Search Results - "SEGAL, Brahm H"

The role of neutrophils in host defense and disease by Lehman, Heather K., Segal, Brahm H.

“…Neutrophils, the most abundant circulating leukocyte, are critical for host defense. Granulopoiesis is under the control of transcriptional factors and…”
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NOX2-dependent regulation of inflammation by Singel, Kelly L, Segal, Brahm H

“…NADPH oxidase (NOX) isoforms together have multiple functions that are important for normal physiology and have been implicated in the pathogenesis of a broad…”
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Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America by Patterson, Thomas F, Thompson, 3rd, George R, Denning, David W, Fishman, Jay A, Hadley, Susan, Herbrecht, Raoul, Kontoyiannis, Dimitrios P, Marr, Kieren A, Morrison, Vicki A, Nguyen, M Hong, Segal, Brahm H, Steinbach, William J, Stevens, David A, Walsh, Thomas J, Wingard, John R, Young, Jo-Anne H, Bennett, John E

“…It is important to realize that guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment…”
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Nicotine induces neutrophil extracellular traps by Hosseinzadeh, Ava, Thompson, Paul R., Segal, Brahm H., Urban, Constantin F.

“…Nicotine induces neutrophils to release DNA traps via activation of Akt, but independently of NADPH oxidase. NETs serve to ensnare and kill microbial…”
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Executive Summary: Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America by Patterson, Thomas F, Thompson, 3rd, George R, Denning, David W, Fishman, Jay A, Hadley, Susan, Herbrecht, Raoul, Kontoyiannis, Dimitrios P, Marr, Kieren A, Morrison, Vicki A, Nguyen, M Hong, Segal, Brahm H, Steinbach, William J, Stevens, David A, Walsh, Thomas J, Wingard, John R, Young, Jo-Anne H, Bennett, John E

“…It is important to realize that guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment…”
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T-cell CX3CR1 expression as a dynamic blood-based biomarker of response to immune checkpoint inhibitors by Yamauchi, Takayoshi, Hoki, Toshifumi, Oba, Takaaki, Jain, Vaibhav, Chen, Hongbin, Attwood, Kristopher, Battaglia, Sebastiano, George, Saby, Chatta, Gurkamal, Puzanov, Igor, Morrison, Carl, Odunsi, Kunle, Segal, Brahm H., Dy, Grace K., Ernstoff, Marc S., Ito, Fumito

“…Immune checkpoint inhibitors (ICI) have revolutionized treatment for various cancers; however, durable response is limited to only a subset of patients…”
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Nrf2 Amplifies Oxidative Stress via Induction of Klf9 by Zucker, Shoshanna N., Fink, Emily E., Bagati, Archis, Mannava, Sudha, Bianchi-Smiraglia, Anna, Bogner, Paul N., Wawrzyniak, Joseph A., Foley, Colleen, Leonova, Katerina I., Grimm, Melissa J., Moparthy, Kalyana, Ionov, Yurij, Wang, Jianmin, Liu, Song, Sexton, Sandra, Kandel, Eugene S., Bakin, Andrei V., Zhang, Yuesheng, Kaminski, Naftali, Segal, Brahm H., Nikiforov, Mikhail A.

“…Reactive oxygen species (ROS) activate NF-E2-related transcription factor 2 (Nrf2), a key transcriptional regulator driving antioxidant gene expression and…”
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Identification of myeloid cell subsets in murine lungs using flow cytometry by Zaynagetdinov, Rinat, Sherrill, Taylor P, Kendall, Peggy L, Segal, Brahm H, Weller, Kevin P, Tighe, Robert M, Blackwell, Timothy S

“…Although the antibody-based recognition of cell-surface markers has been widely used for the identification of immune cells, overlap in the expression of…”
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Cancer in primary immunodeficiency diseases: Cancer incidence in the United States Immune Deficiency Network Registry by Mayor, Paul C., MD, Eng, Kevin H., PhD, Singel, Kelly L., BS, Abrams, Scott I., PhD, Odunsi, Kunle, MD PhD, Moysich, Kirsten B., PhD, Fuleihan, Ramsay, MD, Garabedian, Elizabeth, RN, Lugar, Patricia, MD, Ochs, Hans D., MD, Bonilla, Francisco A., MD PhD, Buckley, Rebecca H., MD, Sullivan, Kathleen E., MD PhD, Ballas, Zuhair K., MD, Cunningham-Rundles, Charlotte, MD PhD, Segal, Brahm H., MD

“…Abstract Background We evaluated the overall and site-specific incidence of cancer in subjects with primary immunodeficiency diseases (PIDD) enrolled in the…”
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Mitochondrial DNA released by trauma induces neutrophil extracellular traps by Itagaki, Kiyoshi, Kaczmarek, Elzbieta, Lee, Yen Ting, Tang, I Tien, Isal, Burak, Adibnia, Yashar, Sandler, Nicola, Grimm, Melissa J, Segal, Brahm H, Otterbein, Leo E, Hauser, Carl J

“…Neutrophil extracellular traps (NETs) are critical for anti-bacterial activity of the innate immune system. We have previously shown that mitochondrial…”
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NADPH oxidase promotes neutrophil extracellular trap formation in pulmonary aspergillosis by Röhm, Marc, Grimm, Melissa J, D'Auria, Anthony C, Almyroudis, Nikolaos G, Segal, Brahm H, Urban, Constantin F

“…NADPH oxidase is a crucial enzyme in antimicrobial host defense and in regulating inflammation. Chronic granulomatous disease (CGD) is an inherited disorder of…”
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Mitochondrial hypoxic stress induces widespread RNA editing by APOBEC3G in natural killer cells by Sharma, Shraddha, Wang, Jianmin, Alqassim, Emad, Portwood, Scott, Cortes Gomez, Eduardo, Maguire, Orla, Basse, Per H, Wang, Eunice S, Segal, Brahm H, Baysal, Bora E

“…Protein recoding by RNA editing is required for normal health and evolutionary adaptation. However, de novo induction of RNA editing in response to…”
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Editorial: Neutrophils in Cancer by Segal, Brahm H, Fridlender, Zvi

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Treatment of Aspergillosis: Clinical Practice Guidelines of the Infectious Diseases Society of America by Walsh, Thomas J., Anaissie, Elias J., Denning, David W., Herbrecht, Raoul, Kontoyiannis, Dimitrios P., Marr, Kieren A., Morrison, Vicki A., Segal, Brahm H, Steinbach, William J., Stevens, David A., van Burik, Jo-Anne, Wingard, John R., Patterson, Thomas F.

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Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease by Romani, Luigina, Puccetti, Paolo, Fallarino, Francesca, De Luca, Antonella, Montagnoli, Claudia, D'Angelo, Carmen, Zelante, Teresa, Vacca, Carmine, Bistoni, Francesco, Fioretti, Maria C, Grohmann, Ursula, Segal, Brahm H

“…Half a century ago, chronic granulomatous disease (CGD) was first described as a disease fatally affecting the ability of children to survive infections…”
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Neutrophil interactions with T cells, platelets, endothelial cells, and of course tumor cells by Segal, Brahm H., Giridharan, Thejaswini, Suzuki, Sora, Khan, ANM Nazmul H., Zsiros, Emese, Emmons, Tiffany R., Yaffe, Michael B., Gankema, Angela A. F., Hoogeboom, Mark, Goetschalckx, Ines, Matlung, Hanke L., Kuijpers, Taco W.

“…Summary Neutrophils sense microbes and host inflammatory mediators, and traffic to sites of infection where they direct a broad armamentarium of antimicrobial…”
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Current Approaches to Diagnosis and Treatment of Invasive Aspergillosis by Segal, Brahm H, Walsh, Thomas J

“…Filamentous fungi (moulds) are ubiquitous soil inhabitants whose conidia are inhaled into the respiratory tract, where they may cause life-threatening…”
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LYVE1+ macrophages of murine peritoneal mesothelium promote omentum-independent ovarian tumor growth by Zhang, Nan, Kim, Seung Hyeon, Gainullina, Anastasiia, Erlich, Emma C, Onufer, Emily J, Kim, Jiseon, Czepielewski, Rafael S, Helmink, Beth A, Dominguez, Joseph R, Saunders, Brian T, Ding, Jie, Williams, Jesse W, Jiang, Jean X, Segal, Brahm H, Zinselmeyer, Bernd H, Randolph, Gwendalyn J, Kim, Ki-Wook

“…Two resident macrophage subsets reside in peritoneal fluid. Macrophages also reside within mesothelial membranes lining the peritoneal cavity, but they remain…”
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Regulation of innate immunity by NADPH oxidase by Segal, Brahm H., Grimm, Melissa J., Khan, A. Nazmul H., Han, Wei, Blackwell, Timothy S.

“…NADPH oxidase is a critical regulator of both antimicrobial host defense and inflammation. Activated in nature by microbes and microbial-derived products, the…”
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Impact of ascites volume on clinical outcomes in ovarian cancer: A cohort study by Szender, J. Brian, Emmons, Tiffany, Belliotti, Sarah, Dickson, Danielle, Khan, Aalia, Morrell, Kayla, Khan, A.N.M. Nazmul, Singel, Kelly L, Mayor, Paul C, Moysich, Kirsten B, Odunsi, Kunle, Segal, Brahm H, Eng, Kevin H

“…Abstract Objectives To investigate the impact of ascites volume on ovarian cancer outcomes. Methods Clinicopathologic features of a cohort of patients with…”
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