Search Results - "SEETHARAM, Saraswathy"

Targeting IL-13Rα2-positive cancer with a novel recombinant immunotoxin composed of a single-chain antibody and mutated Pseudomonas exotoxin by Kioi, Mitomu, Seetharam, Saraswathy, Puri, Raj K.

“…We have shown previously that high-affinity receptors for interleukin-13 (IL-13Rα2) are overexpressed on a variety of solid cancer cells, diseased fibroblasts,…”
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Increased cytotoxic activity of Pseudomonas exotoxin and two chimeric toxins ending in KDEL by SARASWATHY SEETHARAM, CHAUDHARY, V. K, FITZGERALD, D, PASTAN, I

“…Pseudomonas exotoxin (PE) is a 66,000 molecular weight protein secreted by Pseudomonas aeruginosa. PE is made up of three domains, and PE40 is a form of PE…”
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Targeting IL-13Ra2-positive cancer with a novel recombinant immunotoxin composed of a single-chain antibody and mutated Pseudomonas exotoxin by Kioi, Mitomu, Seetharam, Saraswathy, Puri, Raj K

“…We have shown previously that high-affinity receptors for interleukin-13 (IL-13Ra2) are overexpressed on a variety of solid cancer cells, diseased fibroblasts,…”
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Multiple Point Mutations in a Shuttle Vector Propagated in Human Cells: Evidence for an Error-Prone DNA Polymerase Activity by Seidman, Michael M., Bredberg, Anders, Seetharam, Saraswathy, Kraemer, Kenneth H.

“…Mutagenesis was studied at the DNA-sequence level in human fibroblast and lymphoid cells by use of a shuttle vector plasmid, pZ189, containing a suppressor…”
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Modulation of ultraviolet light mutational hotspots by cellular stress by Seetharam, S, Seidman, M M

“…Stressful treatments of cells provoke broad, transient, changes in cellular physiology and gene expression. In addition to these effects, DNA-damaging agents…”
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N-linked glycosylation of IL-13R alpha2 is essential for optimal IL-13 inhibitory activity by Kioi, Mitomu, Seetharam, Saraswathy, Puri, Raj K

“…A high-affinity receptor for interleukin (IL)-13 (interleukin-13R alpha 2) is over-expressed in disease-related fibroblasts and neoplastic cells and is…”
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Modulation of an ultraviolet mutational hotspot in a shuttle vector in xeroderma cells by SARASWATHY SEETHARAM, SEIDMAN, M. M

“…Ultraviolet mutagenesis of the shuttle vector plasmid pZ189 in Xeroderma Pigmentosum cells yields a mutational pattern marked by hotspots at photoproduct sites…”
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Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation by GORSKI, D. H, BECKETT, M. A, WEICHSELBAUM, R. R, JASKOWIAK, N. T, CALVIN, D. P, MAUCERI, H. J, SALLOUM, R. M, SEETHARAM, S, KOONS, A, HARI, D. M, KUFE, D. W

“…The family of vascular endothelial growth factor (VEGF) proteins include potent and specific mitogens for vascular endothelial cells that function in the…”
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Targeting IL-13Ralpha2-positive cancer with a novel recombinant immunotoxin composed of a single-chain antibody and mutated Pseudomonas exotoxin by Kioi, Mitomu, Seetharam, Saraswathy, Puri, Raj K

“…We have shown previously that high-affinity receptors for interleukin-13 (IL-13Ralpha2) are overexpressed on a variety of solid cancer cells, diseased…”
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N-linked glycosylation of IL-13R alpha 2 is essential for optimal IL-13 inhibitory activity by Kioi, M, Seetharam, S, Puri, R K

“…A high-affinity receptor for interleukin (IL)-13 (interleukin-13R alpha 2) is over-expressed in disease-related fibroblasts and neoplastic cells and is…”
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Ultraviolet Hypermutablity of a Shuttle Vector Propagated in Xeroderma Pigmentosum Variant Cells by Waters, Haywood L, Seetharam, Saraswathy, Seidman, Michael M, Kraemer, Kenneth H

“…Patients with the variant form of xeroderma pigmentosum (XP) have clinical XP including a high frequency of skin cancer but, in contrast to the other forms of…”
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N‐linked glycosylation of IL‐13R0'2 is essential for optimal IL‐13 inhibitory activity by Kioi, Mitomu, Seetharam, Saraswathy, Puri1, Raj K.

“…A high‐affinity receptor for interleukin (IL)‐13 (interleukin‐13Rα 2) is over‐expressed in disease‐related fibroblasts and neoplastic cells and is involved in…”
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Mutational hotspot variability in an ultraviolet-treated shuttle vector plasmid propagated in xeroderma pigmentosum and normal human lymphoblasts and fibroblasts by Seetharam, S, Kraemer, K H, Waters, H L, Seidman, M M

“…The mutagenesis shuttle vector, pZ189, was treated with ultraviolet (u.v.) radiation in vitro and passed through a DNA repair-deficient lymphoblastoid cell…”
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Protection against tumorigenesis by 3-methylcholanthrene in mice by β-naphthoflavone as a function of inducibility of methylcholanthrene metabolism by ANDERSON, L. M, SARASWATHY SEETHARAM

“…The noncarcinogenic enzyme inducer beta-naphthoflavone (beta-NF) causes an increase in both rate of activation and of detoxification of polycyclic aromatic…”
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N-linked glycosylation of IL-13Rα2 is essential for optimal IL-13 inhibitory activity by Kioi, Mitomu, Seetharam, Saraswathy, Puri, Raj K

“…A high-affinity receptor for interleukin (IL)-13 (interleukin-13Rα 2) is over-expressed in disease-related fibroblasts and neoplastic cells and is involved in…”
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Prolonged treatment with angiostatin reduces metastatic burden during radiation therapy by GORSKI, David H, MAUCERI, Helena J, SALLOUM, Rabih M, HALPERN, Arielle, SEETHARAM, Saraswathy, WEICHSELBAUM, Ralph R

“…Ionizing radiation (IR) and concomitant angiostatin (AS) produce greater than additive local antitumor effects. We examined whether prolonged AS treatment…”
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Combined gene therapy and ionizing radiation is a novel approach to treat human esophageal adenocarcinoma by Gupta, Vinay K, Park, James O, Jaskowiak, Nora T, Mauceri, Helena J, Seetharam, Saraswathy, Weichselbaum, Ralph R, Posner, Mitchell C

“…The ability to infect tumor cells limits the antitumor effects of gene therapy. The addition of radiotherapy to treatment with Ad.Egr.TNF.11D, a…”
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NM-3, an isocoumarin, increases the antitumor effects of radiotherapy without toxicity by SALLOUM, Rabih M, JASKOWIAK, Nora T, POSNER, Mitchell C, HELLMAN, Samuel, KUFE, Donald W, WEICHSELBAUM, Ralph R, MAUCERI, Helena J, SEETHARAM, Saraswathy, BECKETT, Michael A, KOONS, Ann M, HARI, Danielle M, GUPTA, Vinay K, REIMER, Corinne, KALLURI, Raghu

“…We examined the effects of a new antiangiogenic isocoumarin, NM-3, as a radiation modifier in vitro and in vivo. The present studies demonstrate that NM-3 is…”
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Tumor production of angiostatin is enhanced after exposure to TNF‐α by Mauceri, Helena J., Seetharam, Saraswathy, Beckett, Michael A., Lee, John Y., Gupta, Vinay K., Gately, Stephen, Stack, M. Sharon, Brown, Charles K., Swedberg, Kirsten, Kufe, Donald W., Weichselbaum, Ralph R.

“…Infection of tumors with an adenoviral vector expressing a chimeric gene composed of the CArG elements of the Egr‐1 promoter and a cDNA encoding TNF‐α…”
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Ultraviolet mutational spectrum in a shuttle vector propagated in xeroderma pigmentosum lymphoblastoid cells and fibroblasts by Seetharam, S, Kraemer, K H, Waters, H L, Seidman, M M

“…In order to examine possible cell-type specificity in mutagenic events, a shuttle-vector plasmid, pZ189, carrying a bacterial suppressor tRNA marker gene, was…”
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