeelis, John S., Bresnick, Anne R., Cox, Dianne

“…A paracrine interaction between epidermal growth factor (EGF)-secreting tumor-associated macrophages (TAMs) and colony-stimulating factor 1 (CSF-1)-secreting…”
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Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors by WEIGANG WANG, GOSWAMI, Sumanta, LAPIDUS, Kyle, WELLS, Amber L, WYCKOFF, Jeffrey B, SAHAI, Erik, SINGER, Robert H, SEGALL, Jeffrey E, CONDEELIS, John S

“…We subjected cells collected using an in vivo invasion assay to cDNA microarray analysis to identify the gene expression profile of invasive carcinoma cells in…”
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Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors by WEIGANG WANG, WYCKOFF, Jeffrey B, GOSWAMI, Sumanta, YARONG WANG, SIDANI, Mazen, SEGALL, Jeffrey E, CONDEELIS, John S

“…Correlating tumor cell behavior in vivo with patterns of gene expression has led to new insights into the microenvironment of tumor cells in the primary tumor…”
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Classifying collective cancer cell invasion by Friedl, Peter, Locker, Joseph, Sahai, Erik, Segall, Jeffrey E.

“…Most invasive solid tumours display predominantly collective invasion, in which groups of cells invade the peritumoral stroma while maintaining cell–cell…”
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Loss of amphiregulin reduces myoepithelial cell coverage of mammary ducts and alters breast tumor growth by Mao, Serena P H, Park, Minji, Cabrera, Ramon M, Christin, John R, Karagiannis, George S, Oktay, Maja H, Zaiss, Dietmar M W, Abrams, Scott I, Guo, Wenjun, Condeelis, John S, Kenny, Paraic A, Segall, Jeffrey E

“…Amphiregulin (AREG), a ligand of the epidermal growth factor receptor, is not only essential for proper mammary ductal development, but also associated with…”
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